Research output per year
Research output per year
- 29 results
Search results
-
2025
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
Ahel, J., Balci, A., Faas, V., Grabarczyk, D. B., Harmo, R., Squair, D. R., Zhang, J., Roitinger, E., Lamoliatte, F., Mathur, S., Deszcz, L., Bell, L. E., Lehner, A., Williams, T. L., Sowar, H., Meinhart, A., Wood, N. T., Clausen, T. (Lead / Corresponding author), Virdee, S. (Lead / Corresponding author) & Fletcher, A. J., 13 May 2025, (E-pub ahead of print) In: Nature Communications. 16, 19 p., 4414.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
2024
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
Barnsby-Greer, L., Mabbitt, P. D., Dery, M.-A., Squair, D. R., Wood, N. T., Lamoliatte, F., Lange, S. M. & Virdee, S. (Lead / Corresponding author), Feb 2024, In: Nature Structural & Molecular Biology. 31, 2, p. 351-363 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)83 Downloads (Pure) -
2023
An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates
Barnsby-Greer, L., Mabbitt, P., Dery, M.-A., Squair, D., Wood, N., Lange, S. & Virdee, S., 9 May 2023, BioRxiv.Research output: Working paper/Preprint › Preprint
Open AccessFile52 Downloads (Pure) -
2022
Activity-Based Probe Profiling of RNF12 E3 Ubiquitin Ligase Function in Tonne-Kalscheuer Syndrome
Bustos, F., Mathur, S., Espejo-Serrano, C., Toth, R., Hastie, C. J., Virdee, S. (Lead / Corresponding author) & Findlay, G. M. (Lead / Corresponding author), Nov 2022, In: Life Science Alliance. 5, 11, 12 p., e202101248.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)93 Downloads (Pure) -
An atypical ubiquitin ligase at the heart of neural development and programmed axon degeneration
Virdee, S. (Lead / Corresponding author), Nov 2022, In: Neural Regeneration Research. 17, 11, p. 2347-2350 4 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile11 Citations (Scopus)128 Downloads (Pure) -
A new dawn beyond lysine ubiquitination
Squair, D. R. & Virdee, S. (Lead / Corresponding author), Aug 2022, In: Nature Chemical Biology. 18, 8, p. 802-811 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)510 Downloads (Pure) -
Beyond Lysine Ubiquitination
Virdee, S., 13 May 2022, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36, S1Research output: Contribution to journal › Article › peer-review
Open Access -
Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering
Spear, L. A., Huang, Y., Chen, J., Nödling, A. R., Virdee, S. (Lead / Corresponding author) & Tsai, Y.-H. (Lead / Corresponding author), 30 Apr 2022, In: Journal of Molecular Biology. 434, 8, 13 p., 167524.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)96 Downloads (Pure) -
2021
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases
De Cesare, V., Carbajo Lopez, D., Mabbitt, P. D., Fletcher, A. J., Soetens, M., Antico, O., Wood, N. T. & Virdee, S. (Lead / Corresponding author), 26 Jan 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 4, 12 p., e2006947118.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)232 Downloads (Pure) -
E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
Ahel, J. (Lead / Corresponding author), Fletcher, A., Grabarczyk, D. B., Roitinger, E., Deszcz, L., Lehner, A., Virdee, S. (Lead / Corresponding author) & Clausen, T. (Lead / Corresponding author), 10 May 2021, BioRxiv 59 p.Research output: Contribution to specialist publication › Article
-
2020
Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases
Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. & Virdee, S. (Lead / Corresponding author), 16 Jan 2020, In: Cell Chemical Biology. 27, 1, p. 74-82.e6 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)174 Downloads (Pure) -
Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity
Mabbitt, P. D., Loreto, A., Déry, M.-A., Fletcher, A. J., Stanley, M., Pao, K.-C., Wood, N. T., Coleman, M. P. & Virdee, S. (Lead / Corresponding author), 1 Nov 2020, In: Nature Chemical Biology. 16, 11, p. 1227-1236 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)188 Downloads (Pure) -
2018
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity
Pao, K.-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S. (Lead / Corresponding author), 11 Apr 2018, In: Nature. 556, 7701, p. 381-385 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile215 Citations (Scopus)1232 Downloads (Pure) -
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
Kwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. (Lead / Corresponding author) & Kulathu, Y. (Lead / Corresponding author), 5 Apr 2018, In: Molecular Cell. 70, 1, p. 150-164.e6 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile156 Citations (Scopus)402 Downloads (Pure) -
2017
2016 EMBO Chemical Biology Conference
Virdee, S. (Lead / Corresponding author), 3 Jan 2017, In: ChemBioChem. 18, 1, p. 66-71 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile319 Downloads (Pure) -
2016
Chemical Ubiquitination for Decrypting a Cellular Code
Stanley, M. & Virdee, S. (Lead / Corresponding author), 11 May 2016, In: Biochemical Journal. 473, 10, p. 1297-1314 18 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile10 Citations (Scopus)249 Downloads (Pure) -
Genetically directed production of recombinant, isosteric and non-hydrolyzable ubiquitin conjugates
Stanley, M. & Virdee, S. (Lead / Corresponding author), 27 Jun 2016, In: ChemBioChem. 17, 15, p. 1472-1480 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)161 Downloads (Pure) -
ICBS & ECBS Chemical Biology Meeting 2015 - Let them come to Berlin!
Komatsu, T. (Lead / Corresponding author) & Virdee, S., 20 May 2016, In: ACS Chemical Biology. 11, 5, p. 1159-1166 8 p.Research output: Contribution to journal › Article
Open AccessFile3 Citations (Scopus)171 Downloads (Pure) -
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation
Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M. K. & Virdee, S. (Lead / Corresponding author), May 2016, In: Nature Chemical Biology. 12, 5, p. 324-331 8 p.Research output: Contribution to journal › Article › peer-review
93 Citations (Scopus) -
2015
A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation
Han, C., Pao, K.-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. (Lead / Corresponding author), 27 Jul 2015, In: ChemBioChem. 16, 11, p. 1574-1579 6 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes
Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N. & Virdee, S. (Lead / Corresponding author), 19 Jun 2015, In: ACS Chemical Biology. 10, 6, p. 1542-1554 13 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers
Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T. (Lead / Corresponding author), 15 Mar 2015, In: Biochemical Journal. 466, 3, p. 489-498 10 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Citations (Scopus) -
2014
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. & Trost, M. (Lead / Corresponding author), 27 Aug 2014, In: Nature Communications. 5, 11 p., 4763.Research output: Contribution to journal › Article › peer-review
Open AccessFile269 Citations (Scopus)419 Downloads (Pure) -
2012
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains
Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D., Jan 2012, In: Nature Structural & Molecular Biology. 19, 1, p. 62-U83 11 p.Research output: Contribution to journal › Article › peer-review
108 Citations (Scopus) -
2011
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains
Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D., 8 Feb 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.Research output: Contribution to journal › Article › peer-review
119 Citations (Scopus) -
Traceless and site-specific ubiquitination of recombinant proteins
Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W. (Lead / Corresponding author), 20 Jul 2011, In: Journal of the American Chemical Society. 133, 28, p. 10708-10711 4 p.Research output: Contribution to journal › Article › peer-review
161 Citations (Scopus) -
2010
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase
Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. (Lead / Corresponding author) & Chin, J. W. (Lead / Corresponding author), Oct 2010, In: Nature Chemical Biology. 6, 10, p. 750-757 8 p.Research output: Contribution to journal › Article › peer-review
264 Citations (Scopus) -
Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones
Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W., 29 Oct 2010, In: Chemistry & Biology. 17, 10, p. 1072-1076 5 p.Research output: Contribution to journal › Article › peer-review
82 Citations (Scopus) -
Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives
Virdee, S., Macmillan, D. & Waksman, G., 26 Mar 2010, In: Chemistry & Biology. 17, 3, p. 274-284 11 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus)