Lis, Pawel

Dr

  • 288 Citations
  • 8 h-Index
20162019
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Fingerprint Dive into the research topics where Pawel Lis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Phosphorylation Chemical Compounds
Parkinson Disease Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
rab GTP-Binding Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences
Leucine Medicine & Life Sciences
Proteins Chemical Compounds
Guanosine Triphosphate Medicine & Life Sciences

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Research Output 2016 2019

  • 288 Citations
  • 8 h-Index
  • 10 Article
46 Downloads (Pure)

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

Gomez, R. C., Wawro, P., Lis, P., Alessi, D. & Pfeffer, S. R., 2 Dec 2019, In : Journal of Cell Biology. 218, 12, p. 4157-4170 14 p.

Research output: Contribution to journalArticle

Open Access
File
Guanine Nucleotide Dissociation Inhibitors
rab GTP-Binding Proteins
Guanosine Triphosphate
Phosphorylation
Membranes
22 Downloads (Pure)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D., 12 Nov 2019, In : eLife. 8, p. 1-37 37 p., e50416.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Monoester Hydrolases
Phosphorylation
Phosphoprotein Phosphatases
Parkinson Disease
rab GTP-Binding Proteins
21 Citations (Scopus)
247 Downloads (Pure)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Kinases
Parkinson Disease
Phosphotransferases
Antibodies
Proteins
26 Citations (Scopus)
152 Downloads (Pure)

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. & Sammler, E., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 23-44 22 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Leucine
Parkinson Disease
Neutrophils
Phosphotransferases
18 Citations (Scopus)
120 Downloads (Pure)

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Madero-Pérez, J., Fdez, E., Fernández, B., Lara Ordóñez, A. J., Blanca Ramírez, M., Gómez-Suaga, P., Waschbüsch, D., Lobbestael, E., Baekelandt, V., Nairn, A. C., Ruiz-Martínez, J., Aiastui, A., López de Munain, A., Lis, P., Comptdaer, T., Taymans, J-M., Chartier-Harlin, M-C., Beilina, A., Gonnelli, A., Cookson, M. R. & 2 others, Greggio, E. & Hilfiker, S., 23 Jan 2018, In : Molecular Neurodegeneration. 13, 1, p. 1-22 22 p., 3.

Research output: Contribution to journalArticle

Open Access
File
Parkinson Disease
Phosphorylation
Mutation
Centrosome
Phosphotransferases