Kulathu, Yogesh


  • United Kingdom


Research output per year

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Personal profile


Yogesh graduated with a Bachelor’s degree in Chemical Engineering in 2000 from Birla Institute of Technology and Science (BITS), Pilani, India. An elective course on recombinant DNA technology that he took during his engineering sparked his interest in molecular biology. This prompted him to stay on at BITS, Pilani to do a Masters degree in Biotechnology. He then went on to do a PhD in Immunology under the guidance of Prof. Michael Reth at the Max Planck Institute of Immunobiology and University of Freiburg in Germany, where he worked on B cell antigen receptor signalling and protein tyrosine kinase regulation. To apply structural biology methods to study cell signalling, Yogesh moved to Cambridge in 2009 to work with Dr. David Komander at the MRC Laboratory of Molecular Biology. He was awarded a Marie Curie Intra-European Fellowship and an EMBO Long term fellowship to work on the structural basis driving linkage specificity in ubiquitin binding domains and in the ovarian tumour (OTU) family of deubiquitinases.

In February 2013, Yogesh relocated to the MRC PPU to establish his research program, focussing on ubiquitin signalling mechanisms. In 2015 Yogesh received a prestigious ERC Starting Grant, and was selected as a member of the EMBO Young Investigator Programme.

Yogesh is a recipient of the Lister Prize from the Lister Institute of Preventive Medicine.

Research interests

Undertaking research on COVID-19 to address the current coronavirus pandemic.


  • Q Science (General)
  • Signal transduction
  • Cancer Biology
  • Immunology
  • structural Biology
  • post-translational modifications
  • Biochemistry
  • ubiquitin

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Research Output

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling

Kelsall, I. R., Kristariyanto, Y. A., Knebel, A., Wood, N. T., Kulathu, Y. & Alpi, A. F., 22 Feb 2019, In : Journal of Biological Chemistry. 294, 8, p. 2651-2664 14 p.

Research output: Contribution to journalArticle

Open Access
  • 3 Citations (Scopus)
    115 Downloads (Pure)

    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

    Kwasna, D., Rehman, S. A. A., Natarajan, J., Matthews, S., Madden, R., De Cesare, V., Weidlich, S., Virdee, S., Ahel, I., Gibbs-Seymour, I. & Kulathu, Y., 5 Apr 2018, In : Molecular Cell. 70, 1, p. 150-164.e6 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 37 Citations (Scopus)
    141 Downloads (Pure)

    Expansion of DUB functionality generated by alternative isoforms: USP35, a case study

    Leznicki, P., Natarajan, J., Bader, G., Spevak, W., Schlattl, A., Rehman, S. A. A., Pathak, D., Weidlich, S., Zoephel, A., Bordone, M. C., Barbosa-Morais, N. L., Boehmelt, G. & Kulathu, Y., 16 May 2018, In : Journal of Cell Science. 131, 10, p. 1-16 16 p., jcs212753 .

    Research output: Contribution to journalArticle

    Open Access
  • 6 Citations (Scopus)
    115 Downloads (Pure)
  • 1 Citation (Scopus)

    A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains

    Kristariyanto, Y., Rehman, S. A. A., Weidlich, S., Knebel, A. & Kulathu, Y., 1 Mar 2017, In : EMBO Reports. 18, 3, p. 392-402 11 p., e201643205.

    Research output: Contribution to journalArticle

    Open Access
  • 17 Citations (Scopus)
    148 Downloads (Pure)