Projects per year
Yogesh graduated with a Bachelor’s degree in Chemical Engineering in 2000 from Birla Institute of Technology and Science (BITS), Pilani, India. An elective course on recombinant DNA technology that he took during his engineering sparked his interest in molecular biology. This prompted him to stay on at BITS, Pilani to do a Masters degree in Biotechnology. He then went on to do a PhD in Immunology under the guidance of Prof. Michael Reth at the Max Planck Institute of Immunobiology and University of Freiburg in Germany, where he worked on B cell antigen receptor signalling and protein tyrosine kinase regulation. To apply structural biology methods to study cell signalling, Yogesh moved to Cambridge in 2009 to work with Dr. David Komander at the MRC Laboratory of Molecular Biology. He was awarded a Marie Curie Intra-European Fellowship and an EMBO Long term fellowship to work on the structural basis driving linkage specificity in ubiquitin binding domains and in the ovarian tumour (OTU) family of deubiquitinases.
In February 2013, Yogesh relocated to the MRC PPU to establish his research program, focussing on ubiquitin signalling mechanisms. In 2015 Yogesh received a prestigious ERC Starting Grant, and was selected as a member of the EMBO Young Investigator Programme.
Yogesh is a recipient of the Lister Prize from the Lister Institute of Preventive Medicine.
Undertaking research on COVID-19 to address the current coronavirus pandemic.
Expertise related to UN SDGs
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
- Q Science (General)
- Signal transduction
- Cancer Biology
- structural Biology
- post-translational modifications
1/09/20 → 31/08/23
1/10/17 → 30/09/22
Dimeric structure of the pseudokinase IRAK3 suggests an allosteric mechanism for negative regulationLange, S., Nelen, M. I., Cohen, P. & Kulathu, Y., 4 Mar 2021, In: Structure. 29, 3, p. 238-251.e4 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile3 Citations (Scopus)19 Downloads (Pure)
Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodelingKelsall, I. R., Kristariyanto, Y. A., Knebel, A., Wood, N. T., Kulathu, Y. & Alpi, A. F., 22 Feb 2019, In: Journal of Biological Chemistry. 294, 8, p. 2651-2664 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Citations (Scopus)99 Downloads (Pure)
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome StabilityKwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. & Kulathu, Y., 5 Apr 2018, In: Molecular Cell. 70, 1, p. 150-164.e6 15 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile65 Citations (Scopus)130 Downloads (Pure)
Rehman, S. A. A., Pathak, D., Weidlich, S., Zoephel, A., Bordone, M. C., Barbosa-Morais, N. L., Boehmelt, G. & Kulathu, Y., 16 May 2018, In: Journal of Cell Science. 131, 10, p. 1-16 16 p., jcs212753 .
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile8 Citations (Scopus)111 Downloads (Pure)
Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approachKulathu, Y., Zuern, C., Yang, J. & Reth, M., Nov 2018, In: Biological Chemistry.
Research output: Contribution to journal › Article › peer-review