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Research Output 2010 2018

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Article
2018
17 Citations (Scopus)
105 Downloads (Pure)

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
19 Citations (Scopus)
61 Downloads (Pure)

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

Kwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. & Kulathu, Y., 5 Apr 2018, In : Molecular Cell. 70, 1, p. 150-164.e6 15 p.

Research output: Contribution to journalArticle

Open Access
File
Genomic Instability
Ubiquitin
Polyubiquitin
DNA Damage
Catalysis
2017
91 Downloads (Pure)

2016 EMBO Chemical Biology Conference

Virdee, S., 3 Jan 2017, In : ChemBioChem. 18, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Open Access
File
Molecular biology
Molecular Biology
Posters
Biological Science Disciplines
Research
2016
7 Citations (Scopus)
37 Downloads (Pure)

Genetically directed production of recombinant, isosteric and non-hydrolyzable ubiquitin conjugates

Stanley, M. & Virdee, S., 27 Jun 2016, In : ChemBioChem. 17, 15, p. 1472-1480 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Methanosarcina barkeri
Polyubiquitin
Amino Acyl-tRNA Synthetases
Oximes
2 Citations (Scopus)
60 Downloads (Pure)

ICBS & ECBS Chemical Biology Meeting 2015 - Let them come to Berlin!

Komatsu, T. & Virdee, S., 20 May 2016, In : ACS Chemical Biology. 11, 5, p. 1159-1166 8 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)

Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M. K. & Virdee, S., May 2016, In : Nature Chemical Biology. 12, 5, p. 324-331 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Parkinson Disease
Dissection
Ubiquitin-Conjugating Enzymes
Biomarkers
2015
4 Citations (Scopus)

A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S., 27 Jul 2015, In : ChemBioChem. 16, 11, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin
Phosphorylation
Disulfides
Crystals
Ubiquitin-Protein Ligases
10 Citations (Scopus)

Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes

Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N. & Virdee, S., 19 Jun 2015, In : ACS Chemical Biology. 10, 6, p. 1542-1554 13 p.

Research output: Contribution to journalArticle

Open Access
Sulfhydryl Compounds
Cysteine
Enzymes
Ubiquitins
Ubiquitin-Protein Ligases
13 Citations (Scopus)

Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T., 15 Mar 2015, In : Biochemical Journal. 466, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin Thiolesterase
Ubiquitin
Homopolymerization
Peptides
Hydrolases
2014
115 Citations (Scopus)
115 Downloads (Pure)

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. & Trost, M., 27 Aug 2014, In : Nature Communications. 5, 11 p., 4763.

Research output: Contribution to journalArticle

Open Access
File
enzyme activity
regulators
Ubiquitin
linkages
inhibitors
2012
61 Citations (Scopus)

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D., Jan 2012, In : Nature Structural & Molecular Biology. 19, 1, p. 62-U83 11 p.

Research output: Contribution to journalArticle

2011
72 Citations (Scopus)

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D., 8 Feb 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Traceless and site-specific ubiquitination of recombinant proteins

Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W., 20 Jul 2011, In : Journal of the American Chemical Society. 133, 28, p. 10708-10711 4 p.

Research output: Contribution to journalArticle

2010
198 Citations (Scopus)

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W., Oct 2010, In : Nature Chemical Biology. 6, 10, p. 750-757 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones

Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W., 29 Oct 2010, In : Chemistry & Biology. 17, 10, p. 1072-1076 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives

Virdee, S., Macmillan, D. & Waksman, G., 26 Mar 2010, In : Chemistry & Biology. 17, 3, p. 274-284 11 p.

Research output: Contribution to journalArticle