Ibbotson, Sally

Professor

  • 5042 Citations
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1991 …2020
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Personal profile

Teaching

 

Undergraduate: I am involved in the Phase II and Phase III medical student dermatology teaching programme and implementation of the Curriculum.  Within this I give formal lectures, teach at integrated sessions and in clinical teaching sessions.  I teach the Phase III students at my general dermatology clinic and I previously established a “teaching clinic” in Perth.  I also hold a fortnightly “Photodermatology” tutorial for Phase III.  I participate in the OSCE and portfolio examinations and in interviewing prospective medical students.  I have been involved in the significant revision of our undergraduate teaching programme and in the establishment of a dermatology core curriculum for undergraduates.  I am involved in the development of changes in our undergraduate teaching programme and in lecturing and clinical teaching in our recently revised Phase II undergraduate course.  I have a central role in curriculum development including: Co-Chair of Steering Committee for dermatology teaching programme; appointment of Technical Assistant for development of audio-visual teaching methods and was co-applicant in IVIMEDS undergraduate virtual learning programme (collaborative proposal with University of Queensland).  I have been involved in the supervision and grading of the 4th Year pathology BMedSci medical student essays and in Special Study Modules and fourth year projects in photodermatology for medical students (more than 20 students to date and 5 during 2012/13).  I supervise SSCs in photodynamic therapy in years 1 and 2/3.  I have been project supervisor for five St Andrew’s medical students, who have each had an eight to 12-week attachment.  I have been involved in undergraduate curriculum developments in my role as committee member on the BAD Education Sub-committee and the BAD Dermatology Teachers Group.  I am tutor via the Student Support Scheme as academic and pastoral tutor for 12 medical students and I am a student mentor and careers advisor (Speciality Advisory Group for medical students since 2009) for the British Association of Dermatologists.  I am author of the Dermatology chapter for Davidson’s Textbook of Medicine 2012.  I also authored a chapter for Treatment of Skin Disease, 4th Edition 2012.  I have recently agreed to write two additional chapters for Rook’s Textbook of Dermatology and a third chapter for an American Photodermatology textbook.  I am External Examiner for the 4th year undergraduate curriculum in Edinburgh and my role involves committee participation four times per year and standard setting and quality assurance for all the 4th year online assessments.  I have co-supervised two undergraduate students recently who were awarded Carnegie Trust and Biochemistry Society Summer Vacation Scholarships.

 

Postgraduate: I have a major role in postgraduate training as Training Programme Director for Dermatology in the Eastern Deanery and am involved in all stages of training of Specialist trainees.  I was involved in the appointment process for an NES Foundation Course for Dermatology. 

 

I give tutorials, lectures and practical demonstrations in a yearly Photodermatology Course for trainee dermatologists in Dundee and London and in a separate course for Consultants.  I also give lectures and practical demonstrations at the Photodermatology nursing course, at the Paediatric Dermatology Annual Course and the Dermatology Pharmacists Course.  I was involved in meetings of the British Association of University Teachers of Dermatology (BAUTOD).  I am a member of the Scottish Clinical Research Excellence Development Scheme (SCREDS) approval and appointment committee.  I was also instrumental in securing a SCRED post in Dermatology and in appointing a postholder who has now gone on to be awarded a Wellcome Trust PhD Fellowship.  I have supervised and examined MD and PhD students.  I have been invited to other centres in the UK to speak on areas of interest in Photodermatology.  I have been involved in teaching both local and European primary care physicians.

 

I regularly attend and participate in the British Association of Dermatologists and British Society of Investigative Dermatologists annual meetings in order to ensure continuation of my own training.  I am also regularly invited to speak at National and International meetings and attend at least one International general dermatology meeting each year, typically either the annual meeting of the American Academy of Dermatologists or the European Academy of Dermato-Venereology.  I additionally ensure that I present at and attend at least one investigative meeting each year, particularly the National and International Photobiology meetings.

Biography

DATE OF BIRTH:      18.02.62                                              PLACE OF BIRTH:     Newcastle upon Tyne

 

ADDRESS:               Photobiology Unit, Dermatology Department,

                                University of Dundee, Ninewells Hospital & Medical School,

                                Dundee, DD1 9SY

                                Tel: (01382) 425 717

                                Fax: (01382) 646 047

                                E-mail: s.h.ibbotson@dundee.ac.uk

 

 

QUALIFICATIONS:   BSc (Hons)

                                MBChB (Hons)

                                FRCP (UK)

                                MD (with Commendation)

                                CCST in Dermatology

 

GMC No:                  3125050

 

 

 

ACADEMIC RECORD

 

SECONDARY EDUCATION

1973-1980                 Central Newcastle High School, Newcastle upon Tyne

 

MEDICAL SCHOOL

1980-1986                 School of Medicine, University of Leeds

1983                         Intercalated BSc (First Class Honours), Biochemistry in Relation to Medicine

                                University of Leeds

1986                         MBChB (Honours)

 

 

UNIVERSITY AWARDS AND DISTINCTIONS

 

DISTINCTIONS

1982                         Anatomy, Biochemistry, Physiology

1984                         Pathology, Microbiology

1985                         Obstetrics and Gynaecology, Psychiatry

1986   General Surgery

 

HONOURS

1985                         Paediatrics

1986                                 General Medicine

 

UNIVERSITY PRIZES

1981                         The Anatomy Prize for the Best Student

1982                         The Infirmary Prize for the Most Outstanding Student

1983                         The Frank Happold Prize for Biochemistry

1984                         The Matthew Stewart Prize for Pathology

1985                         The John Ingram Prize for Dermatology

1986                         The Scattergood Prize for Obstetrics & Gynaecology

1986                         The Tomlin Prize for Ophthalmology

1986                                 The William Hey Medal for the Most Distinguished Undergraduate

1986                         The Mayo Robson Prize for Surgery

 

 

POSTGRADUATE QUALIFICATIONS

 

1989                         MRCP (UK)

1994                         MD (with Commendation), Leeds University

1997                                 CCST in Dermatology

2001                         FRCP (Edinburgh)

 

PRESENT APPOINTMENT

 

 

09/11/98 to date:       Clinical Senior Lecturer in Photobiology

                                Honorary Consultant in Dermatology

                                Photobiology Unit, Dermatology Department, University of Dundee,

                                Ninewells Hospital & Medical School, Dundee, DD1 9SY

 

                                Colleagues:  Drs A Affleck, A Bryden, S Brown, R Dawe, C Fleming, J Foerster,

                                S Ghaffar, C Green, R Hearn, C Proby

 

 

PREVIOUS APPOINTMENTS

 

DERMATOLOGY TRAINING

01/09/94-17/08/95      Senior Registrar

23/09/95-03/02/96      The Royal Victoria Infirmary

01/04/97-08/11/98      Newcastle upon Tyne

 

04/02/96-31/03/97      Research Fellow with Dr IE Kochevar

Wellman Laboratories of Photomedicine,

Harvard Medical School, Massachusetts General Hospital, Boston, USA

 

18/08/95-22/09/95      Locum Consultant for Dr PM Farr

                                The Royal Victoria Infirmary, Newcastle upon Tyne

 

01/08/92-31/08/94      Registrar

                                The Royal Victoria Infirmary, Newcastle upon Tyne

 

 

GENERAL MEDICAL TRAINING

1989-1992                 Emma and Leslie Reid Research Fellowship

                                Research Fellow (Honorary Registrar), University of Leeds,

                                Academic Unit of Medicine, General Infirmary at Leeds,

                                Professor JA Davies, Professor CRM Prentice

 

1987-1989                 Teaching Fellow in Medicine

                                Academic Unit of Medicine, General Infirmary at Leeds

                                Professor CRM Prentice, Professor JA Davies, Dr M Feely,

                                Professor PJ Grant, Dr JK Wales

 

1987                         House Surgeon

                                Professorial Surgical and Orthopaedic Units

                                St James's University Teaching Hospital, Leeds.

                                Professor GRG Giles, Mr PJ Guillou,

                                Mr RI Hall, Professor RA Dixon

 

1986-1987                 House Physician

                                Academic Unit of Medicine

                                And Department of Neurology

                                General Infirmary at Leeds.

                                Professor CRM Prentice, Professor JA Davies, Dr M Feely,

                                Dr JK Wales, Dr MR Parsons, Dr EGS Spokes

 

 

CAREER SUMMARY AND AIMS

 

During my medical training and initial postgraduate period I obtained a BSc (First Class Honours), MBChB (Honours) and MRCP and I have always wanted to pursue an academic career.  I spent three years as Research Fellow and investigated hypercoagulability, particularly in relation to diabetes mellitus, and was awarded an MD with Commendation.  My dermatology training was in Newcastle upon Tyne and it was during this period that I became particularly interested in photobiology.  I spent fourteen months at the Wellman Laboratories of Photomedicine in Boston, as a Harvard Medical School Research Fellow and this period of laboratory research complemented my clinical training.  I was appointed Clinical Senior Lecturer in Photobiology in Dundee in November 1998 and this has enabled me to concentrate on and develop my photobiology clinical and research interests.  My main areas of interest are in photosensitive skin diseases, phototherapy and photodynamic therapy.  I took over the running of the Photobiology Unit in April 2013 and I have major involvement in clinical Photodermatology, undergraduate and postgraduate training and teaching and research.

 

EXPERIENCE OBTAINED DURING DERMATOLOGY AND GENERAL MEDICAL TRAINING

 

1      DERMATOLOGY CLINICAL EXPERIENCE

The University Department in Newcastle upon Tyne provided general and specialist dermatology services.  Departmental areas of clinical and research interest included therapeutic and investigative photodermatology, skin cancer, genodermatoses and inflammatory skin diseases.  I performed general dermatology clinics, inpatient care, weekly cutaneous surgery and regular on-call duties.  There was a major academic emphasis in the Department and I was fortunate to work with Professors JL Rees, PM Farr, E Healy, A Quinn and NJ Reynolds during this period, which enhanced my training, and independent research was strongly encouraged.

 

Specialty attachments, each of six months duration, were pursued in dermatological surgery, dermatopathology, contact dermatitis and genital dermatoses.  I developed a particular interest in photobiology and spent almost two years in this attachment.

 

Photobiology and Photochemotherapy:  I was involved in therapeutic and diagnostic photodermatology and worked with Professor Peter Farr to establish a regional and extra-regional investigative service.  I was also involved in the management of patients with cutaneous lymphomas, in conjunction with the radiotherapists.  During this period I had major involvement in clinical research and management.

 

2    GENERAL MEDICAL EXPERIENCE

Throughout my clinical training in general medicine I was also actively involved in research, teaching, audit and management.

 

3    TEACHING EXPERIENCE

I had an active role in under- and post-graduate teaching throughout my training in medicine and dermatology.  This involved organisation of medical student final examinations and teaching of medical and dental students, MRCP candidates, scientists, general practitioners, nurses and special interest groups.

 

4    AUDIT

I was involved in regular audit and clinical governance throughout my training.

 

5    ADMINISTRATION

I had a major role in supervision and organisation of departmental procedures during my medical and dermatology training.  During my time in Boston, I was Editorial Assistant to Dr IE Kochevar for the journal Photochemistry & Photobiology.

 

 

6          RESEARCH EXPERIENCE

 

 

BIOCHEMISTRY IN RELATION TO MEDICINE – BSc YEAR

I studied metabolism of neuropeptides by membrane-bound endopeptidase 24.11. and, in particular, luteinising hormone releasing hormone, the enkephalins, substance P and neurotensin.  The research involved enzyme assays and product analysis by high-performance liquid chromatography.

 

GENERAL MEDICINE

(i)   Teaching Fellow in Medicine.  During this clinical period I investigated the influence of DDAVP-induced increases in coagulation factor VIII on the anticoagulant effect of hirudin.

 

(ii) Emma and Leslie Reid Research Fellow – MD.  "Plasma procoagulant activity and coagulation factor VIII in relation to accelerated thrombogenesis and diabetes mellitus". 

I investigated the existence of a "hypercoagulable state".  I established an assay allowing the rate of thrombin production to be studied in vitro.  The method was based on a technique using defibrinated plasma, with cleavage of a chromogenic substrate by thrombin as the end point.  I initially used a manual assay and subsequently incorporated computerised timing and data analysis to enhance the precision of the system.  The method had the advantage of enabling thrombin production to be assessed as a generation rate, rather than as an absolute quantity.  I studied the effect of procoagulants (in particular, high concentrations of factors V and VIII) on thrombin generation in vitro

 

I also examined the influence of age on the rate of thrombin production in healthy volunteers.  In order to study the effect of factor VIII induction in vivo on thrombin generation rate, subjects were investigated during and after DDAVP infusion, exercise and induced hypoglycaemia.  I applied the in vitro technique to samples from patient groups in which procoagulant changes (elevated factor VIII levels) may have contributed to the underlying pathology of the condition.  I additionally studied the contribution of procoagulant changes and elevated factor VIII levels to the pathogenesis of vascular disease in diabetes.  This work was supported by a grant (£15,971) from the Medical Research Council.

 

As Research Fellow, I collaborated with the Dermatology Department and used the method of assessing thrombin generation rate to study the role of hypercoagulability in patients with Raynaud’s phenomenon.  I also used the technique to investigate patients with venous leg ulceration.  The laboratory findings led to a clinical study of the effect of aspirin on the healing rate of chronic venous ulcers and to a change in clinical practice.

 

DERMATOLOGY RESEARCH

(i) Research Fellow with Dr IE Kochevar

Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, USA

I was interested in studying the acute and chronic effects of UVR, particularly the oxidative stress induced, on parameters of cell damage.  The specific studies completed were:

(a) The effects of benzoyl peroxide (BPO) and UVA on lipid peroxidation and plasma membrane damage.

(b)   The chronic effects of ultraviolet B radiation (UVB) and BPO on mouse skin.

 

This research period involved the application of several techniques including:

(1)     Cell culture, irradiations and viability assays

(2)    UVR and Nd-YAG laser calibration and dosimetry

(3)    Biochemical assays of lipid peroxidation

(4)    Animal studies involving mice handling

 

 

This 14-month attachment was made possible by grants, which I was competitively awarded, amounting to £34,000.  The funding was provided by:

 

  • National Institutes of Health Grant/Dr IE Kochevar
  • British Association of Dermatologists/Dowling Club Study Fellowship
  • Peel Medical Trust Travelling Fellowship
  • Psoriasis Association Research Grant
  • Wellcome Research Travel Grant
  • University of Newcastle Medical Research Fund
  • Albert M Kligman Fellowship
  • Minor funding from drug companies

 

(ii) Research in University Department of Dermatology, Newcastle upon Tyne

 

Photobiology and Photochemotherapy

(a) I examined the wavelength-dependence of the effect of indomethacin on ultraviolet erythema

(b) I investigated the DNCB responses of high-dose PUVA patients in order to assess whether cutaneous immunosuppression is relevant to the development of skin cancer in these patients.

(c) I investigated the effect of high-dose local PUVA on the resolution of localised plaques of psoriasis.

(d) I investigated the time-course of PUVA erythema.

(e) I examined the effect of 8-methoxypsoralen dose on PUVA erythema.

(Funded by The Newcastle University Special Trustees Award (£3000)).

 

Contact Dermatitis

I investigated the prevalence and relevance of mercury hypersensitivity in patients with oral lichenoid reactions and the effect of amalgam replacement in selected subjects. The results of this project were clinically relevant and provided evidence, which led to a change in patient management.

 

Skin Cancer

I examined experimental contact sensitivity to DNCB in subjects with non-melanoma skin cancer.

 

Audit

I reviewed cases of malignant melanoma seen in the Dermatology Department in Newcastle over a two-year period.

 

Throughout my training I enjoyed a multi-disciplinary collaborative approach to research.

 

 

CURRENT POSITION SINCE NOVEMBER 1998

 

CLINICAL SENIOR LECTURER IN PHOTOBIOLOGY & HONORARY CONSULTANT IN DERMATOLOGY, UNIVERSITY OF DUNDEE

 

CLINICAL: The Photobiology Unit is a tertiary referral centre offering a National Service for the investigation and management of patients with photosensitivity disorders.  I have taken over leading the Unit and the responsibilities  of this National Service since Professor James Ferguson’s retirement in March 2013.  I also have responsibility for the supervision and management of patients referred for phototherapy and photochemotherapy.  The Alf Stewart Laser Charitable Trust has provided support for my role in developing photodynamic therapy (PDT) and laser therapy and I am the lead for the PDT Service.  I also undertake general dermatology clinics at Ninewells.  I am responsible for inpatient care and participate in the weekly academic afternoon, which includes histopathology, clinical cases and research presentations.  I have a regular on-call commitment for Dermatology and as Co-ordinator of major incidents.

AUDIT: Audit areas include laser and photodynamic therapy services, photodiagnostic and phototherapy services and the use of phototherapy in the management of eczema, urticaria and pruritus.  I have organised and led a National PDT Audit of PDT Centres in Scotland and I am currently leading a proposal to establish a National Managed Clinical Network for PDT Services in Dermatology which has met with initial approval to move to the next stage.

 

ADMINISTRATION & COMMITTEES: I am jointly involved with my consultant colleagues in the organisation and administration of dermatology clinical services, teaching and audit.  I have been responsible for the administration of the Photobiology Services since Professor Ferguson’s retiral in March 2013 and I am responsible for PDT and Laser Service provision.  I am a reviewer for the British Journal of Dermatology, Journal of Investigative Dermatology, Journal of Dermatological Treatment, Clinical and Experimental Dermatology, British Journal of Plastic Surgery, American Journal of Clinical Dermatology, Acta-Derm Venereologica, Archives of Dermatology, Photodermatology, Photoimmunology & Photomedicine, Expert Review of Anticancer Therapy and the Australasian Journal of Dermatology, Future Oncology, Journal of Oral Pathology and Medicine and I am Associate Editor and reviewer for the journal Photodiagnosis and Photodynamic Therapy.  I am a member of the British Skin Foundation Grants Advisory Committee.  I administer the grants, for which I am principal applicant and I am responsible for interviewing, appointing and managing the Personnel recruited on these grants.  I have been on several other appointing committees for Senior Lecturer, Consultant, Lecturer, Specialist Registrar and SHO appointments.  I review grants for the British Skin Foundation and the Association of International Cancer Research.  I am a member of the SCREDS appointing committee.

 

My administration role has markedly increased since taking over as Photobiology Unit Lead in March 2013, with responsibility for staff, services and finance in the Unit.

Research

In my position as Clinical Senior Lecturer, I have developed several areas of research.  I have undertaken many presentations based on these areas of research, at both National and International meetings.  I am involved in the BAD Research Network.

 

 

LABORATORY-BASED PHOTOBIOLOGY RESEARCH

 

Mechanisms regulation individuality in Cytochrome P450 CYP2S1 expression in human skinDr Gillian Smith, Biomedical Research Institute and I appointed a Postdoctoral Scientist to work on this project which investigated in detail the mechanisms of regulation of CYP2S1 in skin, and this work was also the subject of a Proof of Concept application (2007).  (Chief Scientist Office, £170,353, 2006 – 2012)

 

Expression and regulation of cytoprotective genes in human skinI collaborated with Professor CR Wolf in the Biomedical Research Institute, University of Dundee.  We examined individuality of cytoprotective gene and drug metabolising enzyme expression and regulation by chemical agents and UVR, in patients with psoriasis and in healthy controls.  I was awarded funding from the Photobiology Trust Fund for a Technician, to perform the preliminary work for this project and I obtained a grant from the Chief Scientist Office for substantive funding.  A postdoctoral scientist was appointed on this grant. We showed regulation in expression of several of the genes studied, by UVR and chemicals used to treat psoriasis and global up-regulation of drug metabolism in psoriatic plaque. 

 

We also discovered that a novel P450, CYP2S1 was expressed in skin and regulated by topical anti-psoriatic therapies, including retinoids and this was under patent as a potential therapeutic target.  We published this work in the Lancet and J Invest Dermatol and obtained an “excellent” outcome for the final grant report to the CSO.  We were also awarded further funding to extend this work in order to clarify whether these genes were implicated as predictive markers of treatment outcome or toxicity.  (CSO grants, £101,845, 2000 – 2002; £20,911, 2004 - 2005).

 

Factors affecting individuality in response to psoralen-UVA (PUVA) photochemotherapyI was awarded an MRC Component grant for a postdoctoral scientist and a photobiology technician to work on a study examining genetic factors, which may determine individuality in 8-methoxypsoralen metabolism and response to PUVA photochemotherapy. This was a collaborative study with Professor CR Wolf and the study is complete, with a published manuscript in the British Journal of Dermatology.  (MRC Component Grant, £242,180, 2001 - 2005).

 

The Dundee Molecular Pharmacology MRC Co-operative GroupWe were awarded an MRC Co-operative Group grant in order to provide a genotyping and analytical facility for pharmacogenetic research.  This grant provided the core facility in the Biomedical Research Centre required for collaboration between the co-applicants and was an essential part of the MRC Component Grant detailed above. 

(MRC Co-operative Group Grant, £342,948, 2001 - 2006).

 

The influence of glutathione S-transferase (GST) genotype on response to TL-01 phototherapy:  This study arose as a consequence of the findings from our CSO-funded study.  We examined the role of GST genotype as a possible predictor of therapeutic response to TL-01.  (British Skin Foundation, £9,250, 2003 - 2008).

 

The effect of ultraviolet radiation and photochemotherapy on p53 activation pathways in human skin in vivoI worked with Professor T Hupp in the Department of Molecular and Cellular Pathology and we examined the pathways of UVR-induced activation of p53 in human skin in vivo.  A Research Assistant funded by the British Skin Foundation undertook this project and we made some interesting findings, which were published.  (British Skin Foundation, £35,654, 2001 - 2002).

 

UV-dependent regulation of p53 function by a novel protein kinase pathwayDr Ted Hupp and I were awarded a three-year PhD studentship to work on this project, and Lee Finlan was awarded a PhD for this project.  (British Skin Foundation, £54,000, 2002 – 2005).

 

Mechanism –based chemoprotective agents for reducing the risk of ultraviolet radiation-induced skin cancerI am a collaborator with Dr Albena Dinko-Kostova in a study examining the possible photoprotective role of sulforaphane.  (Cancer Research UK- £690,000, 2009-2014).

 

 

CLINICALLY-BASED PHOTOBIOLOGY RESEARCH

 

Photodynamic therapy (PDT)I supervised a study examining the nature of phototoxicity induced by PDT in human skin in vivo.  I was awarded funding for this project by the Dundee Teaching Hospitals Grant scheme.  I have undertaken studies of the use of PDT for mycosis fungoides and psoriasis.  I am supervising studies to optimise PDT regimes for management of non-melanoma skin cancer and Bowen’s disease and to compare PDT with other established treatment regimes.  We are developing LEDs and polymers for use in PDT, with a view to ambulatory home PDT and I have recently initiated a randomised controlled clinical trial to investigate this.  I have been involved in laboratory-based studies of hypericin as a photosensitiser for PDT.  I supervised a medical student in a study examining pain relief during PDT and we are doing further studies in this area using in vivo models in collaboration with Professor Tim Hales with additional undergraduate student supervision on a Carnegie Scholarship.  I have recently established a photobiology tissue bank for future genetic studies including photobiology and PDT patients.  I am involved in several studies of the fluorescence of ALA and MAL and have been co-supervisor of an MD student and a PhD student.  I am currently co-supervising a PhD student in photophysics.  I have collaborations with PDT colleagues in Falkirk/Glasgow and Leeds.  I am responsible for the PDT skin research programme at Ninewells and I find PDT a most enjoyable and fascinating major part of my clinical, teaching and research activities.

 

Sabbatical period working with Professor Ross Barnetson, Dept of Dermatology, University of Sydney, Royal Prince Alfred Hospital, Sydney, Australia, April – July 2003:  I undertook a sabbatical period at the University of Sydney as I was keen to develop my clinical and research interests in PDT.  I undertook a study of the characteristics of 5-aminolaevulinic-induced protoporphyrin IX fluorescence in normal human skin in vivo using a fluorescence spectrometer that I took to Sydney.  This was presented at the British Society of Investigative Dermatologists Annual Meeting in 2004 and at the Scottish Dermatology Society and was subsequently published.  I also used the fluorescence spectrometer to assess protoporphyrin IX fluorescence in patients receiving ALA PDT for skin cancers.  These fluorescence studies complemented my ongoing PDT research programme in Dundee and the sabbatical allowed me to dedicate the time required to undertake these detailed experiments. 

 

I also spent time with Professor Gary Halliday and attended the Department’s academic research meetings.  Professor Halliday has a large research group consisting of approximately twenty postdoctoral scientists and research students all working on a wide range of photobiology studies, including the effects of ultraviolet radiation on immunosuppression and dendritic cell function and the role of immunity in skin carcinogenesis.  

During my sabbatical I also participated in the Annual Meeting of the Australasian College of Dermatologists in Brisbane and I was invited to the Dermatology department in Melbourne in order to spend time with Dr Peter Foley who has interests in photobiology and PDT.  I was also invited to present my work and experience in the Departments in both Sydney and Melbourne.  I found the experience of the sabbatical period in Sydney invaluable both from a clinical and research viewpoint and the experience gained in working in another academic department was most beneficial.

 

Non-invasive imaging:

I am involved in several studies of non-invasive skin imaging to assist in diagnosis and monitoring of treatment responses for skin malignancies.  My role is as PI and co-investigator.  This work includes work with autofluorescence, PpIX imaging, Raman spectroscopy and skin erythema measurements.

 

PUVA therapyI supervised a study examining persistence of photosensitivity after PUVA therapy.  I was awarded funding from the “Anonymous Trust” for this project.  On the basis of the preliminary findings of this experimental work, we are performing a clinical study, which compares topical PUVA treatment regimes, with a view to optimising patient therapy and this is funded by a grant from the British Skin Foundation. 

I supervised studies of the characteristics of erythema induced by topical and systemic PUVA, in an attempt to optimise treatment and minimise the risk of burning.  The results of these studies have led to changes in our methods of delivery of PUVA.  The Tayside University Hospitals NHS Trust, Anonymous Trust Grant Scheme and Psoriasis Association awarded funding for these projects. 

 

Ultraviolet erythemaI supervised studies of TL-01 UVB and UVA1 erythema.

 

Blackcurrant juice and antioxidant content: effect on endothelial and skin behaviour:  I participated in a study of possible photoprotective effects of berry juice, jointly with Professor J Belch’s team, and this is now at the stage of analysis and write-up.

 

Photopatch testingI participated in the supervision and conduction of a prospective multicentre UK photopatch test study, which aimed to clarify the incidence of photocontact allergy and standardise the photopatch test regime.  I was also involved in a study in which we studied possible mechanisms of induction of false positive photopatch tests.  I was involved in a European Photopatch Test Study Group, which had the aim of standardising European photopatch test methodology by undertaking further studies and this was the basis of an MD thesis in our department, which I acted as co-supervisor for.

 

LaserI was involved in a study examining the optimal parameters for laser treatment of facial telangiectasia.

 

The PhotodermatosesI am undertaking several research studies investigating the aetiology and management of the photodermatoses.  These include the effect of topical steroids in the treatment of polymorphic light eruption and the outcome of photosensitivity in young patients with chronic actinic dermatitis.  I was involved in a study examining the natural history of solar urticaria.  I also have an interest in patients with late-onset porphyrias.

 

Phototherapy studiesI have been involved in studies, which aim to optimise phototherapy and PUVA regimes and in retrospective studies of the efficacy of phototherapy in the management of urticaria and pruritus.  We have established the use of high-output UVA1 in the department and I supervised studies of the erythemal characteristics of UVA1 and the effect of St John’s wort and psoralens which resulted in my Research Fellow being awarded an MD and a BSF Fellowship Prize.  I am also involved in clinical studies of UVA1 for scleroderma and eczema. 

 

ImiquimodI undertook a dose-ranging study examining the use of imiquimod in the treatment of superficial basal cell carcinoma and a study of the use of imiquimod in the treatment of lentigo maligna. 3M provided funding (£20K) for a research nurse to facilitate the dose-ranging study. 

 

Evidence-based guidelinesAs a Member and as Committee Member and Chairman of the British Photodermatology Group I have been involved in several workshops to review specific areas of photobiology with a view to publication of evidence-based guidelines.  These have been in the areas of photoallergy and photopatch testing, topical PUVA, UV calibration and dosimetry, PDT and extracorporeal photopheresis.  I organised the 2002 Workshop, which reviewed the use of TL-01 UVB phototherapy.  I am currently a co-author of a developing guideline on the use of PUVA.

 

Radiotherapy-induced erythemaI was involved in a collaborative project with Professor A Munro to investigate radiotherapy-induced erythema as a possible predictor of therapeutic toxicity.  The Anonymous Trust Grant Scheme funded this project.

 

Photobiology Tissue Bank:  I set up a Photobiology Tissue Bank in 2012 and all patients attending the Photobiology Unit are invited to participate.  This will allow us to undertake future genotype-phenotype studies and we have already collected >400 samples.

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Projects 2013 2020

Research Output 1991 2019

1 Citation (Scopus)
10 Downloads (Pure)

Daylight photodynamic therapy: patient willingness to undertake home treatment

McLellan, L. J., O'Mahoney, P., Logan, S., Yule, S., Goodman, C., Lesar, A., Fullerton, L., Ibbotson, S. & Eadie, E., 28 Mar 2019, In : British Journal of Dermatology. 2 p.

Research output: Contribution to journalLetter

Open Access
File
Actinic Keratosis
Photochemotherapy
Dermatology
Scalp
Patient Satisfaction

Factors influencing pain and efficacy of topical photodynamic therapy: a retrospective study

Lydon, E., Dawe, R. S. & Ibbotson, S. H., Jan 2019, In : British Journal of Dermatology. 180, 1, p. 205-206 2 p.

Research output: Contribution to journalLetter

Photochemotherapy
Retrospective Studies
Pain
Actinic Keratosis
Skin Neoplasms

Shedding light on the itch of cholestasis

Ibbotson, S., 9 Aug 2019, In : The British journal of dermatology. 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

The effects of sunscreen use and window glass on daylight photodynamic therapy dosimetry

O'Mahoney, P., Khazova, M., Ibbotson, S. & Eadie, E., 1 Jul 2019, In : British Journal of Dermatology. 181, 1, p. 220-221 2 p.

Research output: Contribution to journalLetter

Prizes

Distinction - Anatomy, Biochemistry, Physiology

Sally Ibbotson (Recipient), 1982

Prize: Other distinction

Distinction - General Surgery

Sally Ibbotson (Recipient), 1986

Prize: Other distinction

Distinction - Pathology, Microbiology

Sally Ibbotson (Recipient), 1984

Prize: Other distinction

Honours - General Medicine

Sally Ibbotson (Recipient), 1986

Prize: Prize (including medals and awards)

Activities 1992 2015

Photodermatology, photoimmunology & photomedicine (Journal)

Sally Ibbotson (Peer reviewer)
Jan 2015

Activity: Publication peer-review and editorial work typesPublication peer-review

British Journal of Dermatology (Journal)

Sally Ibbotson (Peer reviewer)
Feb 2015

Activity: Publication peer-review and editorial work typesPublication peer-review

Photochemical & Photobiological Sciences (Journal)

Sally Ibbotson (Peer reviewer)
Mar 2015

Activity: Publication peer-review and editorial work typesPublication peer-review

British Society for Investigative Dermatology Annual Meeting (Event)

Sally Ibbotson (Member)
Apr 2014

Activity: Membership typesMembership of external research organisation

Euro PDT

Sally Ibbotson (Participant)
Apr 2014

Activity: Participating in or organising an event typesParticipation in conference

Thesis

Photoallergic contact dermatitis in Europe

Author: Kerr, A., 2012

Supervisor: Ferguson, J. (Supervisor) & Ibbotson, S. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Medicine

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