Tanaka, Tomoyuki

Professor

  • United Kingdom

20012022
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Research Output 2001 2019

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Article
2019
3 Citations (Scopus)
48 Downloads (Pure)

Aurora B–INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast

García-Rodríguez, L. J., Kasciukovic, T., Denninger, V. & Tanaka, T., 6 May 2019, In : Current Biology. 29, 9, p. 1536-1544.e4 13 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
kinetochores
Saccharomycetales
Centromere
centromeres
26 Downloads (Pure)

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

Booth, A. J. R., Yue, Z., Eykelenboom, J. K., Stiff, T., Luxton, G. W. G., Hochegger, H. & Tanaka, T., 3 Jul 2019, In : eLife. 8, e46902.

Research output: Contribution to journalArticle

Open Access
File
pioglitazone
Nuclear Envelope
Human Chromosomes
Myosins
Chromosomes
1 Citation (Scopus)
57 Downloads (Pure)

Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

Eykelenboom, J., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T., 6 May 2019, In : Journal of Cell Biology. 218, 5, p. 1531-1552 22 p.

Research output: Contribution to journalArticle

Open Access
File
Mitosis
Chromatids
Chromosomes
Prophase
G2 Phase
2018
38 Downloads (Pure)
File
Kinetochores
Microtubules
Chromosome Segregation
Aurora Kinase B
Spindle Poles
33 Downloads (Pure)

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

Eykelenboom, J. K., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T. U., 17 May 2018, In : BioRxiv. 53 p.

Research output: Contribution to journalArticle

File
Chromatids
Chromosomes
Prophase
Genomic Instability
G2 Phase
2017
76 Downloads (Pure)

Mechanisms mitigating problems with multiple kinetochores on one microtubule in early mitosis

Yue, Z., Komoto, S., Gierlinski, M., Pasquali, D., Kitamura, E. & Tanaka, T. U., 15 Jul 2017, In : Journal of Cell Science. 130, 14, p. 2266-2276 11 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Mitosis
Microtubules
Spindle Poles
Chromosome Segregation
6 Citations (Scopus)
74 Downloads (Pure)

Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules

Vasileva, V., Gierlinski, M., Yue, Z., O'Reilly, N., Kitamura, E. & Tanaka, T. U., 26 Apr 2017, In : Journal of Cell Biology. 216, 6, p. 1809-1822 14 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Microtubules
Saccharomycetales
Mitosis
9 Citations (Scopus)
95 Downloads (Pure)
Open Access
File
Anaphase
Chromatids
Acetylation
S Phase
Separase
2016
6 Citations (Scopus)
131 Downloads (Pure)
Open Access
File
Cell Division
Chromatin
Genes
Workflow
Eukaryota
2015
13 Citations (Scopus)
126 Downloads (Pure)

Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres

Kobayashi, N., Suzuki, Y., Schoenfeld, L., Müller, C., Nieduszynski, C., Wolfe, K. & Tanaka, T., 3 Aug 2015, In : Current Biology. 25, 15, p. 2026-2033 8 p.

Research output: Contribution to journalArticle

Open Access
File
Saccharomycetales
Centromere
centromeres
Yeast
yeasts
23 Citations (Scopus)
211 Downloads (Pure)

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes

Kalantzaki, M., Kitamura, E., Zhang, T., Mino, A., Novák, B. & Tanaka, T. U., Apr 2015, In : Nature Cell Biology. 17, 4, p. 421-433 13 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Microtubules
Aurora Kinase B
Spindle Poles
Chromosome Segregation
2013
79 Citations (Scopus)

Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment

Natsume, T., Müller, C. A., Katou, Y., Retkute, R., Gierlinski, M., Araki, H., Blow, J. J., Shirahige, K., Nieduszynski, C. A. & Tanaka, T. U., 6 Jun 2013, In : Molecular Cell. 50, 5, p. 661-674 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Stochastic association of neighboring replicons creates replication factories in budding yeast

Saner, N., Karschau, J., Natsume, T., Gierlinski, M., Retkute, R., Hawkins, M., Nieduszynski, C. A., Blow, J. J., de Moura, A. P. S. & Tanaka, T. U., 2013, In : Journal of Cell Biology. 202, 7, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

Replicon
Saccharomycetales
Microscopy
DNA-Directed DNA Polymerase
DNA Replication
2012
61 Citations (Scopus)

Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore

Bock, L. J., Pagliuca, C., Alfieri, C., Golfieri, C., Dal Maschio, M., De Wulf, P., Kobayashi, N., Oku, Y., Tanaka, T. U., Grove, R. A., Shrestha, K., Hazbun, T. R., Oldani, A. & Bermejo, R., 2012, In : Nature Cell Biology. 14, 6, p. 614-624 11 p.

Research output: Contribution to journalArticle

Kinetochores
Yeasts
Phosphotransferases
Chromosome Segregation
Anaphase
2011
34 Citations (Scopus)

Kinetochore-Dependent Microtubule Rescue Ensures Their Efficient and Sustained Interactions in Early Mitosis

Gandhi, S. R., Gierlinski, M., Mino, A., Tanaka, K., Kitamura, E., Clayton, L. & Tanaka, T. U., 15 Nov 2011, In : Developmental Cell. 21, 5, p. 920-933 14 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End

Maure, J-F., Komoto, S., Oku, Y., Mino, A., Pasqualato, S., Natsume, K., Clayton, L., Musacchio, A. & Tanaka, T. U., 8 Feb 2011, In : Current Biology. 21, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
71 Downloads (Pure)

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T., 18 May 2011, In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

Research output: Contribution to journalArticle

Open Access
File
2010
45 Citations (Scopus)

Condensins Promote Chromosome Recoiling during Early Anaphase to Complete Sister Chromatid Separation

Renshaw, M. J., Ward, J. J., Kanemaki, M., Natsume, K., Nedelec, F. J. & Tanaka, T. U., 17 Aug 2010, In : Developmental Cell. 19, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Kinetochores Generate Microtubules with Distal Plus Ends: Their Roles and Limited Lifetime in Mitosis

Kitamura, E., Tanaka, K., Komoto, S., Kitamura, Y., Antony, C. & Tanaka, T. U., 16 Feb 2010, In : Developmental Cell. 18, 2, p. 248-259 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Live-cell analysis of kinetochore-microtubule interaction in budding yeast

Tanaka, K., Kitamura, E. & Tanaka, T. U., 2010, In : Methods (San Diego, Calif.). 51, 2, p. 206-13 8 p.

Research output: Contribution to journalArticle

Kinetochores
Saccharomycetales
Microtubules
Yeast
Dissection
20 Citations (Scopus)

Spatial regulation and organization of DNA replication within the nucleus

Natsume, T. & Tanaka, T. U., Jan 2010, In : Chromosome Research. 18, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

2009
37 Citations (Scopus)

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores

Keating, P., Rachidi, N., Tanaka, T. U. & Stark, M. J. R., 1 Dec 2009, In : Journal of Cell Science. 122, 23, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

2008
8 Citations (Scopus)

Three-dimensional electron microscopy analysis of ndc10-1 mutant reveals an aberrant organization of the mitotic spindle and spindle pole body defects in Saccharomyces cerevisiae

Romao, M., Tanaka, K., Sibarita, J-B., Ly-Hartig, N. T. B., Tanaka, T. U. & Antony, C., Jul 2008, In : Journal of Structural Biology. 163, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

2007
80 Citations (Scopus)

Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae

Kitamura, E., Tanaka, K., Kitamura, Y. & Tanaka, T. U., 15 Dec 2007, In : Genes & Development. 21, 24, p. 3319-3330 12 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles

Tanaka, K., Kitamura, E., Kitamura, Y. & Tanaka, T. U., 2007, In : Journal of Cell Biology. 178, 2, p. 269-81 13 p.

Research output: Contribution to journalArticle

Spindle Poles
Kinetochores
Microtubules
Kinesin
Mitosis
75 Citations (Scopus)

Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism

Maure, J-F., Kitamura, E. & Tanaka, T. U., 18 Dec 2007, In : Current Biology. 17, 24, p. 2175-2182 8 p.

Research output: Contribution to journalArticle

2006
139 Citations (Scopus)

Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories

Kitamura, E., Blow, J. J. & Tanaka, T. U., 2006, In : Cell. 125, 7, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

Replicon
Industrial plants
DNA Replication
Imaging techniques
DNA
2005
31 Citations (Scopus)

Chromosome bi-orientation on the mitotic spindle

Tanaka, T. U., 2005, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 360, 1455, p. 581-9 9 p.

Research output: Contribution to journalArticle

Kinetochores
kinetochores
mitotic spindle apparatus
Spindle Apparatus
Chromosomes
83 Citations (Scopus)

Kinetochore capture and bi-orientation on the mitotic spindle

Tanaka, T. U., Stark, M. J. R. & Tanaka, K., 2005, In : Nature Reviews Molecular Cell Biology. 6, 12, p. 929-42 14 p.

Research output: Contribution to journalArticle

Kinetochores
Spindle Apparatus
Microtubules
Spindle Poles
Prometaphase
202 Citations (Scopus)

Molecular mechanisms of kinetochore capture by spindle microtubules

Tanaka, K., Mukae, N., Dewar, H., Breugel, M. V., James, E. K., Prescott, A. R., Antony, C. & Tanaka, T. U., 2005, In : Nature. 434, 7036, p. 987-994 8 p.

Research output: Contribution to journalArticle

kinetochores
microtubules
kinesin
chromosome segregation
centromeres
34 Citations (Scopus)

The chromosome cycle: coordinating replication and segregation

Blow, J. J. & Tanaka, T. U., 2005, In : EMBO Reports. 6, 11, p. 1028-34 7 p.

Research output: Contribution to journalArticle

Chromosomes
Cell Cycle
DNA
Licensure
Cells
2004
148 Citations (Scopus)

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

Dewar, H., Tanaka, K., Nasmyth, K. & Tanaka, T. U., 2004, In : Nature. 428, 6978, p. 93-97 5 p.

Research output: Contribution to journalArticle

Kinetochores
Spindle Apparatus
Microtubules
Chromatids
Spindle Poles
2003
154 Citations (Scopus)

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I

Rabitsch, K. P., Petronczki, M., Javerzat, J-P., Genier, S., Chwalla, B., Schleiffer, A., Tanaka, T. U. & Nasmyth, K., 2003, In : Developmental Cell. 4, 4, p. 535-48 14 p.

Research output: Contribution to journalArticle

Kinetochores
Meiosis
Nuclear Proteins
Chromosomes
Centromere
2002
52 Citations (Scopus)

Bi-orienting chromosomes on the mitotic spindle

Tanaka, T. U., 2002, In : Current Opinion in Cell Biology. 14, 3, p. 365-71 7 p.

Research output: Contribution to journalArticle

Spindle Poles
Kinetochores
Spindle Apparatus
Microtubules
Chromosomes
513 Citations (Scopus)

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

Tanaka, T. U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M. J. R. & Nasmyth, K., 2002, In : Cell. 108, 3, p. 317-329 13 p.

Research output: Contribution to journalArticle

Aurora Kinases
Spindle Pole Bodies
Spindle Poles
Kinetochores
Chromosomes
135 Citations (Scopus)

Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation

Janke, C., Ortíz, J., Tanaka, T. U., Lechner, J. & Schiebel, E., 2002, In : EMBO Journal. 21, 1-2, p. 181-93 13 p.

Research output: Contribution to journalArticle

Kinetochores
Poles
Centromere
Spindle Pole Bodies
Anaphase
2001
199 Citations (Scopus)

Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex

Pereira, G., Tanaka, T. U., Nasmyth, K. & Schiebel, E., 2001, In : EMBO Journal. 20, 22, p. 6359-70 12 p.

Research output: Contribution to journalArticle

Spindle Pole Bodies
Poles
Proteins
GTPase-Activating Proteins
Microtubules