Lis, Pawel

Dr

  • 231 Citations
  • 8 h-Index
20162018
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Fingerprint Dive into the research topics where Pawel Lis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Phosphorylation Chemical Compounds
Parkinson Disease Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
rab GTP-Binding Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences
Leucine Medicine & Life Sciences
Guanosine Triphosphate Medicine & Life Sciences
Guanine Nucleotide Dissociation Inhibitors Medicine & Life Sciences

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Research Output 2016 2018

  • 231 Citations
  • 8 h-Index
  • 8 Article
18 Citations (Scopus)
196 Downloads (Pure)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Kinases
Parkinson Disease
Phosphotransferases
Antibodies
Proteins
21 Citations (Scopus)
113 Downloads (Pure)

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. & Sammler, E., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 23-44 22 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Leucine
Parkinson Disease
Neutrophils
Phosphotransferases
14 Citations (Scopus)
87 Downloads (Pure)

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Madero-Pérez, J., Fdez, E., Fernández, B., Lara Ordóñez, A. J., Blanca Ramírez, M., Gómez-Suaga, P., Waschbüsch, D., Lobbestael, E., Baekelandt, V., Nairn, A. C., Ruiz-Martínez, J., Aiastui, A., López de Munain, A., Lis, P., Comptdaer, T., Taymans, J-M., Chartier-Harlin, M-C., Beilina, A., Gonnelli, A., Cookson, M. R. & 2 others, Greggio, E. & Hilfiker, S., 23 Jan 2018, In : Molecular Neurodegeneration. 13, 1, p. 1-22 22 p., 3.

Research output: Contribution to journalArticle

Open Access
File
Parkinson Disease
Phosphorylation
Mutation
Centrosome
Phosphotransferases
18 Citations (Scopus)
56 Downloads (Pure)

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human

Mir, R., Tonelli, F., Lis, P., Macartney, T., Polinski, N. K., Martinez, T. N., Chou, M-Y., Howden, A., König, T., Hotzy, C., Milenkovic, I., Brücke, T., Zimprich, A., Sammler, E. & Alessi, D., 6 Jun 2018, In : Biochemical Journal. 475, 11, p. 1861-1883 19 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Parkinson Disease
Mutation
Proteins
Phosphotransferases
34 Citations (Scopus)
108 Downloads (Pure)

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

Purlyte, E., Dhekne, H. S., Sarhan, A. R., Gomez, R., Lis, P., Wightman, M., Martinez, T. N., Tonelli, F., Pfeffer, S. R. & Alessi, D. R., 15 Dec 2017, In : EMBO Journal. 36, 24, p. 3549-3681 18 p., e201798099.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Parkinson Disease
Phosphotransferases
Chemical activation
Biomarkers