Satpal Virdee

2024

UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4

Barnsby-Greer, L., Mabbitt, P. D., Dery, M.-A., Squair, D. R., Wood, N. T., Lamoliatte, F., Lange, S. M. & Virdee, S. (Lead / Corresponding author), Feb 2024, In: Nature Structural & Molecular Biology. 31, 2, p. 351-363 13 p.

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3 Citations (Scopus)

38 Downloads (Pure)

2022

Activity-Based Probe Profiling of RNF12 E3 Ubiquitin Ligase Function in Tonne-Kalscheuer Syndrome

Bustos, F., Mathur, S., Espejo-Serrano, C., Toth, R., Hastie, C. J., Virdee, S. (Lead / Corresponding author) & Findlay, G. M. (Lead / Corresponding author), Nov 2022, In: Life Science Alliance. 5, 11, 12 p., e202101248.

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3 Citations (Scopus)

72 Downloads (Pure)

A new dawn beyond lysine ubiquitination

Squair, D. R. & Virdee, S. (Lead / Corresponding author), Aug 2022, In: Nature Chemical Biology. 18, 8, p. 802-811 10 p.

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43 Citations (Scopus)

380 Downloads (Pure)

Beyond Lysine Ubiquitination

Virdee, S., 13 May 2022, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36, S1

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Open Access

Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering

Spear, L. A., Huang, Y., Chen, J., Nödling, A. R., Virdee, S. (Lead / Corresponding author) & Tsai, Y.-H. (Lead / Corresponding author), 30 Apr 2022, In: Journal of Molecular Biology. 434, 8, 13 p., 167524.

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2 Citations (Scopus)

73 Downloads (Pure)

2021

Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases

De Cesare, V., Carbajo Lopez, D., Mabbitt, P. D., Fletcher, A. J., Soetens, M., Antico, O., Wood, N. T. & Virdee, S. (Lead / Corresponding author), 26 Jan 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 4, 12 p., e2006947118.

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46 Citations (Scopus)

192 Downloads (Pure)

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

Ahel, J. (Lead / Corresponding author), Fletcher, A., Grabarczyk, D. B., Roitinger, E., Deszcz, L., Lehner, A., Virdee, S. (Lead / Corresponding author) & Clausen, T. (Lead / Corresponding author), 10 May 2021, BioRxiv 59 p.

Research output: Contribution to specialist publication › Article

2020

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases

Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. & Virdee, S. (Lead / Corresponding author), 16 Jan 2020, In: Cell Chemical Biology. 27, 1, p. 74-82.e6 16 p.

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26 Citations (Scopus)

157 Downloads (Pure)

Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity

Mabbitt, P. D., Loreto, A., Déry, M.-A., Fletcher, A. J., Stanley, M., Pao, K.-C., Wood, N. T., Coleman, M. P. & Virdee, S. (Lead / Corresponding author), 1 Nov 2020, In: Nature Chemical Biology. 16, 11, p. 1227-1236 10 p.

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48 Citations (Scopus)

151 Downloads (Pure)

2018

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K.-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S. (Lead / Corresponding author), 11 Apr 2018, In: Nature. 556, 7701, p. 381-385 5 p.

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182 Citations (Scopus)

1125 Downloads (Pure)

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

Kwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. (Lead / Corresponding author) & Kulathu, Y. (Lead / Corresponding author), 5 Apr 2018, In: Molecular Cell. 70, 1, p. 150-164.e6 15 p.

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146 Citations (Scopus)

313 Downloads (Pure)

2017

2016 EMBO Chemical Biology Conference

Virdee, S. (Lead / Corresponding author), 3 Jan 2017, In: ChemBioChem. 18, 1, p. 66-71 6 p.

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302 Downloads (Pure)

2016

Genetically directed production of recombinant, isosteric and non-hydrolyzable ubiquitin conjugates

Stanley, M. & Virdee, S. (Lead / Corresponding author), 27 Jun 2016, In: ChemBioChem. 17, 15, p. 1472-1480 9 p.

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21 Citations (Scopus)

144 Downloads (Pure)

ICBS & ECBS Chemical Biology Meeting 2015 - Let them come to Berlin!

Komatsu, T. (Lead / Corresponding author) & Virdee, S., 20 May 2016, In: ACS Chemical Biology. 11, 5, p. 1159-1166 8 p.

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3 Citations (Scopus)

160 Downloads (Pure)

Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M. K. & Virdee, S. (Lead / Corresponding author), May 2016, In: Nature Chemical Biology. 12, 5, p. 324-331 8 p.

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

2015

A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

Han, C., Pao, K.-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. (Lead / Corresponding author), 27 Jul 2015, In: ChemBioChem. 16, 11, p. 1574-1579 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes

Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N. & Virdee, S. (Lead / Corresponding author), 19 Jun 2015, In: ACS Chemical Biology. 10, 6, p. 1542-1554 13 p.

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Open Access

20 Citations (Scopus)

Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T. (Lead / Corresponding author), 15 Mar 2015, In: Biochemical Journal. 466, 3, p. 489-498 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

2014

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. & Trost, M. (Lead / Corresponding author), 27 Aug 2014, In: Nature Communications. 5, 11 p., 4763.

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257 Citations (Scopus)

381 Downloads (Pure)

2012

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

Licchesi, J. D. F., Mieszczanek, J., Mevissen, T. E. T., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., Bienz, M. & Komander, D., Jan 2012, In: Nature Structural & Molecular Biology. 19, 1, p. 62-U83 11 p.

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

2011

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D., 8 Feb 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Traceless and site-specific ubiquitination of recombinant proteins

Virdee, S., Kapadnis, P. B., Elliott, T., Lang, K., Madrzak, J., Nguyen, D. P., Riechmann, L. & Chin, J. W. (Lead / Corresponding author), 20 Jul 2011, In: Journal of the American Chemical Society. 133, 28, p. 10708-10711 4 p.

Research output: Contribution to journal › Article › peer-review

159 Citations (Scopus)

2010

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. (Lead / Corresponding author) & Chin, J. W. (Lead / Corresponding author), Oct 2010, In: Nature Chemical Biology. 6, 10, p. 750-757 8 p.

Research output: Contribution to journal › Article › peer-review

258 Citations (Scopus)

Genetically directing epsilon-N, N-dimethyl-L-lysine in recombinant histones

Nguyen, D. P., Alai, M. M. G., Virdee, S. & Chin, J. W., 29 Oct 2010, In: Chemistry & Biology. 17, 10, p. 1072-1076 5 p.

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives

Virdee, S., Macmillan, D. & Waksman, G., 26 Mar 2010, In: Chemistry & Biology. 17, 3, p. 274-284 11 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Virdee, Satpal

Research output

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