Research output
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2020
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Taylor, M. & Alessi, D. (Lead / Corresponding author), Apr 2020, In: Current Opinion in Cell Biology. 63, p. 102-113 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile102 Link opens in a new tab Citations (Scopus)376 Downloads (Pure) -
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2
Waschbüsch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D. R. & Khan, A. R. (Lead / Corresponding author), 7 Apr 2020, In: Structure. 28, 4, p. 406-417.e6 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Link opens in a new tab Citations (Scopus)215 Downloads (Pure) -
2016
Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases
Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. (Lead / Corresponding author) & Mann, M. (Lead / Corresponding author), 29 Jan 2016, In: eLife. 5, p. 1-28 28 p., e12813.Research output: Contribution to journal › Article › peer-review
Open AccessFile778 Link opens in a new tab Citations (Scopus)529 Downloads (Pure) -
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
Ito, G. (Lead / Corresponding author), Katsemonova, K., Tonelli, F., Lis, P., Baptista, M., Shpiro, N., Duddy, G., Wilson, S., Wing-Lok Ho, P., Ho, S.-L., Reith, A. D. & Alessi, D. R. (Lead / Corresponding author), 30 Aug 2016, In: Biochemical Journal. 473, 17, p. 2671-2685 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile138 Link opens in a new tab Citations (Scopus)647 Downloads (Pure) -
2015
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. (Lead / Corresponding author), 1 Aug 2015, In: EMBO Reports. 16, 8, p. 939-954 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile217 Link opens in a new tab Citations (Scopus)379 Downloads (Pure) -
Structural characterization of LRRK2 inhibitors
Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. (Lead / Corresponding author), 14 May 2015, In: Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.Research output: Contribution to journal › Article › peer-review
33 Link opens in a new tab Citations (Scopus) -
2014
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65
Kazlauskaite, A. (Lead / Corresponding author), Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. (Lead / Corresponding author), 15 May 2014, In: Biochemical Journal. 460, 1, p. 127-139 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile689 Link opens in a new tab Citations (Scopus)332 Downloads (Pure) -
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. A. & Muqit, M. M. K., 19 Mar 2014, In: Open Biology. 4, 14 p., 130213.Research output: Contribution to journal › Article › peer-review
121 Link opens in a new tab Citations (Scopus) -
2012
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., MacArtney, T. J., Deak, M., Knebel, A., Alessi, D. R. & Muqit, M. M. K. (Lead / Corresponding author), 2012, In: Open Biology. 2, 120080.Research output: Contribution to journal › Article › peer-review
804 Link opens in a new tab Citations (Scopus)