Aref#d: 20586. What are the Roles of Oomycete RXLR Effectors in the Establishment of Plant Disease? (joint with Warwick University). Was CO0221

2022

A Phytophthora effector promotes homodimerization of host transcription factor StKNOX3 to enhance susceptibility

Zhou, J., Qi, Y., Nie, J., Guo, L., Luo, M., McLellan, H., Boevink, P. C., Birch, P. R. J. & Tian, Z. (Lead / Corresponding author), 2 Nov 2022, In: Journal of Experimental Botany. 73, 19, p. 6902-6915 14 p.

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12 Citations (Scopus)

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Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance

McLellan, H., Harvey, S. E., Steinbrenner, J., Armstrong, M. R., He, Q., Clewes, R., Pritchard, L., Wang, W., Wang, S., Nussbaumer, T., Dohai, B., Luo, Q., Kumari, P., Duan, H., Roberts, A., Boevink, P. C., Neumann, C., Champouret, N., Hein, I. & Falter-Braun, P. & 3 others, Beynon, J., Denby, K. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), 30 Aug 2022, In: Proceedings of the National Academy of Sciences. 119, 35, 12 p., e2114064119.

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15 Citations (Scopus)

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2020

All roads lead to susceptibility: the many modes-of-action of fungal and oomycete intracellular effectors

He, Q., McLellan, H., Boevink, P. C. & Birch, P. R. J., 13 Jul 2020, In: Plant Communications. 1, 4, 12 p., 100050.

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87 Citations (Scopus)

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The ubiquitin E3 ligase PUB17 positively regulates immunity by targeting a negative regulator, KH17, for degradation

McLellan, H., Chen, K., He, Q., Wu, X., Boevink, P. C., Tian, Z. (Lead / Corresponding author) & Birch, P. (Lead / Corresponding author), 13 Jul 2020, In: Plant Communications. 1, 4, 12 p., 100020.

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19 Citations (Scopus)

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2019

AVR2 Targets BSL Family Members, Which Act as Susceptibility Factors to Suppress Host Immunity

Turnbull, D., Wang, H., Breen, S., Malec, M., Naqvi, S., Yang, L., Welsh, L., Hemsley, P., Tian, Z., Brunner, F., Gilroy, E. M. & Birch, P. (Lead / Corresponding author), 1 May 2019, In: Plant Physiology. 180, 1, p. 571-581 11 p.

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Phytophthora infestans effector SFI3 targets potato UBK to suppress early immune transcriptional responses

He, Q., McLellan, H., Hughes, R. K., Boevink, P. C., Armstrong, M., Lu, Y., Banfield, M. J., Tian, Z. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), Apr 2019, In: New Phytologist. 222, 1, p. 438-454 18 p.

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33 Citations (Scopus)

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Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization

Wang, S., McLellan, H., Bukharova, T., He, Q., Murphy, F., Shi, J., Sun, S., van Weymers, P., Ren, Y., Thilliez, G., Wang, H., Chen, X., Engelhardt, S., Vleeshouwers, V., Gilroy, E. M., Whisson, S. C., Hein, I., Wang, X., Tian, Z. & Birch, P. R. J. & 1 others, Boevink, P. C. (Lead / Corresponding author), 1 Jan 2019, In: Journal of Experimental Botany. 70, 1, p. 343-356 14 p.

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65 Citations (Scopus)

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Phytophthora infestans RXLR effectors target parallel steps in an immune signal transduction pathway

Ren, Y., Armstrong, M., Qi, Y., McLellan, H., Zhong, C., Du, B., Birch, P. R. J. & Tian, Z., Aug 2019, In: Plant Physiology. 180, 4, p. 2227-2239 13 p.

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38 Citations (Scopus)

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2018

Phytophthora infestans RXLR effector SFI5 requires association with calmodulin for PTI/MTI suppressing activity

Zheng, X., Wagener, N., McLellan, H., Boevink, P. C., Hua, C., Birch, P. R. J. & Brunner, F. (Lead / Corresponding author), 1 Sept 2018, In: New Phytologist. 219, 4, p. 1433-1446 14 p.

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33 Citations (Scopus)

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Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70

He, Q., Naqvi, S., McLellan, H., Boevink, P., Champouret, N., Hein, I. & Birch, P. (Lead / Corresponding author), 14 Aug 2018, In: Proceedings of the National Academy of Sciences. 115, 33, p. E7834-E7843 10 p.

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59 Citations (Scopus)

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The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease

Murphy, F., He, Q., Armstrong, M., Giuliani, L. M., Boevink, P. C., Zhang, W., Tian, Z., Birch, P. R. J. (Lead / Corresponding author) & Gilroy, E. M. (Lead / Corresponding author), May 2018, In: Plant Physiology. 177, 1, p. 398-410 13 p.

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56 Citations (Scopus)

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Why did filamentous plant pathogens evolve the potential to secrete hundreds of effectors to enable disease?

Thordal-Christensen, H. (Lead / Corresponding author), Birch, P. R. J., Spanu, P. D. & Panstruga, R., 1 Apr 2018, In: Molecular Plant Pathology. 19, 4, p. 781-785 5 p.

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29 Citations (Scopus)

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2017

A new proteinaceous pathogen-associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae

Franco-Orozco, B., Berepiki, A., Ruiz, O., Gamble, L., Griffe, L. L., Wang, S., Birch, P. R. J., Kanyuka, K. & Avrova, A. (Lead / Corresponding author), Jun 2017, In: New Phytologist. 214, 4, p. 1657-1672 16 p.

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44 Citations (Scopus)

BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation

Orosa, B., He, Q., Mesmar, J., Gilroy, E. M., McLellan, H., Yang, C., Craig, A., Bailey, M., Zhang, C., Moore, J. D., Boevink, P. C., Tian, Z., Birch, P. R. J. (Lead / Corresponding author) & Sadanandom, A. (Lead / Corresponding author), 5 Jan 2017, In: PLoS Genetics. 13, 1, p. 1-26 26 p., e1006540.

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33 Citations (Scopus)

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Delivery of cytoplasmic and apoplastic effectors from Phytophthora infestans haustoria by distinct secretion pathways

Wang, S., Boevink, P. C., Welsh, L., Zhang, R., Whisson, S. C. & Birch, P. J. R. (Lead / Corresponding author), 29 Aug 2017, In: New Phytologist. 29, 8, p. 205-215 11 p.

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106 Citations (Scopus)

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RXLR Effector AVR₂ Up-Regulates a Brassinosteroid-Responsive bHLH Transcription Factor to Suppress Immunity

Turnbull, D., Yang, L., Naqvi, S., Breen, S., Welsh, L., Stephens, J., Morris, J., Boevink, P. C., Hedley, P. E., Zhan, J., Birch, P. R. J. & Gilroy, E. M. (Lead / Corresponding author), May 2017, In: Plant Physiology. 174, 1, p. 356-369 14 p.

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62 Citations (Scopus)

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2016

A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J. (Lead / Corresponding author), 29 Jan 2016, In: Nature Communications. 7, 10311.

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109 Citations (Scopus)

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Oomycetes seek help from the plant : phytophthora infestans effectors target host susceptibility factors

Boevink, P. C., McLellan, H., Gilroy, E. M., Naqvi, S., He, Q., Yang, L., Wang, X., Turnbull, D., Armstrong, M. R., Tian, Z. & Birch, P. R. J. (Lead / Corresponding author), 2 May 2016, In: Molecular Plant. 9, 5, p. 636-638 3 p.

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34 Citations (Scopus)

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Opening the effector protein toolbox for plant-parasitic cyst-nematode interactions

Eves-van den Akker, S. (Lead / Corresponding author) & Birch, P., 7 Nov 2016, In: Molecular Plant. 9, 11, p. 1451-1453 3 p.

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27 Citations (Scopus)

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Potato NPH3/RPT2-like protein StNRL1, targeted by a Phytophthora infestans RXLR effector, is a susceptibility factor

Yang, L., McLellan, H., Naqvi, S., He, Q., Boevink, P. C., Armstrong, M., Giuliani, L. M., Zhang, W., Tian, Z., Zhan, J. (Lead / Corresponding author), Gilroy, E. M. & Birch, P. R. J. (Lead / Corresponding author), May 2016, In: Plant Physiology. 171, 1, p. 645-657 2 p.

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68 Citations (Scopus)

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The cell biology of late blight disease

Whisson, S. C., Boevink, P. C., Wang, S. & Birch, P. R. J. (Lead / Corresponding author), Dec 2016, In: Current Opinion in Microbiology. 34, p. 127-135 9 p.

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104 Citations (Scopus)

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2015

A host KH RNA-binding protein is a susceptibility factor targeted by an RXLR effector to promote late blight disease

Wang, X., Boevink, P., McLellan, H., Armstrong, M., Bukharova, T., Qin, Z. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), 7 Sept 2015, In: Molecular Plant. 8, 9, p. 1385-1395 11 p.

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64 Citations (Scopus)

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Five reasons to consider Phytophthora infestans a reemerging pathogen

Fry, W. E. (Lead / Corresponding author), Birch, P. R. J., Judelson, H. S., Grünwald, N. J., Danies, G., Everts, K. L., Gevens, A. J., Gugino, B. K., Johnson, D. A., Johnson, S. B., McGrath, M. T., Myers, K. L., Ristaino, J. B., Roberts, P. D., Secor, G. & Smart, C. D., Jul 2015, In: Phytopathology. 105, 7, p. 966-981 16 p.

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249 Citations (Scopus)

Phytophthora infestans RXLR Effector AVR1 Interacts with Exocyst Component Sec5 to Manipulate Plant Immunity

Du, Y., Mpina, M. H., Birch, P. R. J., Bouwmeester, K. & Govers, F. (Lead / Corresponding author), Nov 2015, In: Plant Physiology. 169, 3, p. 1975-1990 16 p.

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105 Citations (Scopus)

The Top 10 oomycete pathogens in molecular plant pathology

Kamoun, S. (Lead / Corresponding author), Furzer, O., Jones, J. D. G., Judelson, H. S., Ali, G. S., Dalio, R. J. D., Roy, S. G., Schena, L., Zambounis, A., Panabières, F., Cahill, D., Ruocco, M., Figueiredo, A., Chen, X. R., Hulvey, J., Stam, R., Lamour, K., Gijzen, M., Tyler, B. M. & Grünwald, N. J. & 14 others, Mukhtar, M. S., Tomé, D. F. A., Tör, M., Van Den Ackerveken, G., McDowell, J., Daayf, F., Fry, W. E., Lindqvist-Kreuze, H., Meijer, H. J. G., Petre, B., Ristaino, J., Yoshida, K., Birch, P. R. J. & Govers, F., May 2015, In: Molecular Plant Pathology. 16, 4, p. 413-434 22 p.

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631 Citations (Scopus)

U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans

He, Q., McLellan, H., Boevink, P. C., Sadanandom, A., Xie, C., Birch, P. R. J. (Lead / Corresponding author) & Tian, Z. (Lead / Corresponding author), Jun 2015, In: Journal of Experimental Botany. 66, 11, p. 3189-3199 11 p.

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50 Citations (Scopus)

2014

Functionally Redundant RXLR Effectors from Phytophthora infestans Act at Different Steps to Suppress Early flg22-Triggered Immunity

Zheng, X., McLellan, H., Fraiture, M., Liu, X., Boevink, P. C., Gilroy, E. M., Chen, Y., Kandel, K., Sessa, G., Birch, P. R. J. (Lead / Corresponding author) & Brunner, F. (Lead / Corresponding author), 2014, In: PLoS Pathogens. 10, 4, 17 p., e1004057.

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108 Citations (Scopus)

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Phytophthora infestans RXLR effector PexRD2 interacts with host MAPKKKε to suppress plant immune signaling

King, S. R. F., McLellan, H., Boevink, P. C., Armstrong, M. R., Bukharov, T., Sukarta, O., Win, J., Kamoun, S., Birch, P. R. J. & Banfield, M. J., Mar 2014, In: The Plant Cell. 26, 3, p. 1345-1359 15 p.

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157 Citations (Scopus)

The role of effectors in nonhost resistance to filamentous plant pathogens

Stam, R. (Lead / Corresponding author), Mantelin, S., McLellan, H. & Thilliez, G., 5 Nov 2014, In: Frontiers in Plant Science. 5, 582.

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56 Citations (Scopus)

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The zigzag model of plant-microbe interactions: is it time to move on?

Pritchard, L. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), Dec 2014, In: Molecular Plant Pathology. 15, 9, p. 865-870 6 p.

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53 Citations (Scopus)

2013

An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus

McLellan, H., Boevink, P., Armstrong, M., Pritchard, L., Gomez, S. (Contributing member), Morales, J. (Supervisor), Whisson, S. & Birch, P. R. J. (Lead / Corresponding author), 10 Oct 2013, In: PLoS Pathogens. 9, 10, e1003670.

Research output: Contribution to journal › Article › peer-review

192 Citations (Scopus)

The early days of late blight

Birch, P. R. J. & Cooke, D. E. L., 2013, In: eLife. 2013, 2, e00954.

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10 Citations (Scopus)

2012

Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P., 2012, In: Journal of Biological Chemistry. 287, 45, p. 38101-38109 9 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Genome Analyses of an Aggressive and Invasive Lineage of the Irish Potato Famine Pathogen

Cooke, D. E. L., Cano, L. M., Raffaele, S., Bain, R. A., Cooke, L. R., Etherington, G. J., Deahl, K. L., Farrer, R. A., Gilroy, E. M., Goss, E. M., Grünwald, N. J., Hein, I., MacLean, D., McNicol, J. W., Randall, E., Oliva, R. F., Pel, M. A., Shaw, D. S., Squires, J. N. & Taylor, M. C. & 4 others, Vleeshouwers, V. G. A. A., Birch, P. R. J., Lees, A. K. & Kamoun, S., 4 Oct 2012, In: PLoS Pathogens. 8, 10, 14 p., e1002940.

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305 Citations (Scopus)

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Host Protein BSL1 Associates with Phytophthora infestans RXLR Effector AVR2 and the Solanum demissum Immune Receptor R2 to Mediate Disease Resistance: Effector AVR2 Associates with BSL1

Saunders, D. G. O., Breen, S., Win, J., Schornack, S., Hein, I., Bozkurt, T. O., Champouret, N., Vleeshouwers, V. G. A. A., Birch, P. R. J., Gilroy, E. M. & Kamoun, S. (Lead / Corresponding author), Aug 2012, In: The Plant Cell. 24, 8, p. 3420-3434 14 p.

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Relocalization of late blight resistance protein r3a to endosomal compartments is associated with effector recognition and required for the immune response.

Engelhardt, S., Boevink, P. C., Armstrong, M. R., Ramos, M. B., Hein, I. & Birch, P. R. J. (Lead / Corresponding author), Dec 2012, In: The Plant Cell. 24, 12, p. 5142-5158 16 p.

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

2011

CMPG1-dependent cell death follows perception of diverse pathogen elicitors at the host plasma membrane and is suppressed by Phytophthora infestans RXLR effector AVR3a

Gilroy, E. M., Taylor, R. M., Hein, I., Boevink, P., Sadanandom, A. & Birch, P. R. J., 2011, In: New Phytologist. 190, 3, p. 653-666 14 p.

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Presence/absence, differential expression and sequence polymorphisms between PiAVR2 and PiAVR2-like in Phytophthora infestans determine virulence on R2 plants

Gilroy, E. M., Breen, S., Whisson, S. C., Squires, J., Hein, I., Kaczmarek, M., Turnbull, D., Boevink, P. C., Lokossou, A., Cano, L. M., Morales, J., Avrova, A. O., Pritchard, L., Randall, E., Lees, A., Govers, F., van West, P., Kamoun, S., Vleeshouwers, V. G. A. A. & Cooke, D. E. L. & 1 others, Birch, P. R. J. (Lead / Corresponding author), 2011, In: New Phytologist. 191, 3, p. 763-776 14 p.

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

2010

Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1

Bos, J., Armstrong, M. R., Gilroy, E. M., Boevink, P. C., Hein, I., Taylor, R. M., Tian, Z., Engelhardt, S., Vetukuri, R. R., Harrower, B., Dixelius, C., Bryan, G., Sadanandom, A., Whisson, S. C., Kamoun, S. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), 25 May 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9909-9914 6 p.

Research output: Contribution to journal › Article › peer-review

338 Citations (Scopus)

2009

Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

Haas, B. J., Kamoun, S., Zody, M. C., Jiang, R. H. Y., Handsaker, R. E., Cano, L. M., Grabherr, M., Kodira, C. D., Raffaele, S., Torto-Alalibo, T., Bozkurt, T. O., Ah-Fong, A. M. V., Alvarado, L., Anderson, V. L., Armstrong, M. R., Avrova, A., Baxter, L., Beynon, J., Boevink, P. C. & Bollmann, S. R. & 76 others, Bos, J. I. B., Bulone, V., Cai, G., Cakir, C., Carrington, J. C., Chawner, M., Conti, L., Costanzo, S., Ewan, R., Fahlgren, N., Fischbach, M. A., Fugelstad, J., Gilroy, E. M., Gnerre, S., Green, P. J., Grenville-Briggs, L. J., Griffith, J., Gruenwald, N. J., Horn, K., Horner, N. R., Hu, C.-H., Huitema, E., Jeong, D.-H., Jones, A. M. E., Jones, J. D. G., Jones, R. W., Karlsson, E. K., Kunjeti, S. G., Lamour, K., Liu, Z., Ma, L., MacLean, D., Chibucos, M. C., McDonald, H., McWalters, J., Meijer, H. J. G., Morgan, W., Morris, P. F., Munro, C. A., O'Neill, K., Ospina-Giraldo, M., Pinzon, A., Pritchard, L., Ramsahoye, B., Ren, Q., Restrepo, S., Roy, S., Sadanandom, A., Savidor, A., Schornack, S., Schwartz, D. C., Schumann, U. D., Schwessinger, B., Seyer, L., Sharpe, T., Silvar, C., Song, J., Studholme, D. J., Sykes, S., Thines, M., van de Vondervoort, P. J. I., Phuntumart, V., Wawra, S., Weide, R., Win, J., Young, C., Zhou, S., Fry, W., Meyers, B. C., van West, P., Ristaino, J., Govers, F., Birch, P. R. J., Whisson, S. C., Judelson, H. S. & Nusbaum, C., 17 Sept 2009, In: Nature. 461, 7262, p. 393-398 6 p.

Research output: Contribution to journal › Article › peer-review

1152 Citations (Scopus)

Aref#d: 20586. What are the Roles of Oomycete RXLR Effectors in the Establishment of Plant Disease? (joint with Warwick University). Was CO0221

Research output

Search results