Projects per year
Personal profile
Biography
Yogesh graduated with a Bachelor’s degree in Chemical Engineering in 2000 from Birla Institute of Technology and Science (BITS), Pilani, India. An elective course on recombinant DNA technology that he took during his engineering sparked his interest in molecular biology. This prompted him to stay on at BITS, Pilani to do a Masters degree in Biotechnology. He then went on to do a PhD in Immunology under the guidance of Prof. Michael Reth at the Max Planck Institute of Immunobiology and University of Freiburg in Germany, where he worked on B cell antigen receptor signalling and protein tyrosine kinase regulation. To apply structural biology methods to study cell signalling, Yogesh moved to Cambridge in 2009 to work with Dr. David Komander at the MRC Laboratory of Molecular Biology. He was awarded a Marie Curie Intra-European Fellowship and an EMBO Long term fellowship to work on the structural basis driving linkage specificity in ubiquitin binding domains and in the ovarian tumour (OTU) family of deubiquitinases.
In February 2013, Yogesh relocated to the MRC PPU to establish his research program, focussing on ubiquitin signalling mechanisms. In 2015 Yogesh received a prestigious ERC Starting Grant, and was selected as a member of the EMBO Young Investigator Programme.
Yogesh is a recipient of the Lister Prize from the Lister Institute of Preventive Medicine. Yogesh received an ERC Consolidator Grant in 2020 and was promoted to Professor of Cellular Biochemistry in 2022.
Research interests
Undertaking research on COVID-19 to address the current coronavirus pandemic.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Signal transduction
- Cancer Biology
- Immunology
- structural Biology
- post-translational modifications
- Biochemistry
- ubiquitin
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Network
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Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)
Kulathu, Y., Labib, K., Masson, G., Moraga Gonzalez, I., Murray, D., Owen-Hughes, T., Stanley-Wall, N. & Wyatt, P.
1/12/21 → 31/12/26
Project: Research
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Defining Mechanisms of Protein Ufmylation
Biotechnology and Biological Sciences Research Council
1/09/20 → 29/02/24
Project: Research
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A guide to UFMylation, an emerging posttranslational modification
Millrine, D., Peter, J. J. & Kulathu, Y., 20 Jan 2023, (E-pub ahead of print) In: FEBS Journal. 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)21 Downloads (Pure) -
A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation
Peter, J. J., Magnussen, H. M., DaRosa, P. A., Millrine, D., Matthews, S. P., Lamoliatte, F., Sundaramoorthy, R., Kopito, R. R. & Kulathu, Y., 2 Nov 2022, In: EMBO Journal. 41, 21, 19 p., e111015.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)63 Downloads (Pure) -
Chemical biology tools to study Deubiquitinases and Ubl proteases
Gorka, M., Magnussen, H. M. & Kulathu, Y., Dec 2022, In: Seminars in Cell & Developmental Biology. 132, p. 86-96 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)35 Downloads (Pure) -
Deubiquitinases: from mechanisms to their inhibition by small molecules
Lange, S. M., Armstrong, L. A. & Kulathu, Y., 6 Jan 2022, In: Molecular Cell. 82, 1, p. 15-29 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile40 Citations (Scopus)112 Downloads (Pure) -
Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation
Millrine, D., Cummings, T., Matthews, S., Peter, J., Magnussen, H., Macartney, T., Lamoliatte, F., Knebel, A. & Kulathu, Y., 9 Aug 2022, In: Cell Reports. 40, 5, 21 p., 111168.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)106 Downloads (Pure)
Prizes
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Discovery Days 2023
Jon Urch (Organiser), Shabnam Wasim (Organiser), Emma Preston (Contributor), Iain Gillespie (Chair), Blair Grubb (Chair), Jeff Blackford (Speaker), Beth Hannah (Presenter), Yogesh Kulathu (Presenter), Michael MacDonald (Presenter), Gill Milner (Presenter), Jacques Hartmann (Presenter), Ian Ganley (Presenter), Sucharita Nanjappa (Presenter), Peter Hoskins (Presenter), Frank Ruda (Presenter), Dana Leslie (Presenter), Susie Schofield (Presenter), Linda Martindale (Presenter), Natasha Lushetich (Presenter), Thomas Anker (Presenter), Vicky Armstrong (Presenter), Ellie Harrison (Presenter), Gary Kennedy (Presenter) & Linsey McIntosh (Presenter)
11 Jan 2023 → 13 Jan 2023Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Mechanism of UFMylation
Yogesh Kulathu (Speaker)
7 Dec 2021Activity: Talk or presentation types › Invited talk