A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

2015

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. (Lead / Corresponding author) & Abramov, A. Y. (Lead / Corresponding author), Apr 2015, In: BBA - General Subjects. 1850, 4, p. 794-801 8 p.

Research output: Contribution to journal › Article › peer-review

517 Citations (Scopus)

2014

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, R. (Lead / Corresponding author), Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. (Lead / Corresponding author), Nov 2014, In: Biochemical Journal. 463, 3, p. 413-427 15 p.

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229 Citations (Scopus)

373 Downloads (Pure)

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Banerjee, S., Buhrlage, S. J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. (Lead / Corresponding author) & Gray, N. S. (Lead / Corresponding author), 1 Jan 2014, In: Biochemical Journal. 457, 1, p. 215-225 11 p.

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

Dunn, L. (Lead / Corresponding author), Allen, G. F. G., Mamais, A., Ling, H., Li, A., Duberley, K. E., Hargreaves, I. P., Pope, S., Holton, J. L., Lees, A., Heales, S. J. & Bandopadhyay, R., May 2014, In: Neurobiology of Aging. 35, 5, p. 1111-1115 5 p.

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189 Citations (Scopus)

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Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β^MYPT1phosphatase complex and the SCF^βTrCP E3 ubiquitin ligase

Banerjee, S. (Lead / Corresponding author), Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. (Lead / Corresponding author), 15 Jul 2014, In: Biochemical Journal. 461, 2, p. 233-245 13 p.

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21 Citations (Scopus)

239 Downloads (Pure)

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Houde, V. P. (Lead / Corresponding author), Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R. (Lead / Corresponding author), 15 Feb 2014, In: Biochemical Journal. 458, 1, p. 41-56 16 p.

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42 Citations (Scopus)

234 Downloads (Pure)

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

van der Wijst, J. (Lead / Corresponding author), Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J. & Alessi, D. R. (Lead / Corresponding author), 13 May 2014, In: Biochemical Journal. 460, 2, p. 165-175 11 p.

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14 Citations (Scopus)

193 Downloads (Pure)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. (Lead / Corresponding author) & Dinkova-Kostova, A. T. (Lead / Corresponding author), 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journal › Article › peer-review

208 Citations (Scopus)

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine⁶⁵

Kazlauskaite, A. (Lead / Corresponding author), Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. (Lead / Corresponding author), 15 May 2014, In: Biochemical Journal. 460, 1, p. 127-139 13 p.

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649 Citations (Scopus)

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Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K., 19 Mar 2014, In: Open Biology. 4, 14 p., 130213.

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. & Trost, M. (Lead / Corresponding author), 27 Aug 2014, In: Nature Communications. 5, 11 p., 4763.

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266 Citations (Scopus)

410 Downloads (Pure)

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

Schumacher, F.-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. (Lead / Corresponding author) & Kurz, T. (Lead / Corresponding author), 1 Jun 2014, In: Biochemical Journal. 460, 2, p. 237-246 10 p.

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63 Citations (Scopus)

275 Downloads (Pure)

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K⁺-Cl^- co-transporters

De Los Heros, P., Alessi, D. R. (Lead / Corresponding author), Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., Kahle, K. T. & Zhang, J. (Lead / Corresponding author), 15 Mar 2014, In: Biochemical Journal. 458, 3, p. 559-573 15 p.

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161 Citations (Scopus)

340 Downloads (Pure)

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

Alessi, D. R., Zhang, J., Khanna, A., Hochdörfer, T., Shang, Y. & Kahle, K. T. (Lead / Corresponding author), 15 Jul 2014, In: Science Signaling. 7, 334, 10 p., re3.

Research output: Contribution to journal › Article › peer-review

217 Citations (Scopus)

2013

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Fakiola, M., Strange, A., Cordell, H. J., Miller, E. N., Pirinen, M., Su, Z., Mishra, A., Mehrotra, S., Monteiro, G. R., Band, G., Bellenguez, C., Dronov, S., Edkins, S., Freeman, C., Giannoulatou, E., Gray, E., Hunt, S. E., Lacerda, H. G., Langford, C. & Pearson, R. & 32 others, Pontes, N. N., Rai, M., Singh, S. P., Smith, L., Sousa, O., Vukcevic, D., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Wilson, M. E., Deloukas, P., Peltonen, L., Christiansen, F., Witt, C., Jeronimo, S. M. B., Sundar, S., Spencer, C. C. A., Blackwell, J. M., LeishGEN Consortium & Wellcome Trust Case Control, 2013, In: Nature Genetics. 45, 2, p. 208-213 6 p.

Research output: Contribution to journal › Letter › peer-review

92 Citations (Scopus)

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Davies, P., Hinkle, K. M., Sukar, N. N., Sepulveda, B., Mesias, R., Serrano, G., Alessi, D. R., Beach, T. G., Benson, D. L., White, C. L., Cowell, R. M., Das, S. S., West, A. B. (Lead / Corresponding author) & Melrose, H. L. (Lead / Corresponding author), 1 Jul 2013, In: Biochemical Journal. 453, 1, p. 101-113 13 p.

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

Delbroek, L., Van Kolen, K., Steegmans, L., da Cunha, R., Mandemakers, W., Daneels, G., De Bock, P.-J., Zhang, J., Gevaert, K., De Strooper, B., Alessi, D. R., Verstreken, P. & Moechars, D. W., 25 Mar 2013, In: Journal of Pharmaceutical and Biomedical Analysis. 76, p. 49-58 10 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Kinase drug discovery: What's next in the field?

Cohen, P. & Alessi, D. R., 2013, In: ACS Chemical Biology. 8, 1, p. 96-104 9 p.

Research output: Contribution to journal › Article › peer-review

335 Citations (Scopus)

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L. & Chen, S. G., 15 Jan 2013, In: Human Molecular Genetics. 22, 2, p. 328-344 17 p.

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. (Lead / Corresponding author) & Abramov, A. Y. (Lead / Corresponding author), 15 Aug 2013, In: Open Biology. 2, 8, p. 761-770 10 p.

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372 Citations (Scopus)

318 Downloads (Pure)

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J.-D., Sim, T., Kim, N., Alessi, D. R., Lizcano, J. M., Knapp, S. & Gray, N. S., Dec 2013, In: European Journal of Medicinal Chemistry. 70, p. 758-767 10 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

2012

Brain penetrant LRRK2 inhibitor

Choi, H. G., Zhang, J., Deng, X., Hatcher, J. M., Patricelli, M. P., Zhao, Z., Alessi, D. R. & Gray, N. S., 9 Aug 2012, In: ACS Medicinal Chemistry Letters. 3, 8, p. 658-662 5 p.

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

Zhang, J., Deng, X., Choi, H. G., Alessi, D. R. (Lead / Corresponding author) & Gray, N. S. (Lead / Corresponding author), 1 Mar 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 5, p. 1864-1869 6 p.

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

Lewis, P. A. & Alessi, D. R., 2012, In: Biochemical Society Transactions. 40, 5, p. 1039-1041 3 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Discovery of potent and selective covalent inhibitors of JNK

Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S., 27 Jan 2012, In: Chemistry & Biology. 19, 1, p. 140-154 15 p.

Research output: Contribution to journal › Article › peer-review

288 Citations (Scopus)

G2019s leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

Papkovskaia, T. D., Chau, K.-Y., Inesta-vaquera, F., Papkovsky, D. B., Healy, D. G., Nishio, K., Staddon, J., Duchen, M. R., Hardy, J., Schapira, A. H. V. & Cooper, J. M., 2012, In: Human Molecular Genetics. 21, 19, p. 4201-4213 13 p.

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

GSK2578215A: a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

Reith, A. D., Bamborough, P., Jandu, K., Andreotti, D., Mensah, L., Dossang, P., Choi, H. G., Deng, X., Zhang, J., Alessi, D. R. & Gray, N. S., 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 17, p. 5625-5629 5 p.

Research output: Contribution to journal › Article › peer-review

133 Citations (Scopus)

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., MacArtney, T. J., Deak, M., Knebel, A., Alessi, D. R. & Muqit, M. M. K. (Lead / Corresponding author), 2012, In: Open Biology. 2, 120080.

Research output: Contribution to journal › Article › peer-review

741 Citations (Scopus)

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P., 2012, In: PLoS ONE. 7, 6, e39132.

Research output: Contribution to journal › Article › peer-review

176 Citations (Scopus)

2011

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K. (Lead / Corresponding author), 1 Nov 2011, In: Open Biology. 1, NOVEMBER, 110012.

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21

Spencer, C. C. A., Plagnol, V., Strange, A., Gardner, M., Paisan-Ruiz, C., Band, G., Barker, R. A., Bellenguez, C., Bhatia, K., Blackburn, H., Blackwell, J. M., Bramon, E., Brown, M. A., Brown, M. A., Burn, D., Casas, J.-P., Chinnery, P. F., Clarke, C. E., Corvin, A. & Craddock, N. & 31 others, Deloukas, P., Edkins, S., Evans, J., Freeman, C., Gray, E., Hardy, J., Hudson, G., Hunt, S., Jankowski, J., Langford, C., Lees, A. J., Markus, H. S., McCarthy, M. I., Mathew, C. G., Morrison, K. E., Palmer, C. N. A., Pearson, J. P., Peltonen, L., Pirinen, M., Plomin, R., Potter, S., Rautanen, A., Sawcer, S. J., Su, Z., Trembath, R. C., Viswanathan, A. C., Williams, N. W., Morris, H. R., Donnelly, P., Wood, N. W. & UK Parkinson's Disease Consortium, 2011, In: Human Molecular Genetics. 20, 2, p. 345-53 9 p.

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189 Citations (Scopus)

190 Downloads (Pure)

2010

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J., 15 Sept 2010, In: Biochemical Journal. 430, p. 405-413 9 p.

Research output: Contribution to journal › Article › peer-review

318 Citations (Scopus)

A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

Research output

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