Personal profile

Research

Chromatin structure and gene regulation

Chromatin Structure and function.

The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.

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  • 45 Similar Profiles
Nucleosomes Medicine & Life Sciences
Histones Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Chromatin Assembly and Disassembly Medicine & Life Sciences
DNA Medicine & Life Sciences
Histone Chaperones Medicine & Life Sciences
Genome Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences

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Research Output 2003 2017

Deciphering Subunit-Specific Functions within SWI/SNF Complexes

Hughes, A. & Owen-Hughes, T. 28 Feb 2017 In : Cell Reports. 18, 9, p. 2075-2076 2 p.

Research output: Contribution to journalComment/debate

Open Access
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29 Citations

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

Hauer, M. H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. & Gasser, S. M. Feb 2017 In : Nature Structural & Molecular Biology. 24, 2, p. 99-107 13 p.

Research output: Contribution to journalArticle

Open Access
File
Histones
Genetic Recombination
DNA Damage
Chromatin
Nucleosomes
10 Citations

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Bottcher, B., Norman, D. G. & Owen-Hughes, T. 13 Apr 2017 In : eLife. 6, 28 p., e22510

Research output: Contribution to journalArticle

Open Access
File
Chromatin Assembly and Disassembly
Nucleosomes
Chromatin
DNA
Enzymes
1 Citations

Unlocking the nucleosome

Flaus, A. & Owen-Hughes, T. 20 Jan 2017 In : Science. 355, 6322, p. 245-246 2 p.

Research output: Contribution to journalArticle

Nucleosomes
Histones
Genome
Chromatin Assembly and Disassembly
DNA
12 Citations

Establishment of a promoter based chromatin architecture on recently replicated DNA can accommodate variable internucleosome spacing

Fennessy, R. T. & Owen-Hughes, T. 6 Sep 2016 In : Nucleic Acids Research. 44, 15, p. 7189-7203 15 p.

Research output: Contribution to journalArticle

Open Access
File
Nucleosomes
Chromatin
DNA
DNA Replication
Chromatin Assembly and Disassembly

Thesis

A study of chromatin dynamics during transcription by fluorescence light microscopy

Author: Dickerson, D., 2010

Supervisor: T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones

Author: Bowman, A., 2010

Supervisor: T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Chromatin Dynamics During DNA Replication

Author: Fennessy, R., 2014

Supervisor: T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Investigating the mechanisms of action of the SNF2-homolog protein Fun30

Author: Mahmoud, S. A., 2011

Supervisor: T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Structural Investigation of the Chromatin Remodeller Fun30

Author: Faherty, J., 2016

Supervisor: T. (Supervisor)

Student thesis: Master's ThesisMaster of Science

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