Owen-Hughes, Tom

Professor

Professor & Personal Chair of Chromatin Structure & Dynamics, Gene Regulation and Expression

https://orcid.org/0000-0002-0618-8185

United Kingdom

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research

Chromatin structure and gene regulation

Chromatin Structure and function.

The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.

Fingerprint

Dive into the research topics where Tom Owen-Hughes is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

39 Similar Profiles

Network

Recent external collaboration on country level. Dive into details by clicking on the dots.

5 Active
26 Finished

Machine Learning Methods to Re-Annotate Histone Modifications with Locus-specific Functional Classification (Future Leaders Fellowship)
Owen-Hughes, T. & Schweikert, G.
Medical Research Council
1/11/20 → 31/10/24
Project: Research
Aberrant DNA Methylation and its Impact in Blood Cancer Development (Career Development Fellowship)
Owen-Hughes, T. & Rasmussen, K.
Cancer Research UK
1/06/19 → 31/05/25
Project: Research
Structure and Function of Chromatin Remodelling ATPases and their Dysfunction in Human Disease
Owen-Hughes, T. & Sundaramoorthy, R.
Medical Research Council
1/04/19 → 31/03/24
Project: Research
Impact of DNA Replication on Epigenetics (IDRE)
Alabert, C. & Owen-Hughes, T.
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/17 → 30/04/22
Project: Research
Chromatin Replication and Cancer (Career Development Fellowship)
Alabert, C. & Owen-Hughes, T.
Cancer Research UK
1/01/17 → 31/12/22
Project: Research

56 Article
3 Review article
2 Comment/debate
1 Chapter (peer-reviewed)
1 More
- 1 Editorial

Chromatin remodelling comes into focus
Sundaramoorthy, R. & Owen-Hughes, T., 20 Aug 2020, In : F1000Research. 9, 14 p., 1011.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
12 Downloads (Pure)
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
60 Citations (Scopus)

75 Downloads (Pure)
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., Mcconnell, D. B. & Ciulli, A., 2 Jul 2019, In : Nature Chemical Biology. 15, 8, p. 846 1 p.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
The Face of Chromatin Variants
Flaus, A. & Owen-Hughes, T., 5 Sep 2019, In : Cell. 178, 6, p. 1284-1286 3 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
11 Downloads (Pure)
Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC
Yoshikawa, H., Larance, M., Harney, D. J., Sundaramoorthy, R., Ly, T., Owen-Hughes, T. & Lamond, A. I., 10 Aug 2018, In : eLife. 7, 7, p. 1-26 26 p., e36530.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

147 Downloads (Pure)

High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.
Owen-Hughes, T. (Creator), Dickerson, D. (Creator), Gierlinski, M. (Contributor), Singh, V. (Contributor), Kitamura, E. (Contributor), Ball, G. (Contributor) & Tanaka, T. (Contributor), University of Dundee, 2016
DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151
Dataset

1 Public engagement and outreach - festival/exhibition

Science Saturdays: Guardians of the Genome
Rolf Black (Organiser), Christine Millar (Host), Nicola Wiechens (Presenter), Thomas Owen-Hughes (Contributor), Abigail Corsie (Contributor), Matthias Toman (Contributor), Meng-Ying Wu (Contributor), Seraina Blümli (Contributor), Mahamadou-Lamine Niakate (Contributor) & Jason Sharpe (Contributor)
1 Dec 2018
Activity: Other activity types › Public engagement and outreach - festival/exhibition