Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where William Farnaby is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Unlocking Mitophagy Activation With Small Molecule Targeted Protein Stabilisers - Fellowship (Joint with UCL/Francis Crick Institute)
Farnaby, W. (Investigator)
1/10/23 → 30/09/28
Project: Research
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KinoGlu: A Chemical Strategy to Illuminate CNS Biology
Farnaby, W. (Investigator)
Engineering and Physical Sciences Research Council
1/07/23 → 30/06/26
Project: Research
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Novel Bifunctional Chemistries For Unbiased Exploration Of Targeted Protein Degradation Mechanisms
Ciulli, A. (Investigator) & Farnaby, W. (Investigator)
Project: Research
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Early Career - Target Protein Degradation Network (Joint with University of Glasgow and University of Strathclyde)
Ciulli, A. (Investigator), Eugui Anta, A. (Investigator), Farnaby, W. (Investigator), Haubrich, K. (Investigator), Mojsa, B. (Investigator) & Spiteri, V. (Investigator)
Project: Research
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Confounding Factors in Targeted Degradation of Short-Lived Proteins
Vetma, V., Perez, L. C., Eliaš, J., Stingu, A., Kombara, A., Gmaschitz, T., Braun, N., Ciftci, T., Dahmann, G., Diers, E., Gerstberger, T., Greb, P., Kidd, G., Kofink, C., Puoti, I., Spiteri, V., Trainor, N., Weinstabl, H., Westermaier, Y. & Whitworth, C. & 6 others, , 19 Jul 2024, In: ACS Chemical Biology. 19, 7, p. 1484-1494 11 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Kroupova, A., Spiteri, V., Rutter, Z., Furihata, H., Darren, D., Ramachandran, S., Chakraborti, S., Haubrich, K., Pethe, J., Gonzales, D., Wijaya, A., Rodriguez-Rios, M., Sturbaut, M., Lynch, D., Farnaby, W., Nakasone, M., Zollman, D. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), 15 Oct 2024, In: Nature Communications. 15, 1, p. 8885 14 p., 8885.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)61 Downloads (Pure) -
Targeting cancer with small molecule pan-KRAS degraders
Popow, J., Farnaby, W., Gollner, A., Kofink, C., Fischer, G., Wurm, M., Zollman, D., Wijaya, A., Mischerikow, N., Hasenoehrl, C., Prokofeva, P., Arnhof, H., Arce-Solano, S., Bell, S., Boeck, G., Diers, E., Frost, A. B., Goodwin-Tindall, J., Karolyi-Oezguer, J. & Khan, S. & 23 others, , 20 Sept 2024, In: Science. 385, 6715, p. 1338-1347 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)279 Downloads (Pure) -
Breaking free from the crystal lattice: Structural biology in solution to study protein degraders
Haubrich, K., Spiteri, V., Farnaby, W., Sobott, F. & Ciulli, A. (Lead / Corresponding author), Apr 2023, In: Current Opinion in Structural Biology. 79, 9 p., 102534.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)188 Downloads (Pure) -
Crystallization of VHL-based PROTAC-induced ternary complexes
Wijaya, A. J., Farnaby, W. & Ciulli, A. (Lead / Corresponding author), 2023, Targeted Protein Degradation. Burslem, G. L. (ed.). Academic Press Inc., Vol. 681. p. 241-263 23 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Citations (Scopus)
Datasets
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Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
Zollman, D. (Creator), Farnaby, W. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qw7/pdb
Dataset
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Crystal Structure of compound 3 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
Zollman, D. (Creator), Farnaby, W. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qw6/pdb
Dataset
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KRAS-G12C in Complex with Compound 1
Popow, J. (Creator), Farnaby, W. (Creator), Gollner, A. (Creator), Kofink, C. (Creator), Fischer, G. (Creator), Wurm, M. (Creator), Zollman, D. (Creator), Wijaya, A. (Creator), Mischerikow, N. (Creator), Hasenoehrl, C. (Creator), Prokofeva, P. (Creator), Arnhof, H. (Creator), Arce-Solano, S. (Creator), Bell, S. (Creator), Boeck, G. (Creator), Diers, E. (Creator), Frost, A. (Creator), Goodwin-Tindall, J. (Creator), Karolyi-Oezguer, J. (Creator), Khan, S. (Creator), Klawatsch, T. (Creator), Koegl, M. (Creator), Kousek, R. (Creator), Kratochvil, B. (Creator), Kropatsch, K. (Creator), Lauber, A. A. (Creator), McLennan, R. (Creator), Olt, S. (Creator), Peter, D. (Creator), Petermann, O. (Creator), Roessler, V. (Creator), Stolt-Bergner, P. (Creator), Strack, P. (Creator), Strauss, E. (Creator), Trainor, N. (Creator), Vetma, V. (Creator), Whitworth, C. (Creator), Zhong, S. (Creator), Quant, J. (Creator), Weinstabl, H. (Creator), Kuster, B. (Creator), Ettmayer, P. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8QUG/pdb
Dataset
Activities
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Dundee Research Interest Group Open Doors Day 2025
Alessi, D. (Participant), Sammler, E. (Organiser), Howden, A. (Organiser), Muqit, M. (Participant), Ganley, I. (Participant), Gilbertson, T. (Participant), Farnaby, W. (Participant), Hardie, G. (Participant), Hawdon, B. (Organiser), Goodburn, J. (Organiser), Coxe, M. (Participant), Milne, J. (Participant), Rigg, D. (Participant), Vangheluwe, P. (Participant), Kerr, J. (Participant), Stewart, T. (Participant), Lacey-Solymar, G. (Participant), Patrick, S. (Participant), Nash, L. (Participant), Langlands, A. (Participant), Hirons, Z. (Organiser), Grayson, L. (Contributor), Bishnu, A. (Participant), Wilhelm, L. (Participant), Appleton, P. (Participant), Filipe Soares, R. (Participant), Robertson, J. (Participant), Ibba, R. (Participant), Hallatt, A. (Participant) & Wieske, L. (Participant)
28 Feb 2025Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Nuffield Research Placement Hosting
Farnaby, W. (Member)
24 Jun 2024 → 5 Jul 2024Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Parkinson's Dundee Research Interest Group Open Doors Day
Howden, A. (Member), Alessi, D. (Member), Muqit, M. (Member), Farnaby, W. (Member), Sammler, E. (Member) & Lloyd, A. (Member)
6 Feb 2024Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Proximity-inducing pharmacology: Targeted protein degradation and beyond
Farnaby, W. (Speaker)
22 May 2023Activity: Talk or presentation types › Invited talk
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EMBO Training: Laboratory Leadership for Group Leaders
Farnaby, W. (Participant)
24 Apr 2023 → 27 Apr 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course