Research Output per year
Research Output 2010 2018
2018
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity
Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.Research output: Contribution to journal › Article
Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
Kwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. & Kulathu, Y., 5 Apr 2018, In : Molecular Cell. 70, 1, p. 150-164.e6 15 p.Research output: Contribution to journal › Article
Open Access
File
Genomic Instability
Ubiquitin
Polyubiquitin
DNA Damage
Catalysis
2017
2016 EMBO Chemical Biology Conference
Virdee, S., 3 Jan 2017, In : ChemBioChem. 18, 1, p. 66-71 6 p.Research output: Contribution to journal › Article
Open Access
File
Molecular biology
Molecular Biology
Posters
Biological Science Disciplines
Research
2016
Chemical Ubiquitination for Decrypting a Cellular Code
Stanley, M. & Virdee, S., 11 May 2016, In : Biochemical Journal. 473, 10, p. 1297-1314 18 p.Research output: Contribution to journal › Review article
Open Access
File
Polyubiquitin
Ubiquitination
Ubiquitin
Substrates
Proteins
Genetically directed production of recombinant, isosteric and non-hydrolyzable ubiquitin conjugates
Stanley, M. & Virdee, S., 27 Jun 2016, In : ChemBioChem. 17, 15, p. 1472-1480 9 p.Research output: Contribution to journal › Article
Open Access
File
Ubiquitin
Methanosarcina barkeri
Polyubiquitin
Amino Acyl-tRNA Synthetases
Oximes
ICBS & ECBS Chemical Biology Meeting 2015 - Let them come to Berlin!
Komatsu, T. & Virdee, S., 20 May 2016, In : ACS Chemical Biology. 11, 5, p. 1159-1166 8 p.Research output: Contribution to journal › Article
Open Access
File
38
Citations
(Scopus)
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation
Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M. K. & Virdee, S., May 2016, In : Nature Chemical Biology. 12, 5, p. 324-331 8 p.Research output: Contribution to journal › Article
Ubiquitin-Protein Ligases
Parkinson Disease
Dissection
Ubiquitin-Conjugating Enzymes
Biomarkers
2015
4
Citations
(Scopus)
A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation
Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S., 27 Jul 2015, In : ChemBioChem. 16, 11, p. 1574-1579 6 p.Research output: Contribution to journal › Article
Open Access
Ubiquitin
Phosphorylation
Disulfides
Crystals
Ubiquitin-Protein Ligases
Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes
Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N. & Virdee, S., 19 Jun 2015, In : ACS Chemical Biology. 10, 6, p. 1542-1554 13 p.Research output: Contribution to journal › Article
Open Access
Sulfhydryl Compounds
Cysteine
Enzymes
Ubiquitins
Ubiquitin-Protein Ligases
Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers
Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T., 15 Mar 2015, In : Biochemical Journal. 466, 3, p. 489-498 10 p.Research output: Contribution to journal › Article
Open Access
Ubiquitin Thiolesterase
Ubiquitin
Homopolymerization
Peptides
Hydrolases
2014
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. & Trost, M., 27 Aug 2014, In : Nature Communications. 5, 11 p., 4763.Research output: Contribution to journal › Article
Open Access
File
enzyme activity
regulators
Ubiquitin
linkages
inhibitors
2012
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains
Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D., Jan 2012, In : Nature Structural & Molecular Biology. 19, 1, p. 62-U83 11 p.Research output: Contribution to journal › Article
2011
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains
Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D., 8 Feb 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.Research output: Contribution to journal › Article
Traceless and site-specific ubiquitination of recombinant proteins
Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W., 20 Jul 2011, In : Journal of the American Chemical Society. 133, 28, p. 10708-10711 4 p.Research output: Contribution to journal › Article
2010
198
Citations
(Scopus)
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase
Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W., Oct 2010, In : Nature Chemical Biology. 6, 10, p. 750-757 8 p.Research output: Contribution to journal › Article
Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones
Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W., 29 Oct 2010, In : Chemistry & Biology. 17, 10, p. 1072-1076 5 p.Research output: Contribution to journal › Article
Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives
Virdee, S., Macmillan, D. & Waksman, G., 26 Mar 2010, In : Chemistry & Biology. 17, 3, p. 274-284 11 p.Research output: Contribution to journal › Article