Projects per year
Personal profile
Research
Chromosome duplication and segregation in the cell division cycle
To maintain genetic integrity, eukaryotic cells must duplicate their chromosomes and then segregate them to their daughter cells with high fidelity during each cell division cycle. The unravelling of the mechanisms ensuring these processes should improve our understanding of various human diseases such as cancers and congenital disorders, which are characterized by chromosome instability and aneuploidy.
For our studies, we use budding yeast because of the amenable genetics and detailed proteomic information available for this organism. Overwhelming evidence suggests that the basic mechanisms of chromosome regulation are well conserved from yeast to humans. Budding yeast is therefore an excellent model organism for the study of chromosome duplication and segregation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Understanding Error Correction For Chromosome Bi-orientation Using In Vitro Reconstruction
Tanaka, T. (Investigator)
Biotechnology and Biological Sciences Research Council
1/04/24 → 31/03/27
Project: Research
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Kinetochore-Microtubule Interactions: Steps Towards Bi-Orientation (Investigator Award)
Tanaka, T. (Investigator)
1/12/20 → 31/12/26
Project: Research
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Molecular Mechanisms of Chromosome Segregation (Vacation Scholarship)
Tanaka, T. (Investigator)
Project: Research
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Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition
Coats, J. (Lead / Corresponding author), Li, S., Tanaka, T., Tauro, S., Sutherland, C. & Saurin, A. T. (Lead / Corresponding author), Nov 2024, In: Cancer Research Communications. 4, 11, p. 3013-3024 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Kinetochore-microtubule error correction for biorientation: lessons from yeast
Li, S. (Lead / Corresponding author), Kasciukovic, T. & Tanaka, T. U. (Lead / Corresponding author), Feb 2024, In: Biochemical Society Transactions. 52, 1, p. 29-39 11 p., BST20221261.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)60 Downloads (Pure) -
Chromosome biorientation requires Aurora B’s spatial separation from its outer kinetochore substrates but not its turnover at kinetochores
Li, S., Garcia-Rodriguez, L. J. & Tanaka, T. U. (Lead / Corresponding author), 6 Nov 2023, In: Current Biology. 33, 21, p. 4557-4569.e3 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)187 Downloads (Pure) -
SWAP, SWITCH, and STABILIZE: Mechanisms of Kinetochore–Microtubule Error Correction
Tanaka, T. U. (Lead / Corresponding author) & Zhang, T., 1 May 2022, In: Cells. 11, 9, 16 p., 1462.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)114 Downloads (Pure) -
Swap and stop – kinetochores play error correction with microtubules
Doodhi, H. (Lead / Corresponding author) & Tanaka, T. U. (Lead / Corresponding author), May 2022, In: BioEssays. 44, 5, 12 p., 2100246.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)165 Downloads (Pure)
Datasets
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Smc3 deacetylation by Hos1 facilitates efficient dissolution of sister chromatid cohesion during early anaphase
Yue, Z. (Contributor), Tanaka, T. (Creator) & Li, S. (Contributor), Mendeley Data, 4 Nov 2017
DOI: 10.17632/m64mz2tbvh.2, https://data.mendeley.com/datasets/m64mz2tbvh
Dataset
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High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.
Owen-Hughes, T. (Creator), Dickerson, D. (Creator), Gierlinski, M. (Contributor), Singh, V. (Contributor), Kitamura, E. (Contributor), Ball, G. (Contributor) & Tanaka, T. (Contributor), University of Dundee, 2016
DOI: 10.17867/10000102, http://idr-demo.openmicroscopy.org/webclient/?show=project-151
Dataset
Prizes
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Cancer Research UK Senior Research Fellowship
Tanaka, T. (Recipient), 2006
Prize: Fellowship awarded competitively
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EMBO Young Investigator Program Award
Tanaka, T. (Recipient), 2000
Prize: Prize (including medals and awards)
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Activities
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Invited seminar at BSRC, Uni St Andrews
Tanaka, T. (Speaker)
11 Apr 2024Activity: Talk or presentation types › Invited talk
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External examiner for PhD thesis
Tanaka, T. (Examiner)
11 Nov 2024Activity: Examination types › Examination
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Invited seminar at Inst Med Sci, Uni Aberdeen
Tanaka, T. (Speaker)
22 Feb 2024Activity: Talk or presentation types › Invited talk
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International Symposium on Genome Stability and Impacts of Genetic Variants
Tanaka, T. (Speaker)
9 Jul 2024Activity: Talk or presentation types › Invited talk