Research output per year
Research output per year
- 12 results
Search results
-
2024
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease
Jackson, R. J. (Lead / Corresponding author), Keiser, M. S., Meltzer, J. C., Fykstra, D. P., Dierksmeier, S. E., Hajizadeh, S., Kreuzer, J., Morris, R., Melloni, A., Nakajima, T., Tecedor, L., Ranum, P. T., Carrell, E., Chen, Y. H., Nishtar, M. A., Holtzman, D. M., Haas, W., Davidson, B. L. & Hyman, B. T., 1 May 2024, In: Molecular Therapy. 32, 5, p. 1373-1386 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)38 Downloads (Pure) -
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription
Jackson, R. J., Melloni, A., Fykstra, D. P., Serrano-Pozo, A., Shinobu, L. & Hyman, B. T. (Lead / Corresponding author), 14 Aug 2024, In: Acta Neuropathologica Communications. 12, 11 p., 132.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Downloads (Pure) -
Multifaceted roles of APOE in Alzheimer disease
Jackson, R. J., Hyman, B. T. (Lead / Corresponding author) & Serrano-Pozo, A. (Lead / Corresponding author), Aug 2024, In: Nature Reviews Neurology. 20, 8, p. 457-474 18 p.Research output: Contribution to journal › Review article › peer-review
6 Citations (Scopus) -
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Colom-Cadena, M., Toombs, J., Simzer, E., Holt, K., McGeachan, R., Tulloch, J., Jackson, R. J., Catterson, J. H., Spires-Jones, M. P., Rose, J., Waybright, L., Caggiano, A. O., King, D., Gobbo, F., Davies, C., Hooley, M., Dunnett, S., Tempelaar, R., Meftah, S. & Tzioras, M. & 7 others, , 6 Feb 2024, In: Acta Neuropathologica. 147, 22 p., 32.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)35 Downloads (Pure) -
2022
APOE4 derived from astrocytes leads to blood-brain barrier impairment
Jackson, R. J., Meltzer, J. C., Nguyen, H., Commins, C., Bennett, R. E., Hudry, E. & Hyman, B. T. (Lead / Corresponding author), Oct 2022, In: Brain. 145, 10, p. 3582-3593 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile73 Citations (Scopus)53 Downloads (Pure) -
2021
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model
Litvinchuk, A., Huynh, T. P. V., Shi, Y., Jackson, R. J., Finn, M. B., Manis, M., Francis, C. M., Tran, A. C., Sullivan, P. M., Ulrich, J. D., Hyman, B. T., Cole, T. & Holtzman, D. M. (Lead / Corresponding author), May 2021, In: Annals of Neurology. 89, 5, p. 952-966 15 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease
Serrano-Pozo, A., Li, Z., Noori, A., Nguyen, H. N., Mezlini, A., Li, L., Hudry, E., Jackson, R. J., Hyman, B. T. & Das, S. (Lead / Corresponding author), 11 Oct 2021, In: Nature Aging. 1, 10, p. 919-931 13 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: Cohort study
Schon, K. R., Horvath, R., Wei, W., Calabrese, C., Tucci, A., Ibañez, K., Ratnaike, T., Pitceathly, R. D. S., Bugiardini, E., Quinlivan, R., Hanna, M. G., Clement, E., Ashton, E., Sayer, J. A., Brennan, P., Josifova, D., Izatt, L., Fratter, C., Nesbitt, V. & Barrett, T. & 11 others, , 4 Nov 2021, In: BMJ. 375, 16 p., e066288.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)32 Downloads (Pure) -
2019
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease
Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., Calkin, W., Murison, L., Jackson, R. J., Tzioras, M., Stevenson, A., d'Orange, M., Hooley, M., Davies, C., Colom-Cadena, M. & Anton-Fernandez, A. & 10 others, , 10 Dec 2019, In: Cell Reports. 29, 11, p. 3592-3604.e5 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile111 Citations (Scopus)153 Downloads (Pure) -
Clusterin accumulates in synapses in Alzheimer’s disease and is increased in Apolipoprotein E4 carriers
Jackson, R., Rose, J., Tulloch, J., Henstridge, C., Smith, C. & Spires-Jones, T. L. (Lead / Corresponding author), 2019, In: Brain Communications. 1, 1, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)115 Downloads (Pure) -
Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
Hesse, R., Hurtado, M. L., Jackson, R. J., Eaton, S. L., Herrmann, A. G., Colom-Cadena, M., Tzioras, M., King, D., Rose, J., Tulloch, J., McKenzie, C.-A., Smith, C., Henstridge, C., Lamont, D., Wishart, T. M. (Lead / Corresponding author) & Spires-Jones, T. L. (Lead / Corresponding author), 20 Dec 2019, (E-pub ahead of print) In: Acta Neuropathologica Communications. 7, 18 p., 214.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)110 Downloads (Pure) -
2015
Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse
Henstridge, C., Jackson, R. J., Kim, J. M., Herrmann, A. G., Wright, A. K., Harris, S. E., Bastin, M., Starr, J., Wardlaw, J., Gillingwater, T. H., Smith, C., McKenzie, C.-A., Cox, S. R., Deary, I. J. (Lead / Corresponding author) & Spires-Jones, T. L. (Lead / Corresponding author), 4 Sept 2015, In: Acta Neuropathologica Communications. 3, 53, 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)144 Downloads (Pure)