• 20086 Citations
  • 86 h-Index
1977 …2019
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  • 8 Similar Profiles
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Glutathione Transferase Medicine & Life Sciences
Cytochrome P-450 CYP2D6 Medicine & Life Sciences
Liver Medicine & Life Sciences
NADPH-Ferrihemoprotein Reductase Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Genes Medicine & Life Sciences

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Research Output 1977 2019

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In : Molecular Pharmacology. 95, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptional Activation
Chromatin
Hepatocytes
Xenobiotics
constitutive androstane receptor
1 Citations

Discovery of common and rare genetic risk variants for colorectal cancer

Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K. & 179 othersArnau-Collell, C., Arndt, V., Bamia, C., Banbury, B. L., Baron, J. A., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chirlaque, M-D., Cho, S. H., Connolly, C. M., Cross, A. J., Cuk, K., Curtis, K. R., de la Chapelle, A., Doheny, K. F., Duggan, D., Easton, D. F., Elias, S. G., Elliott, F., English, D. R., Feskens, E. J. M., Figueiredo, J. C., Fischer, R., FitzGerald, L. M., Forman, D., Gala, M., Gallinger, S., Gauderman, W. J., Giles, G. G., Gillanders, E., Gong, J., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hampel, H., Harlid, S., Hayes, R. B., Hofer, P., Hoffmeister, M., Hopper, J. L., Hsu, W-L., Huang, W-Y., Hudson, T. J., Hunter, D. J., Ibañez-Sanz, G., Idos, G. E., Ingersoll, R., Jackson, R. D., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Joshu, C. E., Keku, T. O., Key, T. J., Kim, H. R., Kobayashi, E., Kolonel, L. N., Kooperberg, C., Kühn, T., Küry, S., Kweon, S-S., Larsson, S. C., Laurie, C. A., Le Marchand, L., Leal, S. M., Lee, S. C., Lejbkowicz, F., Lemire, M., Li, C. I., Li, L., Lieb, W., Lin, Y., Lindblom, A., Lindor, N. M., Ling, H., Louie, T. L., Männistö, S., Markowitz, S. D., Martín, V., Masala, G., McNeil, C. E., Melas, M., Milne, R. L., Moreno, L., Murphy, N., Myte, R., Naccarati, A., Newcomb, P. A., Offit, K., Ogino, S., Onland-Moret, N. C., Pardini, B., Parfrey, P. S., Pearlman, R., Perduca, V., Pharoah, P. D. P., Pinchev, M., Platz, E. A., Prentice, R. L., Pugh, E., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Rodríguez-Barranco, M., Romm, J., Sakoda, L. C., Schafmayer, C., Schoen, R. E., Seminara, D., Shah, M., Shelford, T., Shin, M-H., Shulman, K., Sieri, S., Slattery, M. L., Southey, M. C., Stadler, Z. K., Stegmaier, C., Su, Y-R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Thomas, S. S., Toland, A. E., Trichopoulou, A., Ulrich, C. M., Van Den Berg, D. J., van Duijnhoven, F. J. B., Van Guelpen, B., van Kranen, H., Vijai, J., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Win, A. K., Wolf, C. R., Wolk, A., Woods, M. O., Wu, A. H., Zaidi, S. H., Zanke, B. W., Zhang, Q., Zheng, W., Scacheri, P. C., Potter, J. D., Bassik, M. C., Kundaje, A., Casey, G., Moreno, V., Abecasis, G. R., Nickerson, D. A., Gruber, S. B., Hsu, L. & Peters, U., Jan 2019, In : Nature Genetics. 51, 1, p. 76-87 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Kruppel-Like Transcription Factors
Long Noncoding RNA
Preclinical Drug Evaluations
Genome-Wide Association Study
7 Citations

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice

Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 24 Jan 2018, In : Archives of Toxicology. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Metabolism
Cytochrome P-450 Enzyme System
Oxidoreductases
1 Citations

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Cytochrome P-450 CYP3A
Therapeutics
Pharmaceutical Preparations
Cytochrome P-450 CYP1A2
1 Citations

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Sheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 othersBurn, J. & Bishop, D. T., 9 Feb 2018, In : PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.

Research output: Contribution to journalArticle

Open Access
File
aspirin
Metabolic Networks and Pathways
case-control studies
Polymorphism
colorectal neoplasms

Activities 2001 2006

  • 5 Participation in conference

14th North American ISSX Meeting

Roland Wolf (Participant)
22 Oct 200626 Oct 2006

Activity: Participating in or organising an event typesParticipation in conference

Newcastle Pathology 2005: 3rd Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland

Roland Wolf (Participant)
5 Jul 20058 Jul 2005

Activity: Participating in or organising an event typesParticipation in conference

British Society for Investigative Dermatology Annual Meeting

Roland Wolf (Participant)
7 Apr 20039 Apr 2003

Activity: Participating in or organising an event typesParticipation in conference

184th Meeting of the Pathological Society of Great Britain and Ireland

Roland Wolf (Participant)
2 Jul 20025 Jul 2002

Activity: Participating in or organising an event typesParticipation in conference

51st Annual Meeting of the American Society of Human Genetics

Roland Wolf (Participant)
12 Oct 200116 Oct 2001

Activity: Participating in or organising an event typesParticipation in conference

Press / Media

Gene helps predict which ovarian cancer sufferers will benefit most from chemotherapy

Gillian Smith, Michael Ng, C Simon Herrington, Michelle Ferguson & C Wolf

19/09/12

1 item of media coverage

Press/Media: Research

Thesis

Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection

Author: McGarry, D., 2012

Supervisor: Henderson, C. J. (Supervisor) & Wolf, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File
File

Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib

Author: Sharp, S. L., 2014

Supervisor: Wolf, C. (Supervisor) & Henderson, C. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

microRNA expression in colorectal tumours: identification of novel mechanisms of gene regulation

Author: Amankwatia, E. B., 2014

Supervisor: Smith, G. (Supervisor) & Wolf, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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