Research output per year
Research output per year
- 18 results
Search results
-
2022
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants
MacGowan, S. A., Barton, M. I., Kutuzov, M., Dushek, O., van der Merwe, P. A. & Barton, G. J. (Lead / Corresponding author), 2 Mar 2022, In: PLoS Computational Biology. 18, 3, p. 1-25 25 p., e1009922.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)118 Downloads (Pure) -
2021
Ankyrin repeats in context with human population variation
Utgés, J. S., Tsenkov, M. I., Dietrich, N. J. M., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), 30 May 2021, BioRxiv, 26 p.Research output: Working paper/Preprint › Preprint
Open AccessFile73 Downloads (Pure) -
Ankyrin repeats in context with human population variation
Utgés,, J. S., Tsenkov, M. I., Dietrich, N. J. M., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), Aug 2021, In: PLoS Computational Biology. 17, 8, 26 p., e1009335.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)138 Downloads (Pure) -
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human ACE2 receptor on binding affinity and kinetics
Barton, M. I., MacGowan, S. A., Kutuzov, M. A., Dushek, O., Barton, G. J. (Lead / Corresponding author) & van der Merwe, P. A. (Lead / Corresponding author), Aug 2021, In: eLife. 10, 19 p., e70658.Research output: Contribution to journal › Article › peer-review
Open AccessFile254 Citations (Scopus)144 Downloads (Pure) -
Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics
Barton, M. I., MacGowan, S., Kutuzov, M., Dushek, O., Barton, G. J. (Lead / Corresponding author) & Merwe, P. A. V. D. (Lead / Corresponding author), 24 May 2021, BioRxiv, 39 p.Research output: Working paper/Preprint › Preprint
File135 Downloads (Pure) -
Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike
MacGowan, S. A., Barton, M. I. (Lead / Corresponding author), Kutuzov, M., Dushek, O., Merwe, P. A. V. D. & Barton, G. J., 21 May 2021, BioRxiv, 28 p.Research output: Working paper/Preprint › Preprint
File109 Downloads (Pure) -
2020
Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19
MacGowan, S. A. (Lead / Corresponding author) & Barton, G. J. (Lead / Corresponding author), 4 May 2020, Cold Spring Harbor Laboratory: BioRxiv, 38 p.Research output: Working paper/Preprint › Preprint
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PDBE-KB: A community-driven resource for structural and functional annotations
PDBe-KB consortium, 8 Jan 2020, In: Nucleic Acids Research. 48, D1, p. D344-D353 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile89 Citations (Scopus)120 Downloads (Pure) -
The Dundee Resource for Sequence Analysis and Structure Prediction
MacGowan, S., Madeira, F., Britto-Borges, T., Warowny, M., Drozdetskiy, A., Procter, J. & Barton, G. (Lead / Corresponding author), Jan 2020, In: Protein Science. 29, 1, p. 277-297 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)142 Downloads (Pure) -
2018
JABAWS 2.2 Distributed Web Services for Bioinformatics: Protein Disorder, Conservation and RNA Secondary Structure
Troshin, P. V., Procter, J. B., Sherstnev, A., Barton, D. L., Madeira, F. & Barton, G. J. (Lead / Corresponding author), 1 Jun 2018, In: Bioinformatics. 34, 11, p. 1939-1940 2 p., byt045.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)293 Downloads (Pure) -
Visualization of Biomedical Data
O'Donoghue, S. I. (Lead / Corresponding author), Baldi, B. F., Clark, S. J., Darling, A. E., Hogan, J. M., Kaur, S., Maier-Hein, L., McCarthy, D. J., Moore, W., Stenau, E., Swedlow, J., Vuong, J. & Procter, J., 20 Jul 2018, In: Annual Review of Biomedical Data Science. 1Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Human Missense Variation is Constrained by Domain Structure and Highlights Functional and Pathogenic Residues
MacGowan, S., Madeira, F., Britto Borges, T., Schmittner, M. S., Cole, C. & Barton, G., 13 Apr 2017, Cold Spring Harbor Laboratory: BioRxiv, 35 p.Research output: Working paper/Preprint › Preprint
File370 Downloads (Pure) -
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: A proposed framework
Glusman, G. (Lead / Corresponding author), Rose, P. W., Prlić, A., Dougherty, J., Duarte, J. M., Hoffman, A. S., Barton, G. J., Bendixen, E., Bergquist, T., Bock, C., Brunk, E., Buljan, M., Burley, S. K., Cai, B., Carter, H., Gao, J. J., Godzik, A., Heuer, M., Hicks, M. & Hrabe, T. & 17 others, , 18 Dec 2017, In: Genome Medicine. 9, 1, p. 1-10 10 p., 113.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)232 Downloads (Pure) -
2015
JPred4: a protein secondary structure prediction server
Drozdetskiy, A., Cole, C., Procter, J. & Barton, G. J. (Lead / Corresponding author), 1 Jul 2015, In: Nucleic Acids Research. 43, W1, p. W389-W394 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1345 Citations (Scopus)467 Downloads (Pure) -
Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1
Lai, Y.-C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J.-C., Campbell, D. G., Itzen, A., Trost, M. (Lead / Corresponding author) & Muqit, M. M. (Lead / Corresponding author), 12 Nov 2015, In: EMBO Journal. 34, 22, p. 2840-2861 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile144 Citations (Scopus)182 Downloads (Pure) -
2011
Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA
Troshin, P. V., Procter, J. B. & Barton, G. J., 15 Jul 2011, In: BMC Bioinformatics. 27, 14, p. 2001-2002 2 p.Research output: Contribution to journal › Article › peer-review
107 Citations (Scopus) -
2010
Visualization of multiple alignments, phylogenies and gene family evolution
Procter, J. B., Thompson, J., Letunic, I., Creevey, C., Jossinet, F. & Barton, G. J., 1 Mar 2010, In: Nature Methods. 7, 3, p. S16-S25 10 p.Research output: Contribution to journal › Review article › peer-review
67 Citations (Scopus) -
2009
Jalview Version 2-a multiple sequence alignment editor and analysis workbench
Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. & Barton, G. J. (Lead / Corresponding author), 1 May 2009, In: Bioinformatics. 25, 9, p. 1189-1191 3 p.Research output: Contribution to journal › Article › peer-review
7318 Citations (Scopus)