Owen-Hughes, Tom

Professor

  • United Kingdom

20032025
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Personal profile

Research

Chromatin structure and gene regulation

Chromatin Structure and function.

The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.

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  • 36 Similar Profiles
Nucleosomes Medicine & Life Sciences
Histones Medicine & Life Sciences
Chromatin Assembly and Disassembly Medicine & Life Sciences
Chromatin Medicine & Life Sciences
DNA Medicine & Life Sciences
Histone Chaperones Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Adenosine Triphosphatases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2025

Research Output 2003 2019

12 Citations (Scopus)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journalArticle

Proteolysis
Adenosine Triphosphatases
Biophysics
Neoplasms
Chromatin Assembly and Disassembly

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., Mcconnell, D. B. & Ciulli, A., 2 Jul 2019, In : Nature Chemical Biology. 15, 8, p. 846 1 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Ubiquitin-Protein Ligases
Nucleosomes
DNA Repair
Chromatin

The Face of Chromatin Variants

Flaus, A. & Owen-Hughes, T., 5 Sep 2019, In : Cell. 178, 6, p. 1284-1286 3 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Hinges
Histones
Chromatin
Protein Isoforms
1 Citation (Scopus)
71 Downloads (Pure)

Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC

Yoshikawa, H., Larance, M., Harney, D. J., Sundaramoorthy, R., Ly, T., Owen-Hughes, T. & Lamond, A. I., 10 Aug 2018, In : eLife. 7, 7, p. 1-26 26 p., e36530.

Research output: Contribution to journalArticle

Open Access
File
Polyribosomes
Tissue
Size exclusion chromatography
Ribosome Subunits
Liver
69 Downloads (Pure)

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., Nov 2018, In : PLoS Genetics. 14, 11, p. 1-20 20 p., e1007783.

Research output: Contribution to journalArticle

Open Access
File
DNA replication
DNA Replication
Chromatin
chromatin
Proliferating Cell Nuclear Antigen

Activities 2018 2018

  • 1 Public engagement and outreach - festival/exhibition

Science Saturdays: Guardians of the Genome

Rolf Black (Organiser), Christine Millar (Host), Nicola Wiechens (Presenter), Thomas Owen-Hughes (Contributor), Abigail Corsie (Contributor), Matthias Toman (Contributor), Meng-Ying Wu (Contributor), Seraina Blümli (Contributor), Mahamadou-Lamine Niakate (Contributor), Jason Sharpe (Contributor)
1 Dec 2018

Activity: Other activity typesPublic engagement and outreach - festival/exhibition

Thesis

A study of chromatin dynamics during transcription by fluorescence light microscopy

Author: Dickerson, D., 2010

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones

Author: Bowman, A., 2010

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Chromatin Dynamics During DNA Replication

Author: Fennessy, R., 2014

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigating the mechanisms of action of the SNF2-homolog protein Fun30

Author: Mahmoud, S. A., 2011

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma

Author: Wu, M., 2019

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy