A Systems Approach for Understanding Cell Surface Dynamics in Trypanosomes (Investigator Award)

Research output

Research output per year 2017 2020 2021 2022 2023

• 23 Article
• 7 Review article
• 1 Chapter (peer-reviewed)

Research output per year

Research output per year

Search results

• 2023

  Extracellular vesicles secreted by Echinococcus multilocularis: Important players inangiogenesis promotion

  Liu, C., Cao, J., Zhang, H., Field, M. C. & Yin, J., 2 May 2023, (E-pub ahead of print) In: Microbes and Infection. 105147.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Echinococcus multilocularis 100%
  • Extracellular Vesicles 76%
  • Echinococcus 35%
  • Parasites 33%
  • Helminths 19%
  1 Downloads (Pure)

• Impact of inherent biases built into proteomic techniques: Proximity labeling and affinity capture compared

  Moreira, C. M. D. N., Kelemen, C. D., Obado, S. O., Zahedifard, F., Zhang, N., Holetz, F. B., Gauglitz, L., Dallagiovanna, B., Field, M. C., Kramer, S. & Zoltner, M., Jan 2023, In: Journal of Biological Chemistry. 299, 1, 15 p., 102726.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proteomics 100%
  • Protein 44%
  • Proteins 40%
  • Nuclear Pore 23%
  • Pore 19%
  15 Downloads (Pure)

• The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes

  Makarov, A., Began, J., Mautone, I. C., Pinto, E., Ferguson, L., Zoltner, M., Zoll, S. & Field, M. C., Feb 2023, In: Microbial Cell. 10, 2, p. 18-35 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Suramin 100%
  • Trypanosoma 93%
  • Membrane Glycoproteins 84%
  • Xenobiotics 81%
  • Naphthols 21%
  9 Downloads (Pure)
• 2022

  A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila

  Kuppannan, A., Jiang, Y-Y., Maier, W., Liu, C., Lang, C. F., Cheng, C-Y., Field, M. C., Zhao, M., Zoltner, M. & Turkewitz, A. P., 19 May 2022, In: PLoS Genetics. 18, 5, 33 p., e1010194.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tetrahymena thermophila 100%
  • exocytosis 74%
  • Exocytosis 71%
  • lysosomes 66%
  • Lysosomes 65%
  2 Citations (Scopus)

  24 Downloads (Pure)

• Coatomer in the universe of cellular complexity

  Field, M. C. & Rout, M. P., 1 Dec 2022, In: Molecular Biology of the Cell. 33, 14, 5 p., pe8.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eukaryotic Cells 100%
  • Eukaryota 95%
  • Coatomer Protein 78%
  • Protein Domains 46%
  • Membranes 27%
  2 Downloads (Pure)

• Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei

  Bezerra, M. J. R., Moura, D. M. N., Freire, E. R., Holetz, F. B., Reis, C. R. S., Monteiro, T. T. S., Pinto, A. R. S., Zhang, N., Rezende, A. M., Pereira-Neves, A., Figueiredo, R. C. B. Q., Clayton, C., Field, M. C., Carrington, M. & de Melo Neto, O. P., 7 Oct 2022, In: Frontiers in Molecular Biosciences. 9, 22 p., 971811.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma brucei brucei 100%
  • Messenger RNA 43%
  • Protein 31%
  • Poly(A)-Binding Protein II 29%
  • Proteins 28%
  1 Citation (Scopus)

  21 Downloads (Pure)

• Evolution of factors shaping the endoplasmic reticulum

  Kontou, A., Herman, E. K., Field, M. C., Dacks, J. B. & Koumandou, V. L., Sept 2022, In: Traffic. 23, 9, p. 462-473 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Endoplasmic Reticulum 100%
  • Eukaryota 46%
  • Protein 43%
  • Alveolata 30%
  • Modification 29%
  2 Citations (Scopus)

  47 Downloads (Pure)

• Microbe Profile: Euglena gracilis: photogenic, flexible and hardy

  Zoltner, M. & Field, M. C., 30 Sept 2022, In: Microbiology. 168, 9, 3 p., 001241.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Euglena gracilis 100%
  • Euglena 52%
  • Kinetoplastida 52%
  • Plastids 45%
  • Meiotic Prophase I 44%
  1 Citation (Scopus)

  25 Downloads (Pure)

• Proteomics uncovers novel components of an interactive protein network supporting RNA export in trypanosomes

  Inoue, A. H., Domingues, P. F., Serpeloni, M., Hiraiwa, P. M., Vidal, N. M., Butterfield, E. R., Del Pino, R. C., Ludwig, A., Boehm, C., Field, M. C. & Ávila, A. R., 1 Mar 2022, In: Molecular & Cellular Proteomics. 21, 3, 25 p., 100208.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Proteomics 72%
  • RNA 55%
  • Messenger RNA 33%
  • Protein 32%
  2 Citations (Scopus)

  38 Downloads (Pure)

• Sending the message: specialized RNA export mechanisms in trypanosomes

  Obado, S. O., Rout, M. P. & Field, M. C., Oct 2022, In: Trends in Parasitology. 38, 10, p. 854-867 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • RNA transport 100%
  • Trypanosoma 87%
  • eukaryotic cells 60%
  • RNA 48%
  • Trypanosomatidae 44%
  8 Downloads (Pure)
• 2021

  A hub and spoke nuclear lamina architecture in trypanosomes

  Padilla-Mejia, N., Koreny, L., Holden, J., Vancová, M., Lukeš, J., Zoltner, M. & Field, M. C., 21 Jun 2021, In: Journal of Cell Science. 134, 12, 16 p., jcs251264.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nuclear Lamina 100%
  • Trypanosoma 84%
  • Lamins 48%
  • Membrane Glycoproteins 38%
  • Nuclear Envelope 38%
  1 Citation (Scopus)

  46 Downloads (Pure)

• Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins

  Quintana, J. F. & Field, M. C., Sept 2021, In: Parasitology. 148, 10, p. 1137-1142 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Aquaglyceroporins 100%
  • Trypanosoma 73%
  • life events 42%
  • drugs 38%
  • uptake mechanisms 38%
  3 Citations (Scopus)

  20 Downloads (Pure)

• Evolution and diversification of the nuclear envelope

  Padilla-Mejia, N. E., Makarov, A. A., Barlow, L. D., Butterfield, E. R. & Field, M. C., 9 Feb 2021, In: Nucleus. 12, 1, p. 21-41 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nuclear Envelope 100%
  • Nuclear Pore 23%
  • Molecular Evolution 22%
  • Lipid Bilayers 20%
  • Eukaryotic Cells 18%
  3 Citations (Scopus)

  52 Downloads (Pure)

• Evolution and diversification of the nuclear pore complex

  Makarov, A. A., Padilla-Mejia, N. E. & Field, M. C., 27 Aug 2021, In: Biochemical Society Transactions. 49, 4, p. 1601-1619 19 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Nuclear Pore 100%
  • Pore 48%
  • Eukaryotic Cells 10%
  • Eukaryota 9%
  • Polypeptide 7%
  4 Citations (Scopus)

  48 Downloads (Pure)

• Evolving differentiation in African trypanosomes

  Quintana, J. F., Zoltner, M. & Field, M. C., Apr 2021, In: Trends in Parasitology. 37, 4, p. 296-303 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Parasites 65%
  • parasites 54%
  • Insecta 41%
  • insects 24%
  20 Citations (Scopus)

  31 Downloads (Pure)

• Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase

  Aguado, M. E., González-Matos, M., Izquierdo, M., Quintana, J., Field, M. C. & González-Bacerio, J., Jul 2021, In: Protein Expression and Purification. 183, 12 p., 105877.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aminopeptidases 100%
  • Leishmania major 99%
  • ubenimex 75%
  • Kinetics 53%
  • Escherichia coli 51%
  2 Citations (Scopus)

  41 Downloads (Pure)

• The distinctive flagellar proteome of Euglena gracilis illuminates the complexities of protistan flagella adaptation

  Hammond, M., Zoltner, M., Garrigan, J., Butterfield, E., Varga, V., Lukeš, J. & Field, M. C., Nov 2021, In: New Phytologist. 232, 3, p. 1323-1336 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Euglena gracilis 100%
  • Flagella 72%
  • Proteome 61%
  • flagellum 60%
  • proteome 56%
  7 Citations (Scopus)

  105 Downloads (Pure)
• 2020

  A uniquely complex mitochondrial proteome from Euglena gracilis

  Hammond, M. J., Nenarokova, A., Butenko, A., Zoltner, M., Lacová Dobáková, E., Field, M. & Lukeš, J., 1 Aug 2020, In: Molecular Biology and Evolution. 37, 8, p. 2173-2191 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Euglena gracilis 100%
  • mitochondrion 66%
  • Proteome 61%
  • proteome 56%
  • protist 54%
  12 Citations (Scopus)

  65 Downloads (Pure)

• Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

  Izquierdo, M., Lin, D., O'Neill, S., Zoltner, M., Webster, L., Hope, A., Gray, D. W., Field, M. C. & González-Bacerio, J., 1 Oct 2020, In: SLAS Discovery. 25, 9, p. 1064-1071 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • rapidFire Mass Spectrometry 100%
  • Leucyl Aminopeptidase 74%
  • High-Throughput Screening Assays 69%
  • Trypanosoma cruzi 59%
  • High Throughput Screening 52%
  5 Citations (Scopus)

  29 Downloads (Pure)

• Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila

  Sparvoli, D., Zoltner, M., Cheng, C-Y., Field, M. C. & Turkewitz, A., 12 Feb 2020, In: Journal of Cell Science. 133, 3, p. 1-18 18 p., jcs238659.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tetrahymena thermophila 100%
  • Tetrahymena 93%
  • Endosomes 71%
  • Protein Transport 70%
  • Eukaryota 66%
  10 Citations (Scopus)

  73 Downloads (Pure)

• Instability of aquaglyceroporin (Aqp) 2 contributes to drug resistance in trypanosoma brucei

  Quintana, J. F., Bueren-Calabuig, J., Zuccotto, F., Zoltner, M., Canavate Del Pino, R., de Koning, H. P., Horn, D. & Field, M. C., 9 Jul 2020, In: PLoS Neglected Tropical Diseases. 14, 7, 26 p., e0008458.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aquaglyceroporins 100%
  • Pentamidine 83%
  • Trypanosoma brucei brucei 75%
  • Drug Resistance 53%
  • drug 39%
  8 Citations (Scopus)

  60 Downloads (Pure)

• Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

  Alghamdi, A. H., Munday, J. C., Campagnaro, G. D., Gurvic, D., Svensson, F., Okpara, C. E., Kumar, A., Quintana, J. F., Abril, M. E. M., Milić, P., Watson, L., Paape, D., Settimo, L., Dimitriou, A., Wielinska, J., Smart, G., Anderson, L. F., Woodley, C. M., Kelley, S. P. Y., Ibrahim, H. M. S., & 12 othersHulpia, F., Al-Salabi, M. I., Eze, A. A., Gudin, S., Field, M., Dardonville, C., Tidwell, R. R. ., Carrington, M., O'Neill, P. M., Boykin, D. W. ., Zachariae, U. & de Koning, H. P., 4 Sept 2020, In: eLife. 9, 33 p., e56416.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pentamidine 100%
  • Trypanosoma brucei brucei 83%
  • Aquaporins 55%
  • Pore 42%
  • Modification 35%
  12 Citations (Scopus)

  90 Downloads (Pure)

• Sorting the Muck from the Brass: Analysis of Protein Complexes and Cell Lysates

  Zoltner, M., Del Pino, R. C. & Field, M. C., 2020, Trypanosomatids: Methods and Protocols. Michels, P. A. M., Ginger, M. L. & Zilberstein, D. (eds.). New York: Humana Press, p. 645-653 9 p. (Methods in Molecular Biology; vol. 2116).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  • brass 100%
  • Statistical Data Interpretation 40%
  • Costs and Cost Analysis 40%
  • Data Accuracy 34%
  • Proteomics 29%
  3 Citations (Scopus)

• Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

  Zoltner, M., Campagnaro, G. D., Taleva, G., Burrell, A., Cerone, M., Leung, K-F., Achcar, F., Horn, D., Vaughan, S., Gadelha, C., Zíková, A., Barrett, M. P., de Koning, H. P. & Field, M., 12 Jun 2020, In: Journal of Biological Chemistry. 295, 24, p. 8331-8347 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Suramin 100%
  • Trypanosoma 80%
  • Energy Metabolism 58%
  • Pharmacological Metabolism 49%
  • Energy 30%
  18 Citations (Scopus)

  64 Downloads (Pure)

• The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

  Henrici, R. C., Edwards, R. L., Zoltner, M., van Schalkwyk, D. A., Hart, M. N., Mohring, F., Moon, R. W., Nofal, S. D., Patel, A., Flueck, C., Baker, D. A., Odom John, A. R., Field, M. C. & Sutherland, C. J., Feb 2020, In: MBio. 11, 1, 16 p., e02918-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Schizonts 100%
  • artemisinine 90%
  • Clathrin 86%
  • Plasmodium falciparum 73%
  • Parasites 57%
  17 Citations (Scopus)

  50 Downloads (Pure)
• 2019

  Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex

  Boehm, C. & Field, M. C., 26 Jul 2019, In: Wellcome Open Research. 4, 19 p., 112.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Exocytosis 100%
  • Streptophyta 97%
  • Vacuoles 95%
  • Euglenozoa 91%
  • Embryophyta 80%
  1 Citation (Scopus)

  74 Downloads (Pure)

• Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei

  Wiedemar, N., Zwyer, M., Zoltner, M., Cal, M., Field, M. C. & Mäser, P., Oct 2019, In: FASEB bioAdvances. 1, 10, p. 595-608 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Suramin 100%
  • Trypanosoma brucei brucei 83%
  • Membrane Glycoproteins 73%
  • Endocytosis 64%
  • Glycoprotein 58%
  7 Citations (Scopus)

  48 Downloads (Pure)

• Pore timing: the evolutionary origins of the nucleus and nuclear pore complex

  Field, M. C. & Rout, M. P., 3 Apr 2019, In: F1000Research. 8, p. 1-11 11 p., 369.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Nuclear Pore 100%
  • Eukaryota 76%
  • Pore 48%
  • Archaea 15%
  • Cell Nucleus 12%
  16 Citations (Scopus)

  163 Downloads (Pure)
• 2018

  Evolutionary origins and specialisation of membrane transport

  Dacks, J. B. & Field, M. C., 1 Aug 2018, In: Current Opinion in Cell Biology. 53, p. 70-76 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Organelles 100%
  • Intracellular Membranes 66%
  • Membranes 62%
  • Eukaryotic Cells 56%
  • Cellular Structures 55%
  30 Citations (Scopus)

  219 Downloads (Pure)

• Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins

  Herman, E. K., Ali, M., Field, M. C. & Dacks, J. B., Jul 2018, In: Traffic. 19, 7, p. 546-563 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Endosomes 100%
  • Eukaryota 92%
  • Endocytosis 45%
  • Trypanosoma brucei brucei 38%
  • Protein 36%
  9 Citations (Scopus)

  244 Downloads (Pure)
• 2017

  Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

  Field, M. C., Horn, D., Fairlamb, A. H., Ferguson, M. A. J., Gray, D. W., Read, K. D., De Rycker, M., Torrie, L. S., Wyatt, P. G., Wyllie, S. & Gilbert, I. H., Apr 2017, In: Nature Reviews Microbiology. 15, 4, p. 217-231 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Drug Discovery 100%
  • Public Health 69%
  • African Trypanosomiasis 68%
  • Disease Eradication 68%
  • Neglected Diseases 64%
  256 Citations (Scopus)

  395 Downloads (Pure)