• 1309 Citations
  • 21 h-Index
20042022
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  • 8 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
Leishmania donovani Medicine & Life Sciences
Parasites Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Visceral Leishmaniasis Medicine & Life Sciences
Nitroreductases Medicine & Life Sciences
Leishmania Medicine & Life Sciences
Nifurtimox Medicine & Life Sciences

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Projects 2013 2022

Research Output 2004 2019

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, É., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H. & 5 othersValentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P. & Azas, N., 10 Jan 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Open Access
File
Pyridines
Inhibitory Concentration 50
sulfoxide
miltefosine
Display devices
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
1 Citations

8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases

Fersing, C., Boudot, C., Pedron, J., Hutter, S., Primas, N., Castera-Ducros, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Moreau, A., Cohen, A., Stigliani, J-L., Pratviel, G., Crozet, M. D., Wyllie, S., Fairlamb, A., Valentin, A., Rathelot, P., Azas, N., Courtioux, B., Verhaeghe, P. & 1 othersVanelle, P., 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 115-126 12 p.

Research output: Contribution to journalArticle

Nitroreductases
Inhibitory Concentration 50
Molecules
miltefosine
Scaffolds
1 Citations

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei

Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions

Pedron, J., Boudot, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Paloque, L., Rastegari, M., Abdoulaye, M., El-Kashef, H., Bonduelle, C., Pratviel, G., Wyllie, S., Fairlamb, A. H., Courtioux, B., Verhaeghe, P. & Valentin, A., 22 Oct 2018, In : ChemMedChem. 13, 20, p. 2217-2228 12 p.

Research output: Contribution to journalArticle

Nitroquinolines
Leishmania infantum
Trypanosoma brucei brucei
Cross Reactions
Palladium