A Systems Approach for the Fragment-based Development of Selective Chemical Probes of Bromodomain Function (joint with University of Oxford)

Project Details

StatusFinished
Effective start/end date8/04/137/06/15

Funding

  • Biotechnology and Biological Sciences Research Council (BB/J001201/2): £317,431.00

Research Output

  • 12 Article
  • 1 Chapter (peer-reviewed)
  • 1 Short survey
  • 1 Review article
Open Access
File
  • 51 Citations (Scopus)
    150 Downloads (Pure)

    Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

    Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 7 Mar 2018, In : Chemical Science. 9, 9, p. 2452-2468 17 p., 2452.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    162 Downloads (Pure)

    Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand

    Khan, R., Marsh, G., Felix, R., Kemmitt, P. D., Baud, M. G. J., Ciulli, A. & Spencer, J., Aug 2017, In : ACS Omega. 2, 8, p. 4328-4332 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    98 Downloads (Pure)