Activation of the Heat Shock Response by Sulfhydryl-Reactive Chemoprotective Agents

2020

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

Zhang, Y., VanHecke, G. C., Ahn, Y.-H., Proby, C. M. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.

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4 Citations (Scopus)

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2017

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

Dinkova-Kostova, A. T. (Lead / Corresponding author), Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

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260 Citations (Scopus)

328 Downloads (Pure)

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C. & Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G. (Lead / Corresponding author), 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

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112 Citations (Scopus)

272 Downloads (Pure)

2016

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 15 Sept 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

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59 Citations (Scopus)

390 Downloads (Pure)

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T. & Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 849-861 13 p.

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78 Citations (Scopus)

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2015

Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G. (Lead / Corresponding author), 24 Sept 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

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101 Citations (Scopus)

New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C.-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T. (Lead / Corresponding author), 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

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28 Citations (Scopus)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J.T.-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T. (Lead / Corresponding author), Jun 2015, In: Cancer Prevention Research. 8, 6, p. 475-486 12 p.

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99 Citations (Scopus)

The emerging role of Nrf2 in mitochondrial function

Dinkova-Kostova, A. T. (Lead / Corresponding author) & Abramov, A. Y. (Lead / Corresponding author), Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

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763 Citations (Scopus)

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The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

Dinkova-Kostova, A. T. (Lead / Corresponding author), Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y. (Lead / Corresponding author), Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

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74 Citations (Scopus)

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T. (Lead / Corresponding author), Jan 2015, In: Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

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117 Citations (Scopus)

2014

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y.-H. (Lead / Corresponding author) & Dinkova-Kostova, A. T. (Lead / Corresponding author), 7 Jan 2014, In: British Journal of Cancer. 110, 1, p. 71-82 12 p.

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26 Citations (Scopus)

Synthesis of ¹³C₂¹⁵N₂-labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([¹³C₂¹⁵N₂]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method

Zheng, S., Huang, J. T.-J., Knatko, E. V., Sharp, S., Higgins, M., Ojima, I., Dinkova-Kostova, A. T. & Honda, T. (Lead / Corresponding author), Aug 2014, In: Journal of Labelled Compounds and Radiopharmaceuticals. 57, 10, p. 606-610 5 p.

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3 Citations (Scopus)

2012

Glucosinolates and isothiocyanates in health and disease

Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In: Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

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523 Citations (Scopus)

Activation of the Heat Shock Response by Sulfhydryl-Reactive Chemoprotective Agents

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