Land, Stephen

Dr

  • 3316 Citations
  • 28 h-Index
19932018
If you made any changes in Pure these will be visible here soon.

Research Output 1993 2018

2018
2 Citations (Scopus)
58 Downloads (Pure)
Open Access
File
Response Elements
Fibroblast Growth Factor 10
Vascular Endothelial Growth Factor A
Blood Vessels
Epithelial Cells
2016
8 Citations (Scopus)
89 Downloads (Pure)

Dexamethasone and insulin activate serum and glucocorticoid-inducible kinase 1 (SGK1) via different molecular mechanisms in cortical collecting duct cells

Mansley, M. K., Watt, G. B., Francis, S. L., Walker, D. J., Land, S. C., Bailey, M. A. & Wilson, S. M., 24 May 2016, In : Physiological Reports. 4, 10, 11 p., e12792.

Research output: Contribution to journalArticle

Open Access
File
Dexamethasone
Glucocorticoids
Phosphatidylinositol 3-Kinase
Insulin
serum-inducible kinase
6 Citations (Scopus)
227 Downloads (Pure)

Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance

Tosoni, K., Cassidy, D., Kerr, B., Land, S. C. & Mehta, A., 29 Feb 2016, In : PLoS ONE. 11, 2, 20 p., e0149550.

Research output: Contribution to journalArticle

Open Access
File
Airway Resistance
Precision Medicine
medicine
Epithelium
Medicine
2014
8 Citations (Scopus)
57 Downloads (Pure)

mTOR signalling, embryogenesis and the control of lung development

Land, S. C., Scott, C. L. & Walker, D., 2014, In : Seminars in Cell & Developmental Biology. 36, p. 68-78 11 p.

Research output: Contribution to journalArticle

Open Access
File
Embryonic Development
Lung
Growth
Food
Stem Cell Niche
2013
42 Citations (Scopus)

Birt-hogg-dube syndrome is a novel ciliopathy

Luijten, M., Claessens, T., Basten, S., Vernooij, M., Menko, F., Nookala, R., Scott, C., van Geel, M., Janssen, R., Easton, J., Vreeburg, M., Kamps, M., Land, S., Tee, A., Giles, R., Coull, B. & van Steensel, M., 2013, In : Journal of Investigative Dermatology. 133, S1, p. S136 1 p., 800.

Research output: Contribution to journalMeeting abstract

42 Citations (Scopus)

Birt-Hogg-Dubé syndrome is a novel ciliopathy

Luijten, M. N. H., Basten, S. G., Claessens, T., Vernooij, M., Scott, C. L., Janssen, R., Easton, J. A., Kamps, M. A. F., Vreeburg, M., Broers, J. L. V., van Geel, M., Menko, F. H., Harbottle, R. P., Nookala, R. K., Tee, A. R., Land, S. C., Giles, R. H., Coull, B. J. & van Steensel, M., 2013, In : Human Molecular Genetics. 22, 21, p. 4383-4397 15 p.

Research output: Contribution to journalArticle

Estrone
Kidney Neoplasms
Kidney
Ciliopathies
Centrosome
6 Citations (Scopus)

Cardioprotective SUR2A promotes stem cell properties of cardiomyocytes

Land, S. C., Walker, D. J., Du, Q. & Jovanovic, A., 12 Oct 2013, In : International journal of cardiology. 168, 5, p. 5090-5092 3 p.

Research output: Contribution to journalLetter

2012
14 Citations (Scopus)

Epithelial Na⁺ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1

Watt, G. B., Ismail, N. A. S., Caballero, A. G., Land, S. C. & Wilson, S. M., Jun 2012, In : British Journal of Pharmacology. 166, 4, p. 1272-1289 18 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
Melanocortins
Melanocyte-Stimulating Hormones
Cues
Epithelial Cells
Inflammation
2011
48 Citations (Scopus)

Absence of the Birt-Hogg-Dube gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

Preston, R. S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, E. A., Harper, K. T., Brinkhuizen, T., Menko, F. H., Davies, D. M., Land, S. C., Pause, A., Baar, K., van Steensel, M. & Tee, A. R., 2011, In : Oncogene. 30, 10, p. 1159-1173 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence

Dunlop, E. A., Dodd, K. M., Land, S. C., Davies, P. A., Martins, N., Stuart, H., McKee, S., Kingswood, C., Saggar, A., Corderio, I., Medeira, A. M. D., Kingston, H., Sampson, J. R., Davies, D. M. & Tee, A. R., 2011, In : European Journal of Human Genetics. 19, 7, p. 789-795 7 p.

Research output: Contribution to journalArticle

348 Downloads (Pure)

Vascular Growth in the Fetal Lung

Land, S., Nov 2011, Vasculogenesis and Angiogenesis - from Embryonic Development to Regenerative Medcine. Simionescu, D. (ed.). Croatia: In Tech - Open Access Publisher, p. 49-72 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
File
gas exchange
cavity
surface area
blood
airflow
2010
19 Citations (Scopus)

Control of HIF-1 alpha and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock

Scott, C. L., Walker, D. J., Cwiklinski, E., Tait, C., Tee, A. R. & Land, S. C., 2010, In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 299, 4, p. L455-L471 17 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Expression of Wild-Type CFTR Suppresses NF-kappa B-Driven Inflammatory Signalling

Hunter, M. J., Treharne, K. J., Winter, A. K., Cassidy, D. M., Land, S. & Mehta, A., 14 Jul 2010, In : PLoS ONE. 5, 7, p. - 9 p., e11598.

Research output: Contribution to journalArticle

2007

HIF1 alpha mediated angiogenesis and mammalian Target of Rapamycin (mTOR) activation: implications for treatment of tuberous sclerosis

Tee, A., Land, S. C., Dunlop, E. A., Davies, M., Shen, M. H. & Sampson, J. R., 2007, In : Journal of Medical Genetics. 44, p. S17 1 p.

Research output: Contribution to journalBook/Film/Article review

308 Citations (Scopus)

Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

Land, S. C. & Tee, A. R., Jul 2007, In : Journal of Biological Chemistry. 282, 28, p. 20534-20543 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Sirolimus
Brain
TOR Serine-Threonine Kinases
Guanine Nucleotides
2006
4 Citations (Scopus)

Endotoxin-induced nitric oxide production rescues airway growth and maturation in atrophic fetal rat lung explants

Rae, C., Cherry, J. I., Land, F. M. & Land, S. C., 2006, In : Biochemical and Biophysical Research Communications. 349, 1, p. 416-25 10 p.

Research output: Contribution to journalArticle

Endotoxins
Rats
Nitric Oxide
Lung
Growth
2005
12 Citations (Scopus)
Cell Survival
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase
Nitric Oxide
Carbocyanines
30 Citations (Scopus)

Redox regulation of lung development and perinatal lung epithelial function

Land, S. C. & Wilson, S. M., 2005, In : Antioxidants & Redox Signaling. 7, 1-2, p. 92-107 16 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Thioredoxins
Oxygen
Lung
Reactive Oxygen Species
2004
35 Citations (Scopus)

A regulated apical Na+ conductance in dexamethasone-treated H441 airway epithelial cells

Ramminger, S. J., Richard, K., Inglis, S. K., Land, S. C., Olver, R. E. & Wilson, S. M., Aug 2004, In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 287, 2, p. L411-L419

Research output: Contribution to journalArticle

Dexamethasone
Epithelial Cells
Cations
Permeability
Epithelial Sodium Channels
12 Citations (Scopus)
Oxygen
Morphogenesis
Gases
Fluids and Secretions
Lung
18 Citations (Scopus)
Circulating Thymic Factor
CCAAT-Enhancer-Binding Protein-beta
Endotoxins
Lipopolysaccharides
Interleukin-6
2003
11 Citations (Scopus)

O2 can raise fetal pneumocyte Na+ conductance without affecting ENaC mRNA abundance

Richard, K., Ramminger, S. J., Inglis, S. K., Olver, R. E., Land, S. C. & Wilson, S. M., 2003, In : Biochemical and Biophysical Research Communications. 305, 3, p. 671-6 6 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Alveolar Epithelial Cells
Messenger RNA
Gene expression
Hormones
28 Citations (Scopus)
Gases
Oxygen
Morphogenesis
Lung
Placenta
2002
51 Citations (Scopus)
Amiloride
Biosynthesis
Amplification
Lipopolysaccharides
Anti-Inflammatory Agents
77 Citations (Scopus)
Alveolar Epithelial Cells
Phosphoric Diester Hydrolases
Lipopolysaccharides
Interleukin-6
Tumor Necrosis Factor-alpha
53 Citations (Scopus)

Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-κB/Nuclear Factor-κB-Sensitive Pathway in Alveolar Epithelial Cells

Haddad, J. J., Land, S. C., Tarnow-Mordi, W. O., Zembala, M., Kowalczyk, D. & Lauterbach, R., 1 Feb 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 2, p. 567-576 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Phosphoric Diester Hydrolases
Endotoxins
Pentoxifylline
Lipopolysaccharides
119 Citations (Scopus)
Mitogen-Activated Protein Kinases
Oxidation-Reduction
Lipopolysaccharides
Phosphorylation
Acetylcysteine
34 Citations (Scopus)
Alveolar Epithelial Cells
Biosynthesis
Oxidation-Reduction
Lipopolysaccharides
Phosphorylation
2001
204 Citations (Scopus)

A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α

Haddad, J. J. & Land, S. C., 14 Sep 2001, In : FEBS Letters. 505, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
Chemical activation
Mitochondria
68 Citations (Scopus)

Chemioxyexcitation (ΔpO2/ROS)-dependent release of IL-1β, IL-6 and TNF-α: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E., Kanaan, S. A. & Land, S. C., 7 Feb 2001, In : Cytokine. 13, 3, p. 138-147 10 p.

Research output: Contribution to journalArticle

Interleukin-1
Interleukin-6
Reactive Oxygen Species
Epithelium
Cytokines
19 Citations (Scopus)

Detection of Cl- flux in the apical microenvironment of cultured foetal distal lung epithelial cells

Land, S. C. & Collett, A., 2001, In : Journal of Experimental Biology. 204, Pt 4, p. 785-95 11 p.

Research output: Contribution to journalArticle

Microelectrodes
epithelial cells
Epithelial Cells
lungs
Lung
2 Citations (Scopus)

Hypoxic activation of an amiloride-sensitive cation conductance in alveolar epithelial cells

Jovanovic, S., Land, S. C., Olver, R. E. & Wilson, S. M., 2001, In : Biochemical and Biophysical Research Communications. 286, 3, p. 622-7 6 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Oxidative stress
Amiloride
Glucocorticoids
Cations
21 Citations (Scopus)

NF-κB blockade reduces the O2-evoked rise in Na+ conductance in fetal alveolar cells

Haddad, J. J. E., Collett, A., Land, S. C., Olver, R. E. & Wilson, S. M., 9 Mar 2001, In : Biochemical and Biophysical Research Communications. 281, 4, p. 987-992 6 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Sulfasalazine
Chemical activation
Electrophoretic mobility
Rats
19 Citations (Scopus)
Alveolar Epithelial Cells
Biosynthesis
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Sulfasalazine
55 Citations (Scopus)

Oxygen-evoked Na+ transport in rat fetal distal lung epithelial cells

Baines, D. L., Ramminger, S. J., Collett, A., Haddad, J. J. E., Best, O. G., Land, S. C., Olver, R. E. & Wilson, S. M., 2001, In : Journal of Physiology. 532, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Epithelial Cells
Oxygen
Lung
Epithelial Sodium Channels
Atmosphere
25 Citations (Scopus)

The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., May 2001, In : British Journal of Pharmacology. 133, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

Interleukin-10
Epithelium
Anti-Inflammatory Agents
Cytokines
Interleukin-1
20 Citations (Scopus)
Oxygenation
Respiration
Apoptosis
Lung
Proto-Oncogenes
72 Citations (Scopus)

Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., 1 Mar 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 3, p. 996-1005 10 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Glutathione
Reactive Oxygen Species
Epithelium
Cytokines
68 Citations (Scopus)
prolylvaline
Interleukins
Melanocytes
Endotoxins
Lipopolysaccharides
2000
222 Citations (Scopus)

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1a and NF-kB Redox Sensitivity: EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS

Haddad, J. J. E., Olver, R. E. & Land, S. C., 14 Jul 2000, In : Journal of Biological Chemistry. 275, 28, p. 21130-21139 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Glutathione Disulfide
NF-kappa B
Oxidation-Reduction
Glutathione
23 Citations (Scopus)
Circulating Thymic Factor
Endotoxins
Interleukin-10
Inhibitory Concentration 50
Amplification
113 Citations (Scopus)
Hypoxia-Inducible Factor 1
Alveolar Epithelial Cells
Glutathione
Epithelium
Lung
71 Citations (Scopus)

Scaling effects on hypoxia tolerance in the Amazon fish Astronotus ocellatus (Perciformes: Cichlidae): Contribution of tissue enzyme levels

Almeida-Val, V. M. F., Val, A. L., Duncan, W. P., Souza, F. C. A., Paula-Silva, M. N. & Land, S., 19 May 2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 125, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

Perciformes
Cichlids
Fish
Fishes
Tissue
54 Citations (Scopus)
Alveolar Epithelial Cells
Oxidation-Reduction
Epithelium
Apoptosis
Glutamate-Cysteine Ligase
1999
82 Citations (Scopus)

The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells

Land, S. C., Porterfield, D. M., Sanger, R. H. & Smith, P. J. S., 1999, In : Journal of Experimental Biology. 202, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Microelectrodes
Oxygen
oxygen
cells
Chloroplasts
1997
5 Citations (Scopus)

Consumption of Oxygen by Isolated Skate Retinal Photoreceptors

Malchow, R. P., Land, S. C., Patel, L. S. & Smith, P. J. S., Oct 1997, In : Biological Bulletin. 193, 2, p. 231-232 2 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

O2 availability modulates transmembrane Ca2+ flux via second- messenger pathways in anoxia-tolerant hepatocytes

Land, S. C., Sanger, R. H. & Smith, P. J. S., 1 Mar 1997, In : Journal of Applied Physiology. 82, 3, p. 776-783 8 p.

Research output: Contribution to journalArticle

Second Messenger Systems
Adenosine
Protein Kinase C
Hepatocytes
Sphingosine
56 Citations (Scopus)

Oxygen Sensing and Signal Transduction in Metabolic Defense Against Hypoxia: Lessons from Vertebrate Facultative Anaerobes

Hochachka, P. W., Land, S. C. & Buck, L. T., 1 Sep 1997, In : Comparative Biochemistry and Physiology - A Physiology. 118, 1, p. 23-29 7 p.

Research output: Contribution to journalReview article

Vertebrates
Signal Transduction
Oxygen
Down-Regulation
Adenosine Triphosphate
1996
755 Citations (Scopus)

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack

Hochachka, P. W., Buck, L. T., Doll, C. J. & Land, S. C., 3 Sep 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 18, p. 9493-9498 6 p.

Research output: Contribution to journalArticle

Oxygen
Adenosine Triphosphate
Hepatocytes
Hemeproteins
Hypoxia