Fleming, Stewart

Professor

  • 9070 Citations
  • 44 h-Index
1981 …2019

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Research Output

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2019

Periprostatic Fat Adipokines Expression Correlated with Prostate Cancer Aggressiveness in Men Undergoing Radical Prostatectomy for Clinically Localised Disease

Dahran, N., Szewczyk-Bieda, M., Vinnicombe, S., Fleming, S. & Nabi, G., Jun 2019, In : BJU International. 123, 6, p. 985-994 10 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
119 Downloads (Pure)
2018

Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists

Williamson, S. R., Rao, P., Hes, O., Epstein, J. I., Smith, S. C., Picken, M. M., Zhou, M., Tretiakova, M. S., Tickoo, S. K., Chen, Y-B., Reuter, V. E., Fleming, S., Maclean, F. M., Gupta, N. S., Kuroda, N., Delahunt, B., Mehra, R., Przybycin, C. G., Cheng, L., Eble, J. N. & 11 others, Grignon, D. J., Moch, H., Lopez, J. I., Kunju, L. P., Tamboli, P., Srigley, J. R., Amin, M. B., Martignoni, G., Hirsch, M. S., Bonsib, S. M. & Trpkov, K., Sep 2018, In : American Journal of Surgical Pathology. 42, 9, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin

Buckley, C., Nelson, R. J., Mullins, L. J., Sharp, M. G. F., Fleming, S., Kenyon, C. J., Semprini, S., Steppan, D., Peti-Peterdi, J., Kurtz, A., Christian, H. & Mullins, J. J., 26 Jan 2018, In : Journal of Biological Chemistry. 293, 4, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
175 Downloads (Pure)
2017

Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists

Williamson, S. R., Gadde, R., Trpkov, K., Hirsch, M. S., Srigley, J. R., Reuter, V. E., Cheng, L., Priya Kunju, L., Barod, R., Rogers, C. G., Delahunt, B., Hes, O., Eble, J. N., Zhou, M., McKenney, J. K., Martignoni, G., Fleming, S., Grignon, D. J., Moch, H. & Gupta, N. S., May 2017, In : Human Pathology. 63, p. 149-156 8 p.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
191 Downloads (Pure)
Open Access
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2 Citations (Scopus)
123 Downloads (Pure)

Multiple socioeconomic deprivation and impact on survival in patients with primary glomerulonephritis

McQuarrie, E. P., Mackinnon, B., Bell, S., Fleming, S., McNeice, V., Stewart, G., Fox, J. G., Geddes, C. C. & on behalf of the Scottish Renal Biopsy Registry, Feb 2017, In : Clinical Kidney Journal. 10, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
128 Downloads (Pure)

Papillary Renal Cell Carcinoma With Osteosarcomatous Heterologous Differentiation: A Case Report With Molecular Genetic Analysis and Review of the Literature

Aird, J. J., Nic An Riogh, A. U., Fleming, S., Hislop, R. G., Sweeney, P. & Mayer, N., 1 Dec 2017, In : International Journal of Surgical Pathology. 28, 8, p. 745-750 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Palmer, S., Litvinova, K., Dunaev, A., Fleming, S., McGloin, D. & Nabi, G., 7 Mar 2016, In : Biomedical Optics Express. 7, 4, p. 1193-2000 8 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
183 Downloads (Pure)

Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection.

El-Mokadem, I., Alison, L., Kidd, T., Garret, K., Pratt, N., Batty, G. D., Fleming, S. & Nabi, G., 31 Jul 2016, In : BMC Cancer. 16, p. 1-10 10 p., 546.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
173 Downloads (Pure)

Renal squamous cell carcinoma of a native kidney after renal transplant: a case report

Jakes, A., Jani, P., Menon, M., Adams, K., Edey, M., Fleming, S. & Bhandari, S., 2016, In : Transplantation Proceedings. 48, 1, p. 259-261 3 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
177 Downloads (Pure)

Tumour suppressor gene (CDKNA2) status on chromosome 9p in resected renal tissue improves prognosis of localised kidney cancer

El-Mokadem, I., Kidd, T., Pratt, N., Fleming, S. & Nabi, G., 22 Sep 2016, In : Oncotarget. 7, 45, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
146 Downloads (Pure)
2015

Acute tubulointerstitial nephritis in Scotland

Valluri, A., Hetherington, L., McQuarrie, E., Fleming, S., Kipgen, D., Geddes, C. C., Mackinnon, B. & Bell, S., 2015, In : QJM : an International Journal of Medicine. 108, 7, p. 527-532 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Distal nephron neoplasms

Fleming, S., Mar 2015, In : Seminars in Diagnostic Pathology. 32, 2, p. 114-123 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Idiopathic hypocomplementemic interstitial nephritis

Kidder, D., Stewart, G. A., Furrie, E. & Fleming, S., Feb 2015, In : Kidney International. 87, 2, p. 485-486 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Kidney biopsy findings in primary Sjogren syndrome

Kidder, D., Rutherford, E., Kipgen, D., Fleming, S., Geddes, C. & Stewart, G. A., 2015, In : Nephrology Dialysis Transplantation. 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Cardaci, S., Zheng, L., Mackay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., Vazquez, A., Fleming, S., Schiavi, F., Kalna, G., Blyth, K., Strathdee, D. & Gottlieb, E., 24 Aug 2015, In : Nature Cell Biology. 17, 10, p. 1317-1326 13 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

Kovac, M., Navas, C., Horswell, S., Salm, M., Bardella, C., Rowan, A., Stares, M., Castro-Giner, F., Fisher, R., de Bruin, E. C., Kovacova, M., Gorman, M., Makino, S., Williams, J., Jaeger, E., Jones, A., Howarth, K., Larkin, J., Pickering, L., Gore, M. & 25 others, Nicol, D. L., Hazell, S., Stamp, G., O'Brien, T., Challacombe, B., Matthews, N., Phillimore, B., Begum, S., Rabinowitz, A., Varela, I., Chandra, A., Horsfield, C., Polson, A., Tran, M., Bhatt, R., Terracciano, L., Eppenberger-Castori, S., Protheroe, A., Maher, E., El Bahrawy, M., Fleming, S., Ratcliffe, P., Heinimann, K., Swanton, C. & Tomlinson, I., 19 Mar 2015, In : Nature Communications. 6, 11 p., 6336.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2014

Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

El-Mokadem, I., Fitzpatrick, J., Bondad, J., Rauchhaus, P., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G., 23 Sep 2014, In : British Journal of Cancer. 111, 7, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
144 Downloads (Pure)

Evidence for aldosterone-dependent growth of renal cell carcinoma

King, S., Bray, S., Galbraith, S., Christie, L. & Fleming, S., Aug 2014, In : International Journal of Experimental Pathology. 95, 4, p. 244-250 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G., 2014, In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

Research output: Contribution to journalArticle

Open Access
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39 Citations (Scopus)
165 Downloads (Pure)

Risk of AKI with gentamicin as surgical prophylaxis

Bell, S., Davey, P., Nathwani, D., Marwick, C., Vadiveloo, T., Sneddon, J., Patton, A., Bennie, M., Fleming, S. & Donnan, P. T., Nov 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2625-2632 8 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Signalling pathways in succinate dehydrogenase B-associated renal carcinoma

Fleming, S., Mayer, N. J., Vlatkovic, L. J., McLean, J., McConachie, M. & Baty, D., Mar 2014, In : Histopathology. 64, 4, p. 477-483 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Significance of chromosome 9p status in renal cell carcinoma: a systematic review and quality of the reported studies

El-Mokadem, I., Fitzpatrick, J., Rai, B., Cunningham, J., Pratt, N., Fleming, S. & Nabi, G., 2014, In : BioMed Research International. 2014, 11 p., 521380.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
120 Downloads (Pure)

Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients

Gill, A. J., Hes, O., Papathomas, T., Sedivcová, M., Tan, P. H., Agaimy, A., Andresen, P. A., Kedziora, A., Clarkson, A., Toon, C. W., Sioson, L., Watson, N., Chou, A., Paik, J., Clifton-Bligh, R. J., Robinson, B. G., Benn, D. E., Hills, K., Maclean, F., Niemeijer, N. D. & 18 others, Vlatkovic, L., Hartmann, A., Corssmit, E. P. M., van Leenders, G. J. L. H., Przybycin, C., McKenney, J. K., Magi-Galluzzi, C., Yilmaz, A., Yu, D., Nicoll, K. D., Yong, J. L., Sibony, M., Yakirevich, E., Fleming, S., Chow, C. W., Miettinen, M., Michal, M. & Trpkov, K., Dec 2014, In : American Journal of Surgical Pathology. 38, 12, p. 1588-1602 15 p.

Research output: Contribution to journalArticle

Open Access
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134 Citations (Scopus)
159 Downloads (Pure)
2013

Generation and characterisation of keratin 7 (K7) knockout mice

Sandilands, A., Smith, F. J. D., Lunny, D. P., Campbell, L. E., Davidson, K. M., MacCallum, S. F., Corden, L. D., Christie, L., Fleming, S., Lane, E. B. & McLean, W. H. I., 31 May 2013, In : PLoS ONE. 8, 5, 11 p., e64404.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations

Trpkov, K., Grignon, D. J., Bonsib, S. M., Amin, M. B., Billis, A., Lopez-Beltran, A., Samaratunga, H., Tamboli, P., Delahunt, B., Egevad, L., Montironi, R., Srigley, J. R. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1505–1517 13 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Renal tumors: diagnostic and prognostic biomarkers

Tan, P. H., Cheng, L., Rioux-Leclercq, N., Merino, M. J., Netto, G., Reuter, V. E., Shen, S. S., Grignon, D. J., Montironi, R., Egevad, L., Srigley, J. R., Delahunt, B., Moch, H. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1518–1531 14 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

Delahunt, B., Cheville, J. C., Martignoni, G., Humphrey, P. A., Magi-Galluzzi, C., McKenney, J., Egevad, L., Algaba, F., Moch, H., Grignon, D. J., Montrioni, R., Srigley, J. R. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1490–1504 15 p.

Research output: Contribution to journalArticle

337 Citations (Scopus)

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley, J. R., Delahunt, B., Eble, J. N., Egevad, L., Epstein, J. I., Grignon, D., Hes, O., Moch, H., Montironi, R., Tickoo, S. K., Zhou, M., Argani, P. & ISUP Renal Tumor Panel, Oct 2013, In : American Journal of Surgical Pathology. 37, 10, p. 1469-89 21 p.

Research output: Contribution to journalArticle

612 Citations (Scopus)

Translocation renal cell carcinomas: an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors

Bambury, R. M., Battley, J. E., McCarthy, A., Brady, C., O'Reilly, S., Kelly, P. J., O'Brien, F., Sweeney, P., Fleming, S., Mayer, N. J. & Power, D. G., Sep 2013, In : Clinical Genitourinary Cancer. 11, 3, p. 357-361 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2012

Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B., 15 Feb 2012, In : Biochemical Journal. 442, p. 151-159 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Phenformin as prophylaxis and therapy in breast cancer xenografts

Appleyard, M. V. C. L., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. & Thompson, A. M., 13 Mar 2012, In : British Journal of Cancer. 106, 6, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2011

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C., May 2011, In : FASEB Journal. 25, 5, p. 1606-1617 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L., 29 Mar 2011, In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., Jan 2011, In : Disease Models & Mechanisms. 4, 1, p. 95-103 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Renal Tumors Associated With Germline SDHB Mutation Show Distinctive Morphology

Gill, A. J., Pachter, N. S., Chou, A., Young, B., Clarkson, A., Tucker, K. M., Winship, I. M., Earls, P., Benn, D. E., Robinson, B. G., Fleming, S. & Clifton-Bligh, R. J., Oct 2011, In : American Journal of Surgical Pathology. 35, 10, p. 1578-1585 8 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

The D153del Mutation in GNB3 Gene Causes Tissue Specific Signalling Patterns and an Abnormal Renal Morphology in Rge Chickens

Tummala, H., Fleming, S., Hocking, P. M., Wehner, D., Naseem, Z., Ali, M., Inglehearn, C. F., Zhelev, N. & Lester, D. H., 22 Aug 2011, In : PLoS ONE. 6, 8, p. - 11 p., e21156.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2010

Role of the WNK-activated SPAK kinase in regulating blood pressure

Rafiqi, F. H., Zuber, A. M., Glover, M., Richardson, C., Fleming, S., Jovanovic, S., Jovanovic, A., O'Shaughnessy, K. M. & Alessi, D. R., Feb 2010, In : Embo Molecular Medicine. 2, 2, p. 63-75 13 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)
2009

Angiotensin-converting enzyme Ii a modifier of hypertensive end organ damage

Liu, X., Bellamy, C. O. C., Bailey, M. A., Mullins, L. J., Dunbar, D. R., Kenyon, C. J., Brooker, G., Kantachuvesiri, S., Maratou, K., Ashek, A., Clark, A. F., Fleming, S. & Mullins, J. J., 5 Jun 2009, In : Journal of Biological Chemistry. 284, 23, p. 15564-15572 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Centre variation in incidence, indication and diagnosis of adult native renal biopsy in Scotland

McQuarrie, E. P., Mackinnon, B., Young, B., Yeoman, L., Stewart, G., Fleming, S., Robertson, S., Simpson, K., Fox, J., Geddes, C. C. & Scottish Renal Biopsy Registry, May 2009, In : Nephrology Dialysis Transplantation. 24, 5, p. 1524-1528 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat

Nobrega, M. A., Woods, L. C. S., Fleming, S. & Jacob, H. J., Sep 2009, In : Physiological Genomics. 39, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Histological evaluation of AMPK signalling in primary breast cancer

Hadad, S. M., Baker, L., Quinlan, P. R., Robertson, K. E., Bray, S. E., Thomson, G., Kellock, D., Jordan, L. B., Purdie, C. A., Hardie, D. G., Fleming, S. & Thompson, A. M., 1 Sep 2009, In : BMC Cancer. 9, p. - 9 p., 307.

Research output: Contribution to journalArticle

122 Citations (Scopus)
2008

Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene

Heath, E., Tahri, D., Andermarcher, E., Schofield, P., Fleming, S. & Boulter, C. A., 20 Feb 2008, In : BMC Developmental Biology. 8, p. - 17 p., 18.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1(tmT396))

Patek, C. E., Brownstein, D. G., Fleming, S., Wroe, C., Rose, L., Webb, A., Berry, R. L., Devenney, P. S., Walker, M., Maddocks, O. D. K., Lawrence, N. J., Harrison, D. J., Wood, K. M., Miles, C. G. & Hooper, M. L., 2008, In : Transgenic Research. 17, 3, p. 459-475 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R., 1 Jun 2008, In : Biochemical Journal. 412, p. 211-221 11 p.

Research output: Contribution to journalArticle

290 Citations (Scopus)

Pathology of tumours of the male genital tract

Kamal, I. & Fleming, S., 1 May 2008, In : Surgery (Oxford). 26, 5, p. 183-187 5 p.

Research output: Contribution to journalArticle

Pathology of tumours of the urinary tract

Christie, L. & Fleming, S., 1 Apr 2008, In : Surgery (Oxford). 26, 4, p. 161-164 4 p.

Research output: Contribution to journalArticle

The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer

Clark, E. L., Coulson, A., Dalgliesh, C., Rajan, P., Nicol, S. M., Fleming, S., Heer, R., Gaughan, L., Leung, H. Y., Elliott, D. J., Fuller-Pace, F. V. & Robson, C. N., 1 Oct 2008, In : Cancer Research. 68, 19, p. 7938-7946 9 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)
2007

Cerebral metastasis of peripheral primitive neuroectodermal tumour (pPNET): use of cytogenetic abnormalities in diagnosis

Ross, J., Whittle, I. R., Fleming, S. & Kurian, K. M., 2007, In : Neuropathology and Applied Neurobiology. 33, 4, p. 471-4 4 p.

Research output: Contribution to journalArticle

2005

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

Bayascas, J. R., Leslie, N., Parsons, R., Fleming, S. & Alessi, D., Oct 2005, In : Current Biology. 15, 20, p. 1839-1846 8 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)