Projects per year
Personal profile
Research
Chromatin structure and gene regulation
Chromatin Structure and function.
The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.
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Projects
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Aberrant DNA Methylation and its Impact in Blood Cancer Development (Career Development Fellowship)
Owen-Hughes, T. & Rasmussen, K.
1/06/19 → 31/05/25
Project: Research
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Structure and Function of Chromatin Remodelling ATPases and their Dysfunction in Human Disease
Owen-Hughes, T. & Sundaramoorthy, R.
1/04/19 → 31/03/24
Project: Research
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Impact of DNA Replication on Epigenetics (IDRE)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/17 → 30/04/22
Project: Research
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Research output
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Histone isoforms and the oncohistone code
Flaus, A., Downs, J. A. & Owen-Hughes, T., Apr 2021, In: Current Opinion in Genetics & Development. 67, p. 61-66 6 p.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Chromatin remodelling comes into focus
Sundaramoorthy, R. & Owen-Hughes, T., 20 Aug 2020, In: F1000Research. 9, 14 p., 1011.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, , Jul 2019, In: Nature Chemical Biology. 15, 7, p. 672-680 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile89 Citations (Scopus)43 Downloads (Pure) -
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, , 2 Jul 2019, In: Nature Chemical Biology. 15, 8, p. 846 1 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
The Face of Chromatin Variants
Flaus, A. & Owen-Hughes, T., 5 Sep 2019, In: Cell. 178, 6, p. 1284-1286 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.
Owen-Hughes, T. (Creator), Dickerson, D. (Creator), Gierlinski, M. (Contributor), Singh, V. (Contributor), Kitamura, E. (Contributor), Ball, G. (Contributor) & Tanaka, T. (Contributor), University of Dundee, 2016
DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151
Dataset
Activities
- 1 Public engagement and outreach - festival/exhibition
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Science Saturdays: Guardians of the Genome
Rolf Black (Organiser), Christine Millar (Host), Nicola Wiechens (Presenter), Thomas Owen-Hughes (Contributor), Abigail Corsie (Contributor), Matthias Toman (Contributor), Meng-Ying Wu (Contributor), Seraina Blümli (Contributor), Mahamadou-Lamine Niakate (Contributor) & Jason Sharpe (Contributor)
1 Dec 2018Activity: Other activity types › Public engagement and outreach - festival/exhibition