Petty, Russell

Professor, BMSc MB ChB PhD MRCPE FRCP

1994 …2022
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Research Output 1994 2019

2019

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining

Vougas, K., Sakelaropoulos, T., Kotsinas, A., Foukas, G-R. P., Ntargaras, A., Koinis, F., Polyzos, A., Myrianthopoulos, V., Zhou, H., Narang, S., Georgoulias, V., Alexopoulos, L., Aifantis, I., Townsend, P. A., Sfikakis, P., Fitzgerald, R., Thanos, D., Bartek, J., Petty, R., Tsirigos, A. & 1 others, Gorgoulis, V. G., 30 Jul 2019, In : Pharmacology & Therapeutics. 28 p., 107395.

Research output: Contribution to journalReview article

Data Mining
Computer Simulation
Pharmaceutical Preparations
Neoplasms
Precision Medicine
2018

Pembrolizumab versus paclitaxel in gastro-oesophageal adenocarcinoma

Smyth, E. C. & Petty, R. D., 14 Jul 2018, In : The Lancet. 392, 10142, p. 97-98 2 p.

Research output: Contribution to journalComment/debate

2017
18 Citations (Scopus)
58 Downloads (Pure)

A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification

Van Cutsem, É., Bang, Y-J., Mansoor, W., Petty, R. D., Chao, Y., Cunningham, D., Ferry, D. R., Smith, N. R., Frewer, P., Rarnayake, J., Stockman, P. K., Kilgour, E. & Landers, D., 1 Jun 2017, In : Annals of Oncology. 28, 6, p. 1316-1324 8 p.

Research output: Contribution to journalArticle

Open Access
File
Receptor, Fibroblast Growth Factor, Type 2
Gene Amplification
Paclitaxel
Stomach
Adenocarcinoma
23 Citations (Scopus)
4 Downloads (Pure)

Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer

Petty, R. D., Dahle-Smith, A., Stevenson, D. A. J., Osborne, A., Massie, D., Clark, C., Murray, G. I., Dutton, S. J., Roberts, C., Chong, I. Y., Mansoor, W., Thompson, J., Harrison, M., Chatterjee, A., Falk, S. J., Elyan, S., Garcia-Alonso, A., Fyfe, D. W., Wadsley, J., Chau, I. & 2 others, Ferry, D. R. & Miedzybrodzka, Z., Jul 2017, In : Journal of Clinical Oncology. 35, 20, p. 2279-2287 9 p.

Research output: Contribution to journalArticle

Open Access
File
erbB-1 Genes
Gene Dosage
Esophageal Neoplasms
Epidermal Growth Factor Receptor
Fluorescence In Situ Hybridization

Prognostic RNAs in oesophageal squamous cell carcinoma: small is beautiful

Tan, P. & Petty, R., 1 Feb 2017, In : Gut. 66, 2, p. 210-211 2 p.

Research output: Contribution to journalComment/debate

2016

HMGB1 as a Prognostic Biomarker in The Progression of Barrett’s Oesophagus

Porter, R., Murray, G., Petty, R., El-Omar, E. M., Hold, G. L. & McLean, MH., 1 Jun 2016, In : Gut. 65, Suppl 1, p. A133 1 p., PTU-154.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phase Ib/II study of elisidepsin in metastatic or advanced gastroesophageal cancer (IMAGE trial)

Petty, R., Anthoney, A., Metges, J-P., Alsina, M., Gonçalves, A., Brown, J. R., Montagut, C., Gunzer, K., Laus, G., Iglesias Dios, J. L., Miguel-Lillo, B., Bohan, P. & Salazar, R., Apr 2016, In : Cancer Chemotherapy and Pharmacology. 77, 4, p. 819-27 9 p.

Research output: Contribution to journalArticle

Appointments and Schedules
Neoplasms
Intravenous Infusions
Tumors
Esophagogastric Junction

PLATFORM: Planning treatment of oesophago-gastric (OG) cancer-A randomised maintenance therapy trial

Cafferkey, C., Chau, I., Thistlethwaite, F., Petty, R., Starling, N., Watkins, D., Rao, S., Saffery, C., Patel, B., Peckitt, C. & Cunningham., D., 2016, In : Journal of Clinical Oncology. 34, 4_Suppl, TPS187.

Research output: Contribution to journalArticle

Stomach Neoplasms
Drug Therapy
Therapeutics
Survival
Platinum
1 Citation (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., Mckiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, J. K., Nanthakumaran, S., Matula, K. M., Grabsch, H. I., Tan, S. P., Welch, L. A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M. & 1 others, Petty, R. D., 14 Jun 2016, In : British Journal of Cancer. 114, 12, p. e18 1 p.

Research output: Contribution to journalArticle

Leptin
Adenocarcinoma
Drug Therapy
Neoplasms
Therapeutics
2015
5 Citations (Scopus)

Biomarkers and novel agents in esophago-gastric cancer: are we making progress?

Dahle-Smith, A. & Petty, R. D., 2015, In : Expert Review of Anticancer Therapy. 15, 9, p. 1103-1119 17 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Biomarkers
Climate
Immune System
Intercellular Signaling Peptides and Proteins
8 Citations (Scopus)

Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

Dahle-Smith, Å., Stevenson, D., Massie, D., Murray, G. I., Dutton, S. J., Roberts, C., Ferry, D., Osborne, A., Clark, C., Petty, R. D. & Miedzybrodzka, Z., 17 Oct 2015, In : Molecular Cytogenetics. 8, 9 p., 78.

Research output: Contribution to journalArticle

Aberrations
Epidermal Growth Factor
Carcinoma
Fluorescence In Situ Hybridization
Fluorescence
25 Citations (Scopus)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Matula, K., Collie-Duguid, E., Murray, G., Parikh, K., Grabsch, H., Tan, P., Lalwani, S., Garau, R., Ong, Y., Bain, G., Smith, A-D., Urquhart, G., Bielawski, J., Finnegan, M. & Petty, R., 22 Oct 2015, In : BMC Cancer. 15, 1, 14 p., 762.

Research output: Contribution to journalArticle

Sphingosine
Lyases
Drug Therapy
Cell Line
Drug Resistance
3 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., Mckiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, J. K., Nanthakumaran, S., Grabsch, H. I., Tan, S. P., Welch, L. A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M. & 1 others, Petty, R. D., 2015, In : British Journal of Cancer. 113, 11, p. 1641 1 p.

Research output: Contribution to journalArticle

Open Access
Leptin
Adenocarcinoma
Drug Therapy
Neoplasms
Therapeutics
2014
132 Citations (Scopus)

Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial

Dutton, S. J., Ferry, D. R., Blazeby, J. M., Abbas, H., Dahle-Smith, A., Mansoor, W., Thompson, J., Harrison, M., Chatterjee, A., Falk, S., Garcia-Alonso, A., Fyfe, D. W., Hubner, R. A., Gamble, T., Peachey, L., Davoudianfar, M., Pearson, S. R., Julier, P., Jankowski, J., Kerr, R. & 1 others, Petty, R. D., Jul 2014, In : Lancet Oncology. 15, 8, p. 894-904 11 p.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Randomized Controlled Trials
Placebos
Drug Therapy
gefitinib
32 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., Mckiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M. & Petty, R. D., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1525-1534 10 p.

Research output: Contribution to journalArticle

Leptin
Adenocarcinoma
Drug Therapy
Neoplasms
Cell Line
2013
49 Citations (Scopus)

Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report

Okines, A. F. C., Langley, R. E., Thompson, L. C., Stenning, S. P., Stevenson, L., Falk, S., Seymour, M., Coxon, F., Middleton, G. W., Smith, D., Evans, L., Slater, S., Waters, J., Ford, D., Hall, M., Iveson, T. J., Petty, R. D., Plummer, C., Allum, W. H., Blazeby, J. M. & 2 others, Griffin, M. & Cunningham, D., Mar 2013, In : Annals of Oncology. 24, 3, p. 702-709 8 p., mds533.

Research output: Contribution to journalArticle

Epirubicin
Cisplatin
Adenocarcinoma
Safety
Drug Therapy
6 Citations (Scopus)

Serpin B3 is associated with poor survival after chemotherapy and is a potential novel predictive biomarker in advanced non-small-cell lung cancer

Urquhart, G., Kerr, K. M., Nicolson, M., Loo, P. S., Sharma, R., Shrimali, R. & Petty, R. D., Dec 2013, In : Journal of Thoracic Oncology. 8, 12, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

Serpins
Non-Small Cell Lung Carcinoma
Biomarkers
Drug Therapy
Survival
2012
112 Citations (Scopus)

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Su, Z., Gay, L. J., Strange, A., Palles, C., Band, G., Whiteman, D. C., Lescai, F., Langford, C., Nanji, M., Edkins, S., Van Der Winkel, A., Levine, D., Sasieni, P., Bellenguez, C., Howarth, K., Freeman, C., Trudgill, N., Tucker, A. T., Pirinen, M., Peppelenbosch, M. P. & 124 others, Van Der Laan, L. J. W., Kuipers, E. J., Drenth, J. P. H., Peters, W. H., Reynolds, J. V., Kelleher, D. P., McManus, R., Grabsch, H., Prenen, H., Bisschops, R., Krishnadath, K., Siersema, P. D., Van Baal, J. W. P. M., Middleton, M., Petty, R., Gillies, R., Burch, N., Bhandari, P., Paterson, S., Edwards, C., Penman, I., Vaidya, K., Ang, Y., Murray, I., Patel, P., Ye, W., Mullins, P., Wu, A. H., Bird, N. C., Dallal, H., Shaheen, N. J., Murray, L. J., Koss, K., Bernstein, L., Romero, Y., Hardie, L. J., Zhang, R., Winter, H., Corley, D. . A., Panter, S., Risch, H. A., Reid, B. J., Sargeant, I., Gammon, M. D., Smart, H., Dhar, A., McMurtry, H., Ali, H., Liu, G., Casson, A. G., Chow, W-H., Rutter, M., Tawil, A., Morris, D., Nwokolo, C., Isaacs, P., Rodgers, C., Ragunath, K., MacDonald, C., Haigh, C., Monk, D., Davies, G., Wajed, S., Johnston, D., Gibbons, M., Cullen, S., Church, N., Langley, R., Griffin, M., Alderson, D., Deloukas, P., Hunt, S. E., Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Anderson, M., Brooks, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N., Trynka, G., Wijmenga, C., Cazier, J-B., Atherfold, P., Nicholson, A. M., Gellatly, N. L., Glancy, D., Cooper, S. C., Cunningham, D., Lind, T., Hapeshi, J., Ferry, D., Rathbone, B., Brown, J., Love, S., Attwood, S., MacGregor, S., Watson, P., Sanders, S., Ek, W., Harrison, R. F., Moayyedi, P., De Caestecker, J., Barr, H., Stupka, E., Vaughan, T. L., Peltonen, L., Spencer, C. C. A., Tomlinson, I., Donnelly, P. & Jankowski, J. A. Z., 2012, In : Nature Genetics. 44, 10, p. 1131-1136 6 p.

Research output: Contribution to journalArticle

Barrett Esophagus
Chromosomes
Odds Ratio
Confidence Intervals
Hiatal Hernia
3 Citations (Scopus)

Exclusive rights in gastric cancer genomics

Petty, R. D., May 2012, In : Gut. 61, 5, p. 638-640 3 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
Gastrointestinal Stromal Tumors
Therapeutics
Management Audit
Survival
Disease-Free Survival
2010
48 Citations (Scopus)

Increased incidence of visceral metastases in Scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype

Gourley, C., Michie, C. O., Roxburgh, P., Yap, T. A., Harden, S., Paul, J., Ragupathy, K., Todd, R., Petty, R., Reed, N., Hayward, R. L., Mitchell, P., Rye, T., Schellens, J. H. M., Lubinski, J., Carmichael, J., Kaye, S. B., Mackean, M. & Ferguson, M., 20 May 2010, In : Journal of Clinical Oncology. 28, 15, p. 2505-2511 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasm Metastasis
Phenotype
Incidence
Lung
19 Citations (Scopus)

Predicting response to treatment in gastroesophageal junction adenocarcinomas: combining clinical, imaging, and molecular biomarkers

Bain, G. H. & Petty, R. D., Mar 2010, In : Oncologist. 15, 3, p. 270-284 15 p.

Research output: Contribution to journalArticle

Esophagogastric Junction
Molecular Imaging
Adenocarcinoma
Biomarkers
Neoadjuvant Therapy
37 Citations (Scopus)

Predictive biomarkers for personalised anti-cancer drug use: discovery to clinical implementation

Alymani, N. A., Smith, M. D., Williams, D. J. & Petty, R. D., Mar 2010, In : European Journal of Cancer. 46, 5, p. 869-879 11 p.

Research output: Contribution to journalArticle

Drug Discovery
Biomarkers
Neoplasms
Translational Medical Research
Tumor Biomarkers
2009
30 Citations (Scopus)

APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling

Petty, R. D., Samuel, L. M., Murray, G. I., MacDonald, G., O'Kelly, T., Loudon, M., Binnie, N., Aly, E., McKinlay, A., Wang, W., Gilbert, F., Semple, S. & Collie-Duguid, E. S. R., 11 Dec 2009, In : BMC Cancer. 9, 11 p., 434.

Research output: Contribution to journalArticle

Gene Expression Profiling
Fluorouracil
Adenocarcinoma
Biomarkers
Radiotherapy
2006
42 Citations (Scopus)

Tumor transcriptome reveals the predictive and prognostic impact of lysosomal protease inhibitors in non-small-cell lung cancer

Petty, R. D., Kerr, K. M., Murray, G. I., Nicolson, M. C., Rooney, P. H., Bissett, D. & Collie-Duguid, E. S. R., 5 Apr 2006, In : Journal of Clinical Oncology. 24, 11, p. 1729-1744 16 p.

Research output: Contribution to journalArticle

Protease Inhibitors
Transcriptome
Non-Small Cell Lung Carcinoma
Platinum
Drug Therapy
2004
116 Citations (Scopus)

Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application

Petty, R. D., Nicolson, M. C., Kerr, K. M., Collie-Duguid, E. & Murray, G. I., 15 May 2004, In : Clinical Cancer Research. 10, 10, p. 3237-3248 12 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Non-Small Cell Lung Carcinoma
Oligonucleotide Array Sequence Analysis
Premature Mortality
Molecular Biology
8 Citations (Scopus)

Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy

Petty, R. D. & Cassidy, J., 1 Mar 2004, In : Current Cancer Drug Targets. 4, 2, p. 191-204 14 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Neoplasms
Fluorouracil
Therapeutics
DNA
2003
14 Citations (Scopus)

A phase II study of mitomycin C, cisplatin and protracted infusional 5-fluorouracil in advanced pancreatic carcinoma: efficacy and low toxicity

Petty, R. D., Nicolson, M. C., Skaria, S., Sinclair, T. S., Samuel, L. M., Koruth, M. & Aberdeen Pancreatic Cancer Focus Group, Jul 2003, In : Annals of Oncology. 14, 7, p. 1100-1105 6 p.

Research output: Contribution to journalArticle

Mitomycin
Fluorouracil
Cisplatin
gemcitabine
Survival
7 Citations (Scopus)

Is optimal first-line chemotherapy deliverable in all newly diagnosed ovarian cancers? A population-based study

McNally, O. M., Delaney, E., Petty, R. D., Cruickshank, M. E., Hutcheon, A. W. & Parkin, D. E., 15 Sep 2003, In : British Journal of Cancer. 89, 6, p. 966-967 2 p.

Research output: Contribution to journalArticle

Platinum
Ovarian Neoplasms
Drug Therapy
Paclitaxel
Population
2002
5 Citations (Scopus)

Bone metastasis from epithelial ovarian carcinoma

Petty, R. D., Gilbert, F., Hutcheon, A. W., Sarkar, T. K., McNally, O. & Parkin, D., Aug 2002, In : Lancet Oncology. 3, 8, p. 513 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Tumor chemosensitivity and chemoresistance assays

Cree, I. A., Petty, R. D., Kurbacher, C. M. & Untch, M., 1 Nov 1996, In : Cancer. 78, 9, p. 2031-2032 2 p.

Research output: Contribution to journalArticle

1995
173 Citations (Scopus)

Comparison of MTT and ATP-based assays for the measurement of viable cell number

Petty, R. D., Sutherland, L. A., Hunter, E. M. & Cree, I. A., Jan 1995, In : Journal of Bioluminescence and Chemiluminescence. 10, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Assays
Cell Count
Adenosine Triphosphate
Cells
Reading
1994
57 Citations (Scopus)

Expression of the p53 tumour suppressor gene product is a determinant of chemosensitivity

Petty, R. D., Cree, I. A., Sutherland, L. A., Hunter, E. M., Lane, D. P., Preece, P. E. & Andreotti, P. E., 28 Feb 1994, In : Biochemical and Biophysical Research Communications. 199, 1, p. 264-270 7 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
DNA Damage
Tumors
Genes
Cytotoxins