Keyphrases
Trypanosoma Brucei
100%
T. Brucei
38%
Drug Discovery
26%
Drug Target
20%
Active Sites
19%
Bloodstream Forms
19%
Trypanosomatids
18%
Human African Trypanosomiasis
16%
Putative Drug Targets
14%
Leishmania
13%
Pteridine Reductase 1
13%
Pseudomonas Aeruginosa (P. aeruginosa)
13%
Trypanothione Reductase
13%
Plasmodium Falciparum
12%
Escherichia Coli
12%
Protozoan Parasites
12%
African Sleeping Sickness
11%
Leishmania Major
11%
Trypanosome
11%
Visceral Leishmaniasis
11%
Trypanothione Synthetase
11%
African Trypanosomes
11%
Leishmania Donovani
10%
Methylenetetrahydrofolate Reductase (MTHFR)
10%
Virulence
10%
Trypanothione
10%
Angstrom
10%
Staphylococcus Aureus
10%
Phosphoglycan
10%
Procyclic Form
9%
GPI-anchored Protein (GPI-AP)
9%
Causative Agents
9%
Bloodstream
9%
Phosphoinositide 3-kinase (PI3K)
9%
Glucose-6-phosphate Dehydrogenase (G6PD)
8%
Null mutant
8%
Compound Library
8%
Crystal Form
8%
Life Cycle Stages
8%
Malaria
8%
Amino
8%
Spike Glycoprotein
8%
EC50
7%
Double Knockout
7%
Glycoprotein
7%
PTR1
7%
Surface Coat
7%
Binding Mode
7%
High-throughput Screening
7%
Oligosaccharyltransferase
7%
SILAC
7%
Methyl
7%
Proteomic Analysis
7%
Glutathione
7%
Reductase
7%
Chaperone
7%
Tryparedoxin
7%
Recombinant
7%
Type VI Secretion System
6%
Serratia Marcescens
6%
Pyrrolone
6%
Integral Membrane
6%
Membrane Components
6%
Type VII Secretion System
6%
Structure-activity Relationship Studies
6%
Kennedy Pathway
6%
Cyclohydrolase
6%
Phosphoproteomics
6%
Menaquinone Biosynthesis
6%
Inhibitor Discovery
6%
Erythritol
6%
Antitrypanosomal Activity
6%
Amidase
6%
Bifunctional
6%
L. Major
6%
(GlcNAc)2
6%
Leishmania Parasites
6%
Excellent Selectivity
6%
Rodent Models
6%
Protein Kinase
6%
N-acetylglucosamine
6%
Triethanolamine
5%
New Drugs
5%
Fexinidazole
5%
Virtual Screening
5%
Kinome
5%
Gram-negative Bacteria
5%
Trypanosoma Cruzi (T. cruzi)
5%
Isochorismate
5%
Structure-based Approaches
5%
Antibacterial Target
5%
N-glycosylation
5%
Phosphorylation Sites
5%
Galactose
5%
Orthologs
5%
Spermidine
5%
Membrane Anchor
5%
Asymmetric Unit
5%
High Content
5%
Antiparasitic Drug Discovery
5%
Structural Biology
5%
Antimalarial Drugs
5%
Protein Data Bank
5%
Kinetoplastid
5%
Novel Inhibitors
5%
Effector Proteins
5%
Mammalian Cell Lines
5%
Membrane Binding
5%
Glycoconjugates
5%
Biochemistry, Genetics and Molecular Biology
Trypanosoma Brucei
72%
Enzyme
46%
Crystal Structure
29%
Oxidoreductase
28%
Anabolism
21%
Trypanosoma
18%
Active Site
17%
Reductase
17%
Glycoprotein
16%
Synthase
14%
Trypanosomatidae
14%
Trypanothione
14%
Kinase
13%
Phosphotransferase
13%
Pseudomonas aeruginosa
13%
Leishmania Major
11%
Leishmania
11%
C-Terminus
11%
Glycosylation
11%
Protozoon
10%
Dehydrogenase
10%
Staphylococcus Aureus
10%
Glycosylphosphatidylinositol
9%
Proteomics
9%
Escherichia coli
9%
N-Terminus
8%
Secretion (Process)
8%
Lipid
8%
Thiol
7%
Genetics
7%
Oligosaccharyltransferase
7%
Galactose
7%
Polysaccharide
7%
Glutathione
7%
Membrane Component
6%
Type VII Secretion System
6%
Peroxidase
6%
Phosphogluconate Dehydrogenase
6%
Amidase
6%
Dihydrofolate Reductase
6%
Thiamine Pyrophosphate
6%
Kinome
6%
Infectious Agent
6%
Conformational Change
5%
Ligase
5%
Glutathione Peroxidase
5%
Thymidylate Synthase
5%
Amino Acids
5%
Wild Type
5%
Protein Kinases
5%
Threonine
5%
Phosphoinositide 3-Kinase
5%
Trypanosoma Cruzi
5%
Protein Data Bank
5%
Protein Secondary Structure
5%
Tyrosine
5%
Pharmacology, Toxicology and Pharmaceutical Science
Trypanosoma Brucei
59%
Drug Discovery
28%
Trypanosoma
24%
Synthetase
21%
Leishmania
19%
African Trypanosomiasis
18%
Trypanothione
17%
Oxidoreductase
15%
Pteridine
14%
Escherichia coli
13%
Antimalarial Agent
13%
Trypanothione Reductase
13%
Diseases
13%
Protozoon
13%
Trypanosomatidae
10%
Visceral Leishmaniasis
10%
Drug Development
10%
Structure Activity Relationship
9%
Plasmodium falciparum
8%
Dihydrofolate Reductase
8%
Carboxylate
8%
Leishmania Major
8%
Pharmaceutical Chemistry
7%
Fexinidazole
7%
EC50
6%
Methylenetetrahydrofolate Dehydrogenase
6%
Antimalarial Activity
6%
Pseudomonas aeruginosa
6%
Erythritol
6%
Virtual Screening
6%
Menaquinone
6%
Peroxidase
6%
Amidase
6%
Ethanolamine
6%
Adenosine Triphosphate
5%
Ligase
5%
Nitroreductase
5%
Thymidylate Synthase
5%
Glycoprotein
5%
Phosphotransferase
5%
Leishmania donovani
5%
Protein Kinases
5%
Piperidine
5%
Thymidine
5%
Phosphogluconate Dehydrogenase
5%
Thiamine Pyrophosphate
5%