• 303 Citations
  • 7 h-Index
20102019

Research output per year

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Personal profile

Biography

Sourav Banerjee finished his Masters from the University of Glasgow in 2009 and carried out his PhD in Life Sciences from the MRC Protein Phosphorylatyion and Ubiquitylation Unit, University of Dundee under Prof Dario Alessi in 2013. As a PhD student, his work was investigating the regulation, function, and molecular mechanism of action of AMPK-related NUAK1 kinase. Following this, he moved to University of California San Diego, USA to join the laboratory of Prof. Jack E Dixon as a postdoctoral fellow from 2014 to 2020. During that time his research was focused on the role of DYRK2 as a kinase phosphoryating and regulating the 26S proteasome. As a post doctoral scholar, he set up a multi-disciplinary project to identify and characterise a small molecule inhibitor of DYRK2 which showed efficacy in targeting multiple myeloma and triple-negative breast cancer in vivo. In March 2020 he moved to Dundee where he started as a principal investigator and a Ninewells Cancer Campaign Fellow focussing on role of novel kinases in Glioblastoma multiforme.

Research interests

Glioblastoma multiforme of Stage IV glioma has very poor 5 year survival with very limited prognosis. My current research interest is focussed on the role of extracellular post-translational modifications in regulating Glioblastoma multiforme progression. Multiple extracellular substrates like growth factors, interleukins and cytokines are highly overexpressed and phosphorylated during the progression of glioma malignancy. My laboratory will focus on elucidating the oncogenic role(s) of those extracellular phosphorylations and identify novel predictive and prognostic biomarkers for glioblastoma.

External positions

Post doctoral associate, University of California at San Diego

10 Jul 201429 Feb 2020

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Research Output

  • 303 Citations
  • 7 h-Index
  • 9 Article

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Banerjee, S., Wei, T., Wang, J., Lee, J. J., Gutierrez, H. L., Chapman, O., Wiley, S. E., Mayfield, J. E., Tandon, V., Juarez, E. F., Chavez, L., Liang, R., Sah, R. L., Costello, C., Mesirov, J. P., de la Vega, L., Cooper, K. L., Dixon, J. E., Xiao, J. & Lei, X., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24881-24891 11 p.

Research output: Contribution to journalArticle

Open Access
File
  • 3 Citations (Scopus)
    71 Downloads (Pure)

    Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

    Banerjee, S., Ji, C., Mayfield, J. E., Goel, A., Xiao, J., Dixon, J. E. & Guo, X., 7 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. 8155-8160 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 37 Citations (Scopus)
    40 Downloads (Pure)

    Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide

    Qiu, Y., Poppleton, E., Mekkat, A., Yu, H., Banerjee, S., Wiley, S. E., Dixon, J. E., Kaplan, D. L., Lin, Y. S. & Brodsky, B., 18 Dec 2018, In : Biophysical Journal. 115, 12, p. 2327-2335 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)

    Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

    Todoric, J., Antonucci, L., Di Caro, G., Li, N., Wu, X., Lytle, N. K., Dhar, D., Banerjee, S., Fagman, J. B., Browne, C. D., Umemura, A., Valasek, M. A., Kessler, H., Tarin, D., Goggins, M., Reya, T., Diaz-Meco, M., Moscat, J. & Karin, M., 11 Dec 2017, In : Cancer Cell. 32, 6, p. 824-839.e8

    Research output: Contribution to journalArticle

    Open Access
  • 42 Citations (Scopus)

    Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

    Guo, X., Wang, X., Wang, Z., Banerjee, S., Yang, J., Huang, L. & Dixon, J. E., Feb 2016, In : Nature Cell Biology. 18, 2, p. 202-212 11 p.

    Research output: Contribution to journalArticle

  • 69 Citations (Scopus)