Projects per year
Personal profile
Biography
Yogesh graduated with a Bachelor’s degree in Chemical Engineering in 2000 from Birla Institute of Technology and Science (BITS), Pilani, India. An elective course on recombinant DNA technology that he took during his engineering sparked his interest in molecular biology. This prompted him to stay on at BITS, Pilani to do a Masters degree in Biotechnology. He then went on to do a PhD in Immunology under the guidance of Prof. Michael Reth at the Max Planck Institute of Immunobiology and University of Freiburg in Germany, where he worked on B cell antigen receptor signalling and protein tyrosine kinase regulation. To apply structural biology methods to study cell signalling, Yogesh moved to Cambridge in 2009 to work with Dr. David Komander at the MRC Laboratory of Molecular Biology. He was awarded a Marie Curie Intra-European Fellowship and an EMBO Long term fellowship to work on the structural basis driving linkage specificity in ubiquitin binding domains and in the ovarian tumour (OTU) family of deubiquitinases.
In February 2013, Yogesh relocated to the MRC PPU to establish his research program, focussing on ubiquitin signalling mechanisms. In 2015 Yogesh received a prestigious ERC Starting Grant, and was selected as a member of the EMBO Young Investigator Programme.
Yogesh is a recipient of the Lister Prize from the Lister Institute of Preventive Medicine.
Research interests
Undertaking research on COVID-19 to address the current coronavirus pandemic.
Keywords
- Q Science (General)
- Signal transduction
- Cancer Biology
- Immunology
- structural Biology
- post-translational modifications
- Biochemistry
- ubiquitin
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Network
Projects
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Defining Mechanisms of Protein Ufmylation
Biotechnology and Biological Sciences Research Council
1/09/20 → 31/08/23
Project: Research
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MRC QQR
Alessi, D., Davies, P., Ganley, I., Kulathu, Y., Labib, K., Rouse, J., Rousseau, A., Sapkota, G., Virdee, S. & Walden, H.
1/04/18 → 31/03/23
Project: Research
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Regulation and Function of Protein FUBIylation (Lister Institute Research Prize 2017)
Lister Institute of Preventive Medicine
1/10/17 → 30/09/22
Project: Research
Research Output
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Dimeric structure of the pseudokinase IRAK3 suggests an allosteric mechanism for negative regulation
Lange, S., Nelen, M. I., Cohen, P. & Kulathu, Y., 4 Feb 2021, In: Structure. 29, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling
Kelsall, I. R., Kristariyanto, Y. A., Knebel, A., Wood, N. T., Kulathu, Y. & Alpi, A. F., 22 Feb 2019, In: Journal of Biological Chemistry. 294, 8, p. 2651-2664 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)153 Downloads (Pure) -
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
Kwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. & Kulathu, Y., 5 Apr 2018, In: Molecular Cell. 70, 1, p. 150-164.e6 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)182 Downloads (Pure) -
Expansion of DUB functionality generated by alternative isoforms: USP35, a case study
Leznicki, P., Natarajan, J., Bader, G., Spevak, W., Schlattl, A., Rehman, S. A. A., Pathak, D., Weidlich, S., Zoephel, A., Bordone, M. C., Barbosa-Morais, N. L., Boehmelt, G. & Kulathu, Y., 16 May 2018, In: Journal of Cell Science. 131, 10, p. 1-16 16 p., jcs212753 .Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)138 Downloads (Pure) -
Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approach
Kulathu, Y., Zuern, C., Yang, J. & Reth, M., Nov 2018, In: Biological Chemistry.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)