Toth, Rachel

Dr

  • Investigator Scientist (MRC), MRC PPU
  • 4017 Citations
  • 34 h-Index
20042020

Research output per year

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Research Output

  • 4017 Citations
  • 34 h-Index
  • 61 Article
  • 1 Chapter
  • 1 Book/Film/Article review
2020
Open Access
File
5 Downloads (Pure)

Allosteric mechanism for site-specific ubiquitination of FANCD2

Chaugule, V. K., Arkinson, C., Rennie, M. L., Kämäräinen, O., Toth, R. & Walden, H., Mar 2020, In : Nature Chemical Biology. 16, p. 291-301 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Characterization of FANCL variants observed in patient cancer cells

Frost, M. G., Mazloumi Aboukheili, A. M., Toth, R. & Walden, H., 4 Jun 2020, In : Bioscience Reports. 40, 6, p. 1-15 15 p., BSR20191304.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

Vieweg, S., Mulholland, K., Brauning, B., Kacharia, N., Lai, Y-C., Toth, R., Singh, P. K., Volpi, I., Sattler, M., Groll, M., Itzen, A. & Muqit, M. M. K., 11 May 2020, In : Biochemical Journal. 477, 9, p. 1651-1668 18 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
21 Downloads (Pure)
2019

Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins

Chaugule, V. K., Arkinson, C., Toth, R. & Walden, H., 2019, Methods in Enzymology. Hochstrasser, M. (ed.). Cambridge, MA: Academic Press Inc., Vol. 618. p. 73-104 32 p. (Methods in Enzymology; vol. 618).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)
2018

Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544]

Jowsey, P., Morrice, N. A., Hastie, C. J., MacLauchlan, H., Toth, R. & Rouse, J., May 2018, In : DNA Repair. 65, p. 80 1 p.

Research output: Contribution to journalArticle

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Andersen, J. L., Gesser, B., Funder, E. D., Nielsen, C. J. F., Gotfred-Rasmussen, H., Rasmussen, M. K., Toth, R., Gothelf, K. V., Arthur, J. S. C., Iversen, L. & Nissen, P., 19 Oct 2018, In : Nature Communications. 9, 1, 9 p., 4344.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
133 Downloads (Pure)

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase

Munoz, I., Morgan, M., Peltier, J., Weiland, F., Gregorczyk, M., Brown, F. C. M., Macartney, T., Toth, R., Trost, M. & Rouse, J., 14 Dec 2018, In : The EMBO Journal. 37, 24, p. 1-19 19 p., e99559.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
213 Downloads (Pure)

RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation

Bustos, F., Segarra Fas, A., Chaugule, V. K., Brandenburg, L., Branigan, E., Toth, R., Macartney, T., Knebel, A., Hay, R., Walden, H. & Findlay, G., 8 May 2018, In : Cell Reports. 23, 6, p. 1599-1611 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
239 Downloads (Pure)

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

Arkinson, C., Chaugule, V. K., Toth, R. & Walden, H., 12 Oct 2018, In : Life Science Alliance. 1, 5, p. 1-15 15 p., e201800162.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
154 Downloads (Pure)
2017
Open Access
File
121 Downloads (Pure)

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Darling, N. J., Toth, R., Arthur, J. S. C. & Clark, K., 3 Feb 2017, In : Biochemical Journal. 474, 4, p. 521-537 17 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
185 Downloads (Pure)

MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins

Hunter, C., Remenyi, J., Corrêa, S. A. L., Privitera, L., Reyskens, K., Martin, K., Toth, R., Frenguelli, B. & Arthur, J., 5 Jun 2017, In : FEBS Open Bio. 7, 6, p. 821-834 14 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
136 Downloads (Pure)

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Kumar, A., Chaugule, V. K., Condos, T. E. C., Barber, K. R., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Shaw, G. S. & Walden, H., May 2017, In : Nature Structural & Molecular Biology. 24, 5, p. 475-483 9 p.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
276 Downloads (Pure)

RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

Feeney, L., Munoz, I. M., Lachaud, C., Toth, R., Appleton, P. L., Schindler, D. & Rouse, J., 1 Jun 2017, In : Molecular Cell. 66, 5, p. 610-621.e4 16 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
183 Downloads (Pure)

The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen

Abdul-Sada, H., Müller, M., Mehta, R., Toth, R., Arthur, J. S. C., Whitehouse, A. & Macdonald, A., 2 Mar 2017, In : Oncotarget. 8, 15, p. 25418-25432 15 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
234 Downloads (Pure)
2016

Erk5 is a key regulator of naïve-­primed transition and Embryonic Stem Cell identity

Williams, C., Fernandez-Alonso, R., Wang, J., Toth, R., Gray, N. S. & Findlay, G., 16 Aug 2016, In : Cell Reports. 16, 7, p. 1820-1828 9 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
170 Downloads (Pure)

Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in fan1 nuclease-defective knock-in mice

Lachaud, C., Slean, M., Marchesi, F., Lock, C., Odell, E., Castor, D., Toth, R. & Rouse, J., 15 Mar 2016, In : Genes and Development. 30, 6, p. 639-644 6 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
199 Downloads (Pure)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
140 Downloads (Pure)

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J. J. & Rouse, J., 19 Feb 2016, In : Science. 351, 6275, p. 846-849 4 p.

Research output: Contribution to journalArticle

Open Access
60 Citations (Scopus)
2015

14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J., 2015, In : Bioinformatics.

Research output: Contribution to journalArticle

Open Access
File
58 Citations (Scopus)
315 Downloads (Pure)

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

Kristariyanto, Y. A., Choi, S-Y., Rehman, S. A. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R. & Kulathu, Y., 15 Apr 2015, In : Biochemical Journal. 467, 2, p. 345-352 8 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
159 Downloads (Pure)

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

Kumar, A., Aguirre, J. D., Condos, T. E. C., Martinez-Torres, R. J., Chaugule, V. K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D. E., Barber, K. R., Shaw, G. S. & Walden, H., 14 Oct 2015, In : EMBO Journal. 34, 20, p. 2506-2521 16 p.

Research output: Contribution to journalArticle

Open Access
File
89 Citations (Scopus)
350 Downloads (Pure)

Fasting and systemic insulin signaling regulate phosphorylation of brain proteins that modulate cell morphology and link to neurological disorders

Li, M., Quan, C., Toth, R., Campbell, D. G., MacKintosh, C., Wang, H. Y. & Chen, S., 11 Dec 2015, In : Journal of Biological Chemistry. 290, p. 30030-30041 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
167 Downloads (Pure)

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin

Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R. & Kulathu, Y., 2 Apr 2015, In : Molecular Cell. 58, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Open Access
File
74 Citations (Scopus)
135 Downloads (Pure)

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

Munson, M. J., Allen, G. F. G., Toth, R., Campbell, D. G., Lucocq, J. M. & Ganley, I. G., 2 Sep 2015, In : EMBO Journal. 34, 17, p. 2272-2290 19 p.

Research output: Contribution to journalArticle

Open Access
64 Citations (Scopus)
2014

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & Mackintosh, C., 2014, In : Database: the Journal of Biological Databases and Curation. 2014, 15 p., bat085.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
187 Downloads (Pure)

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H. Y. & Chen, S., 2014, In : Cellular Signalling. 26, 8, p. 1636-1648 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Improved genome editing in human cell lines using the CRISPR method

Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J. & Lachaud, C., 10 Oct 2014, In : PLoS ONE. 9, 10, 6 p., e109752.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
133 Downloads (Pure)
2013

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J., 24 Oct 2013, In : Molecular Cell. 52, 2, p. 221-233 13 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Localization-dependent and -independent roles of SLX4 in regulating telomeres

Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J., 12 Sep 2013, In : Cell Reports. 4, 5, p. 853-860 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Loss of iron triggers PINK1/Parkin-independent mitophagy

Allen, G. F. G., Toth, R., James, J. & Ganley, I. G., 2013, In : EMBO Reports. 14, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C., 3 Apr 2013, In : EMBO Journal. 32, 7, p. 1008-22 15 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C., 15 Jan 2013, In : Journal of Immunology. 190, 2, p. 565-577 13 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)
50 Citations (Scopus)
2012

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

Tinti, M., Johnson, C., Toth, R., Ferrier, D. E. K. & MacKintosh, C., 2012, In : Open Biology. 2, 7, 120103.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

Neukamm, S. S., Toth, R., Morrice, N., Campbell, D. G., Mackintosh, C., Lehmann, R., Haering, H-U., Schleicher, E. D. & Weigert, C., 2012, In : PLoS ONE. 7, 8, p. e43296

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P., 1 Jan 2012, In : Biochemical Journal. 441, p. 339-346 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The Dac-tag, an affinity tag based on penicillin-binding protein 5

Lee, D. W., Peggie, M., Deak, M., Toth, R., Gage, Z. O., Wood, N., Schilde, C., Kurz, T. & Knebel, A., 2012, In : Analytical Biochemistry. 428, 1, p. 64-72 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 1 Oct 2012, In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R., 4 May 2011, In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

Nanda, S. K., Venigalla, R. K. C., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. C. & Cohen, P., 6 Jun 2011, In : Journal of Experimental Medicine. 208, 6, p. 1215-1228 14 p.

Research output: Contribution to journalArticle

Open Access
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87 Citations (Scopus)
226 Downloads (Pure)

Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C., Oct 2011, In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2010

Bioinformatic and experimental survey of 14-3-3-binding sites

Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C., 1 Apr 2010, In : Biochemical Journal. 427, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)

Identification of the MMS22L-TONSL complex that promotes homologous recombination

Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T. & Rouse, J., 24 Nov 2010, In : Molecular Cell. 40, 4, p. 632-644 13 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails

Toh, G. W. -L., Sugawara, N., Dong, J., Toth, R., Lee, S. E., Haber, J. E. & Rouse, J., 4 Jun 2010, In : DNA Repair. 9, 6, p. 718-726 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2009

Biochemical characterisation of the SWI/SNF family member HLTF

MacKay, C., Toth, R. & Rouse, J., 11 Dec 2009, In : Biochemical and Biophysical Research Communications. 390, 2, p. 187-191 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J., 10 Jul 2009, In : Molecular Cell. 35, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

235 Citations (Scopus)