Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)

2016

CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription

Aregger, M., Kaskar, A., Varshney, D., Fernandez-Sanchez, M. E., Inesta-Vaquera, F. A., Weidlich, S. & Cowling, V. H. (Lead / Corresponding author), 3 Mar 2016, In: Molecular Cell. 61, 5, p. 734-746 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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45 Citations (Scopus)

218 Downloads (Pure)

c-Myc deregulation induces mRNA capping enzyme dependency

Lombardi, O., Varshney, D., Phillips, N. M. & Cowling, V. H. (Lead / Corresponding author), 16 Oct 2016, In: Oncotarget. 7, 50, p. 82273-82288 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

229 Downloads (Pure)

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM

Varshney, D., Petit, A.-P., Bueren-Calabuig, J. A., Jansen, C., Fletcher, D. A., Peggie, M., Weidlich, S., Scullion, P., Pisliakov, A. V. & Cowling, V. H. (Lead / Corresponding author), 1 Dec 2016, In: Nucleic Acids Research. 44, 21, p. 10423-10436 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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53 Citations (Scopus)

443 Downloads (Pure)

mRNA Cap methylation in pluripotency and differentiation

Grasso, L., Suska, O., Davidson, L., Gonatopoulos-Pournatzis, T., Williamson, R., Wasmus, L., Wiedlich, S., Peggie, M., Stavridis, M. P. & Cowling, V. H. (Lead / Corresponding author), 2 Aug 2016, In: Cell Reports. 16, 5, p. 1352-1365 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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26 Citations (Scopus)

238 Downloads (Pure)

2015

SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation

Varshney, D. (Lead / Corresponding author), Vavrova-Anderson, J., Oler, A. J., Cowling, V. H., Cairns, B. R. & White, R. J. (Lead / Corresponding author), 23 Mar 2015, In: Nature Communications. 6, 12 p., 6569.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Citations (Scopus)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. (Lead / Corresponding author), 4 Aug 2015, In: EMBO Journal. 34, 15, p. 2008-2024 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

133 Citations (Scopus)

Victoria Cowling

Cowling, V. & Bobrowska, A., 15 Aug 2015, In: Journal of Cell Science. 128, 16, p. 2953-2954 2 p.

Research output: Contribution to journal › Special issue › peer-review

2014

Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis

Cowling, V. H., Turner, S. A. & Cole, M. D. (Lead / Corresponding author), 3 Jul 2014, In: Oncogene. 33, p. 3519–3527 9 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

RAM function is dependent on Kapβ2-mediated nuclear entry

Gonatopoulos-Pournatzis, T. & Cowling, V. H., 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 473-484 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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15 Citations (Scopus)

184 Downloads (Pure)

2013

Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

Aregger, M. & Cowling, V. H., 18 Jul 2013, In: Biochemical Journal. 455, 1, p. 67-73 7 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. (Lead / Corresponding author), 2013, In: PLoS ONE. 8, 10, 16 p., e77537.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

2012

E2F1-dependent methyl cap formation requires RNA pol II phosphorylation

Aregger, M. & Cowling, V. H., 1 Jun 2012, In: Cell Cycle. 11, 11, p. 2146-2148 3 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2011

RAM/Fam103a1 is required for mRNA cap methylation

Gonatopoulos-Pournatzis, T., Dunn, S., Bounds, R. & Cowling, V. H. (Lead / Corresponding author), 18 Nov 2011, In: Molecular Cell. 44, 4, p. 585-596 12 p.

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

2010

Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation

Cowling, V. H., 11 Feb 2010, In: Oncogene. 29, 6, p. 930-936 7 p.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Myc regulation of mRNA cap methylation

Cowling, V. H. & Cole, M. D., Jun 2010, In: Genes and Cancer. 1, 6, p. 576-579 4 p.

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Regulation of mRNA cap methylation

Cowling, V. H., 15 Jan 2010, In: Biochemical Journal. 425, p. 295-302 8 p.

Research output: Contribution to journal › Review article › peer-review

169 Citations (Scopus)

2009

A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response

Chandriani, S., Frengen, E., Cowling, V. H., Pendergrass, S. A., Perou, C. M., Whitfield, M. L. & Cole, M. D., 2009, In: PLoS ONE. 4, 8, e6693.

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

Fernandez-Sanchez, M. E., Gonatopoulos-Pournatzis, T., Preston, G., Lawlor, M. A. & Cowling, V. H. (Lead / Corresponding author), 1 Dec 2009, In: Molecular and Cellular Biology. 29, 23, p. 6182-6191 10 p.

Research output: Contribution to journal › Article › peer-review