Projects per year
Personal profile
Research
Chromatin structure and gene regulation
Chromatin Structure and function.
The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)
Kulathu, Y. (Investigator), Labib, K. (Investigator), Masson, G. (Investigator), Moraga Gonzalez, I. (Investigator), Murray, D. (Investigator), Owen-Hughes, T. (Investigator), Stanley-Wall, N. (Investigator) & Wyatt, P. (Investigator)
1/12/21 → 31/12/26
Project: Research
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Machine Learning Methods to Re-Annotate Histone Modifications with Locus-specific Functional Classification (Future Leaders Fellowship)
Owen-Hughes, T. (Investigator) & Schweikert, G. (Investigator)
1/11/20 → 31/10/25
Project: Research
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Aberrant DNA Methylation and its Impact in Blood Cancer Development (Career Development Fellowship)
Owen-Hughes, T. (Investigator) & Rasmussen, K. (Investigator)
1/06/19 → 31/05/25
Project: Research
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Dundee cryo-CLEM platform
Appleton, P. (Investigator), Owen-Hughes, T. (Investigator), Prescott, A. (Investigator), Sundaramoorthy, R. (Investigator) & Tanaka, T. (Investigator)
Project: Research
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GPU-Based Machine Learning System For Fundamental Biological Research
Barton, G. (Investigator), Gilbert, I. (Investigator), Lamond, A. (Investigator), Owen-Hughes, T. (Investigator), Pisliakov, A. (Investigator), Schweikert, G. (Investigator), Sknepnek, R. (Investigator), Swedlow, J. (Investigator), Weijer, K. (Investigator) & Zachariae, U. (Investigator)
Biotechnology and Biological Sciences Research Council
1/08/21 → 31/07/22
Project: Research
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RNA polymerase II promotes the organization of chromatin following DNA replication
Bandau, S., Alvarez, V., Jiang, H., Graff, S., Sundaramoorthy, R., Gierlinski, M., Toman, M., Owen-Hughes, T., Sidoli, S., Lamond, A. & Alabert, C. (Lead / Corresponding author), 12 Mar 2024, In: EMBO Reports. 25, 3, p. 1387-1414 28 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)667 Downloads (Pure) -
Proteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Alvarez, V., Bandau, S., Jiang, H., Rios-Szwed, D., Hukelmann, J., Garcia-Wilson, E., Wiechens, N., Griesser, E., Ten Have, S., Owen-Hughes, T., Lamond, A. & Alabert, C. (Lead / Corresponding author), 31 Jan 2023, In: Cell Reports. 42, 1, 22 p., 111996.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)201 Downloads (Pure) -
Research using cryo-electron microscopy
Sundaramoorthy, R. (Contributing member), Owen-Hughes, T. (Contributing member), Vinciauskaite, V. (Contributing member), Cameron, A. (Producer) & Soave, S. (Film-maker), 2023Research output: Non-textual form › Digital or Visual Products
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Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
Blümli, S., Wiechens, N., Wu, M.-Y., Singh, V., Gierlinski, M., Schweikert, G., Gilbert, N., Naughton, C., Sundaramoorthy, R., Varghese, J., Gourlay, R., Soares, R., Clark, D. & Owen-Hughes, T. (Lead / Corresponding author), 2 Nov 2021, In: Cell Reports. 37, 5, 17 p., 109943.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)183 Downloads (Pure) -
Histone isoforms and the oncohistone code
Flaus, A., Downs, J. A. (Lead / Corresponding author) & Owen-Hughes, T. (Lead / Corresponding author), Apr 2021, In: Current Opinion in Genetics & Development. 67, p. 61-66 6 p.Research output: Contribution to journal › Review article › peer-review
17 Citations (Scopus)
Datasets
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High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.
Owen-Hughes, T. (Creator), Dickerson, D. (Creator), Gierlinski, M. (Contributor), Singh, V. (Contributor), Kitamura, E. (Contributor), Ball, G. (Contributor) & Tanaka, T. (Contributor), University of Dundee, 2016
DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151
Dataset
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Nicolaides-Baraitser Syndrome Foundation Meeting
Owen-Hughes, T. (Speaker)
30 May 2024 → 2 Jun 2024Activity: Talk or presentation types › Keynote
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Accessibility Video Project - Opening our Doors to the Public
Cameron, A. (Organiser), Soave, S. (Contributor), Stanley-Wall, N. (Contributor), Rosazza, T. (Contributor), Ganley, I. (Contributor), Singh, F. (Contributor), Sammler, E. (Contributor), Filipe Soares, R. (Contributor), Spinelli, L. (Contributor), Findlay, G. (Contributor), Hogg, E. (Contributor), Espejo Serrano, C. (Contributor), Prescott, A. (Contributor), Januschke, J. (Contributor), Pelisch, F. (Contributor), Bel Borja, L. (Contributor), Horn, D. (Contributor), Ridgway, M. (Contributor), Owen-Hughes, T. (Contributor), Sundaramoorthy, R. (Contributor), Barton, G. (Contributor), Sknepnek, R. (Contributor), Zachariae, U. (Contributor), Duce, S. (Contributor), McKim, S. (Contributor), Pugh, L. (Contributor), Griffin, J. (Contributor), Hein, I. (Contributor), Gilroy, E. M. (Contributor), McKenzie, G. (Contributor), Ly, T. (Contributor), Kar, A. (Contributor), Hastie, J. (Contributor), Postis, V. (Contributor), Dawson, A. (Contributor), Fyfe, P. (Contributor), Semenova, O. (Contributor), Robinson, D. (Contributor), Gray, D. (Contributor), Cabrita Gulyurtlu, S. (Contributor), Zollman, D. (Contributor), Spiteri, V. (Contributor) & Webb, T. (Contributor)
2022 → …Activity: Other activity types › Other
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Science Saturdays: Guardians of the Genome
Black, R. (Organiser), Millar, C. (Host), Wiechens, N. (Presenter), Owen-Hughes, T. (Contributor), Corsie, A. (Contributor), Toman, M. (Contributor), Wu, M.-Y. (Contributor), Blümli, S. (Contributor), Niakate, M.-L. (Contributor) & Sharpe, J. (Contributor)
1 Dec 2018Activity: Other activity types › Public engagement and outreach - festival/exhibition