Land, Stephen

Dr

  • 3431 Citations
  • 28 h-Index
19932018

Research output per year

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Article
2018
Open Access
File
3 Citations (Scopus)
138 Downloads (Pure)
2016

Dexamethasone and insulin activate serum and glucocorticoid-inducible kinase 1 (SGK1) via different molecular mechanisms in cortical collecting duct cells

Mansley, M. K., Watt, G. B., Francis, S. L., Walker, D. J., Land, S. C., Bailey, M. A. & Wilson, S. M., 24 May 2016, In : Physiological Reports. 4, 10, 11 p., e12792.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
146 Downloads (Pure)

Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance

Tosoni, K., Cassidy, D., Kerr, B., Land, S. C. & Mehta, A., 29 Feb 2016, In : PLoS ONE. 11, 2, 20 p., e0149550.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
291 Downloads (Pure)
2014

mTOR signalling, embryogenesis and the control of lung development

Land, S. C., Scott, C. L. & Walker, D., 2014, In : Seminars in Cell & Developmental Biology. 36, p. 68-78 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
122 Downloads (Pure)
2013

Birt-Hogg-Dubé syndrome is a novel ciliopathy

Luijten, M. N. H., Basten, S. G., Claessens, T., Vernooij, M., Scott, C. L., Janssen, R., Easton, J. A., Kamps, M. A. F., Vreeburg, M., Broers, J. L. V., van Geel, M., Menko, F. H., Harbottle, R. P., Nookala, R. K., Tee, A. R., Land, S. C., Giles, R. H., Coull, B. J. & van Steensel, M., 2013, In : Human Molecular Genetics. 22, 21, p. 4383-4397 15 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2012

Epithelial Na⁺ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1

Watt, G. B., Ismail, N. A. S., Caballero, A. G., Land, S. C. & Wilson, S. M., Jun 2012, In : British Journal of Pharmacology. 166, 4, p. 1272-1289 18 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
8 Citations (Scopus)
2011

Absence of the Birt-Hogg-Dube gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

Preston, R. S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, E. A., Harper, K. T., Brinkhuizen, T., Menko, F. H., Davies, D. M., Land, S. C., Pause, A., Baar, K., van Steensel, M. & Tee, A. R., 2011, In : Oncogene. 30, 10, p. 1159-1173 15 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence

Dunlop, E. A., Dodd, K. M., Land, S. C., Davies, P. A., Martins, N., Stuart, H., McKee, S., Kingswood, C., Saggar, A., Corderio, I., Medeira, A. M. D., Kingston, H., Sampson, J. R., Davies, D. M. & Tee, A. R., 2011, In : European Journal of Human Genetics. 19, 7, p. 789-795 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Control of HIF-1 alpha and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock

Scott, C. L., Walker, D. J., Cwiklinski, E., Tait, C., Tee, A. R. & Land, S. C., 2010, In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 299, 4, p. L455-L471 17 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Expression of Wild-Type CFTR Suppresses NF-kappa B-Driven Inflammatory Signalling

Hunter, M. J., Treharne, K. J., Winter, A. K., Cassidy, D. M., Land, S. & Mehta, A., 14 Jul 2010, In : PLoS ONE. 5, 7, p. - 9 p., e11598.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2007

Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

Land, S. C. & Tee, A. R., Jul 2007, In : Journal of Biological Chemistry. 282, 28, p. 20534-20543 10 p.

Research output: Contribution to journalArticle

333 Citations (Scopus)
2006

Endotoxin-induced nitric oxide production rescues airway growth and maturation in atrophic fetal rat lung explants

Rae, C., Cherry, J. I., Land, F. M. & Land, S. C., 2006, In : Biochemical and Biophysical Research Communications. 349, 1, p. 416-25 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2005
12 Citations (Scopus)

Redox regulation of lung development and perinatal lung epithelial function

Land, S. C. & Wilson, S. M., 2005, In : Antioxidants & Redox Signaling. 7, 1-2, p. 92-107 16 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2004

A regulated apical Na+ conductance in dexamethasone-treated H441 airway epithelial cells

Ramminger, S. J., Richard, K., Inglis, S. K., Land, S. C., Olver, R. E. & Wilson, S. M., Aug 2004, In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 287, 2, p. L411-L419

Research output: Contribution to journalArticle

35 Citations (Scopus)
12 Citations (Scopus)
18 Citations (Scopus)
2003

O2 can raise fetal pneumocyte Na+ conductance without affecting ENaC mRNA abundance

Richard, K., Ramminger, S. J., Inglis, S. K., Olver, R. E., Land, S. C. & Wilson, S. M., 2003, In : Biochemical and Biophysical Research Communications. 305, 3, p. 671-6 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
28 Citations (Scopus)
2002
51 Citations (Scopus)
79 Citations (Scopus)

Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-κB/Nuclear Factor-κB-Sensitive Pathway in Alveolar Epithelial Cells

Haddad, J. J., Land, S. C., Tarnow-Mordi, W. O., Zembala, M., Kowalczyk, D. & Lauterbach, R., 1 Feb 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 2, p. 567-576 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
122 Citations (Scopus)
37 Citations (Scopus)
2001

A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α

Haddad, J. J. & Land, S. C., 14 Sep 2001, In : FEBS Letters. 505, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

Chemioxyexcitation (ΔpO2/ROS)-dependent release of IL-1β, IL-6 and TNF-α: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E., Kanaan, S. A. & Land, S. C., 7 Feb 2001, In : Cytokine. 13, 3, p. 138-147 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Detection of Cl- flux in the apical microenvironment of cultured foetal distal lung epithelial cells

Land, S. C. & Collett, A., 2001, In : Journal of Experimental Biology. 204, Pt 4, p. 785-95 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Hypoxic activation of an amiloride-sensitive cation conductance in alveolar epithelial cells

Jovanovic, S., Land, S. C., Olver, R. E. & Wilson, S. M., 2001, In : Biochemical and Biophysical Research Communications. 286, 3, p. 622-7 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

NF-κB blockade reduces the O2-evoked rise in Na+ conductance in fetal alveolar cells

Haddad, J. J. E., Collett, A., Land, S. C., Olver, R. E. & Wilson, S. M., 9 Mar 2001, In : Biochemical and Biophysical Research Communications. 281, 4, p. 987-992 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
19 Citations (Scopus)

Oxygen-evoked Na+ transport in rat fetal distal lung epithelial cells

Baines, D. L., Ramminger, S. J., Collett, A., Haddad, J. J. E., Best, O. G., Land, S. C., Olver, R. E. & Wilson, S. M., 2001, In : Journal of Physiology. 532, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., May 2001, In : British Journal of Pharmacology. 133, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
20 Citations (Scopus)

Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., 1 Mar 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 3, p. 996-1005 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
69 Citations (Scopus)
2000

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1a and NF-kB Redox Sensitivity: EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS

Haddad, J. J. E., Olver, R. E. & Land, S. C., 14 Jul 2000, In : Journal of Biological Chemistry. 275, 28, p. 21130-21139 10 p.

Research output: Contribution to journalArticle

224 Citations (Scopus)
23 Citations (Scopus)
113 Citations (Scopus)

Scaling effects on hypoxia tolerance in the Amazon fish Astronotus ocellatus (Perciformes: Cichlidae): Contribution of tissue enzyme levels

Almeida-Val, V. M. F., Val, A. L., Duncan, W. P., Souza, F. C. A., Paula-Silva, M. N. & Land, S., 19 May 2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 125, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
54 Citations (Scopus)
1999

The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells

Land, S. C., Porterfield, D. M., Sanger, R. H. & Smith, P. J. S., 1999, In : Journal of Experimental Biology. 202, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
1997

Consumption of Oxygen by Isolated Skate Retinal Photoreceptors

Malchow, R. P., Land, S. C., Patel, L. S. & Smith, P. J. S., Oct 1997, In : Biological Bulletin. 193, 2, p. 231-232 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

O2 availability modulates transmembrane Ca2+ flux via second- messenger pathways in anoxia-tolerant hepatocytes

Land, S. C., Sanger, R. H. & Smith, P. J. S., 1 Mar 1997, In : Journal of Applied Physiology. 82, 3, p. 776-783 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1996

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack

Hochachka, P. W., Buck, L. T., Doll, C. J. & Land, S. C., 3 Sep 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 18, p. 9493-9498 6 p.

Research output: Contribution to journalArticle

785 Citations (Scopus)
1995
40 Citations (Scopus)
3 Citations (Scopus)
1994

Protein turnover during metabolic arrest in turtle hepatocytes: role and energy dependence of proteolysis

Land, S. C. & Hochachka, P. W., 1 Apr 1994, In : American Journal of Physiology: Cell Physiology. 266, 4 , p. C1028-C1036 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
1993

Anoxia-tolerant hepatocytes: Model system for study of reversible metabolic suppression

Buck, L. T., Land, S. C. & Hochachka, P. W., 1 Jul 1993, In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 265, 1 , p. R49-R56 8 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Response of protein synthesis to anoxia and recovery in anoxia-tolerant hepatocytes

Land, S. C., Buck, L. T. & Hochachka, P. W., 1 Jul 1993, In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 265, 1 , p. R41-R48 8 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)