Projects per year
Personal profile
Biography
Yogesh graduated with a Bachelor’s degree in Chemical Engineering in 2000 from Birla Institute of Technology and Science (BITS), Pilani, India. An elective course on recombinant DNA technology that he took during his engineering sparked his interest in molecular biology. This prompted him to stay on at BITS, Pilani to do a Masters degree in Biotechnology. He then went on to do a PhD in Immunology under the guidance of Prof. Michael Reth at the Max Planck Institute of Immunobiology and University of Freiburg in Germany, where he worked on B cell antigen receptor signalling and protein tyrosine kinase regulation. To apply structural biology methods to study cell signalling, Yogesh moved to Cambridge in 2009 to work with Dr. David Komander at the MRC Laboratory of Molecular Biology. He was awarded a Marie Curie Intra-European Fellowship and an EMBO Long term fellowship to work on the structural basis driving linkage specificity in ubiquitin binding domains and in the ovarian tumour (OTU) family of deubiquitinases.
In February 2013, Yogesh relocated to the MRC PPU to establish his research program, focussing on ubiquitin signalling mechanisms. In 2015 Yogesh received a prestigious ERC Starting Grant, and was selected as a member of the EMBO Young Investigator Programme.
Yogesh is a recipient of the Lister Prize from the Lister Institute of Preventive Medicine.
Research interests
Undertaking research on COVID-19 to address the current coronavirus pandemic.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Signal transduction
- Cancer Biology
- Immunology
- structural Biology
- post-translational modifications
- Biochemistry
- ubiquitin
Fingerprint
- 1 Similar Profiles
Network
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Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)
Kulathu, Y., Labib, K., Masson, G., Moraga Gonzalez, I., Murray, D., Owen-Hughes, T., Stanley-Wall, N. & Wyatt, P.
1/12/21 → 31/12/26
Project: Research
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Defining Mechanisms of Protein Ufmylation
Biotechnology and Biological Sciences Research Council
1/09/20 → 31/08/23
Project: Research
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MRC QQR
Alessi, D., Davies, P., Ganley, I., Kulathu, Y., Labib, K., Rouse, J., Rousseau, A., Sapkota, G., Virdee, S. & Walden, H.
1/04/18 → 1/04/23
Project: Research
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Chemical biology tools to study Deubiquitinases and Ubl proteases
Gorka, M., Magnussen, H. M. & Kulathu, Y., 22 Feb 2022, (E-pub ahead of print) In: Seminars in Cell & Developmental Biology. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Deubiquitinases: from mechanisms to their inhibition by small molecules
Lange, S. M., Armstrong, L. A. & Kulathu, Y., 6 Jan 2022, In: Molecular Cell. 82, 1, p. 15-29 15 p.Research output: Contribution to journal › Review article › peer-review
4 Citations (Scopus) -
Purification, crystallization and drug screening of the IRAK pseudokinases
Lange, S. M. & Kulathu, Y., 4 May 2022, Pseudokinases. Jura, N. & Murphy, J. M. (eds.). Academic Press, Vol. 667. p. 101-121 21 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Armstrong, L. A., Lange, S. M., de Cesare, V., Matthews, S. P., Nirujogi, R. S., Cole, I., Hope, A., Cunningham, F., Toth, R., Mukherjee, R., Bojkova, D., Gruber, F., Gray, D., Wyatt, P. G., Cinatl, J., Dikic, I., Davies, P. & Kulathu, Y., 16 Jul 2021, In: PLoS ONE. 16, 7, 25 p., e0253364.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)33 Downloads (Pure) -
Dimeric structure of the pseudokinase IRAK3 suggests an allosteric mechanism for negative regulation
Lange, S., Nelen, M. I., Cohen, P. & Kulathu, Y., 4 Mar 2021, In: Structure. 29, 3, p. 238-251.e4 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)99 Downloads (Pure)
Prizes
Activities
- 1 Invited talk
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Mechanism of UFMylation
Yogesh Kulathu (Speaker)
7 Dec 2021Activity: Talk or presentation types › Invited talk