Research output per year
Research output per year
- 20 results
Search results
-
2024
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
Caldwell, N., Peet, C., Miller, P., Colon, B., Taylor, M., Cocco, M., Dawson, A., Lukac, I., Teixeira, J. E., Robinson, L., Frame, L., Seizova, S., Damerow, S., Tamaki, F., Post, J., Riley, J., Mutter, N., Hanna, J. C., Ferguson, L. & Hu, X. & 13 others, , 23 Oct 2024, In: Science Translational Medicine. 16, 770, p. 1-12 12 p., eadm8631.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)122 Downloads (Pure) -
Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
Aguado, M. E., Carvalho, S., Valdés-Tresanco, M. E., Lin, D., Padilla-Mejia, N., Corpas-Lopez, V., Tesařová, M., Lukeš, J., Gray, D., González-Bacerio, J. (Lead / Corresponding author), Wyllie, S. (Lead / Corresponding author) & Field, M. C. (Lead / Corresponding author), 14 Jun 2024, In: ACS Infectious Diseases. 10, 6, p. 2002-2017 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)52 Downloads (Pure) -
ResMAP – a saturation mutagenesis platform enabling parallel profiling of target-specific resistance conferring mutations in Plasmodium
Wall, R. (Lead / Corresponding author), MacGowan, S., Hallyburton, I., Syed, A., Ajay Castro, S., Dey, G., Milne, R., Patterson, S., Phelan, J., Wiedemar, N. W. & Wyllie, S. (Lead / Corresponding author), Oct 2024, In: MBio. 15, 10, e01708-24.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1
Tulloch, L., Tinti, M., Wall, R., Weidt, S. K., Corpas Lopez, V., Dey, G., Smith, T. K., Fairlamb, A., Barrett, M. P. & Wyllie, S. (Lead / Corresponding author), 11 Jul 2024, In: PLoS Pathogens. 20, 7, 23 p., e1012382.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)51 Downloads (Pure) -
2023
Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates
Smith, R. J., Milne, R., Lopez, V. C., Wiedemar, N., Dey, G., Syed, A. J., Patterson, S. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 17 Mar 2023, In: STAR Protocols. 4, 1, 30 p., 102002.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)133 Downloads (Pure) -
Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation
Al-Rawi, A., Kaye, E., Korolchuk, S., Endicott, J. A. & Ly, T. (Lead / Corresponding author), 28 Mar 2023, In: Cell Reports. 42, 3, 21 p., 112139.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)361 Downloads (Pure) -
Development of a 2,4-diaminothiazole series for the treatment of human African trypanosomiasis highlights the importance of static-cidal screening of analogues
Cleghorn, L. A. T., Wall, R. J., Albrecht, S., MacGowan, S. A., Norval, S., De Rycker, M., Woodland, A., Spinks, D., Thompson, S., Patterson, S., Corpas Lopez, V., Dey, G., Collie, I. T., Hallyburton, I., Kime, R., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Wyatt, P. G. & Read, K. D. & 2 others, , 13 Jul 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8896–8916 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)85 Downloads (Pure) -
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1
Braillard, S., Keenan, M., Breese, K. J., Heppell, J., Abbott, M., Islam, R., Shackleford, D. M., Katneni, K., Crighton, E., Chen, G., Patil, R., Lee, G., White, K. L., Carvalho, S., Wall, R. J., Chemi, G., Zuccotto, F., Gonzalez, S., Marco, M. & Deakyne, J. & 18 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 15 p., eadh9902.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)103 Downloads (Pure) -
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium
Hanna, J. C. .., Corpas Lopez, V., Seizova, S., Colon, B. L., Bacchetti, R., Hall, G. M. J., Sands, E. M., Robinson, L., Baragaña, B., Wyllie, S. (Lead / Corresponding author) & Pawlowic, M. (Lead / Corresponding author), 4 Aug 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 14 p., 1236814.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)109 Downloads (Pure) -
RES-Seq – a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness
Tulloch, L. B., Carvalho, S., Lima, M., Wall, R. J., Tinti, M., Pinto, E. G., MacLean, L. & Wyllie, S. (Lead / Corresponding author), 19 Dec 2023, In: MBio. 14, 6, 15 p., e01803-23.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Downloads (Pure) -
Short-course combination treatment for experimental chronic Chagas disease
González, S., Wall, R. J., Thomas, J., Braillard, S., Brunori, G., Camino Díaz, I., Cantizani, J., Carvalho, S., Castañeda Casado, P., Chatelain, E., Cotillo, I., Fiandor, J. M., Francisco, A. F., Grimsditch, D., Keenan, M., Kelly, J. M., Kessler, A., Luise, C., Lyon, J. J. & MacLean, L. & 10 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 17 p., adg8105.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)94 Downloads (Pure) -
The critical role of mode of action studies in kinetoplastid drug discovery
Fairlamb, A. H. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 10 May 2023, In: Frontiers in Drug Discovery. 3, 13 p., 1185679.Research output: Contribution to journal › Article › peer-review
Open AccessFile68 Downloads (Pure) -
2022
Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas' disease
Lima, M., Tulloch, L., Corpas Lopez, V., Carvalho, S., Wall, R., Milne, R., Rico Vidal, E., Patterson, S., Gilbert, I., Moniz, S., MacLean, L., Torrie, L., Morgillo, C., Horn, D., Zuccotto, F. & Wyllie, S. (Lead / Corresponding author), 18 Jan 2022, In: Antimicrobial Agents and Chemotherapy. 66, 1, 16 p., e01535-21.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)196 Downloads (Pure) -
Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids
Altmann, S., Rico, E., Carvalho, S., Ridgway, M., Trenaman, A., Donnelly, H., Tinti, M., Wyllie, S. & Horn, D. (Lead / Corresponding author), 12 Aug 2022, In: Nucleic Acids Research. 50, 14, p. 1-8 8 p., e79.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)101 Downloads (Pure) -
Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for use in the treatment of African animal trypanosomiasis
Smith, A., Wall, R., Patterson, S., Rowan, T., Rico Vidal, E., Stojanovski, L., Huggett, M., Hampton, S., Thomas, M. G., Corpas Lopez, V., Gillingwater, K., Duke, J., Napier, G., Peter, R., Vitouley, H. S., Harrison, J., Milne, R., Jeacock, L., Baker, N. & Davis, S. & 9 others, , 14 Apr 2022, In: Journal of Medicinal Chemistry. 65, 7, p. 5606-5624 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)153 Downloads (Pure) -
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
Milne, R., Wiedemar, N., Corpas Lopez, V., Moynihan, E., Wall, R. J., Dawson, A., Robinson, D. A., Shepherd, S. M., Smith, R. J., Hallyburton, I., Post, J. M., Dowers, K., Torrie, L. S., Gilbert, I. H., Baragaña, B., Patterson, S. & Wyllie, S. (Lead / Corresponding author), 9 Sept 2022, In: ACS Infectious Diseases. 8, 9, p. 1962-1974 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)192 Downloads (Pure) -
2021
DNDI-6148: A novel benzoxaborole preclinical candidate for the treatment of visceral leishmaniasis
Mowbray, C. E. (Lead / Corresponding author), Braillard, S., Glossop, P. A., Whitlock, G. A., Jacobs, R. T., Speake, J., Pandi, B., Nare, B., Maes, L., Yardley, V., Freund, Y., Wall, R. J., Carvalho, S., Bello, D., Van den Kerkhof, M., Caljon, G., Gilbert, I. H., Corpas-Lopez, V., Lukac, I. & Patterson, S. & 2 others, , 11 Nov 2021, In: Journal of Medicinal Chemistry. 64, 21, p. 16159-16176 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)393 Downloads (Pure) -
Identification of resistance determinants for a promising antileishmanial oxaborole series
Van den Kerkhof, M., Leprohon, P., Mabille, D., Hendrickx, S., Tulloch, L. B., Wall, R. J., Wyllie, S., Chatelain, E., Mowbray, C. E., Braillard, S., Ouellette , M., Maes, L. & Calijon, G. (Lead / Corresponding author), 29 Jun 2021, In: Microorganisms. 9, 7, 15 p., 1408.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)85 Downloads (Pure) -
Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay
Svensen, N., Wyllie, S., Gray, D. W. & De Rycker, M. (Lead / Corresponding author), 11 Oct 2021, In: PLoS Neglected Tropical Diseases. 15, 10, 14 p., e0009870.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)81 Downloads (Pure) -
Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds
Corpas Lopez, V. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 17 Sept 2021, In: STAR Protocols. 2, 3, 19 p., 100704.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)126 Downloads (Pure)