• 557 Citations
  • 8 h-Index
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Research Output 2010 2019

  • 557 Citations
  • 8 h-Index
  • 11 Article
  • 1 Poster
  • 1 Meeting abstract

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)
420 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
Anti-Inflammatory Agents
Interferon Type I
11 Citations (Scopus)
42 Downloads (Pure)

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In : Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to journalArticle

Open Access
Chronic Disease
Cerebral Small Vessel Diseases
Cerebrovascular Disorders
8 Citations (Scopus)
72 Downloads (Pure)

The beta secretase BACE1 regulates the expression of the insulin receptor in the liver

Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F., 3 Apr 2018, In : Nature Communications. 9, p. 1-14 14 p., 1306.

Research output: Contribution to journalArticle

Open Access
Amyloid Precursor Protein Secretases
Insulin Receptor
30 Citations (Scopus)
165 Downloads (Pure)

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

Research output: Contribution to journalArticle

Open Access

BACE1 activity as a determining factor in atherosclerosis development?

Meakin, P., Hamilton, A., Jalicy, S., Khan, F. & Ashford, M., Jul 2015, In : Atherosclerosis. 241, 1, p. e13 1 p., EAS-0263.

Research output: Contribution to journalArticle

Peptide Hydrolases
Temporal Arteries
Apolipoproteins E
81 Citations (Scopus)
141 Downloads (Pure)
Open Access
NF-E2-Related Factor 2
Unfolded Protein Response
High Fat Diet
Fatty Liver
Insulin Resistance
21 Citations (Scopus)

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J., Feb 2013, In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Messenger RNA
AMP-Activated Protein Kinases
56 Citations (Scopus)
131 Downloads (Pure)

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Meakin, P. J., Harper, A. J., Hamilton, D. L., Gallagher, J., McNeilly, A. D., Burgess, L. A., Vaanholt, L. M., Bannon, K. A., Latcham, J., Hussain, I., Speakman, J. R., Howlett, D. R. & Ashford, M. L. J., 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

Chowdhry, S., Nazmy, M. H., Meakin, P. J., Dinkova-Kostova, A. T., Walsh, S. V., Tsujita, T., Dillon, J. F., Ashford, M. L. J. & Hayes, J. D., 2010, In : Free Radical Biology and Medicine. 48, 2, p. 357-371 15 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

Deldicque, L., Cani, P. D., Philp, A., Raymackers, J-M., Meakin, P. J., Ashford, M. L. J., Delzenne, N. M., Francaux, M. & Baar, K., Nov 2010, In : American Journal of Physiology, Endocrinology and Metabolism. 299, 5, p. E695-E705 11 p.

Research output: Contribution to journalArticle