Tanaka, Tomoyuki

Professor

  • United Kingdom

20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research

Chromosome duplication and segregation in the cell division cycle

To maintain genetic integrity, eukaryotic cells must duplicate their chromosomes and then segregate them to their daughter cells with high fidelity during each cell division cycle. The unravelling of the mechanisms ensuring these processes should improve our understanding of various human diseases such as cancers and congenital disorders, which are characterized by chromosome instability and aneuploidy.

For our studies, we use budding yeast because of the amenable genetics and detailed proteomic information available for this organism. Overwhelming evidence suggests that the basic mechanisms of chromosome regulation are well conserved from yeast to humans. Budding yeast is therefore an excellent model organism for the study of chromosome duplication and segregation.

Fingerprint Dive into the research topics where Tomoyuki Tanaka is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 24 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

Zooming in on Chromosome Dynamics

Eykelenboom, J. K. & Tanaka, T. U., 17 Jun 2020, In : Cell Cycle. 19, 12, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

Open Access
File
  • 12 Downloads (Pure)
    Open Access
    File
  • 11 Citations (Scopus)
    120 Downloads (Pure)

    Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

    Booth, A. J. R., Yue, Z., Eykelenboom, J. K., Stiff, T., Luxton, G. W. G., Hochegger, H. & Tanaka, T., 16 Jul 2019, In : eLife. 8, p. 1-21 21 p., e46902.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    80 Downloads (Pure)

    Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

    Eykelenboom, J., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T., 6 May 2019, In : Journal of Cell Biology. 218, 5, p. 1531-1552 22 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    110 Downloads (Pure)
    File
  • 74 Downloads (Pure)

    Datasets

    High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.

    Owen-Hughes, T. (Creator), Dickerson, D. (Creator), Gierlinski, M. (Contributor), Singh, V. (Contributor), Kitamura, E. (Contributor), Ball, G. (Contributor) & Tanaka, T. (Contributor), University of Dundee, 2016

    Dataset