Research output per year
Research output per year
- 1 - 50 out of 100 results
Search results
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2023
Cross-sectional study examining the epidemiology of chronic pain in Nepal
Higgins, C., Sharma, S., Bimali, I., Hales, T. G., Cameron, P. A., Smith, B. H. & Colvin, L., Mar 2023, In: PAIN Reports. 8, 2, 10 p., e1067.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Morphine-induced mechanical hypersensitivity in mice requires δ receptors, β-arrestin2 and c-Src activity
Singleton, S. & Hales, T. G., 1 Mar 2023, (E-pub ahead of print) In: Journal of Physiology. 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes
Kuo, C-W., Dobi, S., Costa, A., Main, A., Baptista-Hon, D., Wypijewski, K. J., Costello, H., Hales, T. G., MacQuaide, N., Smith, G. L. & Fuller, W., 14 Feb 2023, In: Proceedings of the National Academy of Sciences. 120, 7, 12 p., e2207887120.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
Opioid Use Disorder, Cannabinoid Use Disorder and Gabapentinoid Disorder: Compare and Contrast
Hales, T., 25 Nov 2022.Research output: Contribution to conference › Paper
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The Impact of Early Life Adversity on Pain and Responses to Opioids
Hales, T., 14 Jun 2022.Research output: Contribution to conference › Abstract
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Traumatic needle damage to nerves during regional anesthesia: presentation of a novel mechanotransduction hypothesis
McLeod, G. A., Sadler, A. & Hales, T. G., 1 Nov 2022, In: Regional Anesthesia and Pain Medicine. 47, 11, p. 703-706 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Downloads (Pure) -
Validation of the Nepali version of the self-reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) in adults with chronic pain and predominantly low-literacy levels
Sharma, S., Higgins, C., Cameron, P., Bimali, I., Hales, T. G., Bennett, M. I., Colvin, L. & Smith, B. H., 8 Mar 2022, In: Journal of Pain : Official Journal of the American Pain Society. 23, 3, p. 424-433 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
2021
GABAA receptors in GtoPdb v.2021.3
Belelli, D., Hales, T. G., Lambert, J. J., Luscher, B., Olsen, R., Peters, J. A., Rudolph, U. & Sieghart, W., 2 Sept 2021, In: IUPHAR/BPS guide to pharmacology CITE. 2021, 3, 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Downloads (Pure) -
Morphine-induced mechanical hypersensitivity in mice requires δ receptors, β-arrestin2 and c-Src activity
Hales, T., 22 Sept 2021.Research output: Contribution to conference › Poster › peer-review
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Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers
Lopez-Charcas, O., Pukkanasut, P., Velu, S. E., Brackenbury, W. J., Hales, T. G., Besson, P., Gomora, J. C. & Roger, S., 23 Apr 2021, In: iScience. 24, 4, p. 102270 26 p., 102270.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Citations (Scopus)59 Downloads (Pure) -
TRV130 partial agonism and capacity to induce antinociceptive tolerance revealed through reducing available µ opioid receptor number
Singleton, S., Baptista-Hon, D. T., Edelsten, E., McCaughey, K. S., Camplisson, E. & Hales, T. G., Apr 2021, In: British Journal of Pharmacology. 178, 8, p. 1855-1868 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)95 Downloads (Pure) -
2020
Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives
Baptista-Hon, D. T., Smith, M., Singleton, S., Antonides, L. H., Daeid, N. N., McKenzie, C. & Hales, T. G., 9 Jul 2020, In: British Journal of Pharmacology. 177, 15, p. 3436-3448 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)99 Downloads (Pure) -
A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank
Meng, W., Chan, B. W., Harris, C., Freidin, M. B., Hebert, H., Adams, M. J., Campbell, A., Hayward, C., Zheng, H., Zhang, X., Colvin, L., Hales, T., Palmer, C., Williams, F. M. K., McIntosh, A. M. & Smith, B. H., 15 Apr 2020, In: Human Molecular Genetics. 29, 8, p. 1396-1404 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)54 Downloads (Pure) -
A structural rationale for N-methylbicuculline acting as a promiscuous competitive antagonist of inhibitory pentameric ligand gated ion channels
Jones, M. J., Dawson, A., Hales, T. G. & Hunter, W. N., 18 May 2020, In: ChemBioChem. 21, 10, p. 1526-1533 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)90 Downloads (Pure) -
2019
Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA
Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In: Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)94 Downloads (Pure) -
Determining an in vitro dose-response relationship of photodynamic therapy with first and second-generation photosensitisers for high grade tumours
Singh, K., Baptista-Hon, D., Hewitt, M., Kouli, O., Hossain-Ibrahim, K. & Hales, T., 7 Aug 2019, 17th International Photodynamic Association World Congress. Hasan, T. (ed.). Society of Photo-optical Instrumentation Engineers, 110706E. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 11070).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein
Dawson, A., Trumper, P., de Souza, J. O., Parker, H., Jones, M. J., Hales, T. G. & Hunter, W. N., 1 Nov 2019, In: IUCrJ. 6, Part 6, p. 1014-1023 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)101 Downloads (Pure) -
How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence
Forget, P., Aguirre, J. A., Bencic, I., Borgeat, A., Cama, A., Condron, C., Eintrei, C., Eroles, P., Gupta, A., Hales, T. G., Ionescu, D., Johnson, M., Kabata, P., Kirac, I., Ma, D., Mokini, Z., Guerrero Orriach, J. L., Retsky, M., Sandrucci, S., Siekmann, W., & 4 others, 28 Apr 2019, In: Cancers. 11, 5, p. 1-15 15 p., 592.Research output: Contribution to journal › Review article › peer-review
Open AccessFile43 Citations (Scopus)110 Downloads (Pure) -
Peri-operative opioid analgesia - when is enough too much? A review of opioid-induced tolerance and hyperalgesia
Colvin, L., Bull, F. & Hales, T., Apr 2019, In: Lancet. 393, 10180, p. 1558-1568 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile201 Citations (Scopus)1148 Downloads (Pure) -
The search for the 'next' euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning
Sharma, K. K., Hales, T., Rao, V. J., Nic Daeid, N. & McKenzie, C., Jan 2019, In: Forensic Toxicology. 37, 1, p. 1-16 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile36 Citations (Scopus)382 Downloads (Pure) -
2018
Association of opioid prescribing practices with chronic pain and benzodiazepine co-prescription: a primary care data linkage study
Torrance, N., Mansoor, R., Wang, H., Gilbert, S., Macfarlane, G. J., Serpell, M., Baldacchino, A., Hales, T. G., Donnan, P., Wyper, G., Smith, B. H. & Colvin, L., Jun 2018, In: British Journal of Anaesthesia. 120, 6, p. 1345-1355 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)187 Downloads (Pure) -
Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy
Wright, L., Baptista-Hon, D., Bull, F., Dalgaty, F., Gallacher, M., Ibbotson, S. H. & Hales, T. G., 1 Feb 2018, In: Pain. 159, 2, p. 284-297 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)395 Downloads (Pure) -
Potent Inactivation-Dependent Inhibition of Adult and Neonatal NaV1.5 Channels by Lidocaine and Levobupivacaine
Elajnaf, T., Baptista-Hon, D. T. & Hales, T. G., Sept 2018, In: Anesthesia and Analgesia. 127, 3, p. 650-660 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)139 Downloads (Pure) -
2017
Loop G in the GABAA receptor α1 subunit influences gating efficacy
Baptista-Hon, D. T., Gulbinaite, S. & Hales, T. G., 1 Mar 2017, In: Journal of Physiology. 595, 5, p. 1725-1741 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)149 Downloads (Pure) -
Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src
Bull, F. A., Baptista-Hon, D. T., Lambert, J. J., Walwyn, W. & Hales, T. G., 1 Dec 2017, In: Scientific Reports. 7, 1, p. 1-11 11 p., 9969.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)252 Downloads (Pure) -
Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation
Bull, F. A., Baptista-Hon, D. T., Sneddon, C., Wright, L., Walwyn, W. & Hales, T. G., 1 Nov 2017, In: ANESTHESIOLOGY. 127, 5, p. 878-889 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)160 Downloads (Pure) -
2016
A role for loop G in the β1 strand in GABAA receptor activation
Baptista-Hon, D. T., Krah, A., Zachariae, U. & Hales, T. G., 1 Oct 2016, In: Journal of Physiology. 594, 19, p. 5555-5571 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)185 Downloads (Pure) -
2015
Agonist- and antagonist-induced up-regulation of surface 5-HT3A receptors
Morton, R. A., Baptista-Hon, D. T., Hales, T. G. & Lovinger, D. M., Aug 2015, In: British Journal of Pharmacology. 172, 16, p. 4066-4077 12 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Consensus statement from the BJA Workshop on Cancer and Anaesthesia
Buggy, D. J., Borgeat, A., Cata, J., Doherty, D. G., Doornebal, C. W., Forget, P., Gottumukkala, V., Gottschalk, A., Gupta, A., Gupta, K., Hales, T. G., Hemmings, H. C., Hollmann, M. W., Kurz, A., Ma, D., Parat, M. O., Sessler, D. I., Shorten, G. & Singleton, P., Jan 2015, In: BRITISH JOURNAL OF ANAESTHESIA. 114, 1, p. 2-3 2 p.Research output: Contribution to journal › Editorial › peer-review
74 Citations (Scopus) -
Voltage-gated Na+ channel activity increases colon cancertranscriptional activity and invasion via persistent MAPK signaling
House, C. D., Wang, B. D., Ceniccola, K., Williams, R., Simaan, M., Olender, J., Patel, V., Baptista-Hon, D. T., Annunziata, C. M., Gutkind, J. S., Hales, T. G. & Lee, N. H., 22 Jun 2015, In: Scientific Reports. 5, 16 p., 11541.Research output: Contribution to journal › Article › peer-review
Open AccessFile62 Citations (Scopus)234 Downloads (Pure) -
2014
Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function
Baptista-Hon, D. T., Robertson, F. M., Robertson, G. B., Owen, S. J., Rogers, G. W., Lydon, E. L., Lee, N. H. & Hales, T. G., Jul 2014, In: British Journal of Anaesthesia. 113 , Suppl. 1, p. i39-i48 10 p.Research output: Contribution to journal › Article › peer-review
101 Citations (Scopus) -
2013
Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor
Carland, J. E., Cooper, M. A., Livesey, M. R., Hales, T. G., Lambert, J. J. & Peters, J. A., 1 Nov 2013, In: Journal of Biological Chemistry. 288, 44, p. 31592-31601 10 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
The minimum M3-M4 loop length of neurotransmitteractivated pentameric receptors is critical for the structural integrity of cytoplasmic portals
Baptista-Hon, D. T., Deeb, T. Z., Lambert, J. J., Peters, J. A. & Hales, T. G., 26 Jul 2013, In: Journal of Biological Chemistry. 288, 30, p. 21558-21568 11 p.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus) -
2012
Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization
Othman, N. A., Gallacher, M., Deeb, T. Z., Baptista-Hon, D. T., Perry, D. C. & Hales, T. G., 2012, In: Journal of Physiology. 590, 1, p. 163-178 16 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine
Baptista-Hon, D. T., Deeb, T. Z., Othman, N. A., Sharp, D. & Hales, T. G., 2012, In: British Journal of Pharmacology. 165, 3, p. 693-704 12 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Using propofol to differentiate between mixed populations of recombinant GABAA receptors expressed in HEK cells
Gallacher, M., Weir, C. J. & Hales, T. G., Apr 2012, In: British Journal of Anaesthesia. 108, 4, p. 710-711 2 p.Research output: Contribution to journal › Article › peer-review
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2011
Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2
Lam, H., Maga, M., Pradhan, A., Evans, C. J., Maidment, N. T., Hales, T. G. & Walwyn, W., 12 Apr 2011, In: Molecular Pain. 7, p. - 10 p., 24.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Arresting the development of morphine tolerance and dependence
Hales, T. G., 2011, In: British Journal of Anaesthesia. 107, 5, p. 653-655 3 p.Research output: Contribution to journal › Editorial › peer-review
9 Citations (Scopus) -
Fluorophore assisted light inactivation (FALI) of recombinant 5-HT(3)A receptor constitutive internalization and function
Morton, R. A., Luo, G., Davis, M. I., Hales, T. G. & Lovinger, D. M., Jun 2011, In: Molecular and Cellular Neuroscience. 47, 2, p. 79-92 14 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Mechanisms of anaesthetics: lessons learned from creatures great and small
Hales, T. G., May 2011, In: Anaesthesia. 66, 5, p. 334-337 4 p.Research output: Contribution to journal › Editorial › peer-review
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2010
A conserved cysteine residue in the third transmembrane domain is essential for homomeric 5-HT3 receptor function
Wu, D-F., Othman, N. A., Sharp, D., Mahendra, A., Deeb, T. Z. & Hales, T. G., 15 Feb 2010, In: Journal of Physiology. 588, 4, p. 603-615 13 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Communication between propofol and gamma-aminobutyric acid binding sites on gamma-aminobutyric acid type A receptors
Gallacher, M., Deeb, T. Z., Weir, C. & Hales, T. G., Nov 2010, In: British Journal of Anaesthesia. 105, 5, p. 727-728 2 p.Research output: Contribution to journal › Book/Film/Article review › peer-review
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Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors
Peters, J. A., Cooper, M. A., Carland, J. E., Livesey, M. R., Hales, T. G. & Lambert, J. J., 15 Feb 2010, In: Journal of Physiology. 588, 4, p. 587-595 9 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
Voltage-Gated Na+ Channel SCN5A Is a Key Regulator of a Gene Transcriptional Network That Controls Colon Cancer Invasion
House, C. D., Vaske, C. J., Schwartz, A. M., Obias, V., Frank, B., Luu, T., Sarvazyan, N., Irby, R., Strausberg, R. L., Hales, T. G., Stuart, J. M. & Lee, N. H., 1 Sept 2010, In: Cancer Research. 70, 17, p. 6957-6967 11 p.Research output: Contribution to journal › Article › peer-review
197 Citations (Scopus) -
2009
delta Receptors Are Required for Full Inhibitory Coupling of mu Receptors to Voltage-Dependent Ca2+ Channels in Dorsal Root Ganglion Neurons
Walwyn, W., John, S., Maga, M., Evans, C. J. & Hales, T. G., Jul 2009, In: Molecular Pharmacology. 76, 1, p. 134-143 10 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
Development of an undergraduate pharmacogenomics curriculum
O'Brien, T. J., Goodsaid, F., Plack, M., Harralson, A., Harrouk, W., Hales, T. G., Mandel, H. G., Perry, D. C., Kennedy, K., Sarvazyan, N. & Chiappinelli, V. A., Dec 2009, In: Pharmacogenomics Journal. 10, 12, p. 1979-1986 8 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Direct subunit-dependent multimodal 5-hydroxytryptamine(3) receptor antagonism by methadone
Deeb, T. Z., Sharp, D. & Hales, T. G., Apr 2009, In: Molecular Pharmacology. 75, 4, p. 908-917 10 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Ethanol and trafficking of 5-HT3A receptors
Morton, R. A., Luo, G., Davis, M. I., Hales, T. G. & Lovinger, D. M., Jun 2009, In: Alcoholism: Clinical and Experimental Research. 33, 6, p. 19A-19A 1 p.Research output: Contribution to journal › Book/Film/Article review › peer-review
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The 5-HT3 receptor: - the relationship between structure and function
Barnes, N. M., Hales, T. G., Lummis, S. C. R. & Peters, J. A., Jan 2009, In: Neuropharmacology. 56, 1, p. 273-284 12 p.Research output: Contribution to journal › Review article › peer-review
189 Citations (Scopus) -
2008
High affinity binding of epibatidine to serotonin type 3 receptors
Drisdel, R. C., Sharp, D., Henderson, T. N., Hales, T. G. & Green, W. N., 11 Apr 2008, In: Journal of Biological Chemistry. 283, 15, p. 9659-9665 7 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus)