Hawley, Simon

Dr

  • United Kingdom

  • 10671 Citations
  • 27 h-Index
19962020

Research output per year

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Research Output

  • 10671 Citations
  • 27 h-Index
  • 26 Article
  • 2 Chapter (peer-reviewed)
  • 2 Letter
  • 2 Review article
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Article
2020

Mechanism of Activation of AMPK by Cordycepin

Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In : Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.

Research output: Contribution to journalArticle

Open Access
File
47 Downloads (Pure)
2019

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
121 Downloads (Pure)
2017

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G., 20 Jul 2017, In : Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
151 Downloads (Pure)
2016

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

Rutherford, C., Speirs, C., Williams, J. J. L., Ewart, M. A., Mancini, S. J., Hawley, S. A., Delles, C., Viollet, B., Costa-Pereira, A. P., Baillie, G. S., Salt, I. P. & Palmer, T. M., 8 Nov 2016, In : Science Signaling. 9, 453, p. 1-10 10 p., ra109.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
143 Downloads (Pure)

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

Hawley, S., Ford, R. J., Smith, B. K., Gowans, G., Mancini, S. J., Pitt, R. D., A. Day, E., Salt, I. P., Steinberg, G. R. & Hardie, D. G., Sep 2016, In : Diabetes. 65, 9, p. 2784-2794 11 p.

Research output: Contribution to journalArticle

Open Access
File
99 Citations (Scopus)
300 Downloads (Pure)
2015

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V., Feb 2015, In : Diabetes. 64, 2, p. 360-369 10 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
145 Downloads (Pure)
2014

Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K., 17 Jul 2014, In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

Research output: Contribution to journalArticle

Open Access
File
69 Citations (Scopus)
184 Downloads (Pure)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G., 15 Apr 2014, In : Biochemical Journal. 459, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

Open Access
File
93 Citations (Scopus)
145 Downloads (Pure)
2013

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G., 1 Oct 2013, In : Cell Metabolism. 18, 4, p. 556-566 11 p.

Research output: Contribution to journalArticle

Open Access
File
245 Citations (Scopus)
128 Downloads (Pure)
2012

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G., 18 May 2012, In : Science. 336, 6083, p. 918-922 5 p.

Research output: Contribution to journalArticle

462 Citations (Scopus)
2011
38 Citations (Scopus)
2010

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G., 15 Feb 2010, In : Biochemical Journal. 426, p. 109-118 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M. & Hardie, D. G., 9 Jun 2010, In : Cell Metabolism. 11, 6, p. 554-565 12 p.

Research output: Contribution to journalArticle

486 Citations (Scopus)
2008

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G., 15 Nov 2008, In : Biochemical Journal. 416, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L. & Furman, B. L., 2008, In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2007

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

Goransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, K., 2007, In : Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

Research output: Contribution to journalArticle

311 Citations (Scopus)
2006

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

Tamás, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G. & Cantrell, D. A., 10 Jul 2006, In : Journal of Experimental Medicine. 203, 7, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Open Access
221 Citations (Scopus)
2005
94 Citations (Scopus)

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. & Hardie, D. G., Jul 2005, In : Cell Metabolism. 2, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

1102 Citations (Scopus)
2004

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G. & Hardie, D. G., 2004, In : Journal of Clinical Investigation. 113, 2, p. 274-284 11 p.

Research output: Contribution to journalArticle

Open Access
File
564 Citations (Scopus)
181 Downloads (Pure)

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R., Feb 2004, In : The EMBO Journal. 23, 4, p. 833-843 11 p.

Research output: Contribution to journalArticle

911 Citations (Scopus)
2003

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T. & Hardie, D. G., 2003, In : Current Biology. 13, 10, p. 861-866 6 p.

Research output: Contribution to journalArticle

252 Citations (Scopus)

Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. & Hardie, D. G., Sep 2003, In : Journal of Biology. 2, 4, p. 28 1 p.

Research output: Contribution to journalArticle

1248 Citations (Scopus)

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

Sutherland, C. M., Hawley, S. A., McCartney, R. R., Leech, A., Stark, M. J. R., Schmidt, M. C. & Hardie, D. G., 5 Aug 2003, In : Current Biology. 13, 15, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

205 Citations (Scopus)
1998

AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I., Celler, J. W., Hawley, S. A., Prescott, A., Woods, A., Carling, D. & Hardie, D. G., 15 Aug 1998, In : Biochemical Journal. 334, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

354 Citations (Scopus)
1996

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D. & Hardie, D. G., 1 Nov 1996, In : Journal of Biological Chemistry. 271, 44, p. 27879-27887 9 p.

Research output: Contribution to journalArticle

891 Citations (Scopus)