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Arthur, Simon

Professor

 https://orcid.org/0000-0002-8135-1958
1987 …2023
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Personal profile

Education/Academic qualification

Doctor of Philosophy, University of Oxford

Bachelor of Science, University of Durham

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2014 2023

Elucidation of Mechanisms that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases

Arthur, J. & Cohen, P.

Medical Research Council

1/04/18 → 31/03/23

Project: Research

The Role of HMBS Phosphorylation in Acute Intermittent Porphyria

Arthur, J., Ibbotson, S. & McGuire, V.

1/03/18 → 28/02/19

Project: Research

Role of Salt Inducible Kinases in Autoimmunity

Arthur, J. & Cohen, P.

1/04/17 → 31/03/20

Project: Research

Understanding the Regulation of Leukotriene Synthesis by Mast Cells (Vacation Scholarship - Cameron Pollock)

Arthur, J.

Project: Research

Investigation of the Potential Role of Salt-Inducible Kinases in Endothelial Dysfunction and Atherosclerosis

Arthur, J., Khan, F. & Lang, C.

17/10/16 → 16/10/18

Project: Research

Research Output 1987 2018

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journal › Article

Colitis
Neoplasms
Myofibroblasts
Cyclooxygenase 2
Ubiquitin
2 Citations

Differential regulation of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

Sutavani, R. V., Phair, I. R., Barker, R., McFarlane, A., Shpiro, N., Lang, S., Woodland, A. & Arthur, J. S. C., 16 Feb 2018, In : Journal of Biological Chemistry. 293, 7, p. 2302-2317 16 p.

Research output: Contribution to journal › Article

Open Access
File
90-kDa Ribosomal Protein S6 Kinases
Toll-Like Receptor 4
Macrophages
Interleukin-10
B-Lymphocytes

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Andersen, J. L., Gesser, B., Funder, E. D., Nielsen, C. J. F., Gotfred-Rasmussen, H., Rasmussen, M. K., Toth, R., Gothelf, K. V., Arthur, J. S. C., Iversen, L. & Nissen, P., 19 Oct 2018, In : Nature Communications. 9, 1, 9 p., 4344.

Research output: Contribution to journal › Article

Open Access
File
90-kDa Ribosomal Protein S6 Kinases
inhibitors
Phosphotransferases
helices
Mitogens

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3

McCarthy, P. C., Phair, I. R., Greger, C., Pardali, K., McGuire, V. A., Clark, A. R., Gaestel, M. & Arthur, J. S. C., 1 Sep 2018, In : Immunology and Cell Biology. 18 p.

Research output: Contribution to journal › Article

Open Access
File
Neutrophil Infiltration
Mitogen-Activated Protein Kinase Kinases
p38 Mitogen-Activated Protein Kinases
Cytokines
Mast Cells

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

Morgan, E. L., Wasson, C. W., Hanson, L., Kealy, D., Pentland, I., McGuire, V., Scarpini, C., Coleman, N., Arthur, J. S. C., Parish, J. L., Roberts, S. & Macdonald, A., 9 Apr 2018, In : PLoS Pathogens. 14, 4, p. 1-33 33 p., e1006975.

Research output: Contribution to journal › Article

Open Access
File
Life Cycle Stages
Phosphorylation
Keratinocytes
STAT3 Transcription Factor
Cell Cycle

Press / Media

Research reveals how immune cells can be altered to help fight inflammatory diseases

Kristopher Clark, Kirsty MacKenzie, Mark Peggie, Lorna Plater, Patrick G. A. Pedrioli, John Arthur & Philip Cohen

11/10/12

1 item of media coverage

Press/Media: Research

Thesis

Regulation of cytokine and chemokine production in macrophages

Author: Pattison, M. J., 2014

Supervisor: Arthur, J. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Regulation of MyD88 signalling by MAPK activated kinases

Author: McCarthy, P. C., 2015

Supervisor: Arthur, J. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

The innate response to fungal infection

Author: Elcombe, S. E., 2013

Supervisor: Arthur, J. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File