Brown, Sara

Professor, Wellcome Trust Senior Research Fellow, Professor of Molecular and Genetic Dermatology

  • 3512 Citations
  • 28 h-Index
20032020

Research output per year

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Research Output

2003

Subcorneal pustular dermatosis in association with chronic lymphocytic leukaemia

Brown, S. J., Barrett, P. D., Hendrick, A. & Langtry, J. A. A., 2003, In : Acta Dermato-Venereologica. 83, 4, p. 306-307 2 p.

Research output: Contribution to journalLetter

8 Citations (Scopus)
2005

A 6-month prospective study of the incidence and management of dermatological malignancies in an NHS teaching hospital

Brown, S. J., Thirlaway, C. J. & Lawrence, C. M., 2005, In : British Journal of Dermatology. 153, Suppl. 1, p. 74-74 1 p., DS-1.

Research output: Contribution to journalMeeting abstract

38 Citations (Scopus)
2006

Appointment of a paediatric eczema nurse reduces inpatient admissions for atopic eczema

Brown, S. J., Leech, S. N., Eccleston, F. J. & Taylor, A. E. M., 2006, In : British Journal of Dermatology. 155, Suppl. 1, p. 106-106 1 p.

Research output: Contribution to journalMeeting abstract

Atopic and non-atopic eczema

Brown, S. & Reynolds, N. J., 9 Mar 2006, In : BMJ. 332, 584, p. 584-588 5 p.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Chronic cutaneous graft-versus-host disease associated with multiple cutaneous squamous cell carcinomas

Brown, S. J., Jackson, G. H., Reynolds, N. J. & Lawrence, C. M., 2006, In : Clinical and Experimental Dermatology. 31, 3, p. 472-473 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Does biopsy of clinically normal skin facilitate the diagnosis of pseudoxanthoma etasticum?

Brown, S. J., Talks, S. J., Needham, S. J. & Taylor, A. E. M., Jul 2006, In : British Journal of Dermatology. 155, Supplement s1, p. 47-47 1 p., P-58.

Research output: Contribution to journalMeeting abstract

6 Citations (Scopus)

The management of skin malignancy: to what extent should we rely on clinical diagnosis?

Brown, S. J. & Lawrence, C. M., Jul 2006, In : British Journal of Dermatology. 155, 1, p. 100-103 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2007

Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy

Brown, S. J., Kirkham, N., Devlin, A. M. & Leech, S. N., 2007.

Research output: Contribution to conferencePaper

Pseudoxanthoma elasticum: biopsy of clinically normal skin in the investigation of patients with angioid streaks

Brown, S., Talks, S. J., Needham, S. J. & Taylor, A. E. M., Oct 2007, In : British Journal of Dermatology. 157, 4, p. 748-751 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2008

Additional filaggrin polymorphisms in early-onset and persistent atopic eczema

Brown, S. J., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Reynolds, N. J., Barker, J. N. W. N., Trembath, R. C., Cordell, H. J. & McLean, W. H. I., Dec 2008, In : British Journal of Dermatology. 159, 6, p. 1241-1242 2 p., P4.

Research output: Contribution to journalBook/Film/Article review

Are filaggrin mutations associated with hand eczema or contact allergy? we do not know

Brown, S. & Cordell, H. J., Jun 2008, In : British Journal of Dermatology. 158, 6, p. 1383-1384 3 p.

Research output: Contribution to journalLetter

19 Citations (Scopus)

Atopic eczema and the filaggrin story

Brown, S. J. & Irvine, A. D., Jun 2008, In : Seminars in Cutaneous Medicine and Surgery. 27, 2, p. 128-137 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy

Brown, S. J., Kirkham, N., Devlin, A. M. & Leech, S. N., 2008, In : British Journal of Dermatology. 159, 6, p. 1236-1236 1 p.

Research output: Contribution to journalMeeting abstract

Filaggrin mutations in atopic eczema: genotype-phenotype correlation

Brown, S., Relton, C., Liao, H., Zhao, Y., Sandilands, A., Burn, J., Cordell, H., McLean, W. H. I. & Reynolds, N., Jul 2008, In : British Journal of Dermatology. 159, Supplement s1, p. 11-11 1 p.

Research output: Contribution to journalMeeting abstract

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study

Brown, S. J., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., Wilson, I. J., Burn, J., Reynolds, N. J., McLean, W. H. I. & Cordell, H. J., Apr 2008, In : Journal of Allergy and Clinical Immunology. 121, 4, p. 940-946.e3 7 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Filaggrin null mutations in mild-moderate atopic eczema: a population-based case-control study

Brown, S., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., Wilson, I. J., Burn, J., Reynolds, N. J., McLean, W. & Cordell, H. J., Apr 2008, In : Journal of Investigative Dermatology. 128, S1, p. S112-S112 1 p., 670.

Research output: Contribution to journalMeeting abstract

Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

Brown, S. J., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Trembath, R. C., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J. & McLean, W. H. I., Jun 2008, In : Journal of Investigative Dermatology. 128, 6, p. 1591-1594 5 p.

Research output: Contribution to journalLetter

Open Access
77 Citations (Scopus)
2009

Coma blisters in 2 children on anticonvulsant medication.

Basu, A., Brown, S., Kirkham, N., Ramesh, V., Leech, S. & Devlin, A., 8 Apr 2009, In : Journal of Child Neurology. 24, 8, p. 1021-1025 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Eczema genetics: current state of knowledge and future goals

Brown, S. J. & McLean, W. H. I., Mar 2009, In : Journal of Investigative Dermatology. 129, 3, p. 543-552 10 p.

Research output: Contribution to journalReview article

125 Citations (Scopus)
62 Citations (Scopus)
142 Downloads (Pure)

Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease

Van Limbergen, J., Russell, R. K., Nimmo, E. R., Zhao, Y., Liao, H., Drummond, H. E., Davies, G., Gillett, P. M., McGrogan, P., Bisset, W. M., Mahdi, G., Wilson, D. C., Brown, S. J., McLean, W. H. I. & Satsangi, J., Oct 2009, In : Inflammatory Bowel Diseases. 15, 10, p. 1492-1498 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease

Rodriguez, E., Baurecht, H., Herberich, E., Wagenpfeil, S., Brown, S. J., Cordell, H. J., Irvine, A. D. & Weidinger, S., Jun 2009, In : Journal of Allergy and Clinical Immunology. 123, 6, p. 1361-1370.e7 10 p.

Research output: Contribution to journalArticle

291 Citations (Scopus)
2010

A case of haemophagocytic lymphohistiocytosis: role of skin biopsy in the diagnosis

Brown, S. J., Maoldomhnaigh, C. O., Scanlan, B. T., O'Sullivan, M., McMahon, C., Irvine, A. D., Watson, R. M. & Butler, K., 2010.

Research output: Contribution to conferencePaper

A case of haemophagocytic lymphohistiocytosis: role of skin biopsy in the diagnosis

Brown, S. J., Maoldomhnaigh, C. O., Scanlan, B. T., O'Sullivan, M., McMahon, C., Irvine, A. D., Watson, R. M. & Butler, K., 2010, In : British Journal of Dermatology. 162, 5, p. 1163-1163 1 p.

Research output: Contribution to journalMeeting abstract

Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations

O'Regan, G. M., Campbell, L. E., Cordell, H. J., Irvine, A. D., McLean, W. H. I. & Brown, S. J., Jan 2010, In : Journal of Allergy and Clinical Immunology. 125, 1, p. 170-174.e2 5 p.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
157 Downloads (Pure)

Replication of eczema susceptibility loci identified from a genome-wide association study

Brown, S. J., O'Regan, G. M., Campbell, L. E., Cordell, H. J., Irvine, A. D. & McLean, W. H. I., Apr 2010, In : British Journal of Dermatology. 162, 4, p. 925-925 1 p., O30.

Research output: Contribution to journalBook/Film/Article review

2011

Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W., Apr 2011, In : Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63 1 p., 375.

Research output: Contribution to journalBook/Film/Article review

Filaggrin null mutations are not a protective factor for acne vulgaris

Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y. & Lane, E. B., Jun 2011, In : Journal of Investigative Dermatology. 131, 6, p. 1378-1380 3 p.

Research output: Contribution to journalLetter

10 Citations (Scopus)

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Brown, S. J., Asai, Y., Cordell, H. J., Campbell, L. E., Zhao, Y., Liao, H., Northstone, K., Henderson, J., Alizadehfar, R., Ben-Shoshan, M., Morgan, K., Roberts, G., Masthoff, L. J. N., Pasmans, S. G. M. A., van den Akker, P. C., Wijmenga, C., Hourihane, J. OB., Palmer, C. N. A., Lack, G., Clarke, A. & 3 others, Hull, P. R., Irvine, A. D. & McLean, W. H. I., Mar 2011, In : Journal of Allergy and Clinical Immunology. 127, 3, p. 661-667 7 p.

Research output: Contribution to journalArticle

Open Access
File
263 Citations (Scopus)
158 Downloads (Pure)

Neonatal Lupus Erythematosus

Brown, S. J. & Watson, R., 2011, Harper's Textbook of Pediatric Dermatology. Irvine, A. D., Hoeger, P. H. & Yan, A. C. (eds.). 3rd ed. Oxford, Vol. 1. p. 1-12 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Brown, S. J., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L. E., Kroboth, K., Irvine, A. D., Goh, D. L. M., Tang, M. B. Y., van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B., Jul 2011, In : British Journal of Dermatology. 165, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
2012

Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M. & 12 others, Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I., Nov 2012, In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect

Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Kezic, S., Cordell, H. J., McLean, W. H. I. & Irvine, A. D., Jan 2012, In : Journal of Investigative Dermatology. 132, 1, p. 98-104 7 p.

Research output: Contribution to journalArticle

Open Access
File
112 Citations (Scopus)
130 Downloads (Pure)

Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

Sandilands, A., Brown, S. J., Goh, C. S., Pohler, E., Wilson, N. J., Campbell, L. E., Miyamoto, K., Kubo, A., Irvine, A. D., Thawer-Esmail, F., Munro, C. S., McLean, W. H. I., Kudoh, J., Amagai, M. & Matsui, T., May 2012, In : Journal of Investigative Dermatology. 132, 5, p. 1507-1510 4 p.

Research output: Contribution to journalLetter

7 Citations (Scopus)

One remarkable molecule: filaggrin

Brown, S. J. & McLean, W. H. I., Mar 2012, In : Journal of Investigative Dermatology. 132, 3, p. 751-762 12 p.

Research output: Contribution to journalArticle

271 Citations (Scopus)
2013

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis

Weidinger, S., Willis-Owen, S. A. G., Kamatani, Y., Baurecht, H., Morar, N., Liang, L., Edser, P., Street, T., Rodriguez, E., O'Regan, G. M., Beattie, P., Fölster-Holst, R., Franke, A., Novak, N., Fahy, C. M., Winge, M. C. G., Kabesch, M., Illig, T., Heath, S., Söderhäll, C. & 13 others, Melén, E., Pershagen, G., Kere, J., Bradley, M., Lieden, A., Nordenskjold, M., Harper, J. I., McLean, W. H. I., Brown, S. J., Cookson, W. O. C., Lathrop, G. M., Irvine, A. D. & Moffatt, M. F., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4841-4856 16 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans

Goh, C. S., Saunders, S. P., Cole, C., Weidinger, S., Baurecht, H., Lee, Y., Reynolds, N. J., Barker, J. N., Cordell, H. J., Brown, S. J., Irvine, A. D., McLean, I., Sandilands, A. & Fallon, P. G., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S145 1 p., 854.

Research output: Contribution to journalMeeting abstract

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

Asai, Y., Greenwood, C., Hull, P. R., Alizadehfar, R., Ben-Shoshan, M., Brown, S. J., Campbell, L., Michel, D. L., Bussières, J., Rousseau, F., Fujiwara, T. M., Morgan, K., Irvine, A. D., McLean, W. H. I. & Clarke, A., Jul 2013, In : Journal of Allergy and Clinical Immunology. 132, 1, p. 239-242.e7 4 p.

Research output: Contribution to journalLetter

35 Citations (Scopus)

Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover

Pohler, E., Harkins, C., Salas, J., Zamiri, M., Wilson, N. J., Smith, F. J., Brown, S. J. & McLean, I., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S146 1 p., 863.

Research output: Contribution to journalMeeting abstract

Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling

Pohler, E., Zamiri, M., Harkins, C., Salas-Alanis, J. C., Perkins, W., Smith, F. J. D., McLean, W. H. I. & Brown, S. J., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2805-2808 4 p.

Research output: Contribution to journalLetter

11 Citations (Scopus)

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M. & 29 others, Takahashi, A., Nakamura, Y., Tsoi, L. C., Stuart, P., Elder, J. T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M. M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B. O., Duerr, R. H., Büning, C., Brand, S., Glas, J., McAleer, M. A., Fahy, C. M., Kabesch, M., Brown, S., McLean, W. H. I., Irvine, A. D., Schreiber, S., Lee, Y-A., Franke, A. & Weidinger, S., Jul 2013, In : Nature Genetics. 45, 7, p. 808-812 5 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

The pharmacogenetics of body odor: as easy as ABCC?

Brown, S., Jul 2013, In : Journal of Investigative Dermatology. 133, 7, p. 1709-1711 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2014

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y. & Williams, H. C., Oct 2014, In : Journal of Allergy and Clinical Immunology. 134, 4, p. 818-823 6 p.

Research output: Contribution to journalArticle

Open Access
File
376 Citations (Scopus)
202 Downloads (Pure)

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Open Access
File
75 Citations (Scopus)
183 Downloads (Pure)
Open Access
File
16 Citations (Scopus)
374 Downloads (Pure)

Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

Brough, H. A., Simpson, A., Makinson, K., Hankinson, J., Brown, S., Douiri, A., Belgrave, D. C. M., Penagos, M., Stephens, A. C., McLean, W. H. I., Turcanu, V., Nicolaou, N., Custovic, A. & Lack, G., Oct 2014, In : Journal of Allergy and Clinical Immunology. 134, 4, p. 867-875.e1 10 p.

Research output: Contribution to journalArticle

Open Access
File
148 Citations (Scopus)
150 Downloads (Pure)

South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin

Thawer-Esmail, F., Jakasa, I., Todd, G., Wen, Y., Brown, S. J., Kroboth, K., Campbell, L. E., O'Regan, G. M., McLean, W. H. I., Irvine, A. D., Kezic, S. & Sandilands, A., Jan 2014, In : Journal of Allergy and Clinical Immunology. 133, 1, p. 280-282.e1-e2 5 p.

Research output: Contribution to journalLetter

44 Citations (Scopus)
2015

A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. & Thomas, K. S., 2 Sep 2015, In : Trials. 16, 12 p., 390.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
153 Downloads (Pure)

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Brough, H. A., Liu, A. H., Sicherer, S., Makinson, K., Douiri, A., Brown, S. J., Stephens, A. C., McLean, W. H. I., Turcanu, V., Wood, R. A., Jones, S. M., Burks, W., Dawson, P., Stablein, D., Sampson, H. & Lack, G., Jan 2015, In : Journal of Allergy and Clinical Immunology. 135, 1, p. 164-170.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
160 Citations (Scopus)
318 Downloads (Pure)