Hughes, Scott

Dr

  • 75 Citations
  • 3 h-Index
20172019
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Fingerprint Dive into the research topics where Scott Hughes is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 49 Similar Profiles
Proteolysis Chemical Compounds
Ubiquitin-Protein Ligases Medicine & Life Sciences
Degradation Chemical Compounds
Ubiquitination Medicine & Life Sciences
Enzyme kinetics Chemical Compounds
Molecular recognition Chemical Compounds
Ligases Medicine & Life Sciences
Hominidae Medicine & Life Sciences

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Research Output 2017 2019

  • 75 Citations
  • 3 h-Index
  • 4 Article
  • 1 Review article

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Girardini, M., Maniaci, C., Hughes, S., Testa, A. & Ciulli, A., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry. 27, 12, p. 2466-2479 14 p.

Research output: Contribution to journalArticle

Open Access
Proteolysis
Ubiquitin-Protein Ligases
Degradation
Cullin Proteins
Ubiquitination
3 Citations (Scopus)
97 Downloads (Pure)

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

Roy, M., Winkler, S., Hughes, S. J., Whitworth, C., Galant, M., Farnaby, W., Rumpel, K. & Ciulli, A., 15 Mar 2019, In : ACS Chemical Biology. 14, 3, p. 361-368 8 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Enzyme kinetics
Degradation
Ubiquitin-Protein Ligases
Assays
12 Citations (Scopus)
139 Downloads (Pure)

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

Zoppi, V., Hughes, S. J., Maniaci, C., Testa, A., Gmaschitz, T., Wieshofer, C., Koegl, M., Riching, K. M., Daniels, D. L., Spallarossa, A. & Ciulli, A., 12 Dec 2018, In : Journal of Medicinal Chemistry. 28 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitination
Ligases
Proteolysis
Chromatin Assembly and Disassembly
Ubiquitin-Protein Ligases
34 Citations (Scopus)
90 Downloads (Pure)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. & Ciulli, A., 10 Oct 2017, In : Nature Communications. 8, p. 1-14 14 p., 830.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Hominidae
degradation
Degradation
26 Citations (Scopus)
111 Downloads (Pure)
Open Access
File
Molecular recognition
Drug Design
Proteins
Cell signaling
Adhesives