Martins Da Silva, Sarah

Dr

  • 492 Citations
20042021
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Research Output 2004 2019

  • 492 Citations
  • 19 Article
  • 1 Comment/debate
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Article
2019
69 Downloads (Pure)

Continuous behavioural 'switching' in human spermatozoa and its regulation by Ca2+-mobilising stimuli

Achikanu, C., Correia, J., Guidobaldi, H., Giojalas, L., L. R. Barratt, C., Da Silva, S. M. & Publicover, S., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 423-432 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spermatozoa
Sperm Head
Follicular Fluid
4-Aminopyridine
Fractals
22 Downloads (Pure)

Human sperm ion channel (dys)function: implications for fertilization

Brown, S. G., Publicover, S. J., Barratt, C. & Martins Da Silva, S., Nov 2019, In : Human Reproduction Update. 25, 6, p. 758-776 19 p.

Research output: Contribution to journalArticle

Open Access
File
Ion Channels
Fertilization
Spermatozoa
Potassium
Cations
21 Downloads (Pure)

Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function

McBrinn, R. C., Fraser, J., Hope, A. G., Gray, D. W., Barratt, C. L. R., Martins da Silva, S. J. & Brown, S. G., Dec 2019, In : British Journal of Pharmacology. 176, 23, p. 4521-4536 16 p.

Research output: Contribution to journalArticle

Open Access
File
Sperm Motility
Cell Movement
Pharmacology
Spermatozoa
Electrophysiology
2018
7 Citations (Scopus)
51 Downloads (Pure)

Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

Brown, S. G., Miller, M. R., Lishko, P. V., Lester, D. H., Publicover, S. J., Barratt, C. L. R. & Martins Da Silva, S., 1 Oct 2018, In : Human Reproduction. 33, 10, p. 1812-1816 5 p.

Research output: Contribution to journalArticle

Open Access
File
Spermatozoa
Cations
Exons
Exome
Mutation
6 Citations (Scopus)
55 Downloads (Pure)

Single-cell analysis of [Ca2+]i signalling in sub-fertile men: characteristics and relation to fertilization outcome

Kelly, M. C., Brown, S. G., Costello, S. M., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. L. R. & Martins Da Silva, S., Jun 2018, In : Human Reproduction. 33, 6, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Open Access
File
Single-Cell Analysis
Fertilization
Progesterone
Intracytoplasmic Sperm Injections
Tissue Donors
2017
6 Citations (Scopus)
106 Downloads (Pure)

Complex CatSper-dependent and independent [Ca2+] signaling induced by human follicular fluid

Brown, S. G., Costello, S., Kelly, M., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. & Martins Da Silva, S., 1 Oct 2017, In : Human Reproduction. 32, 10, p. 1995-2006 12 p.

Research output: Contribution to journalArticle

Open Access
File
Follicular Fluid
Progesterone
Spermatozoa
Tissue Donors
Research Ethics
7 Citations (Scopus)
136 Downloads (Pure)

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

Martins Da Silva, S. J., Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G., May 2017, In : Human Reproduction. 32, 5, p. 974-984 11 p.

Research output: Contribution to journalArticle

Open Access
File
Male Infertility
Drug Discovery
Spermatozoa
Sperm-Ovum Interactions
Sperm Motility
2016
5 Citations (Scopus)
103 Downloads (Pure)

A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels

Fernandes, G., Dasai, N., Kozlova, N., Mojadadi, A., Gall, M., Drew, E., Barratt, E., Madamidola, O. A., Brown, S. G., Milne, A. M., Martins Da Silva, S. J., Whalley, K. M., Barratt, C. L. R. & Jovanovic, A., Feb 2016, In : Human Reproduction. 31, 2, p. 287-297 11 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Delivery Systems
Metaphase
Oocytes
Adenosine Triphosphate
Pinacidil
21 Citations (Scopus)
124 Downloads (Pure)

Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF

Brown, S. G., Publicover, S. J., Mansell, S., Lishko, P. V., Williams, H. L., Ramalingam, M., Wilson, S. M., Barratt, C. L. R., Sutton, K. A. & Da Silva, S. M., 15 Jun 2016, In : Human Reproduction. 31, 6, p. 1147-1157 11 p.

Research output: Contribution to journalArticle

Open Access
File
Fertilization
Membrane Potentials
Infertility
Spermatozoa
Intracytoplasmic Sperm Injections
6 Citations (Scopus)
114 Downloads (Pure)

Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?

Yeste, M., Jones, C., Amdani, S. N., Yelumalai, S., Mounce, G., Martins da Silva, S. J., Child, T. & Coward, K., 8 Jun 2016, In : Scientific Reports. 6, p. 1-9 9 p., 27543.

Research output: Contribution to journalArticle

Open Access
File
Type C Phospholipases
Spermatozoa
Oocytes
Sperm Head
Sperm Motility
2015
35 Citations (Scopus)
120 Downloads (Pure)

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

Williams, H. L., Mansell, S., Alasmari, W., Brown, S. G., Wilson, S. M., Sutton, K. A., Miller, M. R., Lishko, P. V., Barratt, C. L. R., Publicover, S. J. & Martins da Silva, S., Dec 2015, In : Human Reproduction. 30, 12, p. 2737-2746 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spermatozoa
Progesterone
Tissue Donors
Electrophysiology
Fertilization
29 Citations (Scopus)

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Yelumalai, S., Yeste, M., Jones, C., Amdani, S. N., Kashir, J., Mounce, G., Martins Da Silva, S. J., Barratt, C. L., McVeigh, E. & Coward, K., Sep 2015, In : Fertility and Sterility. 104, 3, p. 561-568.e4 12 p.

Research output: Contribution to journalArticle

Intracytoplasmic Sperm Injections
Type C Phospholipases
Fertilization
Spermatozoa
Oocyte Retrieval
2014
24 Citations (Scopus)
127 Downloads (Pure)

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

Tardif, S., Madamidola, O. A., Brown, S. G., Frame, L., Lefièvre, L., Wyatt, P. G., Barratt, C. L. R. & Martins Da Silva, S. J., 10 Oct 2014, In : Human Reproduction. 29, 10, p. 2123-2135 13 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphodiesterase Inhibitors
Sperm Motility
Spermatozoa
Intracytoplasmic Sperm Injections
Acrosome Reaction
2013
62 Citations (Scopus)

The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation

Alasmari, W., Barratt, C. L. R., Publicover, S. J., Whalley, K. M., Foster, E., Kay, V., Martins Da Silva, S. & Oxenham, S. K., Apr 2013, In : Human Reproduction. 28, 4, p. 866-876 11 p.

Research output: Contribution to journalArticle

Calcium Signaling
4-Aminopyridine
Spermatozoa
Tissue Donors
Progesterone
2010
19 Citations (Scopus)

Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development

Childs, A. J., Bayne, R. A. L., Murray, A. A., Martins Da Silva, S. J., Collins, C. S., Spears, N. & Anderson, R. A., Apr 2010, In : Developmental Dynamics. 239, 4, p. 1211-1219 9 p.

Research output: Contribution to journalArticle

2005
58 Citations (Scopus)

Brain-derived neurotrophic factor promotes bovine oocyte cytoplasmic competence for embryo development

Martins da Silva, S. J., Gardner, J. O., Taylor, J. E., Springbett, A., De Sousa, P. A. & Anderson, R. A., Apr 2005, In : Reproduction. 129, 4, p. 423-34 12 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Mental Competency
Oocytes
Embryonic Development
Blastocyst
62 Citations (Scopus)

Germ cell proliferation and apoptosis in the developing human ovary

Fulton, N., Martins da Silva, S. J., Bayne, R. A. L. & Anderson, R. A., 1 Aug 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4664-70 7 p.

Research output: Contribution to journalArticle

Cell proliferation
Germ Cells
Ovary
Caspase 3
Cell Proliferation
2004
89 Citations (Scopus)

Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation

Martins da Silva, S. J., Bayne, R. A. L., Cambray, N., Hartley, P. S., McNeilly, A. S. & Anderson, R. A., 15 Feb 2004, In : Developmental Biology. 266, 2, p. 334-45 12 p.

Research output: Contribution to journalArticle

Oogonia
Activin Receptors
Germ Cells
Ovary
Cell Survival
56 Citations (Scopus)

Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary

Bayne, R. A. L., Martins da Silva, S. J. & Anderson, R. A., 1 Jun 2004, In : Molecular Human Reproduction. 10, 6, p. 373-81 9 p.

Research output: Contribution to journalArticle

Ovary
Transcription Factors
Oocytes
Pregnancy
Gene Knockout Techniques