Tim Hales

2025

Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review

Senaratne, D. (Lead / Corresponding author), Koponen, M., Barnett, K., Smith, B. H., Hales, T., Marryat, L. & Colvin, L. A., Feb 2025, In: British Journal of Anaesthesia. p. 1-31 31 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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29 Downloads (Pure)

Impact of adverse childhood experiences on sensory thresholds in adults living with multimorbidity and chronic pain (the ACE-MAP study): protocol for an observational feasibility study

Senaratne, D. (Lead / Corresponding author), Smith, B. H., Hales, T., Marryat, L. & Colvin, L., 7 Jan 2025, In: BMJ Open. 15, 1, 7 p., e091053.

Research output: Contribution to journal › Article › peer-review

Open Access

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55 Downloads (Pure)

2024

Activation of µ receptors by SR-17018 through a distinctive mechanism

Singleton, S., Dieterle, C., Walker, D. J., Runeberg, T., Oswald, A. S., Rosenqvist, G., Robertson, L., McCarthy, T., Sarkar, S., Baptista-Hon, D. & Hales, T. G. (Lead / Corresponding author), 1 Nov 2024, In: Neuropharmacology. 258, 12 p., 110093.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice

Abboussi, O. (Lead / Corresponding author), Khan, Z. A., Ibork, H., Zulu, S. S., Daniels, W., Taghzouti, K. & Hales, T. G., Feb 2024, In: Behavioural Pharmacology. 35, 1, p. 26-35 10 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

ENIGMA-Chronic Pain: A worldwide initiative to identify brain correlates of chronic pain

Quidé, Y. (Lead / Corresponding author), Jahanshad, N., Andoh, J., Antoniou, G., Apkarian, A. V., Ashar, Y. K., Badran, B. W., Baird, C. L., Baxter, L., Bell, T. R., Blanco-Hinojo, L., Borckardt, J., Cheung, C. L., Ciampi De Andrade, D., Couto, B. A., Cox, S. R., Cruz-Almeida, Y., Dannlowski, U., De Martino, E. & De Tommaso, M. & 64 others, Deus, J., Domin, M., Egorova-Brumley, N., Elliott, J., Fanton, S., Fauchon, C., Flor, H., Franz, C. E., Gatt, J. M., Gerdhem, P., Gilman, J. M., Gollub, R. L., Govind, V., Graven-Nielsen, T., Håkansson, G., Hales, T., Haswell, C., Heukamp, N. J., Hu, L., Huang, L., Hussain, A., Jensen, K., Kircher, T., Kremen, W. S., Leehr, E. J., Lindquist, M., Loggia, M. L., Lotze, M., Martucci, K. T., Meeker, T. J., Meinert, S., Millard, S. K., Morey, R. A., Murillo, C., Nees, F., Nenadic, I., Park, H. R. P., Peng, X., Ploner, M., Pujol, J., Robayo, L. E., Salan, T., Seminowicz, D. A., Serian, A., Slater, R., Stein, F., Stevens, J., Strauss, S., Sun, D., Vachon-Presseau, E., Valdes-Hernandez, P. A., Vanneste, S., Vernon, M., Verriotis, M., Wager, T. D., Widerstrom-Noga, E., Woodbury, A., Zeidan, F., Bhatt, R. R., Ching, C. R. K., Haddad, E., Thomopoulos, S. I., Thompson, P. M. & Gustin, S. M., Dec 2024, In: Pain. 165, 12, p. 2662-2666 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

85 Downloads (Pure)

Pharmacological interventions for remifentanil-induced hyperalgesia: A systematic review and network meta-analysis of preclinical trials

Koponen, M. E., Naray, E., Hales, T. G. & Forget, P., 5 Dec 2024, In: PLoS ONE. 19, 12, 25 p., e0313749.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

28 Downloads (Pure)

The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis

Senaratne, D. N. S. (Lead / Corresponding author), Thakkar, B., Smith, B. H., Hales, T. G., Marryat, L. & Colvin, L. A., 15 Aug 2024, In: BMC Medicine. 22, 14 p., 315.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

99 Downloads (Pure)

2023

Cross-sectional study examining the epidemiology of chronic pain in Nepal

Higgins, C. (Lead / Corresponding author), Sharma, S., Bimali, I., Hales, T. G., Cameron, P. A., Smith, B. H. & Colvin, L., Mar 2023, In: PAIN Reports. 8, 2, 10 p., e1067.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

145 Downloads (Pure)

Early life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through up-regulation of δ opioid receptors in mice

Singleton, S., Sneddon, C. C., Bakina, A., Lambert, J. J. & Hales, T. G. (Lead / Corresponding author), Oct 2023, In: Pain. 164, 10, p. 2253-2264 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

175 Downloads (Pure)

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy

John, S., Walwyn, D. R., DeFea, K., Hales, T. G. & Walwyn, W. (Lead / Corresponding author), 14 Jul 2023, In: Frontiers in Pharmacology. 14, 2 p., 1251958.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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54 Downloads (Pure)

Local Anesthetics and Cancer

Hales, T. G. & Baptista-Hon, D. T., 2023, Perioperative Care of the Cancer Patient. Philadelphia: Elsevier, p. 117-127 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Morphine-induced mechanical hypersensitivity in mice requires δ receptors, β-arrestin2 and c-Src activity

Singleton, S. & Hales, T. G. (Lead / Corresponding author), 15 Apr 2023, In: Journal of Physiology. 601, 8, p. 1483-1500 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

181 Downloads (Pure)

Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes

Kuo, C.-W., Dobi, S., Costa, A., Main, A., Baptista-Hon, D., Wypijewski, K. J., Costello, H., Hales, T. G., MacQuaide, N., Smith, G. L. & Fuller, W. (Lead / Corresponding author), 14 Feb 2023, In: Proceedings of the National Academy of Sciences. 120, 7, 12 p., e2207887120.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

127 Downloads (Pure)

2022

Opioid Use Disorder, Cannabinoid Use Disorder and Gabapentinoid Disorder: Compare and Contrast

Hales, T., 25 Nov 2022.

Research output: Contribution to conference › Paper

The Impact of Early Life Adversity on Pain and Responses to Opioids

Hales, T., 14 Jun 2022.

Research output: Contribution to conference › Abstract

Traumatic needle damage to nerves during regional anesthesia: presentation of a novel mechanotransduction hypothesis

McLeod, G. A. (Lead / Corresponding author), Sadler, A. & Hales, T. G., 1 Nov 2022, In: Regional Anesthesia and Pain Medicine. 47, 11, p. 703-706 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

339 Downloads (Pure)

Validation of the Nepali version of the self-reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) in adults with chronic pain and predominantly low-literacy levels

Sharma, S. (Lead / Corresponding author), Higgins, C., Cameron, P., Bimali, I., Hales, T. G., Bennett, M. I., Colvin, L. & Smith, B. H., 8 Mar 2022, In: Journal of Pain : Official Journal of the American Pain Society. 23, 3, p. 424-433 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

199 Downloads (Pure)

2021

GABAA receptors in GtoPdb v.2021.3

Belelli, D., Hales, T. G., Lambert, J. J., Luscher, B., Olsen, R., Peters, J. A., Rudolph, U. & Sieghart, W., 2 Sept 2021, In: IUPHAR/BPS guide to pharmacology CITE. 2021, 3, 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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91 Downloads (Pure)

Morphine-induced mechanical hypersensitivity in mice requires δ receptors, β-arrestin2 and c-Src activity

Hales, T., 22 Sept 2021.

Research output: Contribution to conference › Poster › peer-review

Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

Lopez-Charcas, O., Pukkanasut, P., Velu, S. E., Brackenbury, W. J., Hales, T. G., Besson, P., Gomora, J. C. & Roger, S. (Lead / Corresponding author), 23 Apr 2021, In: iScience. 24, 4, p. 102270 26 p., 102270.

Research output: Contribution to journal › Review article › peer-review

Open Access

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32 Citations (Scopus)

154 Downloads (Pure)

TRV130 partial agonism and capacity to induce antinociceptive tolerance revealed through reducing available µ opioid receptor number

Singleton, S., Baptista-Hon, D. T., Edelsten, E., McCaughey, K. S., Camplisson, E. & Hales, T. G. (Lead / Corresponding author), Apr 2021, In: British Journal of Pharmacology. 178, 8, p. 1855-1868 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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36 Citations (Scopus)

246 Downloads (Pure)

2020

Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives

Baptista-Hon, D. T., Smith, M., Singleton, S., Antonides, L. H., Daeid, N. N., McKenzie, C. & Hales, T. G. (Lead / Corresponding author), 9 Jul 2020, In: British Journal of Pharmacology. 177, 15, p. 3436-3448 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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11 Citations (Scopus)

240 Downloads (Pure)

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

Meng, W. (Lead / Corresponding author), Chan, B. W., Harris, C., Freidin, M. B., Hebert, H., Adams, M. J., Campbell, A., Hayward, C., Zheng, H., Zhang, X., Colvin, L., Hales, T., Palmer, C., Williams, F. M. K., McIntosh, A. M. & Smith, B. H., 15 Apr 2020, In: Human Molecular Genetics. 29, 8, p. 1396-1404 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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27 Citations (Scopus)

125 Downloads (Pure)

Assessing pain in models of rheumatoid arthritis

Singleton, S., Nefla, M., Dennison, N., Arthur, S. & Hales, T., Aug 2020, In: Animal Technology and Welfare. 19, 2, p. 149-152 4 p.

Research output: Contribution to journal › Article › peer-review

A structural rationale for N-methylbicuculline acting as a promiscuous competitive antagonist of inhibitory pentameric ligand gated ion channels

Jones, M. J., Dawson, A., Hales, T. G. & Hunter, W. N. (Lead / Corresponding author), 18 May 2020, In: ChemBioChem. 21, 10, p. 1526-1533 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

280 Downloads (Pure)

2019

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T. (Lead / Corresponding author), 15 Feb 2019, In: Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

164 Downloads (Pure)

Determining an in vitro dose-response relationship of photodynamic therapy with first and second-generation photosensitisers for high grade tumours

Singh, K., Baptista-Hon, D., Hewitt, M., Kouli, O., Hossain-Ibrahim, K. & Hales, T., 7 Aug 2019, 17th International Photodynamic Association World Congress. Hasan, T. (ed.). Society of Photo-optical Instrumentation Engineers, 110706E. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 11070).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

Dawson, A., Trumper, P., de Souza, J. O., Parker, H., Jones, M. J., Hales, T. G. & Hunter, W. N. (Lead / Corresponding author), 1 Nov 2019, In: IUCrJ. 6, Part 6, p. 1014-1023 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

147 Downloads (Pure)

How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence

Forget, P. (Lead / Corresponding author), Aguirre, J. A., Bencic, I., Borgeat, A., Cama, A., Condron, C., Eintrei, C., Eroles, P., Gupta, A., Hales, T. G., Ionescu, D., Johnson, M., Kabata, P., Kirac, I., Ma, D., Mokini, Z., Guerrero Orriach, J. L., Retsky, M., Sandrucci, S. & Siekmann, W. & 4 others, Štefančić, L., Votta-Vellis, G., Connolly, C. & Buggy, D., 28 Apr 2019, In: Cancers. 11, 5, p. 1-15 15 p., 592.

Research output: Contribution to journal › Review article › peer-review

Open Access

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58 Citations (Scopus)

185 Downloads (Pure)

Peri-operative opioid analgesia - when is enough too much? A review of opioid-induced tolerance and hyperalgesia

Colvin, L. (Lead / Corresponding author), Bull, F. & Hales, T., Apr 2019, In: Lancet. 393, 10180, p. 1558-1568 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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392 Citations (Scopus)

2069 Downloads (Pure)

The search for the 'next' euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning

Sharma, K. K., Hales, T., Rao, V. J., Nic Daeid, N. & McKenzie, C. (Lead / Corresponding author), Jan 2019, In: Forensic Toxicology. 37, 1, p. 1-16 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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47 Citations (Scopus)

465 Downloads (Pure)

2018

Association of opioid prescribing practices with chronic pain and benzodiazepine co-prescription: a primary care data linkage study

Torrance, N., Mansoor, R., Wang, H., Gilbert, S., Macfarlane, G. J., Serpell, M., Baldacchino, A., Hales, T. G., Donnan, P., Wyper, G., Smith, B. H. (Lead / Corresponding author) & Colvin, L., Jun 2018, In: British Journal of Anaesthesia. 120, 6, p. 1345-1355 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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59 Citations (Scopus)

300 Downloads (Pure)

Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy

Wright, L., Baptista-Hon, D., Bull, F., Dalgaty, F., Gallacher, M., Ibbotson, S. H. & Hales, T. G. (Lead / Corresponding author), 1 Feb 2018, In: Pain. 159, 2, p. 284-297 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

523 Downloads (Pure)

Potent Inactivation-Dependent Inhibition of Adult and Neonatal NaV1.5 Channels by Lidocaine and Levobupivacaine

Elajnaf, T. (Lead / Corresponding author), Baptista-Hon, D. T. & Hales, T. G. (Lead / Corresponding author), Sept 2018, In: Anesthesia and Analgesia. 127, 3, p. 650-660 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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20 Citations (Scopus)

231 Downloads (Pure)

2017

Loop G in the GABA_A receptor α1 subunit influences gating efficacy

Baptista-Hon, D. T., Gulbinaite, S. & Hales, T. G. (Lead / Corresponding author), 1 Mar 2017, In: Journal of Physiology. 595, 5, p. 1725-1741 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

206 Downloads (Pure)

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src

Bull, F. A., Baptista-Hon, D. T., Lambert, J. J., Walwyn, W. & Hales, T. G. (Lead / Corresponding author), 1 Dec 2017, In: Scientific Reports. 7, 1, p. 1-11 11 p., 9969.

Research output: Contribution to journal › Article › peer-review

Open Access

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22 Citations (Scopus)

530 Downloads (Pure)

Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation

Bull, F. A., Baptista-Hon, D. T., Sneddon, C., Wright, L., Walwyn, W. & Hales, T. G. (Lead / Corresponding author), 1 Nov 2017, In: ANESTHESIOLOGY. 127, 5, p. 878-889 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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20 Citations (Scopus)

217 Downloads (Pure)

2016

A role for loop G in the β1 strand in GABA_A receptor activation

Baptista-Hon, D. T., Krah, A., Zachariae, U. & Hales, T. G. (Lead / Corresponding author), 1 Oct 2016, In: Journal of Physiology. 594, 19, p. 5555-5571 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

228 Downloads (Pure)

2015

Agonist- and antagonist-induced up-regulation of surface 5-HT₃A receptors

Morton, R. A., Baptista-Hon, D. T., Hales, T. G. & Lovinger, D. M. (Lead / Corresponding author), Aug 2015, In: British Journal of Pharmacology. 172, 16, p. 4066-4077 12 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Consensus statement from the BJA Workshop on Cancer and Anaesthesia

Buggy, D. J. (Lead / Corresponding author), Borgeat, A., Cata, J., Doherty, D. G., Doornebal, C. W., Forget, P., Gottumukkala, V., Gottschalk, A., Gupta, A., Gupta, K., Hales, T. G., Hemmings, H. C., Hollmann, M. W., Kurz, A., Ma, D., Parat, M. O., Sessler, D. I., Shorten, G. & Singleton, P., Jan 2015, In: BRITISH JOURNAL OF ANAESTHESIA. 114, 1, p. 2-3 2 p.

Research output: Contribution to journal › Editorial › peer-review

80 Citations (Scopus)

Voltage-gated Na⁺ channel activity increases colon cancertranscriptional activity and invasion via persistent MAPK signaling

House, C. D., Wang, B. D., Ceniccola, K., Williams, R., Simaan, M., Olender, J., Patel, V., Baptista-Hon, D. T., Annunziata, C. M., Gutkind, J. S., Hales, T. G. & Lee, N. H. (Lead / Corresponding author), 22 Jun 2015, In: Scientific Reports. 5, 16 p., 11541.

Research output: Contribution to journal › Article › peer-review

Open Access

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77 Citations (Scopus)

336 Downloads (Pure)

2014

Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function

Baptista-Hon, D. T., Robertson, F. M., Robertson, G. B., Owen, S. J., Rogers, G. W., Lydon, E. L., Lee, N. H. & Hales, T. G. (Lead / Corresponding author), Jul 2014, In: British Journal of Anaesthesia. 113 , Suppl. 1, p. i39-i48 10 p.

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

2013

Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor

Carland, J. E., Cooper, M. A., Livesey, M. R., Hales, T. G., Lambert, J. J. (Lead / Corresponding author) & Peters, J. A., 1 Nov 2013, In: Journal of Biological Chemistry. 288, 44, p. 31592-31601 10 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

The minimum M3-M4 loop length of neurotransmitteractivated pentameric receptors is critical for the structural integrity of cytoplasmic portals

Baptista-Hon, D. T., Deeb, T. Z., Lambert, J. J., Peters, J. A. & Hales, T. G. (Lead / Corresponding author), 26 Jul 2013, In: Journal of Biological Chemistry. 288, 30, p. 21558-21568 11 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

2012

Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization

Othman, N. A., Gallacher, M., Deeb, T. Z., Baptista-Hon, D. T., Perry, D. C. & Hales, T. G., 2012, In: Journal of Physiology. 590, 1, p. 163-178 16 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

Baptista-Hon, D. T., Deeb, T. Z., Othman, N. A., Sharp, D. & Hales, T. G. (Lead / Corresponding author), 2012, In: British Journal of Pharmacology. 165, 3, p. 693-704 12 p.

Research output: Contribution to journal › Article › peer-review