Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

Hunter, Bill (Investigator)

Biological Chemistry and Drug Discovery

44 results

2019
Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target
Díaz‐Sáez, L., Torrie, L. S., McElroy, S. P., Gray, D. & Hunter, W. M. (Lead / Corresponding author), 18 Nov 2019, In: FEBS Journal. 286, 22, p. 4509-4524 16 p.
Research output: Contribution to journal › Article › peer-review

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2017
An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain-acivicin complex
de Souza, J. O., Dawson, A. & Hunter, W. N. (Lead / Corresponding author), 20 Apr 2017, In: ChemMedChem. 12, 8, p. 577-579 3 p.
Research output: Contribution to journal › Article › peer-review

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2015
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido based inhibitors of Trypanosoma brucei FolD and testing for antiparasitic activity
Eadsforth, T. C., Pinto, A., Luciani, R., Tamborini, L., Cullia, G., De Micheli, C., Marinelli, L., Cosconati, S., Novellino, E., Lo Presti, L., Cordeiro Da Silva, A., Conti, P. (Lead / Corresponding author), Hunter, W. N. (Lead / Corresponding author) & Costi, M. P. (Lead / Corresponding author), 22 Oct 2015, In: Journal of Medicinal Chemistry. 58, 20, p. 7938-7948 11 p.
Research output: Contribution to journal › Article › peer-review
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Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major
Barrack, K. L., Fyfe, P. K., Finney, A. J. & Hunter, W. N. (Lead / Corresponding author), May 2015, In: Molecular and Biochemical Parasitology. 201, 1, p. 26-30 5 p.
Research output: Contribution to journal › Article › peer-review
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Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form
Baum, B., Lecker, L. S. M., Zoltner, M., Jaenicke, E., Schnell, R., Hunter, W. N. (Lead / Corresponding author) & Brenk, R. (Lead / Corresponding author), Aug 2015, In: Acta Crystallographica Section F: Structural Biology Communications. 71, 8, p. 1020-1026 7 p.
Research output: Contribution to journal › Article › peer-review
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The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly
Barrack, K. L., Fyfe, P. K. & Hunter, W. N. (Lead / Corresponding author), May 2015, In: Acta Crystallographica Section F: Structural Biology Communications. 71, 5, p. 539-546 8 p.
Research output: Contribution to journal › Article › peer-review
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2014
Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment
O'Rourke, P. E. F., Kalinowska-Tłuścik, J., Fyfe, P. K., Dawson, A. & Hunter, W. N. (Lead / Corresponding author), 10 Jan 2014, In: BMC Structural Biology. 14, 12 p., 1.
Research output: Contribution to journal › Article › peer-review

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High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies
Rimsa, V., Eadsforth, T. C., Joosten, R. P. & Hunter, W. N. (Lead / Corresponding author), Feb 2014, In: Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 279-289 11 p.
Research output: Contribution to journal › Article › peer-review

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How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase
Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. & Sargent, F. (Lead / Corresponding author), 28 Feb 2014, In: Biochemical Journal. 458, 3, p. 449-458 10 p.
Research output: Contribution to journal › Article › peer-review

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Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile
Díaz-Sáez, L., Srikannathasan, V., Zoltner, M. & Hunter, W. N. (Lead / Corresponding author), 15 Sept 2014, In: Biochemical Journal. 462, 3, p. 581-589 9 p.
Research output: Contribution to journal › Article › peer-review

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The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei
Lilley, A. C., Major, L., Young, S., Stark, M. J. R. & Smith, T. K. (Lead / Corresponding author), May 2014, In: Molecular Microbiology. 92, 3, p. 453-470 18 p.
Research output: Contribution to journal › Article › peer-review

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2013
Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment
Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 469-477 9 p.
Research output: Contribution to journal › Article › peer-review
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Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens
Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. (Lead / Corresponding author) & Hunter, W. N. (Lead / Corresponding author), Dec 2013, In: Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.
Research output: Contribution to journal › Article › peer-review

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Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii
Dawson, A., Trumper, P., Chrysostomou, G. & Hunter, W. N., 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 6, p. 611-617 7 p.
Research output: Contribution to journal › Article › peer-review
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Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase
Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N., 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.
Research output: Contribution to journal › Article › peer-review
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The architecture of EssB, an integral membrane component of the type VII secretion system
Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. (Lead / Corresponding author), 2 Apr 2013, In: Structure. 21, 4, p. 595-603 9 p.
Research output: Contribution to journal › Article › peer-review
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Two high-resolution structures of the human E3 ubiquitin ligase Siah1
Rimsa, V., Eadsforth, T. C. & Hunter, W. N., Dec 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 12, p. 1339-1343 5 p.
Research output: Contribution to journal › Article › peer-review
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2012
Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target
Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N., 2012, In: PLoS ONE. 7, 4, p. - 11 p., e35973.
Research output: Contribution to journal › Article › peer-review
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Conserved signal peptide recognition systems across the prokaryotic domains
Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F. (Lead / Corresponding author), 28 Feb 2012, In: Biochemistry. 51, 8, p. 1678-1686 9 p.
Research output: Contribution to journal › Article › peer-review
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Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation
Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. (Lead / Corresponding author), 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698 6 p.
Research output: Contribution to journal › Article › peer-review
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New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens
English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. (Lead / Corresponding author), Nov 2012, In: Molecular Microbiology. 86, 4, p. 921-936 16 p.
Research output: Contribution to journal › Article › peer-review
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The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target
Eadsforth, T. C., Cameron, S. & Hunter, W. N., Feb 2012, In: Molecular and Biochemical Parasitology. 181, 2, p. 178-185 8 p.
Research output: Contribution to journal › Article › peer-review
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2011
Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate
Morgan, R. E., Batot, G. O., Dement, J. M., Rao, V. A., Eadsforth, T. C. & Hunter, W. N., 9 May 2011, In: BMC Structural Biology. 11, p. - 9 p., 21.
Research output: Contribution to journal › Article › peer-review
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Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
Sainsbury, S., Bird, L., Rao, V., Shepherd, S. M., Stuart, D. I., Hunter, W. N., Owens, R. J. & Ren, J., 7 Jan 2011, In: Journal of Molecular Biology. 405, 1, p. 173-184 12 p.
Research output: Contribution to journal › Article › peer-review
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Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites
Hunter, W. N., Aug 2011, In: Current Topics in Medicinal Chemistry. 11, 16, p. 2048-2059 12 p.
Research output: Contribution to journal › Review article › peer-review
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Pseudomonas aeruginosa 4-Amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme
O'Rourke, P. E. F., Eadsforth, T. C., Fyfe, P. K., Shepherd, S. M. & Hunter, W. N., 15 Sept 2011, In: PLoS ONE. 6, 9, p. - 8 p., e24158.
Research output: Contribution to journal › Article › peer-review
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The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system
Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N., Dec 2011, In: Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072 8 p.
Research output: Contribution to journal › Article › peer-review
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2010
A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure
Kalinowska-Tluscik, J., Miallau, L., Gabrielsen, M., Leonard, G. A., McSweeney, S. M. & Hunter, W. N., Mar 2010, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 66, p. 237-241 5 p.
Research output: Contribution to journal › Article › peer-review
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Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid
Fleming, J. R., Dawson, A. & Hunter, W. N., Dec 2010, In: Molecular and Biochemical Parasitology. 174, 2, p. 141-144 4 p.
Research output: Contribution to journal › Article › peer-review
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High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target
Dawson, A., Tulloch, L. B., Barrack, K. L. & Hunter, W. N., Dec 2010, In: Acta Crystallographica Section D: Biological Crystallography. 66, p. 1334-1340 7 p.
Research output: Contribution to journal › Article › peer-review
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Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis
Dawson, A., Chen, M., Fyfe, P. K., Guo, Z. & Hunter, W. N., 13 Aug 2010, In: Journal of Molecular Biology. 401, 2, p. 253-264 12 p.
Research output: Contribution to journal › Article › peer-review
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Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the Leishmaniases
Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N. (Lead / Corresponding author), 14 Jan 2010, In: Journal of Medicinal Chemistry. 53, 1, p. 221-229 9 p.
Research output: Contribution to journal › Article › peer-review
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Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
Fyfe, P. K., Dawson, A., Hutchison, M.-T., Cameron, S. & Hunter, W. N., Aug 2010, In: Acta Crystallographica Section D: Biological Crystallography. 66, p. 881-888 8 p.
Research output: Contribution to journal › Article › peer-review
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Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme
Fyfe, P. K., Alphey, M. S. & Hunter, W. N., Apr 2010, In: Molecular and Biochemical Parasitology. 170, 2, p. 93-99 7 p.
Research output: Contribution to journal › Article › peer-review
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2009
A Structure-Based Approach to Ligand Discovery for 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy
Ramsden, N. L., Buetow, L., Dawson, A., Kemp, L. A., Ulaganathan, V., Brenk, R., Klebe, G. & Hunter, W. N., 23 Apr 2009, In: Journal of Medicinal Chemistry. 52, 8, p. 2531-2542 12 p.
Research output: Contribution to journal › Article › peer-review
18 Link opens in a new tab Citations (Scopus)
Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
Cameron, S., Martini, V. P., Iulek, J. & Hunter, W. N., May 2009, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 65, p. 450-454 5 p.
Research output: Contribution to journal › Article › peer-review
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One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening
Mpamhanga, C. P., Spinks, D., Tulloch, L. B., Shanks, E. J., Robinson, D. A., Collie, I. T., Fairlamb, A. H., Wyatt, P. G., Frearson, J. A., Hunter, W. N., Gilbert, I. H. & Brenk, R., 23 Jul 2009, In: Journal of Medicinal Chemistry. 52, 14, p. 4454-4465 12 p.
Research output: Contribution to journal › Article › peer-review
92 Link opens in a new tab Citations (Scopus)
Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide
Fyfe, P. K., Rao, V. A., Zemla, A., Cameron, S. & Hunter, W. N. (Lead / Corresponding author), 2009, In: Angewandte Chemie International Edition. 48, 48, p. 9176-9179 4 p.
Research output: Contribution to journal › Article › peer-review

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Structure-based ligand design and the promise held for antiprotozoan drug discovery
Hunter, W. N., 1 May 2009, In: Journal of Biological Chemistry. 284, 18, p. 11749-11753 5 p.
Research output: Contribution to journal › Review article › peer-review
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The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei
Gibellini, F., Hunter, W. N. & Smith, T. K., Sept 2009, In: Molecular Microbiology. 73, 5, p. 826-843 18 p.
Research output: Contribution to journal › Article › peer-review
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2008
Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases
Gibellini, F., Hunter, W. N. & Smith, T. K., 2008, In: Biochemical Journal. 415, p. 135-144 10 p.
Research output: Contribution to journal › Article › peer-review

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Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
Fyfe, P. K., Oza, S. L., Fairlamb, A. H. & Hunter, W. N. (Lead / Corresponding author), 20 Jun 2008, In: Journal of Biological Chemistry. 283, 25, p. 17672-17680 9 p.
Research output: Contribution to journal › Article › peer-review
93 Link opens in a new tab Citations (Scopus)
Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase)
Dawson, A., Fyfe, P. K. & Hunter, W. N., 31 Dec 2008, In: Journal of Molecular Biology. 384, 5, p. 1353-1368 16 p.
Research output: Contribution to journal › Article › peer-review
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Structure of staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein
Sundaramoorthy, R., Fyfe, P. K. & Hunter, W. N., 14 Nov 2008, In: Journal of Molecular Biology. 383, 3, p. 603-614 12 p.
Research output: Contribution to journal › Article › peer-review
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