Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

Fairlamb, Alan (Investigator)
Ferguson, Michael (Investigator)
Frearson, Julie (Investigator)

90 Article
4 Review article
1 Chapter (peer-reviewed)

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2025
Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes
Ong, H. B., Wyllie, S. & Fairlamb, A. H. (Lead / Corresponding author), Jul 2025, In: PLoS Neglected Tropical Diseases. 19, 7, 16 p., e0013332.
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2020
PDBE-KB: A community-driven resource for structural and functional annotations
PDBe-KB consortium, 8 Jan 2020, In: Nucleic Acids Research. 48, D1, p. D344-D353 10 p.
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2017
Screening a protein kinase inhibitor library against Plasmodium falciparum
Hallyburton, I., Grimaldi, R., Woodland, A., Baragana, B., Luksch, T., Spinks, D., James, D., Leroy, D., Waterson, D., Fairlamb, A. H., Wyatt, P. G., Gilbert, I. H. (Lead / Corresponding author) & Frearson, J. A., 7 Nov 2017, In: Malaria Journal. 16, p. 1-11 11 p., 446.
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2015
Discovery and optimisation studies of antimalarial phenotypic hits
Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H. (Lead / Corresponding author), 20 Oct 2015, In: European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.
Research output: Contribution to journal › Article › peer-review
18 Link opens in a new tab Citations (Scopus)
Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: A potential role for homoserine kinase in insect-stage Trypanosoma brucei
Ong, H. B., Lee, W. S., Patterson, S., Wyllie, S. & Fairlamb, A. H., 1 Jan 2015, In: Molecular Microbiology. 95, 1, p. 143-156 14 p.
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2013
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog
Nguyen, S., Jones, D. C., Wyllie, S., Fairlamb, A. H. & Phillips, M. A., 24 May 2013, In: Journal of Biological Chemistry. 288, 21, p. 15256-15267 12 p.
Research output: Contribution to journal › Article › peer-review

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A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei
Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sept 2013, In: ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.
Research output: Contribution to journal › Article › peer-review
24 Link opens in a new tab Citations (Scopus)
Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation
Wyllie, S., Patterson, S. & Fairlamb, A. H., Feb 2013, In: Antimicrobial Agents and Chemotherapy. 57, 2, p. 901-906 6 p.
Research output: Contribution to journal › Article › peer-review
57 Link opens in a new tab Citations (Scopus)
Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment
Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 469-477 9 p.
Research output: Contribution to journal › Article › peer-review
21 Link opens in a new tab Citations (Scopus)
Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis
Perry, M. R., Wyllie, S., Raab, A., Feldmann, J. & Fairlamb, A. H. (Lead / Corresponding author), 2013, In: Proceedings of the National Academy of Sciences. n/a, n/a.
Research output: Contribution to journal › Article › peer-review
61 Link opens in a new tab Citations (Scopus)
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.
De Rycker, M. (Lead / Corresponding author), Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W., Jul 2013, In: Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.
Research output: Contribution to journal › Article › peer-review
134 Link opens in a new tab Citations (Scopus)
Discovery and structure-activity relationships of pyrrolone antimalarials
Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H. (Lead / Corresponding author), 2013, In: Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.
Research output: Contribution to journal › Article › peer-review
71 Link opens in a new tab Citations (Scopus)
Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design
Pizarro, J. C. (Lead / Corresponding author), Hills, T., Senisterra, G., Wernimont, A. K., Mackenzie, C., Norcross, N. R., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & Hui, R., 17 Oct 2013, In: PLoS Neglected Tropical Diseases. 7, 10, e2492.
Research output: Contribution to journal › Article › peer-review

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Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei
Urbaniak, M. D., Martin, D. M. A. & Ferguson, M. A. J., 3 May 2013, In: Journal of Proteome Research. 12, 5, p. 2233-2244 12 p.
Research output: Contribution to journal › Article › peer-review
152 Link opens in a new tab Citations (Scopus)
Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device
Sullivan, L., Wall, S. J., Carrington, M. & Ferguson, M. A. J., 28 Feb 2013, In: PLoS Neglected Tropical Diseases. 7, 2, 14 p., e2087.
Research output: Contribution to journal › Article › peer-review
48 Link opens in a new tab Citations (Scopus)
Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents
Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H. (Lead / Corresponding author), 2013, In: ChemMedChem.
Research output: Contribution to journal › Article › peer-review
37 Link opens in a new tab Citations (Scopus)
Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi
Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J., 19 Apr 2013, In: Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.
Research output: Contribution to journal › Article › peer-review
22 Link opens in a new tab Citations (Scopus)
Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii
Dawson, A., Trumper, P., Chrysostomou, G. & Hunter, W. N., 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 6, p. 611-617 7 p.
Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus)
Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase
Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N., 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.
Research output: Contribution to journal › Article › peer-review
15 Link opens in a new tab Citations (Scopus)
The architecture of EssB, an integral membrane component of the type VII secretion system
Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. (Lead / Corresponding author), 2 Apr 2013, In: Structure. 21, 4, p. 595-603 9 p.
Research output: Contribution to journal › Article › peer-review
15 Link opens in a new tab Citations (Scopus)
The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis
Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. (Lead / Corresponding author) & Fairlamb, A. H. (Lead / Corresponding author), Oct 2013, In: Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.
Research output: Contribution to journal › Article › peer-review
62 Link opens in a new tab Citations (Scopus)
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy
Ong, H. B., Sienkiewicz, N., Wyllie, S., Patterson, S. & Fairlamb, A. H., Oct 2013, In: Molecular Microbiology. 90, 2, p. 443-455 13 p.
Research output: Contribution to journal › Article › peer-review
21 Link opens in a new tab Citations (Scopus)
2012
Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target
Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N., 2012, In: PLoS ONE. 7, 4, p. - 11 p., e35973.
Research output: Contribution to journal › Article › peer-review
20 Link opens in a new tab Citations (Scopus)
A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes
De Rycker, M. (Lead / Corresponding author), O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H., 29 Nov 2012, In: PLoS Neglected Tropical Diseases. 6, 11, p. e1932
Research output: Contribution to journal › Article › peer-review
31 Link opens in a new tab Citations (Scopus)
Automated design of ligands to polypharmacological profiles
Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X.-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Gilbert, I. H. & Roth, B. L. (Lead / Corresponding author) & 1 others, Hopkins, A. L. (Lead / Corresponding author), 13 Dec 2012, In: Nature. 492, 7428, p. 215-220 8 p.
Research output: Contribution to journal › Article › peer-review
728 Link opens in a new tab Citations (Scopus)
Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. (Lead / Corresponding author), Oct 2012, In: Molecular Microbiology. 86, 1, p. 51-64 14 p.
Research output: Contribution to journal › Article › peer-review
28 Link opens in a new tab Citations (Scopus)
Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei
Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 2012, In: ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.
Research output: Contribution to journal › Article › peer-review
51 Link opens in a new tab Citations (Scopus)
Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages
Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J., 2012, In: PLoS ONE. 7, 5, p. - 8 p., e36619.
Research output: Contribution to journal › Article › peer-review
136 Link opens in a new tab Citations (Scopus)
Conserved signal peptide recognition systems across the prokaryotic domains
Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F. (Lead / Corresponding author), 28 Feb 2012, In: Biochemistry. 51, 8, p. 1678-1686 9 p.
Research output: Contribution to journal › Article › peer-review
24 Link opens in a new tab Citations (Scopus)
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H., 2 Jan 2012, In: ChemMedChem. 7, 1, p. 95-106 12 p.
Research output: Contribution to journal › Article › peer-review
43 Link opens in a new tab Citations (Scopus)

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IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold
Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H.-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H., 29 Jun 2012, In: Journal of Biological Chemistry. 287, 27, p. 22483-22496 14 p.
Research output: Contribution to journal › Article › peer-review
23 Link opens in a new tab Citations (Scopus)
Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation
Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. (Lead / Corresponding author), 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698 6 p.
Research output: Contribution to journal › Article › peer-review
41 Link opens in a new tab Citations (Scopus)
Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei
Mehlert, A., Wormald, M. R. & Ferguson, M. A. J. (Lead / Corresponding author), Apr 2012, In: PLoS Pathogens. 8, 4, p. - 11 p., e1002618.
Research output: Contribution to journal › Article › peer-review
38 Link opens in a new tab Citations (Scopus)
New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens
English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. (Lead / Corresponding author), Nov 2012, In: Molecular Microbiology. 86, 4, p. 921-936 16 p.
Research output: Contribution to journal › Article › peer-review
108 Link opens in a new tab Citations (Scopus)
Quantifying the chemical beauty of drugs
Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. (Lead / Corresponding author), Feb 2012, In: Nature Chemistry. 4, 2, p. 90-98 9 p.
Research output: Contribution to journal › Article › peer-review
1820 Link opens in a new tab Citations (Scopus)
Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials
Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S. (Lead / Corresponding author), González-Pacanowska, D. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 2012, In: Journal of Medicinal Chemistry. 55, 24, p. 10948-57 10 p.
Research output: Contribution to journal › Article › peer-review
36 Link opens in a new tab Citations (Scopus)
The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis
Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H. (Lead / Corresponding author), 1 Feb 2012, In: Science Translational Medicine. 4, 119, p. - 7 p., 119re1.
Research output: Contribution to journal › Article › peer-review
137 Link opens in a new tab Citations (Scopus)
The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target
Eadsforth, T. C., Cameron, S. & Hunter, W. N., Feb 2012, In: Molecular and Biochemical Parasitology. 181, 2, p. 178-185 8 p.
Research output: Contribution to journal › Article › peer-review
8 Link opens in a new tab Citations (Scopus)
The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei
Kuettel, S., Wadum, M. C. T., Guther, M. L. S., Marino, K., Riemer, C. & Ferguson, M. A. J. (Lead / Corresponding author), Apr 2012, In: Molecular Microbiology. 84, 2, p. 340-351 12 p.
Research output: Contribution to journal › Article › peer-review
19 Link opens in a new tab Citations (Scopus)
The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases
Izquierdo, L., Mehlert, A. & Ferguson, M. A. J., May 2012, In: Glycobiology. 22, 5, p. 696-703 8 p.
Research output: Contribution to journal › Article › peer-review
22 Link opens in a new tab Citations (Scopus)
Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases
Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. & Bickle, Q. D. (Lead / Corresponding author), 31 Jul 2012, In: PLoS Neglected Tropical Diseases. 6, 7, 11 p., e1762.
Research output: Contribution to journal › Article › peer-review
89 Link opens in a new tab Citations (Scopus)
2011
Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism
Konig, J., Wyllie, S., Wells, G., Stevens, M. F., Wyatt, P. G. & Fairlamb, A. H., 11 Mar 2011, In: Journal of Biological Chemistry. 286, 10, p. 8523-8533 11 p.
Research output: Contribution to journal › Article › peer-review
37 Link opens in a new tab Citations (Scopus)
A Screen for Novel Phosphoinositide 3-kinase Effector Proteins
Dixon, M. J., Gray, A., Boisvert, F.-M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. & Batty, I. H., Apr 2011, In: Molecular & Cellular Proteomics. 10, 4, p. - 13 p., 003178.
Research output: Contribution to journal › Article › peer-review
27 Link opens in a new tab Citations (Scopus)
Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction
Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J., 25 Nov 2011, In: Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.
Research output: Contribution to journal › Article › peer-review
42 Link opens in a new tab Citations (Scopus)
Computational approaches to selecting and optimising targets for structural biology
Overton, I. M. & Barton, G. J., Sept 2011, In: Journal of Neuroscience Methods. 55, 1, p. 311 9 p.
Research output: Contribution to journal › Article › peer-review
9 Link opens in a new tab Citations (Scopus)
Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate
Morgan, R. E., Batot, G. O., Dement, J. M., Rao, V. A., Eadsforth, T. C. & Hunter, W. N., 9 May 2011, In: BMC Structural Biology. 11, p. - 9 p., 21.
Research output: Contribution to journal › Article › peer-review
18 Link opens in a new tab Citations (Scopus)
Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
Sainsbury, S., Bird, L., Rao, V., Shepherd, S. M., Stuart, D. I., Hunter, W. N., Owens, R. J. & Ren, J., 7 Jan 2011, In: Journal of Molecular Biology. 405, 1, p. 173-184 12 p.
Research output: Contribution to journal › Article › peer-review
85 Link opens in a new tab Citations (Scopus)
Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
Patterson, S., Alphey, M. S., Jones, D. C., Shanks, E. J., Street, I. P., Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H., 13 Oct 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6514-6530 17 p.
Research output: Contribution to journal › Article › peer-review
130 Link opens in a new tab Citations (Scopus)
Investigation of copper(II) tetrafluoroborate catalysed epoxide opening
Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H., 28 Dec 2011, In: Tetrahedron Letters. 52, 52, p. 7091-7094 4 p.
Research output: Contribution to journal › Article › peer-review
12 Link opens in a new tab Citations (Scopus)

13 Downloads (Pure)
Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA
Troshin, P. V., Procter, J. B. & Barton, G. J., 15 Jul 2011, In: BMC Bioinformatics. 27, 14, p. 2001-2002 2 p.
Research output: Contribution to journal › Article › peer-review
129 Link opens in a new tab Citations (Scopus)

Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

Research output

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2025

2020

2017

2015

2013

2012

2011