Keyphrases
Trypanosoma Brucei
69%
Active Sites
67%
Pseudomonas Aeruginosa (P. aeruginosa)
44%
Drug Discovery
40%
Leishmania Major
36%
Putative Drug Targets
32%
Crystal Form
31%
Escherichia Coli
29%
High-resolution Structures
28%
Serratia Marcescens
26%
Burkholderia Cenocepacia
26%
Staphylococcus Aureus
26%
Pteridine Reductase 1
26%
Methyl
24%
T. Brucei
23%
Structure-based Approaches
23%
Antibacterial Target
23%
Gram-negative Bacteria
23%
Erythritol
23%
Amino
21%
Orthologs
21%
Angstrom
21%
Methylenetetrahydrofolate Reductase (MTHFR)
20%
Type VI Secretion System
20%
Bloodstream Forms
19%
Membrane Components
17%
Reductase
17%
Type VII Secretion System
17%
Integral Membrane
17%
Kennedy Pathway
17%
Leishmania
17%
Tubulin Binding
17%
Cyclohydrolase
17%
IspF
17%
Menaquinone Biosynthesis
17%
PTR1
17%
Recombinant
16%
Asymmetric Unit
16%
Immunogenic Proteins
16%
Tubulin
16%
Triethanolamine
15%
Binding Site
15%
Orthologues
15%
Isochorismate
14%
Ligand Complexes
14%
Biochemical Characterization
14%
Binding Mode
14%
Catalytic Cycle
13%
Membrane Binding
13%
Chaperone
13%
Peptidoglycan
13%
Drug Target
13%
African Sleeping Sickness
12%
α-ketoglutarate (α-KG)
11%
Ligase
11%
Zn2+
11%
Cytoplasmic Membrane
11%
Signal Peptide
11%
Carboxylate
11%
Cyclohexadienes
11%
Amidase
11%
Diphosphate
11%
Family Members
11%
Trypanosomatids
11%
Structural Information
11%
Gene Cluster
11%
Virtual Screening
11%
Apicomplexan Parasites
11%
Structure-based Ligand Design
11%
Isoprenoid Compounds
10%
Ssp1
10%
Kinetoplastid
10%
Antibiotics
9%
Medium Resolution
9%
Atomic Structure
9%
Secreted Toxin
8%
Antimonials
8%
Toxin Protein
8%
Dihydropteroate Synthase
8%
Geobacillus Stearothermophilus
8%
PBP3
8%
Ceftazidime
8%
Penicillin-binding Proteins
8%
Transthyretin
8%
Microtubule Assembly
8%
Apo Form
8%
Antiprotozoal
8%
Deglutathionylation
8%
Uracil
8%
NiFe Hydrogenase
8%
Prodrug Activation
8%
Reductase Inhibitors
8%
Thiols
8%
Glutathione S-transferase
8%
IMPDH
8%
10-Formyltetrahydrofolate
8%
Acinetobacter Baumannii (A. baumannii)
8%
Tetragonal Crystal
8%
Control Function
8%
Hydrolytic Activity
8%
Purβ
8%
Synthetic Activity
8%
Adenylosuccinate Lyase
8%
Choline
8%
Ethanolamine Kinase
8%
D-alanine-D-alanine Ligase
8%
Choline Kinase
8%
Glutathione Synthetase
8%
Triclinic Crystals
8%
IspE
8%
Twin-arginine Translocation
8%
Ligand Discovery
8%
Dihydropyrimidin
8%
New Molecular Entity
8%
Kynurenine
8%
Formamidase
8%
FabF
8%
Oxygen Tolerance
8%
Recognition System
8%
Endopeptidase
8%
Cytosolic Carboxypeptidase
8%
PDB-REDO
8%
Glutaminase 1 (GLS1)
8%
Peptide Recognition
8%
CTP Synthetase
8%
Acivicin
8%
Spatial Conservation
8%
Trimeric
8%
EsxA
8%
Large Subunit
8%
Stetter
8%
Conjugate Addition
8%
Bifunctional
8%
Trypanothione Synthetase
8%
Carboxypeptidase
8%
GTPase
8%
Non-mevalonate Pathway
8%
Plasmodium Falciparum
8%
Antiparasitic
8%
ADP-ribosylation Factor
8%
Antimicrobial Therapy
8%
E3 Ubiquitin Ligase
8%
Tyrosine
8%
Lyase
8%
Acyl Carrier Protein
8%
Potassium Ion
8%
Burkholderia Pseudomallei
8%
Target Assessment
8%
Zinc
8%
Binuclear
8%
Bacillus Subtilis (B. subtilis)
8%
Antibiotic Drugs
8%
Nucleophile
8%
Diacylglycerol
8%
Virulence
8%
Ureido
8%
Catalytic Site
8%
SIAH1
8%
Diamino
8%
Ligand Binding Site
8%
Antibiotic Discovery
8%
Conformational Change
8%
Protozoan Parasites
8%
Glucose-6-phosphate Dehydrogenase (G6PD)
8%
Structure-based Design
8%
Adaptor Protein
8%
Inhibitor Discovery
8%
Quaternary Structure
8%
Cytidine
8%
Bound Form
8%
Metal Ions
8%
Glutathione
8%
Trypanosoma Species
8%
Structural Comparison
8%
Two-component Domains
8%
Sequence Comparison
8%
Enzyme Active Site
7%
Ssp2
7%
Pseudokinase
7%
Secretion Systems
7%
Protein Data Bank
7%
Protein-protein Interaction
7%
Compound Library
7%
Human Enzymes
7%
Phosphate
7%
Trypanothione
7%
Leishmania Species
7%
Ligand Binding
7%
Paucity
6%
L. Major
6%
Catalytic Intermediates
6%
Mevalonate
6%
Biosynthetic Pathway
6%
Crystallization
6%
High-resolution
6%
Diether
5%
Thiamine Diphosphate-dependent Enzymes
5%
Lipoproteins
5%
Cysteine
5%
Drug Development
5%
Biochemistry, Genetics and Molecular Biology
Enzyme
100%
Crystal Structure
92%
Active Site
61%
Oxidoreductase
52%
Pseudomonas aeruginosa
44%
Anabolism
38%
C-Terminus
37%
Leishmania Major
36%
Trypanosoma Brucei
33%
Synthase
27%
Staphylococcus Aureus
26%
Dehydrogenase
26%
Reductase
23%
N-Terminus
22%
Secretion (Process)
22%
Infectious Agent
21%
Alanine
20%
Binding Site
19%
Tubulin
19%
DNA Template
18%
Leishmania
17%
Serratia marcescens
17%
Burkholderia cenocepacia
17%
Membrane Component
17%
Type VII Secretion System
17%
Thiamine Pyrophosphate
17%
Gram Negative Bacterium
17%
Escherichia coli
16%
Precursor
16%
Ligase
15%
Peptidoglycan
15%
Type VI Secretion System
13%
Thiol
12%
Ligand Binding
11%
Hydrolase
11%
Signal Peptide
11%
Amidase
11%
Vitamin K2
11%
Conjugate
11%
Cell Membrane
11%
Trypanosomatidae
11%
Trypanosoma
11%
Structure Activity Relation
11%
GTPase
10%
Adenosine Monophosphate
10%
Protozoon
10%
Trypanothione
9%
Carboxypeptidase
8%
Geobacillus stearothermophilus
8%
Microtubule Assembly
8%
Ceftazidime
8%
Kinetoplastida
8%
ADP Ribosylation Factor
8%
Dihydropteroate Synthase
8%
Acyl Carrier Protein
8%
NiFe Hydrogenase
8%
Glutathione S-Transferase
8%
Inosinic Acid
8%
Dihydropyrimidine Dehydrogenase
8%
Acinetobacter Baumannii
8%
Adenylosuccinate Lyase
8%
10-Formyltetrahydrofolate
8%
CTP Synthetase
8%
Glutaminase
8%
Penicillin Binding Protein
8%
Ubiquitin-Conjugating Enzyme
8%
Transthyretin
8%
Burkholderia pseudomallei
8%
Apicomplexa
8%
Phosphogluconate Dehydrogenase
8%
Protease
8%
Kynurenine
8%
Arginine
8%
Tyrosine
8%
Lyase
8%
Phospholipid
8%
Mutagenesis
8%
Site-Directed Mutagenesis
8%
Steady State
8%
Catalytic Efficiency
8%
Glutathione Synthetase
8%
Glutathione Synthase
8%
Conformational Change
8%
Metabolite
8%
Protein Data Bank
7%
Glutamic Acid
6%
Non-Mevalonate Pathway
6%
Genetics
6%
Lipoprotein
5%
Tryptophan
5%
Molecular Recognition
5%
Protein Tertiary Structure
5%
Enzyme Active Site
5%
Pyrophosphate
5%
Glutathione
5%
Gram Positive Bacterium
5%
Protein-Protein Interaction
5%
Pharmacology, Toxicology and Pharmaceutical Science
Trypanosoma Brucei
47%
Drug Discovery
37%
Synthetase
33%
Escherichia coli
31%
Pteridine
26%
Erythritol
26%
Oxidoreductase
26%
Infectious Agent
25%
Diseases
22%
Methylenetetrahydrofolate Dehydrogenase
19%
Isoprenoid
18%
Pseudomonas aeruginosa
17%
Leishmania
17%
Antiinfective Agent
17%
Menaquinone
17%
Carboxylate
17%
Antimicrobial Agent
17%
Ethanolamine
17%
Gram Negative Bacterium
16%
Trypanosoma
16%
Ligase
15%
Alanine
15%
Protozoon
14%
Virtual Screening
13%
Mevalonic Acid
13%
Apicomplexa
13%
Thiamine Pyrophosphate
13%
Trypanosomatidae
11%
Infection
11%
Hydrolase
10%
Adenosine Phosphate
10%
African Trypanosomiasis
10%
Leishmania Major
9%
Phosphotransferase
9%
Metal Ion
9%
Synapsin II
8%
Penicillin Binding Protein
8%
Ceftazidime
8%
Trypanothione
8%
Amidase
8%
Zinc Ion
8%
Staphylococcus Aureus
8%
Antimicrobial Therapy
8%
Dihydrofolate Reductase Inhibitor
8%
Choline Kinase
8%
Ethanolamine Kinase
8%
Folinic Acid
8%
Adenylosuccinate Lyase
8%
Drug Development
8%
Burkholderia pseudomallei
8%
Antibiotic Agent
8%
2 Oxoglutaric Acid
8%
Burkholderia cenocepacia
8%
Glutaminase
8%
Cytidine Triphosphate Synthase
8%
Acivicin
8%
Plasmodium falciparum
8%
Antiparasitic Activity
8%
Hydrogenase
8%
Phospholipid
8%
Adenosine Triphosphate
7%
Binding Site
7%
Farnoquinone
7%
Lead Compound
7%
Tropical Disease
7%
Choline
5%
Phosphoethanolamine
5%
Natural Product
5%
Dimer
5%
Crystallization
5%