Owen-Hughes, Tom

Personal profile

Research

Chromatin structure and gene regulation

Chromatin Structure and function.

The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.

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Projects 2012 2025

10 Active
15 Finished

Aberrant DNA Methylation and its Impact in Blood Cancer Development (Career Development Fellowship)

Owen-Hughes, T. & Rasmussen, K.

Cancer Research UK

1/06/19 → 31/05/25

Project: Research

Structure and Function of Chromatin Remodelling ATPases and their Dysfunction in Human Disease

Owen-Hughes, T. & Sundaramoorthy, R.

Medical Research Council

1/04/19 → 31/03/24

Project: Research

Impact of DNA Replication on Epigenetics (IDRE)

Alabert, C. & Owen-Hughes, T.

1/05/17 → 30/04/22

Project: Research

Chromatin Replication and Cancer (Career Development Fellowship)

Alabert, C. & Owen-Hughes, T.

Cancer Research UK

1/01/17 → 31/12/22

Project: Research

Structural Studies of Chromatin Remodelling Enzymes (EASTBIO)

Owen-Hughes, T.

Biotechnology and Biological Sciences Research Council

5/09/16 → 4/09/20

Project: Research

Research Output 2003 2019

55 Article
2 Comment/debate
2 Review article
1 Chapter (peer-reviewed)
1 More
- 1 Editorial

2 Citations (Scopus)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journal › Article

Proteolysis

Adenosine Triphosphatases

Biophysics

Neoplasms

Chromatin Assembly and Disassembly

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., Mcconnell, D. B. & Ciulli, A., 2 Jul 2019, In : Nature Chemical Biology. 15, 8, p. 846 1 p.

Research output: Contribution to journal › Article

Chromatin Assembly and Disassembly

Ubiquitin-Protein Ligases

Nucleosomes

DNA Repair

Chromatin

1 Citation (Scopus)

53 Downloads (Pure)

Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC

Yoshikawa, H., Larance, M., Harney, D. J., Sundaramoorthy, R., Ly, T., Owen-Hughes, T. & Lamond, A. I., 10 Aug 2018, In : eLife. 7, 7, p. 1-26 26 p., e36530.

Research output: Contribution to journal › Article

Open Access

File

Polyribosomes

Tissue

Size exclusion chromatography

Ribosome Subunits

Liver

45 Downloads (Pure)

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., Nov 2018, In : PLoS Genetics. 14, 11, p. 1-20 20 p., e1007783.

Research output: Contribution to journal › Article

Open Access

File

DNA replication

DNA Replication

Chromatin

chromatin

Proliferating Cell Nuclear Antigen

6 Citations (Scopus)

52 Downloads (Pure)

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, p. 1-28 28 p., e35720.

Research output: Contribution to journal › Article

Open Access

File

Chromatin Assembly and Disassembly

Nucleosomes

Chromatin

Histones

DNA

Datasets

High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.

Owen-Hughes, T. (Creator), Dickerson, D. (Creator), University of Dundee, 2016

DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151

Dataset

Activities 2018 2018

1 Public engagement and outreach - festival/exhibition

Science Saturdays: Guardians of the Genome

Rolf Black (Organiser), Christine Millar (Host), Nicola Wiechens (Presenter), Thomas Owen-Hughes (Contributor), Abigail Corsie (Contributor), Matthias Toman (Contributor), Meng-Ying Wu (Contributor), Seraina Blümli (Contributor), Mahamadou-Lamine Niakate (Contributor), Jason Sharpe (Contributor)

1 Dec 2018

Activity: Other activity types › Public engagement and outreach - festival/exhibition