Brown, Sara

Professor, Wellcome Trust Senior Research Fellow, Professor of Molecular and Genetic Dermatology

  • 3512 Citations
  • 28 h-Index
20032020

Research output per year

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Research Output

A 6-month prospective study of the incidence and management of dermatological malignancies in an NHS teaching hospital

Brown, S. J., Thirlaway, C. J. & Lawrence, C. M., 2005, In : British Journal of Dermatology. 153, Suppl. 1, p. 74-74 1 p., DS-1.

Research output: Contribution to journalMeeting abstract

38 Citations (Scopus)

A case of haemophagocytic lymphohistiocytosis: role of skin biopsy in the diagnosis

Brown, S. J., Maoldomhnaigh, C. O., Scanlan, B. T., O'Sullivan, M., McMahon, C., Irvine, A. D., Watson, R. M. & Butler, K., 2010.

Research output: Contribution to conferencePaper

A case of haemophagocytic lymphohistiocytosis: role of skin biopsy in the diagnosis

Brown, S. J., Maoldomhnaigh, C. O., Scanlan, B. T., O'Sullivan, M., McMahon, C., Irvine, A. D., Watson, R. M. & Butler, K., 2010, In : British Journal of Dermatology. 162, 5, p. 1163-1163 1 p.

Research output: Contribution to journalMeeting abstract

Additional filaggrin polymorphisms in early-onset and persistent atopic eczema

Brown, S. J., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Reynolds, N. J., Barker, J. N. W. N., Trembath, R. C., Cordell, H. J. & McLean, W. H. I., Dec 2008, In : British Journal of Dermatology. 159, 6, p. 1241-1242 2 p., P4.

Research output: Contribution to journalBook/Film/Article review

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis

Weidinger, S., Willis-Owen, S. A. G., Kamatani, Y., Baurecht, H., Morar, N., Liang, L., Edser, P., Street, T., Rodriguez, E., O'Regan, G. M., Beattie, P., Fölster-Holst, R., Franke, A., Novak, N., Fahy, C. M., Winge, M. C. G., Kabesch, M., Illig, T., Heath, S., Söderhäll, C. & 13 others, Melén, E., Pershagen, G., Kere, J., Bradley, M., Lieden, A., Nordenskjold, M., Harper, J. I., McLean, W. H. I., Brown, S. J., Cookson, W. O. C., Lathrop, G. M., Irvine, A. D. & Moffatt, M. F., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4841-4856 16 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., Willis Owen, S. A. G., Moffatt, M., Cookson, W. O., Harper, J. I., Di, W. L., Brown, S. J., Reinheckel, T. & O'Shaughnessy, R. F. L., Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
195 Downloads (Pure)

A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. & Thomas, K. S., 2 Sep 2015, In : Trials. 16, 12 p., 390.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
153 Downloads (Pure)

A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans

Goh, C. S., Saunders, S. P., Cole, C., Weidinger, S., Baurecht, H., Lee, Y., Reynolds, N. J., Barker, J. N., Cordell, H. J., Brown, S. J., Irvine, A. D., McLean, I., Sandilands, A. & Fallon, P. G., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S145 1 p., 854.

Research output: Contribution to journalMeeting abstract

Appointment of a paediatric eczema nurse reduces inpatient admissions for atopic eczema

Brown, S. J., Leech, S. N., Eccleston, F. J. & Taylor, A. E. M., 2006, In : British Journal of Dermatology. 155, Suppl. 1, p. 106-106 1 p.

Research output: Contribution to journalMeeting abstract

A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT)

TREAT Trial Investigators, Irvine, A. D., Jones, A. P., Beattie, P., Baron, S., Browne, F., Ashoor, F., O'Neill, L., Rosala-Hallas, A., Sach, T., Spowart, C., Taams, L., Walker, C., Wan, M., Webb, N., Williamson, P. & Flohr, C., Dec 2018, In : British Journal of Dermatology. 179, 6, p. 1297-1306 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Are filaggrin mutations associated with hand eczema or contact allergy? we do not know

Brown, S. & Cordell, H. J., Jun 2008, In : British Journal of Dermatology. 158, 6, p. 1383-1384 3 p.

Research output: Contribution to journalLetter

19 Citations (Scopus)

Assessment of a causal relationship between body mass index and atopic dermatitis

Budu-Aggrey, A., Watkins, S. H., Brumpton, B., Løset, M., Tyrrell, J., Modalsli, E. H., Vie, G. Å., Palmer, T., Fritsche, L. G., Nielsen, J. B., Romundstad, P. R., Davey Smith, G., Åsvold, B. O., Paternoster, L. & Brown, S., 17 May 2020, In : Journal of Allergy and Clinical Immunology. 3 p.

Research output: Contribution to journalArticle

Open Access

Atopic and non-atopic eczema

Brown, S. & Reynolds, N. J., 9 Mar 2006, In : BMJ. 332, 584, p. 584-588 5 p.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Brough, H. A., Liu, A. H., Sicherer, S., Makinson, K., Douiri, A., Brown, S. J., Stephens, A. C., McLean, W. H. I., Turcanu, V., Wood, R. A., Jones, S. M., Burks, W., Dawson, P., Stablein, D., Sampson, H. & Lack, G., Jan 2015, In : Journal of Allergy and Clinical Immunology. 135, 1, p. 164-170.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
160 Citations (Scopus)
318 Downloads (Pure)

Atopic eczema

Brown, S. J., 1 Feb 2016, In : Clinical Medicine - Journal of the Royal College of Physicians of London. 16, 1, p. 66-69 4 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
353 Downloads (Pure)

Atopic eczema and the filaggrin story

Brown, S. J. & Irvine, A. D., Jun 2008, In : Seminars in Cutaneous Medicine and Surgery. 27, 2, p. 128-137 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations

O'Regan, G. M., Campbell, L. E., Cordell, H. J., Irvine, A. D., McLean, W. H. I. & Brown, S. J., Jan 2010, In : Journal of Allergy and Clinical Immunology. 125, 1, p. 170-174.e2 5 p.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
157 Downloads (Pure)

Chronic cutaneous graft-versus-host disease associated with multiple cutaneous squamous cell carcinomas

Brown, S. J., Jackson, G. H., Reynolds, N. J. & Lawrence, C. M., 2006, In : Clinical and Experimental Dermatology. 31, 3, p. 472-473 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy

Brown, S. J., Kirkham, N., Devlin, A. M. & Leech, S. N., 2007.

Research output: Contribution to conferencePaper

Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy

Brown, S. J., Kirkham, N., Devlin, A. M. & Leech, S. N., 2008, In : British Journal of Dermatology. 159, 6, p. 1236-1236 1 p.

Research output: Contribution to journalMeeting abstract

Coma blisters in 2 children on anticonvulsant medication.

Basu, A., Brown, S., Kirkham, N., Ramesh, V., Leech, S. & Devlin, A., 8 Apr 2009, In : Journal of Child Neurology. 24, 8, p. 1021-1025 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W., Apr 2011, In : Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63 1 p., 375.

Research output: Contribution to journalBook/Film/Article review

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Flohr, C., Mitchell, E. J., Swinden, R., Tarr, S., Davies-Jones, S., Jay, N., Kelleher, M. M., Perkin, M. R., Boyle, R. J. & 1 others, Williams, H. C., 21 Mar 2020, In : Lancet. 395, 10228, p. 962-972 11 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
30 Downloads (Pure)

Does biopsy of clinically normal skin facilitate the diagnosis of pseudoxanthoma etasticum?

Brown, S. J., Talks, S. J., Needham, S. J. & Taylor, A. E. M., Jul 2006, In : British Journal of Dermatology. 155, Supplement s1, p. 47-47 1 p., P-58.

Research output: Contribution to journalMeeting abstract

6 Citations (Scopus)

Eczema genetics: current state of knowledge and future goals

Brown, S. J. & McLean, W. H. I., Mar 2009, In : Journal of Investigative Dermatology. 129, 3, p. 543-552 10 p.

Research output: Contribution to journalReview article

125 Citations (Scopus)

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial

Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Bradshaw, L. E., Montgomery, A. A., Boyle, R. J. & Williams, H. C., 21 Jul 2017, In : Trials. 18, p. 1-11 11 p., 343.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
158 Downloads (Pure)

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y. & Williams, H. C., Oct 2014, In : Journal of Allergy and Clinical Immunology. 134, 4, p. 818-823 6 p.

Research output: Contribution to journalArticle

Open Access
File
376 Citations (Scopus)
202 Downloads (Pure)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
7 Downloads (Pure)

Evidence-based medicine for atopic eczema: identifying the knowns and unknowns

Brown, S. J., Apr 2017, In : British Journal of Dermatology. 176, 4, p. 842-844 3 p.

Research output: Contribution to journalEditorial

Open Access
File
160 Downloads (Pure)

Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

Budu-Aggrey, A., Brumpton, B., Tyrrell, J., Watkins, S., Modalsli, E. H., Celis-Morales, C., Ferguson, L. D., Vie, G. Å., Palmer, T., Fritsche, L. G., Løset, M., Nielsen, J. B., Zhou, W., Tsoi, L. C., Wood, A. R., Jones, S. E., Beaumont, R., Saunes, M., Romundstad, P. R., Siebert, S. & 8 others, McInnes, I. B., Elder, J. T., Davey Smith, G., Frayling, T. M., Åsvold, B. O., Brown, S. J., Sattar, N. & Paternoster, L., 31 Jan 2019, In : PLoS Medicine. 16, 1, p. 1-18 18 p., e1002739.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
121 Downloads (Pure)

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

Asai, Y., Greenwood, C., Hull, P. R., Alizadehfar, R., Ben-Shoshan, M., Brown, S. J., Campbell, L., Michel, D. L., Bussières, J., Rousseau, F., Fujiwara, T. M., Morgan, K., Irvine, A. D., McLean, W. H. I. & Clarke, A., Jul 2013, In : Journal of Allergy and Clinical Immunology. 132, 1, p. 239-242.e7 4 p.

Research output: Contribution to journalLetter

35 Citations (Scopus)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journalLetter

Open Access
File
6 Citations (Scopus)
122 Downloads (Pure)
62 Citations (Scopus)
142 Downloads (Pure)

Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease

Van Limbergen, J., Russell, R. K., Nimmo, E. R., Zhao, Y., Liao, H., Drummond, H. E., Davies, G., Gillett, P. M., McGrogan, P., Bisset, W. M., Mahdi, G., Wilson, D. C., Brown, S. J., McLean, W. H. I. & Satsangi, J., Oct 2009, In : Inflammatory Bowel Diseases. 15, 10, p. 1492-1498 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Filaggrin mutations in atopic eczema: genotype-phenotype correlation

Brown, S., Relton, C., Liao, H., Zhao, Y., Sandilands, A., Burn, J., Cordell, H., McLean, W. H. I. & Reynolds, N., Jul 2008, In : British Journal of Dermatology. 159, Supplement s1, p. 11-11 1 p.

Research output: Contribution to journalMeeting abstract

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study

Brown, S. J., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., Wilson, I. J., Burn, J., Reynolds, N. J., McLean, W. H. I. & Cordell, H. J., Apr 2008, In : Journal of Allergy and Clinical Immunology. 121, 4, p. 940-946.e3 7 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Filaggrin null mutations are not a protective factor for acne vulgaris

Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y. & Lane, E. B., Jun 2011, In : Journal of Investigative Dermatology. 131, 6, p. 1378-1380 3 p.

Research output: Contribution to journalLetter

10 Citations (Scopus)

Filaggrin null mutations in mild-moderate atopic eczema: a population-based case-control study

Brown, S., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., Wilson, I. J., Burn, J., Reynolds, N. J., McLean, W. & Cordell, H. J., Apr 2008, In : Journal of Investigative Dermatology. 128, S1, p. S112-S112 1 p., 670.

Research output: Contribution to journalMeeting abstract

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Open Access
File
75 Citations (Scopus)
183 Downloads (Pure)

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sep 2019, In : Wellcome Open Research. 4, p. 134 28 p.

Research output: Contribution to journalArticle

Open Access
File
60 Downloads (Pure)

Genetic prediction of treatment response in psoriasis is still a work in progress

Foulkes, A. & Brown, S., 18 Aug 2017, In : British Journal of Dermatology. 177, 2, p. 344-345

Research output: Contribution to journalComment/debate

Open Access
File
1 Citation (Scopus)
172 Downloads (Pure)

Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects

Brown, S. J., Elias, M. S. & Bradley, M., 9 Jun 2020, In : Acta Dermato-Venereologica. 100, p. 349-357 9 p.

Research output: Contribution to journalReview article

Open Access
File
9 Downloads (Pure)

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance

Løset, M., Brown, S. J., Saunes, M. & Hveem, K., Aug 2019, In : Dermatology . 235, 5, p. 355-364 10 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
12 Downloads (Pure)

Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A. D., Kabesch, M., Lee, Y. A. E., Lieb, W., Marenholz, I., McLean, W. H. I. & 19 others, Morris, D. W., Mrowietz, U., Nair, R., Nöthen, M. M., Novak, N., O'Regan, G. M., PAGE Consortium, Schreiber, S., Smith, C., Strauch, K., Stuart, P. E., Trembath, R., Tsoi, L. C., Weichenthal, M., Barker, J., Elder, J. T., Weidinger, S., Cordell, H. J. & Brown, S. J., 8 Jan 2015, In : American Journal of Human Genetics. 96, 1, p. 104-120 17 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Hand dermatitis in construction workers: a lesson in genetic epidemiology

Brown, S. J., Feb 2016, In : British Journal of Dermatology. 174, 2, p. 263-265 3 p.

Research output: Contribution to journalComment/debate

Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M. & 12 others, Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I., Nov 2012, In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover

Pohler, E., Harkins, C., Salas, J., Zamiri, M., Wilson, N. J., Smith, F. J., Brown, S. J. & McLean, I., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S146 1 p., 863.

Research output: Contribution to journalMeeting abstract

Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling

Pohler, E., Zamiri, M., Harkins, C., Salas-Alanis, J. C., Perkins, W., Smith, F. J. D., McLean, W. H. I. & Brown, S. J., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2805-2808 4 p.

Research output: Contribution to journalLetter

11 Citations (Scopus)

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M. & 29 others, Takahashi, A., Nakamura, Y., Tsoi, L. C., Stuart, P., Elder, J. T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M. M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B. O., Duerr, R. H., Büning, C., Brand, S., Glas, J., McAleer, M. A., Fahy, C. M., Kabesch, M., Brown, S., McLean, W. H. I., Irvine, A. D., Schreiber, S., Lee, Y-A., Franke, A. & Weidinger, S., Jul 2013, In : Nature Genetics. 45, 7, p. 808-812 5 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)