Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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Towards A Molecular Understanding Of Myddosome Organization And Regulation Of IRAK Kinase Activity
Kulathu, Y. (Investigator) & Lange, S. (Investigator)
Biotechnology and Biological Sciences Research Council
1/01/23 → 31/12/25
Project: Research
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Mechanism of human PINK1 activation at the TOM complex in a reconstituted system
Raimi, O. G., Ojha, H., Ehses, K., Dederer, V., Lange, S. M., Rivera, C. P., Deegan, T. D., Chen, Y., Wightman, M., Toth, R., Labib, K. P. M., Mathea, S., Ranson, N., Fernández-Busnadiego, R. & Muqit, M. M. K. (Lead / Corresponding author), Jun 2024, In: Science Advances. 10, 23, 16 p., eadn7191.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)34 Downloads (Pure) -
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
Barnsby-Greer, L., Mabbitt, P. D., Dery, M.-A., Squair, D. R., Wood, N. T., Lamoliatte, F., Lange, S. M. & Virdee, S. (Lead / Corresponding author), Feb 2024, In: Nature Structural & Molecular Biology. 31, 2, p. 351-363 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)30 Downloads (Pure) -
VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains
Lange, S. M. (Lead / Corresponding author), McFarland, M. R., Lamoliatte, F., Carroll, T., Krshnan, L., Pérez-Ràfols, A., Kwaśna, D., Shen, L., Wallace, I., Cole, I., Armstrong, L. A., Knebel, A., Johnson, C., De Cesare, V. & Kulathu, Y. (Lead / Corresponding author), 8 Jul 2024, (E-pub ahead of print) In: Nature Structural & Molecular Biology. 35 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Downloads (Pure) -
An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates
Barnsby-Greer, L., Mabbitt, P., Dery, M.-A., Squair, D., Wood, N., Lange, S. & Virdee, S., 9 May 2023, BioRxiv.Research output: Working paper/Preprint › Preprint
Open AccessFile38 Downloads (Pure) -
Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processes
Lange, S., McFarland, M., Lamoliatte, F., Kwasna, D., Shen, L., Wallace, I., Cole, I., Armstrong, L., Knebel, A., Johnson, C., De Cesare, V. & Kulathu, Y., 10 Jan 2023, BioRxiv, 31 p.Research output: Working paper/Preprint › Preprint
File76 Downloads (Pure)