Norval, Suzanne

Miss

  • 696 Citations
  • 10 h-Index
20102019
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  • 27 Similar Profiles
African Trypanosomiasis Medicine & Life Sciences
Antimalarials Medicine & Life Sciences
Visceral Leishmaniasis Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
Parasites Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Naphthyridines Medicine & Life Sciences
Antitubercular Agents Medicine & Life Sciences

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Research Output 2010 2019

  • 696 Citations
  • 10 h-Index
  • 19 Article
  • 1 Abstract
3 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 othersLowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility

Substituted aminoacetamides as novel leads for malaria

Norcross, N., Wilson, C., Baragana, B., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Fletcher, D., Sinden, R., Delves, M. J., Ruecker, A., Duffy, S., Meister, S., Antonova-Koch, Y., Crespo, B., de Cózar, C., Sanz, L., Gamo, F-J., Avery, V. M., Frearson, J. A. & 8 othersGray, D., Fairlamb, A., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. & Gilbert, I., 12 Jun 2019, In : ChemMedChem. 16 p.

Research output: Contribution to journalArticle

Open Access
File
Antimalarials
Germ Cells
Malaria
Pharmacokinetics
Plasmodium falciparum
3 Citations (Scopus)
42 Downloads (Pure)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System
1 Citation (Scopus)
52 Downloads (Pure)

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei
32 Downloads (Pure)

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism

Roberts, A., Dunne, J., Scullion, S., Norval, S. & Fairlamb, A., 29 Aug 2018, In : Biochemical Journal. 475, 16, p. 2593-2610 18 p.

Research output: Contribution to journalArticle

Open Access
File
Pyruvaldehyde
Isoprostanes
Glyoxal
Metabolism
Prostaglandins

Press / Media

Automated design for Drug Discovery

Andrew Hopkins, Suzanne Norval, Jeremy Besnard, Laste Stojanovski, Richard Bickerton, Kevin Read & Ian Gilbert

13/12/12

1 item of media coverage

Press/Media: Research