Tanaka, Tomoyuki

Professor

  • United Kingdom

20012022
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Personal profile

Research

Chromosome duplication and segregation in the cell division cycle

To maintain genetic integrity, eukaryotic cells must duplicate their chromosomes and then segregate them to their daughter cells with high fidelity during each cell division cycle. The unravelling of the mechanisms ensuring these processes should improve our understanding of various human diseases such as cancers and congenital disorders, which are characterized by chromosome instability and aneuploidy.

For our studies, we use budding yeast because of the amenable genetics and detailed proteomic information available for this organism. Overwhelming evidence suggests that the basic mechanisms of chromosome regulation are well conserved from yeast to humans. Budding yeast is therefore an excellent model organism for the study of chromosome duplication and segregation.

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  • 31 Similar Profiles
Kinetochores Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Saccharomycetales Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Spindle Poles Medicine & Life Sciences
Spindle Apparatus Medicine & Life Sciences
Centromere Medicine & Life Sciences
kinetochores Agriculture & Biology

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

Research Output 2001 2019

1 Citation (Scopus)
35 Downloads (Pure)

Aurora B–INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast

García-Rodríguez, L. J., Kasciukovic, T., Denninger, V. & Tanaka, T., 6 May 2019, In : Current Biology. 29, 9, p. 1536-1544.e4 13 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
kinetochores
Saccharomycetales
Centromere
centromeres
13 Downloads (Pure)

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

Booth, A. J. R., Yue, Z., Eykelenboom, J. K., Stiff, T., Luxton, G. W. G., Hochegger, H. & Tanaka, T., 3 Jul 2019, In : eLife. 8, e46902.

Research output: Contribution to journalArticle

Open Access
File
pioglitazone
Nuclear Envelope
Human Chromosomes
Myosins
Chromosomes
1 Citation (Scopus)
49 Downloads (Pure)

Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

Eykelenboom, J., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T., 6 May 2019, In : Journal of Cell Biology. 218, 5, p. 1531-1552 22 p.

Research output: Contribution to journalArticle

Open Access
File
Mitosis
Chromatids
Chromosomes
Prophase
G2 Phase
31 Downloads (Pure)
File
Kinetochores
Microtubules
Chromosome Segregation
Aurora Kinase B
Spindle Poles
25 Downloads (Pure)

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

Eykelenboom, J. K., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T. U., 17 May 2018, In : BioRxiv. 53 p.

Research output: Contribution to journalArticle

File
Chromatids
Chromosomes
Prophase
Genomic Instability
G2 Phase

Thesis

Dissecting the role of Ndc80 and Dam1 complexes in tethering kinetochores at the microtubule plus end: an in vivo approach

Author: Kalantzaki, M., 2013

Supervisor: Tanaka, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Kinetochore-derived Microtubules: from Molecular Regulation to their Role in Mitosis

Author: Vasileva, V., 2015

Supervisor: Tanaka, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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