Projects per year
Personal profile
Research
Chromatin structure and gene regulation
Chromatin Structure and function.
The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)
Kulathu, Y., Labib, K., Masson, G., Moraga Gonzalez, I., Murray, D., Owen-Hughes, T., Stanley-Wall, N. & Wyatt, P.
1/12/21 → 31/12/26
Project: Research
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Aberrant DNA Methylation and its Impact in Blood Cancer Development (Career Development Fellowship)
Owen-Hughes, T. & Rasmussen, K.
1/06/19 → 31/05/25
Project: Research
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Structure and Function of Chromatin Remodelling ATPases and their Dysfunction in Human Disease
Owen-Hughes, T. & Sundaramoorthy, R.
1/04/19 → 31/03/24
Project: Research
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Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
Blümli, S., Wiechens, N., Wu, M-Y., Singh, V., Gierlinski, M., Schweikert, G., Gilbert, N., Naughton, C., Sundaramoorthy, R., Varghese, J., Gourlay, R., Soares, R., Clark, D. & Owen-Hughes, T., 2 Nov 2021, In: Cell Reports. 37, 5, 17 p., 109943.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
Histone isoforms and the oncohistone code
Flaus, A., Downs, J. A. & Owen-Hughes, T., Apr 2021, In: Current Opinion in Genetics & Development. 67, p. 61-66 6 p.Research output: Contribution to journal › Review article › peer-review
5 Citations (Scopus) -
Chromatin remodelling comes into focus
Sundaramoorthy, R. & Owen-Hughes, T., 20 Aug 2020, In: F1000Research. 9, 14 p., 1011.Research output: Contribution to journal › Review article › peer-review
Open AccessFile9 Citations (Scopus)28 Downloads (Pure) -
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, , Jul 2019, In: Nature Chemical Biology. 15, 7, p. 672-680 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile166 Citations (Scopus)122 Downloads (Pure) -
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, , 2 Jul 2019, In: Nature Chemical Biology. 15, 8, p. 846 1 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
Datasets
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High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.
Owen-Hughes, T. (Creator), Dickerson, D. (Creator), Gierlinski, M. (Contributor), Singh, V. (Contributor), Kitamura, E. (Contributor), Ball, G. (Contributor) & Tanaka, T. (Contributor), University of Dundee, 2016
DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151
Dataset
Activities
- 1 Public engagement and outreach - festival/exhibition
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Science Saturdays: Guardians of the Genome
Rolf Black (Organiser), Christine Millar (Host), Nicola Wiechens (Presenter), Thomas Owen-Hughes (Contributor), Abigail Corsie (Contributor), Matthias Toman (Contributor), Meng-Ying Wu (Contributor), Seraina Blümli (Contributor), Mahamadou-Lamine Niakate (Contributor) & Jason Sharpe (Contributor)
1 Dec 2018Activity: Other activity types › Public engagement and outreach - festival/exhibition