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Research

Chromatin structure and gene regulation

Chromatin Structure and function.

The genomes of eukaryotes associate with histone proteins to form chromatin. Chromatin is the substrate for all genetic processes and as a result of fundamental importance to a diverse range of biological processes including development and disease. Indeed chromatin is currently of significant interest both in the development of biomarkers for diseases and as a source of new therapeutic targets. Eukaryotes use a range of strategies to alter chromatin structure. These include the use of histone modifications, histone chaperones and ATP dependent remodelling enzymes. We are generally interested in how these different strategies are coordinated to ensure appropriate gene regulation.

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Research Output 2003 2018

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., 12 Nov 2018, In : PLoS Genetics. 14, 11, p. e1007783

Research output: Contribution to journalArticle

Open Access
File
DNA replication
DNA Replication
Chromatin
chromatin
Proliferating Cell Nuclear Antigen

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, 28 p., e35720.

Research output: Contribution to journalArticle

Open Access
File
Chromatin Assembly and Disassembly
Nucleosomes
Chromatin
Histones
DNA
1 Citations

Deciphering Subunit-Specific Functions within SWI/SNF Complexes

Hughes, A. & Owen-Hughes, T., 28 Feb 2017, In : Cell Reports. 18, 9, p. 2075-2076 2 p.

Research output: Contribution to journalComment/debate

Open Access
File
41 Citations

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

Hauer, M. H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. & Gasser, S. M., Feb 2017, In : Nature Structural & Molecular Biology. 24, 2, p. 99-107 13 p.

Research output: Contribution to journalArticle

Open Access
File
Histones
Genetic Recombination
DNA Damage
Chromatin
Nucleosomes
13 Citations

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Bottcher, B., Norman, D. G. & Owen-Hughes, T., 13 Apr 2017, In : eLife. 6, 28 p., e22510.

Research output: Contribution to journalArticle

Open Access
File
Chromatin Assembly and Disassembly
Nucleosomes
Chromatin
DNA
Enzymes

Activities 2018 2018

  • 1 Other event

Outer Space | Inner Space: Science Saturdays 2018/19

Rolf Black (Organiser), Christine Millar (Host), Nicola Wiechens (Organiser), Thomas Owen-Hughes (Contributor), Abigail Corsie (Contributor), Matthias Toman (Contributor), Meng-Ying Wu (Contributor), Seraina Blümli (Contributor), Mahamadou-Lamine Niakate (Contributor), Jason Sharpe (Contributor)
1 Dec 2018

Activity: Participating in or organising an event typesOther event

Thesis

A study of chromatin dynamics during transcription by fluorescence light microscopy

Author: Dickerson, D., 2010

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones

Author: Bowman, A., 2010

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Chromatin Dynamics During DNA Replication

Author: Fennessy, R., 2014

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Investigating the mechanisms of action of the SNF2-homolog protein Fun30

Author: Mahmoud, S. A., 2011

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Structural Investigation of the Chromatin Remodeller Fun30

Author: Faherty, J., 2016

Supervisor: Owen-Hughes, T. (Supervisor)

Student thesis: Master's ThesisMaster of Science

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