Brown, Sara

Professor, Wellcome Trust Senior Research Fellow, Professor of Molecular and Genetic Dermatology

  • 3440 Citations
  • 28 h-Index
20032020

Research output per year

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Research Output

2020

Assessment of a causal relationship between body mass index and atopic dermatitis

Budu-Aggrey, A., Watkins, S. H., Brumpton, B., Løset, M., Tyrrell, J., Modalsli, E. H., Vie, G. Å., Palmer, T., Fritsche, L. G., Nielsen, J. B., Romundstad, P. R., Davey Smith, G., Åsvold, B. O., Paternoster, L. & Brown, S., 17 May 2020, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Flohr, C., Mitchell, E. J., Swinden, R., Tarr, S., Davies-Jones, S., Jay, N., Kelleher, M. M., Perkin, M. R., Boyle, R. J. & 1 others, Williams, H. C., 21 Mar 2020, In : Lancet. 395, 10228, p. 962-972 11 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
23 Downloads (Pure)

Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects

Brown, S. J., Elias, M. S. & Bradley, M., 9 Jun 2020, In : Acta Dermato-Venereologica. 100, p. 349-357 9 p.

Research output: Contribution to journalReview article

Open Access
File
6 Downloads (Pure)

What have we learned from GWAS for atopic dermatitis?

Brown, S. J., 8 Jun 2020, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

2019

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
4 Downloads (Pure)

Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

Budu-Aggrey, A., Brumpton, B., Tyrrell, J., Watkins, S., Modalsli, E. H., Celis-Morales, C., Ferguson, L. D., Vie, G. Å., Palmer, T., Fritsche, L. G., Løset, M., Nielsen, J. B., Zhou, W., Tsoi, L. C., Wood, A. R., Jones, S. E., Beaumont, R., Saunes, M., Romundstad, P. R., Siebert, S. & 8 others, McInnes, I. B., Elder, J. T., Davey Smith, G., Frayling, T. M., Åsvold, B. O., Brown, S. J., Sattar, N. & Paternoster, L., 31 Jan 2019, In : PLoS Medicine. 16, 1, p. 1-18 18 p., e1002739.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
118 Downloads (Pure)
Open Access
File
51 Downloads (Pure)

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance

Løset, M., Brown, S. J., Saunes, M. & Hveem, K., Aug 2019, In : Dermatology . 235, 5, p. 355-364 10 p.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
9 Downloads (Pure)

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

Eyerich, K., Brown, S. J., Perez White, B. E., Tanaka, R. J., Bissonette, R., Dhar, S., Bieber, T., Hijnen, D. J., Guttman-Yassky, E., Irvine, A., Thyssen, J. P., Vestergaard, C., Werfel, T., Wollenberg, A., Paller, A. S. & Reynolds, N. J., 1 Jan 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
81 Downloads (Pure)

Male genital lichen sclerosus and filaggrin

Shim, T. N., Brown, S. J., Francis, N. D., Dinneen, M., Hawkins, D., Muneer, A., Minhas, S., McLean, W. H. I. & Bunker, C. B., 13 Dec 2019, In : Clinical and Experimental Dermatology. 45, 1, p. 127-128 2 p.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)
4 Downloads (Pure)

Position Statement on Atopic Dermatitis in Sub-Saharan Africa: current status and roadmap

Schmid-Grendelmeier, P., Takaoka, R., Ahogo, K. C., Belachew, W. A., Brown, S. J., Correia, J. C., Correia, M., Degboe, B., Dorizy-Vuong, V., Faye, O., Fuller, L. C., Grando, K., Hsu, C., Kayitenkore, K., Lunjani, N., Ly, F., Mahamadou, G., Manuel, R. C. F., Kebe Dia, M., Masenga, E. J. & 7 others, Muteba Baseke, C., Ouedraogo, A. N., Rapelanoro Rabenja, F., Su, J., Teclessou, J. N., Todd, G. & Taïeb, A., Nov 2019, In : Journal of the European Academy of Dermatology and Venereology. 33, 11, p. 2019-2028 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
51 Downloads (Pure)
Open Access
File
65 Downloads (Pure)

What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review

Blakeway, H., Van-de-Velde, V., Allen, V. B., Kravvas, G., Palla, L., Page, M. J., Flohr, C., Weller, R. B., Irvine, A. D., McPherson, T., Roberts, A., Williams, H. C., Reynolds, N., Brown, S. J., Paternoster, L. & Langan, S. M., 3 Dec 2019, In : British Journal of Dermatology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
20 Downloads (Pure)
2018

A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT)

TREAT Trial Investigators, Irvine, A. D., Jones, A. P., Beattie, P., Baron, S., Browne, F., Ashoor, F., O'Neill, L., Rosala-Hallas, A., Sach, T., Spowart, C., Taams, L., Walker, C., Wan, M., Webb, N., Williamson, P. & Flohr, C., Dec 2018, In : British Journal of Dermatology. 179, 6, p. 1297-1306 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification of atopic dermatitis subgroups in children from two longitudinal birth cohorts

Paternoster, L., Savenije, O. E. M., Heron, J., Evans, D. M., Vonk, J. M., Brunekreef, B., Wijga, A. H., Henderson, A. J., Koppelman, G. H. & Brown, S. J., Mar 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 964-971 8 p.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
229 Downloads (Pure)

Research Techniques Are Not Simple

Brown, S. J., Oct 2018, In : Journal of Investigative Dermatology. 138, 10, p. 2089-2090 2 p.

Research output: Contribution to journalEditorial

Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool

Alexander, H., Brown, S., Danby, S. & Flohr, C., Nov 2018, In : Journal of Investigative Dermatology. 138, 11, p. 2295-2300.e1 7 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
74 Downloads (Pure)

The micro-evolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare

Harkins, C., Pettigrew, K. A., Oravcová, K., Gardner, J., Hearn, R. M. R., Rice, D., Mather, A. E., Parkhill, J., Brown, S., Proby, C. & Holden, M. T. G., Feb 2018, In : Journal of Investigative Dermatology. 138, 2, p. 336-343 8 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
189 Downloads (Pure)
2017

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., Willis Owen, S. A. G., Moffatt, M., Cookson, W. O., Harper, J. I., Di, W. L., Brown, S. J., Reinheckel, T. & O'Shaughnessy, R. F. L., Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
192 Downloads (Pure)

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial

Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Bradshaw, L. E., Montgomery, A. A., Boyle, R. J. & Williams, H. C., 21 Jul 2017, In : Trials. 18, p. 1-11 11 p., 343.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
152 Downloads (Pure)

Evidence-based medicine for atopic eczema: identifying the knowns and unknowns

Brown, S. J., Apr 2017, In : British Journal of Dermatology. 176, 4, p. 842-844 3 p.

Research output: Contribution to journalEditorial

Open Access
File
154 Downloads (Pure)

Genetic prediction of treatment response in psoriasis is still a work in progress

Foulkes, A. & Brown, S., 18 Aug 2017, In : British Journal of Dermatology. 177, 2, p. 344-345

Research output: Contribution to journalComment/debate

Open Access
File
1 Citation (Scopus)
167 Downloads (Pure)
Open Access
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161 Downloads (Pure)

Molecular mechanisms in atopic eczema: insight gained from genetic studies

Brown, S. J., Jan 2017, In : Journal of Pathology. 241, 2, p. 140-145 6 p.

Research output: Contribution to journalReview article

Open Access
File
19 Citations (Scopus)
167 Downloads (Pure)

Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial

Thomas, K. S., Bradshaw, L. E., Sach, T. H., Cowdell, F., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Dean, T., Burrows, N. P., Pollock, I., Buckley, H. K., Williams, H. C., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Wake, E. V. & 3 others, Mitchell, E. J., Brown, S. J. & Montgomery, A. A., Apr 2017, In : Health Technology Assessment. 21, 16, p. 1-260 260 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
151 Downloads (Pure)

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)

Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Williams, H. C., Dean, T., Burrows, N. P., Pollock, I., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Mitchell, E. J., Cowdell, F., Brown, S. J. & 2 others, Montgomery, A. A. & UK Dermatology Clinical Trials Network’s CLOTHES Trial Team, 11 Apr 2017, In : PLoS Medicine. 14, 4, p. 1-23 23 p., e1002280.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
147 Downloads (Pure)
3 Citations (Scopus)

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council

Simpson, E. L., Bruin-Weller, M., Flohr, C., Ardern-Jones, M. R., Barbarot, S., Deleuran, M., Bieber, T., Vestergaard, C., Brown, S. J., Cork, M. J., Drucker, A. M., Eichenfield, L. F., Foelster-Holst, R., Guttman-Yassky, E., Nosbaum, A., Reynolds, N. J., Silverberg, J. I., Schmitt, J., Seyger, M. M. B., Spuls, P. I. & 9 others, Stalder, J-F., Su, J. C., Takaoka, R., Traidl-Hoffmann, C., Thyssen, J. P., van der Schaft, J., Wollenberg, A., Irvine, A. D. & Paller, A. S., Oct 2017, In : Journal of the American Academy of Dermatology. 77, 4, p. 623-633 11 p.

Research output: Contribution to journalArticle

Open Access
File
65 Citations (Scopus)
159 Downloads (Pure)
2016

Atopic eczema

Brown, S. J., 1 Feb 2016, In : Clinical Medicine - Journal of the Royal College of Physicians of London. 16, 1, p. 66-69 4 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
343 Downloads (Pure)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journalLetter

Open Access
File
6 Citations (Scopus)
116 Downloads (Pure)

Hand dermatitis in construction workers: a lesson in genetic epidemiology

Brown, S. J., Feb 2016, In : British Journal of Dermatology. 174, 2, p. 263-265 3 p.

Research output: Contribution to journalComment/debate

Propranolol in the treatment of infantile haemangiomas: lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce survey

Wedgeworth, E., Glover, M., Irvine, A. D., Neri, I., Baselga, E., Clayton, T. H., Beattie, P. E., Bjerre, J. V., Burrows, N. P., Foelster-Holst, R., Hedelund, L., Hernandez-Martin, A., Audrain, H., Bhate, K., Brown, S. J., Baryschpolec, S., Darne, S., Durack, A., Dvorakova, V., Gach, J. & 35 others, Goldstraw, N., Goodyear, H., Grabczynska, S., Greenblatt, D., Halpern, J., Hearn, R. M. R., Hoey, S., Hughes, B., Jayaraj, R., Johansson, E. K., Lam, M., Leech, S., O'Regan, G. M., Morrison, D., Porter, W., Ramesh, R., Schill, T., Shaw, L., Taylor, A. E. M., Taylor, R., Thomson, J., Tiffin, P., Tsakok, M., Janmohamed, S. R., Laguda, B., McPherson, T., Oranje, A. P., Patrizi, A., Ravenscroft, J. C., Shahidullah, H., Solman, L., Svensson, A., Wahlgren, C. F., Hoeger, P. H. & Flohr, C., Mar 2016, In : British Journal of Dermatology. 174, 3, p. 594-601 8 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
178 Downloads (Pure)
2015

A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. & Thomas, K. S., 2 Sep 2015, In : Trials. 16, 12 p., 390.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
147 Downloads (Pure)

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Brough, H. A., Liu, A. H., Sicherer, S., Makinson, K., Douiri, A., Brown, S. J., Stephens, A. C., McLean, W. H. I., Turcanu, V., Wood, R. A., Jones, S. M., Burks, W., Dawson, P., Stablein, D., Sampson, H. & Lack, G., Jan 2015, In : Journal of Allergy and Clinical Immunology. 135, 1, p. 164-170.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
157 Citations (Scopus)
311 Downloads (Pure)

Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A. D., Kabesch, M., Lee, Y. A. E., Lieb, W., Marenholz, I., McLean, W. H. I. & 19 others, Morris, D. W., Mrowietz, U., Nair, R., Nöthen, M. M., Novak, N., O'Regan, G. M., PAGE Consortium, Schreiber, S., Smith, C., Strauch, K., Stuart, P. E., Trembath, R., Tsoi, L. C., Weichenthal, M., Barker, J., Elder, J. T., Weidinger, S., Cordell, H. J. & Brown, S. J., 8 Jan 2015, In : American Journal of Human Genetics. 96, 1, p. 104-120 17 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Identification of translational dermatology research priorities in the U.K. Results of an electronic Delphi exercise

Healy, E., Brown, S. J., Langan, S. M., Nicholls, S. G., Shams, K. & Reynolds, N. J., 14 Oct 2015, In : British Journal of Dermatology. 173, 5, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
136 Downloads (Pure)

Insight from the air-skin interface

O'Shaughnessy, R. F. L. & Brown, S. J., Feb 2015, In : Journal of Investigative Dermatology. 135, 2, p. 331-333 3 p.

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Loss-of-function mutations in the gene encoding filaggrin are not strongly associated with chronic actinic dermatitis

Harkins, C. P., Waters, A., Kerr, A., Campbell, L., McLean, W. H. I., Brown, S. J. & Ibbotson, S. H., Jul 2015, In : Journal of Investigative Dermatology. 135, 7, p. 1919-1921 3 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., Den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 130 others, Kalb, B., Pino-Yanes, M., Xu, C. J., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M. A., Arnold, A., Homuth, G., Schmidt, C. O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L. L., Grarup, N., De Jongste, J. C., Rivadeneira, F., Hofman, A., Jaddoe, V. W. V., Pasmans, S. G. M. A., Elbert, N. J., Uitterlinden, A. G., Marks, G. B., Thompson, P. J., Matheson, M. C., Robertson, C. F., Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., McAleer, M. A., O'Regan, G. M., Fahy, C. M. R., Campbell, L. E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D. S., Feenstra, B., Geller, F., Hottenga, J. J., Middeldorp, C. M., Hysi, P., Bataille, V., Spector, T., Tiesler, C. M. T., Thiering, E., Pahukasahasram, B., Yang, J. J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C. L., Myhre, R., Nystad, W., Custovic, A., Weiss, S. T., Meyers, D. A., Söderhäll, C., Melén, E., Ober, C., Raby, B. A., Simpson, A., Jacobsson, B., Holloway, J. W., Bisgaard, H., Sunyer, J., Probst-Hensch, N. M., Williams, L. K., Godfrey, K. M., Wang, C. A., Boomsma, D. I., Melbye, M., Koppelman, G. H., Jarvis, D., McLean, W. H. I., Irvine, A. D., Zhang, X. J., Hakonarson, H., Gieger, C., Burchard, E. G., Martin, N. G., Duijts, L., Linneberg, A., Jarvelin, M. R., Nöthen, M. M., Lau, S., Hübner, N., Lee, Y. A., Tamari, M., Hinds, D. A., Glass, D., Brown, S. J., Heinrich, J., Evans, D. M. & Weidinger, S., Dec 2015, In : Nature Genetics. 47, 12, p. 1449-1456 8 p.

Research output: Contribution to journalLetter

198 Citations (Scopus)
2014

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y. & Williams, H. C., Oct 2014, In : Journal of Allergy and Clinical Immunology. 134, 4, p. 818-823 6 p.

Research output: Contribution to journalArticle

Open Access
File
371 Citations (Scopus)
196 Downloads (Pure)

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Open Access
File
74 Citations (Scopus)
179 Downloads (Pure)
Open Access
File
16 Citations (Scopus)
369 Downloads (Pure)

Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

Brough, H. A., Simpson, A., Makinson, K., Hankinson, J., Brown, S., Douiri, A., Belgrave, D. C. M., Penagos, M., Stephens, A. C., McLean, W. H. I., Turcanu, V., Nicolaou, N., Custovic, A. & Lack, G., Oct 2014, In : Journal of Allergy and Clinical Immunology. 134, 4, p. 867-875.e1 10 p.

Research output: Contribution to journalArticle

Open Access
File
147 Citations (Scopus)
144 Downloads (Pure)

South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin

Thawer-Esmail, F., Jakasa, I., Todd, G., Wen, Y., Brown, S. J., Kroboth, K., Campbell, L. E., O'Regan, G. M., McLean, W. H. I., Irvine, A. D., Kezic, S. & Sandilands, A., Jan 2014, In : Journal of Allergy and Clinical Immunology. 133, 1, p. 280-282.e1-e2 5 p.

Research output: Contribution to journalLetter

42 Citations (Scopus)
2013

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis

Weidinger, S., Willis-Owen, S. A. G., Kamatani, Y., Baurecht, H., Morar, N., Liang, L., Edser, P., Street, T., Rodriguez, E., O'Regan, G. M., Beattie, P., Fölster-Holst, R., Franke, A., Novak, N., Fahy, C. M., Winge, M. C. G., Kabesch, M., Illig, T., Heath, S., Söderhäll, C. & 13 others, Melén, E., Pershagen, G., Kere, J., Bradley, M., Lieden, A., Nordenskjold, M., Harper, J. I., McLean, W. H. I., Brown, S. J., Cookson, W. O. C., Lathrop, G. M., Irvine, A. D. & Moffatt, M. F., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4841-4856 16 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans

Goh, C. S., Saunders, S. P., Cole, C., Weidinger, S., Baurecht, H., Lee, Y., Reynolds, N. J., Barker, J. N., Cordell, H. J., Brown, S. J., Irvine, A. D., McLean, I., Sandilands, A. & Fallon, P. G., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S145 1 p., 854.

Research output: Contribution to journalMeeting abstract

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

Asai, Y., Greenwood, C., Hull, P. R., Alizadehfar, R., Ben-Shoshan, M., Brown, S. J., Campbell, L., Michel, D. L., Bussières, J., Rousseau, F., Fujiwara, T. M., Morgan, K., Irvine, A. D., McLean, W. H. I. & Clarke, A., Jul 2013, In : Journal of Allergy and Clinical Immunology. 132, 1, p. 239-242.e7 4 p.

Research output: Contribution to journalLetter

35 Citations (Scopus)

Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover

Pohler, E., Harkins, C., Salas, J., Zamiri, M., Wilson, N. J., Smith, F. J., Brown, S. J. & McLean, I., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S146 1 p., 863.

Research output: Contribution to journalMeeting abstract

Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling

Pohler, E., Zamiri, M., Harkins, C., Salas-Alanis, J. C., Perkins, W., Smith, F. J. D., McLean, W. H. I. & Brown, S. J., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2805-2808 4 p.

Research output: Contribution to journalLetter

11 Citations (Scopus)