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Shishikura, Yoko

Dr

  • United Kingdom

  • 16 Citations
  • 2 h-Index
20142018
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  • 33 Similar Profiles
Mycobacterium tuberculosis Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Quinazolinones Medicine & Life Sciences
Lysosphingolipid Receptors Medicine & Life Sciences
Thiophenes Medicine & Life Sciences
Morpholinos Medicine & Life Sciences
Triazoles Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences

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Research Output 2014 2018

  • 16 Citations
  • 2 h-Index
  • 5 Article
2 Citations

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 othersGreen, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journal › Article

Open Access
File
Quinazolinones
Structure-Activity Relationship
Mycobacterium tuberculosis
Adenosine Triphosphate
Allosteric Site

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 30 Jul 2018, In : Bioorganic & Medicinal Chemistry Letters. 5 p.

Research output: Contribution to journal › Article

Open Access
File
Lysosphingolipid Receptors
Modulators
Esters
Plasma (human)
Butyrylcholinesterase

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Cleghorn, L., Ray, P., Odingo, J., Kumar, A., Wescott, H., Korkegian, A., Masquelin, T., Lopez Moure, A., Wilson, C., Davis, S., Huggett, M., Turner, P., Smith, A., Epemolu, R., Zuccotto, F., Riley, J., Scullion, S., Shishikura, Y., Ferguson, L., Rullas, J. & 6 othersGuijarro, L., Read, K., Green, S., Hipskind, P., Parish, T. & Wyatt, P., 26 Jun 2018, In : Journal of Medicinal Chemistry.

Research output: Contribution to journal › Article

Open Access
File
Thiophenes
Morpholinos
Mycobacterium tuberculosis
Electron Transport Complex IV
Structure-Activity Relationship
5 Citations

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

Brand, S., Ko, E. J., Viayna, E., Thompson, S., Spinks, D., Thomas, M., Sandberg, L., Francisco, A. F., Jayawardhana, S., Smith, V. C., Jansen, C., De Rycker, M., Thomas, J., MacLean, L., Osuna-Cabello, M., Riley, J., Scullion, P., Stojanovski, L., Simeons, F. R. C., Epemolu, O. & 16 othersShishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J., Read, K. D. & Gilbert, I. H., 14 Sep 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

Research output: Contribution to journal › Article

Open Access
File
Triazoles
Trypanosoma cruzi
Parasites
Chagas Disease
Nifurtimox
9 Citations

Disposition and metabolic profiling of [14C]cerlapirdine using accelerator mass spectrometry

Tse, S., Leung, L., Raje, S., Seymour, M., Shishikura, Y. & Obach, R. S., Dec 2014, In : Drug Metabolism and Disposition. 42, 12, p. 2023-2032 10 p.

Research output: Contribution to journal › Article