Research Output per year
Personal profile
Research
Chromatin structure and gene regulation
Chromatin Structure and function.
The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2003 2018
Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome
Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, 28 p., e35720Research output: Contribution to journal › Article
Open Access
File
Chromatin Assembly and Disassembly
Nucleosomes
Chromatin
Histones
DNA
Deciphering Subunit-Specific Functions within SWI/SNF Complexes
Hughes, A. & Owen-Hughes, T., 28 Feb 2017, In : Cell Reports. 18, 9, p. 2075-2076 2 p.Research output: Contribution to journal › Comment/debate
Open Access
File
Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates
Hauer, M. H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. & Gasser, S. M., Feb 2017, In : Nature Structural & Molecular Biology. 24, 2, p. 99-107 13 p.Research output: Contribution to journal › Article
Open Access
File
Histones
Genetic Recombination
DNA Damage
Chromatin
Nucleosomes
Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Bottcher, B., Norman, D. G. & Owen-Hughes, T., 13 Apr 2017, In : eLife. 6, 28 p., e22510Research output: Contribution to journal › Article
Open Access
File
Chromatin Assembly and Disassembly
Nucleosomes
Chromatin
DNA
Enzymes
Unlocking the nucleosome
Flaus, A. & Owen-Hughes, T., 20 Jan 2017, In : Science. 355, 6322, p. 245-246 2 p.Research output: Contribution to journal › Article
Nucleosomes
Histones
Genome
Chromatin Assembly and Disassembly
DNA
Datasets
High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.
Owen-Hughes, T. (Creator), Dickerson, D. (Creator), University of Dundee, 2016
DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151
Dataset
Thesis
A study of chromatin dynamics during transcription by fluorescence light microscopy
Author: Dickerson, D., 2010Supervisor: Owen-Hughes, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones
Author: Bowman, A., 2010Supervisor: Owen-Hughes, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Chromatin Dynamics During DNA Replication
Author: Fennessy, R., 2014Supervisor: Owen-Hughes, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Investigating the mechanisms of action of the SNF2-homolog protein Fun30
Author: Mahmoud, S. A., 2011Supervisor: Owen-Hughes, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Structural Investigation of the Chromatin Remodeller Fun30
Author: Faherty, J., 2016Supervisor: Owen-Hughes, T. (Supervisor)
Student thesis: Master's Thesis › Master of Science
File