Keyphrases
Bromodomain
92%
Chemical Probes
49%
Bromodomain-containing Protein 4 (BRD4)
45%
Proteolysis Targeting chimera (PROTAC)
41%
Bromo
39%
Bump
31%
Small Molecules
29%
Degrader
25%
Chemical Biology
24%
Bromodomain Inhibitors
24%
Chemical Genetics
20%
Genetic Approach
19%
Small Molecule Ligands
19%
Medicinal Chemistry
18%
Target Validation
16%
Epigenetics
16%
Chemical Drugs
14%
Histone Tails
14%
BET Bromodomain
14%
BAZ2B
14%
NMR Spectroscopy
13%
Biophysical Assays
13%
TIP5
12%
On-target Effects
12%
Extra-terminal Domain
12%
Protein Degradation
12%
E3 Ligase
12%
Targeted Protein Degradation
11%
Benzodiazepines
11%
Histone
11%
Bromodomain Proteins
11%
Epigenetic Reader Domain
11%
Allele-specific
10%
Drug Discovery
10%
Relevant Protein
9%
Plant Homeodomain Finger
9%
Histone H3 Tail
9%
NoRC
9%
PHD Finger
9%
Structure-based Lead Discovery
9%
Pharmacological Inhibitors
9%
Functional Domain
9%
Controlled Selectivity
9%
Stereoselective Synthesis
9%
New Synthetic Route
9%
Laboratory Synthesis
9%
Tetrahydroquinoline
9%
Cooperative Recognition
9%
Gram-scale
9%
Selective Intervention
9%
Target Selectivity
9%
Biological Investigations
9%
Molecular Recognition
9%
Nuclear Magnetic Resonance
9%
Non-canonical
9%
New Frontiers
9%
Structure-guided
9%
Binding Hotspots
9%
Melanoma
9%
Sulfonamides
9%
Chromatin Remodelers
9%
Sex-determining Region Y-box 2 (SOX2)
9%
Bromodomain and Extra-terminal Domain
9%
Protein Complex
9%
Transcriptional Complex
9%
Warhead
9%
Von Hippel-Lindau
9%
Benzo
9%
Imidazole
9%
Induced Degradation
9%
BET Bromodomain Inhibitor
9%
Isothermal Titration Calorimetry
9%
Gli1
9%
Inhibitor Scaffold
9%
Pathway Inhibitors
9%
High Affinity
9%
Membrane Permeability
9%
Solution NMR
9%
Hedgehog
9%
BRD2
9%
Terminal Protein
8%
E3 Ubiquitin Ligase
8%
Post-translational Modification
8%
Structure-activity Relationship
8%
Ligand Screening
8%
High-throughput
8%
BRD3
6%
Ligand Binding
6%
Binding Affinity
6%
JQ-1
6%
Active Chemicals
6%
Potent Inhibitor
6%
C-Myc
5%
Small Molecule Binding
5%
Epigenetic Mechanisms
5%
Co-crystal Structure
5%
Histone Post-translational Modifications
5%
Rationally Designed
5%
Reader Modules
5%
Biochemistry, Genetics and Molecular Biology
Bromodomain
100%
Small Molecule
52%
Protein Catabolism
43%
Histone
30%
BRD4
30%
Chemical Genetics
20%
Epigenetics
20%
Genetic Approach
19%
Allele
19%
Posttranslational Modification
14%
Epigenomics
13%
Epigenetics
13%
Ligase
13%
Histone H3
12%
Solution and Solubility
11%
Membrane Permeability
9%
SOX2
9%
Sulfonamide
9%
Homeodomain
9%
Multiprotein Complex
9%
PHD Finger
9%
GLI1
9%
Magnetism
9%
Molecular Recognition
9%
Gene Linkage
9%
Chromatin Remodeling
9%
Crystal Structure
9%
Hedgehog
8%
Isothermal Titration Calorimetry
8%
Ubiquitin-Conjugating Enzyme
6%
Alkylation
6%
X-Ray Crystallography
6%
BRD2
6%
Structure Activity Relation
5%
Wild Type
5%
Protein Tertiary Structure
5%