• 3756 Citations
  • 31 h-Index
1991 …2018
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Personal profile

Biography

Rory McCrimmon trained at the University of Edinburgh and completed his clinical and speciality training in the South-East of Scotland before becoming an NHS Consultant Physician in Diabetes and Endocrinology at University Hospital Aintree, Liverpool, in 2000. In 2002, he joined the faculty at Yale University, Connecticut, to investigate why people with type 1 and 2 diabetes are very prone to developing low glucose (Hypoglycaemia). He returned to Scotland in 2009 to establish his laboratory at the University of Dundee, where he is currently Dean of Medicine, Professor of Experimental Diabetes and Metabolism and Honorary Consultant He was recently awarded the 2015 RD Lawrence Lecture by Diabetes UK for his research in Hypoglycaemia.

Prof McCrimmon is currently also Lead Clinician for the Scottish Diabetes Research Network (SDRN), which provides the necessary infrastructure to co-ordinate and enable academic and commercial research throughout Scotland. The SDRN hosts a National Research Register of over 11,000 subjects with diabetes pre-consented to be contacted about clinical trials. The register is directly linked to SCI-diabetes, which contains secure clinical and biochemical data on over 350,000 people with diabetes in Scotland.

Prof McCrimmon serves on Editorial Boards of Diabetologia and Diabetes. He is a panel member for: Medical Research Council Population and Systems Medicine Board, Diabetes UK, Clinical Studies Group Management Committee; Diabetes UK, Intermediate Clinical Fellowships Panel; Juvenile Diabetes Research Foundation PEAK Programme; Panel member, International Hypoglycaemia Study Group.

Research

The focus of my research programme has been to define the fundamental mechanisms by which the brain detects low glucose levels (hypoglycaemia) and how these mechanisms are disrupted in type 1 diabetes in response to repeated episodes of hypoglycaemia. Key findings include a series of papers each cited over 100 times, establishing key roles for AMP-activated protein kinase and the ATP-sensitive potassium channel in the detection of hypoglycaemia by the brain.  I have published over 100 peer-reviewed manuscripts, obtained >£16M in grants funds as an independent investigator and have been invited to give key-note lectures in all major national and international diabetes conferences (>40 invited presentations), receiving the named RD Lawrence Lecture in 2015 from Diabetes UK in recognition of my contribution to this field. I also have an interest clinical trials in diabetes and was appointed by interview by the Chief Scientist Office Scotland as Diabetes Champion. In this role I lead the £1.8M funded Scottish Diabetes Research Network (SDRN), comprising clinicians and research nurses in all major centres in Scotland and tasked with enabling high quality clinical research across the country. Unique to the SDRN, we also support the SDRN Epidemiology subgroup that has used the Sci-Diabetes informatics platform to produce a number of high impact publications over the last 5 years (>20 papers). I am also currently Principal Investigator on 9 phase 3 clinical trials. I was UK Chief Investigator for the Lixilan-O trial, VERTIS-CV, PIONEER 6, European Chief Investigator for SUSTAIN-8, on the steering committee for DiRECT and writing groups for Lixilan-O, Lixilan-L and Tandem3.

Teaching

Primary teaching experience is in academic mentoring and supervision of clinicians, post-graduates and undergraduate students. In this capacity, I have served as Programme Lead for the Academic Foundation Doctors in the Eastern Deanery, been a member of the Scottish Translational Medicine Training Initiative, and a member of the Medical Research Council Clinical Fellowship Training and Career Development Awards panel. In addition, I have co-written the Chapter on Diabetes in Davidson’s Principles and Practice of Medicine (Editions 22 and 23), a textbook that has been read by over 2 million medical students since its first edition. As Interim Dean I jointly Chair the new ScotGEM post-graduate Entry Medical Programme with David Crossman, Dean of Medicine, St Andrew’s Univerity and will visit Anglia Ruskin University regularly as it starts its new Medical School adopting the Dundee Curriculum.

Research interests

Chronological List of Invited Lectures 

Agreed Future Lectures

  • Impaired awareness of hypoglycaemia: Causes and Consequences, 21st Nov 2018, Radboud University, Nijmegen, Netherlands
  • The future never looked so Bright: when medicine meets technology. DCV Forum - 26/27th October 2018, Paris, France
  • A combination approach: targeting the right patients. 1st October 2018, European Association for the Study of Diabetes, Berlin, Germany
  • Unified outcomes in diabetes management. European Diabetes Forum 30th Sept 2018, Berlin, Germany

 International Lectures

  • Hypoglycaemia: Forget about it! May 2018, University of Copenhagen, Denmark
  • What do clinicians need to know about hypoglycaemia? Dec 2017 Meet the expert. International Diabetes Federation, Abu Dhabi, UAE
  • Impaired awareness of hypoglycaemia: New discoveries and treatments. Sept 2017 European Association for the Study of Diabetes, Lisbon, Portugal
  • Clinical Inertia: Lessons from Scotland. Sept 2016, European Association for the Study of Diabetes Munich, Germany
  • Exercise in Type 1 Diabetes: Sept 2016, European Association for the Study of Diabetes Munich, Germany
  • Physiology of Exercise in Type 1 Diabetes. April 2016 Juvenile Diabetes Research Foundation PEAK program, Boston, US
  • Impaired hypoglycaemia awareness: The habit of a lifetime. Feb 2016, Steno Diabetes Centre, Denmark
  • Impaired hypoglycaemia awareness: The habit of a lifetime. Oct 2015, International Society of Paediatric and Adolescent Diabetes, Brisbane, Australia
  • Cerebral adaption to recurrent hypoglycaemia. March 2015 Levine Symposium, San Diego, USA
  • The Scylla and Charybdis of glucose control in Type 1 Diabetes. Aug 2014 Norwegian Diabetes Meeting, Oslo
  • Hypoglycaemia: The study of stress, starvation and tolerance. Jan 2014, 3U Meeting, Dublin
  • Diabetes and Dementia. Dec 2013 International Diabetes Federation, Melbourne, Australia
  • The highs and lows of metabolic stress in type 1 diabetes. Oct 2013 International Society of Paediatric and Adolescent Diabetes, Gothenberg, Sweden
  • Another piece of the jigsaw: How the brain regulates pancreatic endocrine function. Dec 2012 International Society of Paediatric and Adolescent Diabetes conference, Istanbul, Turkey
  • Hypoglycaemia Tolerance: An adaptive response to repeated hypoglycaemia. Sept 2012 National Diabetes Symposium, Helsinki, Finland
  • Hypoglycaemia and the brain: does age play and important role. Aug 2012 Lilly peaks and Valleys meeting, Santiago, Chile
  • Hypoglycaemia and the brain: does age play and important role. May 2012 Lilly peaks and Valleys meeting, Kuala Lumpur, Malaysia
  • Hypoglycaemia and the brain: does age play and important role. April 2012 Lilly peaks and Valleys meeting, Amsterdam, Holland
  • Mechanisms of hypoglycaemia sensing. Sept 2011 Diabetes Dialogue, Barcelona, Spain
  • Central regulation of glucose homeostasis.  Oct 2010, FASEB, Kyoto, Japan
  • Mechanisms Underlying Hypoglycemia Unawareness, Aug 2016 International Diabetes Federation, Cape Town, South Africa
  • Mechanisms of Neuronal Glucose-Sensing, June 2016, American Diabetes Association Meeting, Washington, USA
  • Role for AMP Kinase in Hypoglycemia Sensing. Sept 2007 Hypoglycemia Congress, Perugia, Italy
  • The BB Rat Turns Thirty: Lessons and Future Directions. Oct 2004, Ottowa, Canada 

National Lectures

  • Hypoglycaemia: A force of habit. Dec 2016 University of Exeter
  • Impaired hypoglycaemia awareness. Nov 2015 National Paediatric and Adolescent Diabetes Group, Birmingham
  • The Sci is the limit. British Hypertension Society. Sept 2015 Stafford-on-Avon
  • Old habits are hard to break: Lessons from the study of hypoglycaemia. March 2015 RD Lawrence Lecture, Diabetes UK, London, (Plenary Lecture)
  • Inflammation and glucose sensing. March 2015 BHF Queen Margaret Institute, Edinburgh University
  • The Unaware Neuron. May 2014 Institute if Metabolic Science, Aberdeen University,
  • Getting excited about blood sugar: The brain and blood glucose control. April 2014 British Endocrine Society, Liverpool
  • Hypoglycaemia Tolerance: An adaptive response to repeated hypoglycaemia. April 2014 Bristol University
  • Hypoglycaemia: The study of stress, starvation and tolerance. March 2014 Scottish Study Group, Dunblane
  • Hypoglycaemia: The study of stress, starvation and tolerance. March 2014 Diabetes UK, Liverpool
  • Pre-conditioning and Hypoglycaemia. April 2014 University of Manchester
  • Stress, starvation and Hypoglycaemia. March 2013 Institute of Metabolic Research, Cambridge University
  • Central Mechanisms of hypoglycaemia awareness, March 2012 Diabetes UK Conference
  • Hypoglycaemia in type 1 diabetes and the development of hypoglycaemia tolerance. Feb 2012 Oxford Centre for Diabetes, Endocrinology and Metabolism
  • Hypoglycaemia Tolerance. Nov 2010 Queens Medical Research Institute, Edinburgh
  • Hypo or not to hypo, that is the question? Nov 2010 Scottish Study Group, Pitlochry
  • Life as an Academic Physician. Oct 2010  Young Diabetologists Forum, Edinburgh, QMRI
  • Hypoglycaemia Tolerance Sept 2010 Annual Paediatric Endocrinologists Meeting, Sterling
  • Integrated pathways involved in glucosensing. March 2010 Diabetes UK, Liverpool
  • Developments in Hypoglycaemia Research. March 2008 Diabetes UK Conference, Glasgow
  • Hypoglycaemic Stress; Homeostasis Challenged. Oct 2007 Scottish Society for Experimental Medicine, Aberdeen

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 23 Similar Profiles
Hypoglycemia Medicine & Life Sciences
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Scotland Medicine & Life Sciences
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AMP-Activated Protein Kinases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2018

Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational study

Scottish Diabetes Research Network Epidemiology Group, Vadiveloo, T., Jeffcoate, W., Donnan, P. T., Colhoun, H. C., McGurnaghan, S., Wild, S., McCrimmon, R. & Leese, G. P., 31 Aug 2018, In : Diabetologia. 8 p.

Research output: Contribution to journalArticle

Open Access
File
Amputation
Ulcer
Observational Studies
Foot
Scotland
3 Citations

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, p. 1-16 16 p., 55

Research output: Contribution to journalArticle

Open Access
File
Obese Mice
Leptin
Amyloid
Obesity
Homeostasis
6 Citations

Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission

Wild, S. H., Walker, J. J., Morling, J. R., McAllister, D. A., Colhoun, H. M., Farran, B., McGurnaghan, S., McCrimmon, R., Read, S. H., Sattar, N., Byrne, C. D. & Scottish Diabetes Research Network Epidemiology Group, Feb 2018, In : Diabetes Care. 41, 2, p. 341-347 7 p., dc171590

Research output: Contribution to journalArticle

Open Access
File
Alcoholic Fatty Liver
Alcoholic Liver Diseases
Type 2 Diabetes Mellitus
Hospital Records
Cardiovascular Diseases

Cardiovascular disease prevalence and risk factor prevalence in Type 2 diabetes: a contemporary analysis

McGurnaghan, S., Blackbourn, L. A. K., Mocevic, E., Panton, U. H., McCrimmon, R. J., Sattar, N., Wild, S. & Colhoun, H. M., 23 Sep 2018, In : Diabetic Medicine.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Cardiovascular Diseases
Cholesterol
Cerebrovascular Disorders
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans

Iqbal, A., Prince, L. R., Novodvorsky, P., Bernjak, A., Thomas, M. R., Birch, L., Lambert, D., Kay, L. J., Wright, F. J., Macdonald, I. A., Jacques, R. M., Storey, R. F., McCrimmon, R. J., Francis, S., Heller, S. R. & Sabroe, I., 24 Sep 2018, In : Journal of Clinical Endocrinology and Metabolism. 24 p.

Research output: Contribution to journalArticle

Endotoxemia
Platelets
Hypoglycemia
Monocytes
Endotoxins

Prizes

Fellowship, Royal College of Physicians (Edinburgh)

Rory McCrimmon (Recipient), 2010

Prize: Fellowship awarded competitively

RD Lawrence Lecture

Rory McCrimmon (Recipient), 12 Mar 2015

Prize: Prize (including medals and awards)

Diabetes

Activities 2009 2018

  • 5 Editorial activity

Diabetes (Journal)

McCrimmon, R. (Editorial board member)
1 Jan 201831 Dec 2020

Activity: Publication peer-review and editorial workEditorial activity

Diabetologia (Journal)

McCrimmon, R. (Editorial board member)
1 Jan 20161 Jan 2019

Activity: Publication peer-review and editorial workEditorial activity

Diabetes Care (Journal)

McCrimmon, R. (Editorial board member)
1 Jan 201431 Dec 2017

Activity: Publication peer-review and editorial workEditorial activity

Journal of Clinical Endocrinology and Metabolism (Journal)

McCrimmon, R. (Editorial board member)
1 Jan 201231 Dec 2016

Activity: Publication peer-review and editorial workEditorial activity

Diabetic Hypoglycemia (Journal)

McCrimmon, R. (Editorial board member)
1 Jan 200931 Dec 2015

Activity: Publication peer-review and editorial workEditorial activity

Thesis

Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line

Author: Haythorne, E., 2014

Supervisor: Ashford, M. (Supervisor) & McCrimmon, R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigation of the metabolic phenotype and metformin response of ATM heterozygous mice

Author: Tarlton, J. M. R., 2017

Supervisor: McCrimmon, R. (Supervisor) & Sutherland, C. (Supervisor)

Student thesis: Master's ThesisMaster of Science

The role of central IL-6 signalling in the development of Type 2 Diabetes

Author: Yiannakas, A., 2016

Supervisor: McCrimmon, R. (Supervisor) & Ashford, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons

Author: Denwood, G. T., 2015

Supervisor: McCrimmon, R. (Supervisor) & Ashford, M. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File