20082020

Research output per year

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Research Output

2020

Activation of a [NiFe]-hydrogenase-4 isoenzyme by maturation proteases

Finney, A. J., Buchanan, G., Palmer, T., Coulthurst, S. J. & Sargent, F., 30 Jul 2020, In : Microbiology. 7 p., 000963.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)

Interview with Dr Sarah Coulthurst

Coulthurst, S., 11 Jun 2020, In : Cellular Microbiology. 3 p., e13233.

Research output: Contribution to journalArticle

Type VI secretion system effector proteins: effective weapons for bacterial competitiveness

Hernandez, R. E., Gallegos Monterrosa, R. & Coulthurst, S., 27 Jun 2020, In : Cellular Microbiology. 9 p., e13241.

Research output: Contribution to journalArticle

Open Access
File
17 Downloads (Pure)
2019

A family of Type VI secretion system effector proteins that form ion-selective pores

Mariano, G., Trunk, K., Williams, D. J., Monlezun, L., Strahl, H., Pitt, S. J. & Coulthurst, S., 2 Dec 2019, In : Nature Communications. 10, 1, p. 1-15 15 p., 5484.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
70 Downloads (Pure)

A New Front in Microbial Warfare—Delivery of Antifungal Effectors by the Type VI Secretion System

Trunk, K., Coulthurst, S. & Quinn, J., Jun 2019, In : Journal of Fungi. 5, 2, p. 1-13 13 p., 50.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
115 Downloads (Pure)

The plant pathogen Pectobacterium atrosepticum contains a functional formate hydrogenlyase-2 complex

Finney, A. J., Lowden, R., Fleszar, M., Albareda, M., Coulthurst, S. J. & Sargent, F., Nov 2019, In : Molecular Microbiology. 112, 5, p. 1440-1452 13 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
13 Downloads (Pure)

The Type VI secretion system: a versatile bacterial weapon

Coulthurst, S., 1 May 2019, In : Microbiology. 165, 5, p. 503-515 13 p., 000789.

Research output: Contribution to journalReview article

Open Access
File
23 Citations (Scopus)
240 Downloads (Pure)
2018
Open Access
File
8 Citations (Scopus)
161 Downloads (Pure)

Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system

Ostrowski, A., Cianfanelli, F. R., Porter, M., Mariano, G., Peltier, J., Wong, J. J., Swedlow, J. R., Trost, M. & Coulthurst, S. J., 27 Jul 2018, In : PLoS Pathogens. 14, 7, p. 1-25 25 p., e1007230.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
141 Downloads (Pure)

The Type VI secretion system deploys anti-fungal effectors against microbial competitors

Trunk, K., Peltier, J., Liu, Y-C., Dill, B. D., Walker, L., Gow, N. A. R., Stark, M., Quinn, J., Trost, M. & Coulthurst, S., Aug 2018, In : Nature Microbiology. 3, p. 920-931 12 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
193 Downloads (Pure)
2017

Quantitative Determination of Anti-bacterial Activity During Bacterial Co-culture

Alcoforado Diniz, J., Hollmann, B. & Coulthurst, S. J., 2017, Bacterial Protein Secretion Systems: Methods and Protocols. Journet, L. & Cascales, E. (eds.). New York: Springer , p. 517-524 8 p. (Methods in Molecular Biology; vol. 1615).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2016

Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon

Cianfanelli, F. R., Monlezun, L. & Coulthurst, S. J., Jan 2016, In : Trends in Microbiology. 24, 1, p. 51-62 12 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

Cianfanelli, F. R., Alcoforado Diniz, J., Guo, M., De Cesare, V., Trost, M. & Coulthurst, S., 28 Jun 2016, In : PLoS Pathogens. 12, 6, 27 p., e1005735.

Research output: Contribution to journalArticle

Open Access
File
62 Citations (Scopus)
174 Downloads (Pure)
2015

A Snapshot of the Extraordinary World of Social Microbiology

Stanley-Wall, N. R., Coulthurst, S. J. & Holland, I. B., 20 Nov 2015, In : Journal of Molecular Biology. 427, 23, p. 3625-7 3 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Molecular weaponry: diverse effectors delivered by the Type VI secretion system

Alcoforado Diniz, J., Liu, Y-C. & Coulthurst, S. J., Dec 2015, In : Cellular Microbiology. 17, 12, p. 1742-1751 10 p.

Research output: Contribution to journalArticle

Open Access
File
67 Citations (Scopus)
142 Downloads (Pure)

Visualization of the Serratia type VI secretion system reveals unprovoked attacks and dynamic assembly

Gerc, A. J., Diepold, A., Trunk, K., Porter, M., Rickman, C., Armitage, J. P., Stanley-Wall, N. R. & Coulthurst, S. J., 29 Sep 2015, In : Cell Reports. 12, 12, p. 2131-2142 12 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
240 Downloads (Pure)
2014

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens

Hamilton, J. J., Marlow, V. L., Owen, R. A., Costa, M. D. A. A., Guo, M., Buchanan, G., Chandra, G., Trost, M., Coulthurst, S. J., Palmer, T., Stanley-Wall, N. R. & Sargent, F., 8 Dec 2014, In : Journal of Cell Biology. 207, 5, p. 615-626 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
172 Downloads (Pure)
Open Access
38 Citations (Scopus)

Communication, co-operation and social interactions: a report from the third 'Young Microbiologists Symposium on Microbe Signaling, Organization and Pathogenesis'

Caly, D. L., Coulthurst, S. J., An, S-Q., Helaine, S., Malone, J. G. & Ryan, R. P., Oct 2014, In : Journal of Bacteriology. 196, 20, p. 3527-3533 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
85 Downloads (Pure)

Genome evolution and plasticity of Serratia marcescens: an important multidrug resistant nosocomial pathogen

Iguchi, A., Nagaya, Y., Pradel, E., Ooka, T., Ogura, Y., Katsura, K., Kurokawa, K., Oshima, K., Hattori, M., Parkhill, J., Sebaihia, M., Coulthurst, S., Gotoh, N., Thomson, N. R., Ewbank, J. J. & Hayashi, T., Aug 2014, In : Genome Biology and Evolution. 6, 8, p. 2096-2110 15 p.

Research output: Contribution to journalArticle

Open Access
File
81 Citations (Scopus)
148 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
156 Downloads (Pure)
2013

A synthetic system for expression of components of a bacterial microcompartment

Sargent, F., Davidson, F. A., Kelly, C. L., Binny, R., Christodoulides, N., Gibson, D., Johansson, E., Kozyrska, K., Licandro Lado, L., MacCallum, J., Montague, R., Ortmann, B., Owen, R., Coulthurst, S. J., Dupuy, L., Prescott, A. R. & Palmer, T., Nov 2013, In : Microbiology. 159, 11, p. 2427-2436 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Proteomic identification of novel secreted anti-bacterial toxins of the Serratia marcescens Type VI secretion system

Fritsch, M. J., Trunk, K., Alcoforado Diniz, J., Guo, M., Trost, M. & Coulthurst, S. J., Oct 2013, In : Molecular & Cellular Proteomics. 12, 10, p. 2735-2749

Research output: Contribution to journalArticle

58 Citations (Scopus)

Signal peptide etiquette during assembly of a complex respiratory enzyme

James, M. J., Coulthurst, S. J., Palmer, T. & Sargent, F., Oct 2013, In : Molecular Microbiology. 90, 2, p. 400-414 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. & Hunter, W. N., Dec 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
102 Downloads (Pure)

The type VI secretion system - a widespread and versatile cell targeting system

Coulthurst, S. J., 2013, In : Research in Microbiology. 164, 6, p. 640-654 15 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)
2012

Conserved signal peptide recognition systems across the prokaryotic domains

Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F., 28 Feb 2012, In : Biochemistry. 51, 8, p. 1678-1686 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J., Nov 2012, In : Molecular Microbiology. 86, 4, p. 921-936 16 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Socializing, networking and development: A report from the second 'Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis'

Caly, D. L., Coulthurst, S. J., Geoghegan, J. A., Malone, J. G. & Ryan, R. P., 2012, In : Molecular Microbiology. 86, 3, p. 501-512 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The archetype Pseudomonas aeruginosa proteins TssB and TagJ form a novel subcomplex in the bacterial type VI secretion system

Lossi, N. S., Manoli, E., Simpson, P., Jones, C., Hui, K., Dajani, R., Coulthurst, S. J., Freemont, P. & Filloux, A., 2012, In : Molecular Microbiology. 86, 2, p. 437-456 20 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
26 Citations (Scopus)
2011

A multi-repeat adhesin of the phytopathogen, Pectobacterium atrosepticum, is secreted by a Type I pathway and is subject to complex regulation involving a non-canonical diguanylate cyclase

Perez-Mendoza, D., Coulthurst, S. J., Humphris, S., Campbell, E., Welch, M., Toth, I. K. & Salmond, G. P. C., Nov 2011, In : Molecular Microbiology. 82, 3, p. 719-733 15 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

N-Acetylglucosamine-dependent biofilm formation in Pectobacterium atrosepticum is cryptic and activated by elevated c-di-GMP levels

Perez-Mendoza, D., Coulthurst, S. J., Sanjuan, J. & Salmond, G. P. C., Dec 2011, In : Microbiology. 157, 12, p. 3340-3348 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Stable-isotope labeling with amino acids in nematodes

Larance, M., Bailly, A. P., Pourkarimi, E., Hay, R. T., Buchanan, G., Coulthurst, S., Xirodimas, D. P., Gartner, A. & Lamond, A. I., Oct 2011, In : Nature Methods. 8, 10, p. 849-851 3 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

Murdoch, S. L., Trunk, K., English, G., Fritsch, M. J., Pourkarimi, E. & Coulthurst, S. J., Nov 2011, In : Journal of Bacteriology. 193, 21, p. 6057-6069 13 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N., Dec 2011, In : Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

Two mobile Pectobacterium atrosepticum prophages modulate virulence

Evans, T. J., Coulthurst, S. J., Komitopoulou, E. & Salmond, G. P. C., Mar 2010, In : FEMS Microbiology Letters. 304, 2, p. 195-202 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2009

Chaperone-signal peptide interactions on the Tat protein transport pathway

Coulthurst, S. J. & Sargent, F., Jul 2009, In : FEBS Journal. 276, Suppl. 1, p. 3-3 1 p., PL9.

Research output: Contribution to journalMeeting abstract

Nurturing scientific mutualism: A report from the 'Young Microbiologists Mini-Symposium on microbe signalling, organisation and pathogenesis'

Ryan, R. P., Romeo, T., De Keersmaecker, S. C. J. & Coulthurst, S. J., Sep 2009, In : Molecular Microbiology. 73, 5, p. 760-774 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Remnant signal peptides on non-exported enzymes: implications for the evolution of prokaryotic respiratory chains

Ize, B., Coulthurst, S. J., Hatzixanthis, K., Caldelari, I., Buchanan, G., Barclay, E. C., Richardson, D. J., Palmer, T. & Sargent, F., Dec 2009, In : Microbiology. 155, 12, p. 3992-4004 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2008
5 Citations (Scopus)

DsbA plays a critical and multifaceted role in the production of secreted virulence factors by the phytopathogen Erwinia carotovora subsp atroseptica

Coulthurst, S. J., Lilley, K. S., Hedley, P. E., Liu, H., Toth, I. K. & Salmond, G. P. C., 29 Aug 2008, In : Journal of Biological Chemistry. 283, 35, p. 23739-23753 15 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Quorum sensing coordinates brute force and stealth modes of infection in the plant pathogen Pectobacterium atrosepticum

Liu, H., Coulthurst, S. J., Pritchard, L., Hedley, P. E., Ravensdale, M., Humphris, S., Burr, T., Takle, G., Brurberg, M-B., Birch, P. R. J., Salmond, G. P. C. & Toth, I. K., 2008, In : PLoS Pathogens. 4, 6, p. - 11 p., e1000093.

Research output: Contribution to journalArticle

159 Citations (Scopus)