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Farnaby, William

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  • 43 Citations
  • 4 h-Index
20172019
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  • 34 Similar Profiles
Ubiquitin-Protein Ligases Medicine & Life Sciences
Proteolysis Medicine & Life Sciences
Chromatin Assembly and Disassembly Medicine & Life Sciences
Lysophosphatidic Acid Receptors Medicine & Life Sciences
Central Nervous System Agents Medicine & Life Sciences
Enzyme kinetics Chemical Compounds
Nucleosomes Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences

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Research Output 2017 2019

  • 43 Citations
  • 4 h-Index
  • 6 Article
  • 1 Editorial
10 Citations (Scopus)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journal › Article

Proteolysis
Adenosine Triphosphatases
Biophysics
Neoplasms
Chromatin Assembly and Disassembly

Protein degradation for drug discovery

Ciulli, A. & Farnaby, W., Apr 2019, In : Drug Discovery Today: Technologies. 31, p. 1-3 3 p.

Research output: Contribution to journal › Editorial

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., Mcconnell, D. B. & Ciulli, A., 2 Jul 2019, In : Nature Chemical Biology. 15, 8, p. 846 1 p.

Research output: Contribution to journal › Article

Chromatin Assembly and Disassembly
Ubiquitin-Protein Ligases
Nucleosomes
DNA Repair
Chromatin
11 Citations (Scopus)
142 Downloads (Pure)

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

Roy, M., Winkler, S., Hughes, S. J., Whitworth, C., Galant, M., Farnaby, W., Rumpel, K. & Ciulli, A., 15 Mar 2019, In : ACS Chemical Biology. 14, 3, p. 361-368 8 p.

Research output: Contribution to journal › Article

Open Access
File
Proteolysis
Enzyme kinetics
Degradation
Ubiquitin-Protein Ligases
Assays
2 Citations (Scopus)
96 Downloads (Pure)

Identification of compounds acting as negative allosteric modulators of the LPA 1 receptor

Ellery, J., Dickson, L., Cheung, T., Ciuclan, L., Bunyard, P., Mack, S., Buffham, W. J., Farnaby, W., Mitchell, P., Brown, D., Isaacs, R. & Barnes, M., 15 Aug 2018, In : European Journal of Pharmacology. 833, p. 8-15 8 p.

Research output: Contribution to journal › Article

Open Access
File
Lysophosphatidic Acid Receptors
Interferometry
Physiological Phenomena
Arrestin
Benzoic Acid