Aref#d: 19149. Role of Siglecs in Disease (Senior Research Fellowship)

Research output

Research output per year 2007 2009 2010 2011 2014 2014

• 31 Article

Research output per year

Research output per year

Search results

• 2014

  Group B Streptococcus engages an inhibitory siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo

  Chang, Y-C., Olson, J., Beasley, F. C., Tung, C., Zhang, J., Crocker, P. R., Varki, A. & Nizet, V., 2 Jan 2014, In: PLoS Pathogens. 10, 1, e1003846.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Streptococcus agalactiae 80%
  • sialic acid 69%
  • innate immunity 63%
  • immunoglobulins 61%
  98 Citations (Scopus)

  136 Downloads (Pure)

• Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction

  Stephenson, H. N., Mills, D. C., Jones, H., Milioris, E., Copland, A., Dorrell, N., Wren, B. W., Crocker, P. R., Escors, D. & Bajaj-Elliott, M., 1 Nov 2014, In: Journal of Infectious Diseases. 210, 9, p. 1487-1498 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 5,7-diacetamido-3,5,7,9-tetradeoxynonulosonic acid 100%
  • Sialic Acid Binding Immunoglobulin-like Lectins 77%
  • Flagellin 66%
  • Campylobacter jejuni 62%
  • Flagella 60%
  58 Citations (Scopus)

  155 Downloads (Pure)

• Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

  Chang, Y-C., Olson, J., Louie, A., Crocker, P. R., Varki, A. & Nizet, V., Sept 2014, In: Journal of Molecular Medicine. 92, 9, p. 951-959 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Streptococcus agalactiae 70%
  • Sialic Acid 63%
  • Macrophages 40%
  • Exopolysaccharide 39%
  36 Citations (Scopus)

  137 Downloads (Pure)

• Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model

  McMillan, S. J., Richards, H. E. & Crocker, P. R., 2014, In: Immunology Letters. 160, 1, p. 11-16 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Eosinophilia 68%
  • Allergens 59%
  • Theoretical Models 51%
  • Ovalbumin 28%
  17 Citations (Scopus)

  188 Downloads (Pure)
• 2013

  Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

  Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R., 15 Mar 2013, In: Journal of Immunology. 190, 6, p. 2593-2602 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Glycosylation 59%
  • Ligands 40%
  • T-Lymphocytes 35%
  • Lectins 9%
  20 Citations (Scopus)

• Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

  McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R., 14 Mar 2013, In: Blood. 121, 11, p. 2084-2094 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Sialic Acid 69%
  • Integrins 59%
  • Lectin 55%
  • Pneumonia 50%
  83 Citations (Scopus)

• Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation

  Kawasaki, N., Vela, J. L., Nycholat, C. M., Rademacher, C., Khurana, A., van Rooijen, N., Crocker, P. R., Kronenberg, M. & Paulson, J. C., 7 May 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 19, p. 7826-7831 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Natural Killer T-Cells 68%
  • Macrophages 40%
  • Lipids 37%
  • Antigens 36%
  92 Citations (Scopus)
• 2012

  Antigen delivery to macrophages using liposomal nanoparticles targeting Sialoadhesin/CD169

  Chen, W. C., Kawasaki, N., Nycholat, C. M., Han, S., Pilotte, J., Crocker, P. R. & Paulson, J. C., 19 Jun 2012, In: PLoS ONE. 7, 6, e39039.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Nanoparticles 51%
  • Macrophages 40%
  • Antigens 36%
  • Liposomes 24%
  86 Citations (Scopus)

• Sialoadhesin Promotes Rapid Proinflammatory and Type I IFN Responses to a Sialylated Pathogen, Campylobacter jejuni

  Klaas, M., Oetke, C., Lewis, L. E., Erwig, L. P., Heikema, A. P., Easton, A., Willison, H. J. & Crocker, P. R., 1 Sept 2012, In: Journal of Immunology. 189, 5, p. 2414-22 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Campylobacter jejuni 73%
  • Macrophages 12%
  • Spleen 8%
  • Interleukin-12 5%
  64 Citations (Scopus)
• 2011

  An expression system for screening of proteins for glycan and protein interactions

  Otto, D. M. E., Campanero-Rhodes, M. A., Karamanska, R., Powell, A. K., Bovin, N., Turnbull, J. E., Field, R. A., Blackburn, J., Feizi, T. & Crocker, P. R., 15 Apr 2011, In: Analytical Biochemistry. 411, 2, p. 261-270 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Polysaccharides 100%
  • Protein 43%
  • Proteins 39%
  • Sialic Acid Binding Immunoglobulin-like Lectins 30%
  • enhanced green fluorescent protein 24%
  12 Citations (Scopus)

• Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner

  Bax, M., Kuijf, M. L., Heikema, A. P., van Rijs, W., Bruijns, S. C. M., Garcia-Vallejo, J. J., Crocker, P. R., Jacobs, B. C., van Vliet, S. J. & van Kooyk, Y., Jul 2011, In: Infection and Immunity. 79, 7, p. 2681-2689 9 p.

  Research output: Contribution to journal › Article › peer-review

  • lipooligosaccharides 100%
  • lipid-linked oligosaccharides 96%
  • dendritic cells 83%
  • Campylobacter jejuni 81%
  • N-Acetylneuraminic Acid 72%
  64 Citations (Scopus)

• Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion

  Sardzik, R., Sharma, R., Kaloo, S., Voglmeir, J., Crocker, P. R. & Flitsch, S. L., 2011, In: Chemical Communications. 47, 19, p. 5425-5427 3 p.

  Research output: Contribution to journal › Article › peer-review

  • sialooligosaccharides 100%
  • Glycosylation 94%
  • Cell adhesion 79%
  • Carbohydrates 74%
  • Cell Adhesion 50%
  33 Citations (Scopus)

• Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil Siglec-8 expression

  Hudson, S. A., Herrmann, H., Du, J., Cox, P., Haddad, E-B., Butler, B., Crocker, P. R., Ackerman, S. J., Valent, P. & Bochner, B. S., Dec 2011, In: Journal of Clinical Immunology. 31, 6, p. 1045-1053 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Basophils 75%
  • Mast Cells 61%
  • Eosinophils 61%
  • Papio 22%
  51 Citations (Scopus)

• Early murine T-lymphocyte activation is accompanied by a switch from N-glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

  Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M. A., McKenzie, E., Haslam, S. M., Dell, A., Feizi, T. & Crocker, P. R., 7 Oct 2011, In: Journal of Biological Chemistry. 286, 40, p. 34522-34532 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuraminic Acids 100%
  • Sialic Acid Binding Immunoglobulin-like Lectins 99%
  • N-Acetylneuraminic Acid 83%
  • Lymphocyte Activation 67%
  • Lectin 64%
  38 Citations (Scopus)

• Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer

  Aalto, K., Autio, A., Kiss, E. A., Elima, K., Nymalm, Y., Veres, T. Z., Marttila-Ichihara, F., Elovaara, H., Saanijoki, T., Crocker, P. R., Maksimow, M., Bligt, E., Salminen, T. A., Salmi, M., Roivainen, A. & Jalkanen, S., 29 Sept 2011, In: Blood. 118, 13, p. 3725-3733 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Leukocytes 49%
  • Ligands 44%
  • Inflammation 37%
  • Blood Vessels 37%
  84 Citations (Scopus)

• Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids

  Zou, Z., Chastain, A., Moir, S., Ford, J., Trandem, K., Martinelli, E., Cicala, C., Crocker, P., Arthos, J. & Sun, P. D., 8 Sept 2011, In: PLoS ONE. 6, 9, p. - 15 p., e24559.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Sialic Acids 91%
  • HIV-1 54%
  • Mitogen Receptors 47%
  • Virus Diseases 46%
  77 Citations (Scopus)
• 2010

  Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides

  Heikema, A. P., Bergman, M. P., Richards, H., Crocker, P. R., Gilbert, M., Samsom, J. N., van Wamel, W. J. B., Endtz, H. P. & van Belkum, A., Jul 2010, In: Infection and Immunity. 78, 7, p. 3237-3246 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Guillain-Barre Syndrome 90%
  • lipooligosaccharides 90%
  • lipid-linked oligosaccharides 87%
  • Campylobacter jejuni 73%
  76 Citations (Scopus)

• In vivo targeting of B-cell lymphoma with glycan ligands of CD22

  Chen, W. C., Completo, G. C., Sigal, D. S., Crocker, P. R., Saven, A. & Paulson, J. C., 10 Jun 2010, In: Blood. 115, 23, p. 4778-4786 9 p.

  Research output: Contribution to journal › Article › peer-review

  • B-Cell Lymphoma 100%
  • Polysaccharides 90%
  • B-Lymphocytes 74%
  • Ligands 68%
  • Sialic Acid 53%
  164 Citations (Scopus)

• Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition

  Khatua, B., Ghoshal, A., Bhattacharya, K., Mandal, C., Saha, B., Crocker, P. R., Mandal, C. & Sonnino, S. (ed.), 5 Feb 2010, In: FEBS Letters. 584, 3, p. 555-561 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Sialic Acids 91%
  • Sialic Acid 69%
  • Pseudomonas aeruginosa 58%
  • human SIGLEC7 protein 28%
  60 Citations (Scopus)

• The M/GP(5) glycoprotein complex of Porcine Reproductive and Respiratory Syndrome Virus binds the sialoadhesin receptor in a sialic acid-dependent manner

  Van Breedam, W., Van Gorp, H., Zhang, J. Q., Crocker, P. R., Delputte, P. L. & Nauwynck, H. J., 15 Jan 2010, In: PLoS Pathogens. 6, 1, p. - 11 p., e1000730.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Porcine respiratory and reproductive syndrome virus 81%
  • Porcine reproductive and respiratory syndrome virus 73%
  • N-Acetylneuraminic Acid 66%
  • sialic acid 63%
  123 Citations (Scopus)
• 2009

  Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays

  Rinaldi, S., Brennan, K. M., Goodyear, C. S., O'Leary, C., Schiavo, G., Crocker, P. R. & Willison, H. J., Jul 2009, In: Glycobiology. 19, 7, p. 789-796 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycolipids 100%
  • Glycolipid 96%
  • Lectins 87%
  • Lectin 86%
  • Thin Layer Chromatography 22%
  51 Citations (Scopus)

• Analysis of sialoadhesin expression on mouse alveolar macrophages

  Ducreux, J., Crocker, P. R. & Vanbever, R., 4 Jun 2009, In: Immunology Letters. 124, 2, p. 77-80 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Alveolar Macrophages 63%
  • Macrophages 34%
  • Erythrocytes 25%
  • N-Acetylneuraminic Acid 18%
  18 Citations (Scopus)

• Enhancing the receptor affinity of the sialic acid-binding domain of Vibrio cholerae sialidase through multivalency

  Connaris, H., Crocker, P. R. & Taylor, G. L., 13 Mar 2009, In: Journal of Biological Chemistry. 284, 11, p. 7339-7351 13 p.

  Research output: Contribution to journal › Article › peer-review

  • sialic acid receptor 100%
  • Vibrio cholerae 75%
  • N-Acetylneuraminic Acid 69%
  • Neuraminidase 68%
  • Sialic Acid 66%
  35 Citations (Scopus)

• Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6 '-sulfated sialyl Lewis X

  Hudson, S. A., Bovin, N. V., Schnaar, R. L., Crocker, P. R. & Bochner, B. S., Aug 2009, In: Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 608-612 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Sialyl Lewis X Antigen 98%
  • Eosinophils 61%
  • Ligands 44%
  • Polysaccharides 37%
  65 Citations (Scopus)

• Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate

  Kivi, E., Elima, K., Aalto, K., Nymalm, Y., Auvinen, K., Koivunen, E., Otto, D. M., Crocker, P. R., Salminen, T. A., Salmi, M. & Jalkanen, S., 17 Dec 2009, In: Blood. 114, 26, p. 5385-5392 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Primary Amine 60%
  • Glycoprotein 57%
  • Molecular Modeling 56%
  • Hydrogen Peroxide 48%
  65 Citations (Scopus)

• PEGylation of anti-sialoadhesin monoclonal antibodies enhances their inhibitory potencies without impairing endocytosis in mouse peritoneal macrophages

  Ducreux, J., Tyteca, D., Ucakar, B., Medts, T., Crocker, P. R., Courtroy, P. J. & Vanbever, R., Feb 2009, In: Bioconjugate Chemistry. 20, 2, p. 295-303 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Macrophages 96%
  • 3D6 antibody 94%
  • Monoclonal antibodies 89%
  • Peritoneal Macrophages 63%
  9 Citations (Scopus)

• Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression

  Wu, C., Rauch, U., Korpos, E., Song, J., Loser, K., Crocker, P. R. & Sorokin, L. M., 15 May 2009, In: Journal of Immunology. 182, 10, p. 6508-6516 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Regulatory T-Lymphocytes 57%
  • Autoimmune Diseases 49%
  • Disease Progression 45%
  • Macrophages 40%
  71 Citations (Scopus)
• 2008

  Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection

  Zucchini, N., Bessou, G., Robbins, S. H., Chasson, L., Raper, A., Crocker, P. R. & Dalod, M., Jan 2008, In: International Immunology. 20, 1, p. 45-56 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendritic Cells 100%
  • Virus Diseases 82%
  • Cytokines 69%
  • Muromegalovirus 59%
  • Interleukin-12 43%
  51 Citations (Scopus)

• Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils

  Zimmermann, N., McBride, M. L., Yamada, Y., Hudson, S. A., Jones, C., Cromie, K. D., Crocker, P. R., Rothenberg, M. E. & Bochner, B. S., 2008, In: Allergy. 63, 9, p. 1156-1163 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Eosinophils 61%
  • Antibodies 34%
  • Apoptosis 8%
  • Pdgfra-Associated Chronic Eosinophilic Leukemia 8%
  120 Citations (Scopus)

• The inhibitory potencies of monoclonal antibodies to the macrophage adhesion molecule Sialoadhesin are greatly increased following PEGylation

  Ducreux, J., Vanbever, R. & Crocker, P. R., Oct 2008, In: Bioconjugate Chemistry. 19, 10, p. 2088-2094 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Ig-like Lectin 1 100%
  • Macrophages 96%
  • Monoclonal antibodies 89%
  • Antibodies 72%
  • Polyethylene glycols 59%
  5 Citations (Scopus)
• 2007

  Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates

  Jaroenpool, J., Rogers, K. A., Pattanapanyasat, K., Villinger, F., Onlamoon, N., Crocker, P. R. & Ansari, A. A., Nov 2007, In: Cellular Immunology. 250, 1-2, p. 91-104 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Primates 58%
  • Monocytes 52%
  • Sialic Acid Binding Ig-like Lectin 1 47%
  • Cercocebus atys 46%
  16 Citations (Scopus)