Aref#d: 21559. Molecular Mechanisms of Fungal Cell Wall Assembly (Programme Grant)

2015

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. (Lead / Corresponding author), 1 Aug 2015, In: EMBO Reports. 16, 8, p. 939-954 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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211 Citations (Scopus)

352 Downloads (Pure)

Evidence for a functional O-linked N-acetylglucosamine (O-GlcNAc) system in the thermophilic bacterium Thermobaculum terrenum

Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A. & Van Aalten, D. M. F. (Lead / Corresponding author), 18 Dec 2015, In: Journal of Biological Chemistry. 290, 51, p. 30291-30305 15 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD)

van der Beek, S. L., Le Breton, Y., Ferenbach, A. T., Chapman, R. N., van Aalten, D. M. F., Hopkins Navratilova, I., Boons, G. J., Mciver, K. S., van Sorge, N. M. (Lead / Corresponding author) & Dorfmueller, H. (Lead / Corresponding author), 24 Nov 2015, In: Molecular Microbiology. 98, 5, p. 946-962 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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41 Citations (Scopus)

572 Downloads (Pure)

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F. (Lead / Corresponding author), 19 Jun 2015, In: ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

The early metazoan Trichoplax adhaerens possesses a functional O-GlcNAc system

Selvan, N., Mariappa, D., van den Toorn, H. W. P., Heck, A. J. R., Ferenbach, A. T. & van Aalten, D. M. F. (Lead / Corresponding author), 8 May 2015, In: Journal of Biological Chemistry. p. 11969-11982 14 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos

Jank, T., Eckerle, S., Steinemann, M., Trillhaase, C., Schimpl, M., Wiese, S., Van Aalten, D. M. F., Driever, W. & Aktories, K. (Lead / Corresponding author), 20 Jul 2015, In: Nature Communications. 6, 16 p., 7807.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

2014

A structural and biochemical model of processive chitin synthesis

Dorfmueller, H. C. (Lead / Corresponding author), Ferenbach, A. T., Borodkin, V. S. & van Aalten, D. M. F. (Lead / Corresponding author), 15 Aug 2014, In: Journal of Biological Chemistry. 289, p. 23020-23028 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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53 Citations (Scopus)

291 Downloads (Pure)

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. (Lead / Corresponding author), 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 497-502 6 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P. (Lead / Corresponding author), Oct 2014, In: Stem Cells. 32, 10, p. 2605-2615

Research output: Contribution to journal › Article › peer-review

Open Access

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50 Citations (Scopus)

651 Downloads (Pure)

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N -myristoyltransferase inhibitors: Identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human african trypanosomiasis

Brand, S., Norcross, N. R., Thompson, S., Harrison, J. R., Smith, V. C., Robinson, D. A., Torrie, L. S., McElroy, S. P., Hallyburton, I., Norval, S., Scullion, P., Stojanovski, L., Simeons, F. R. C., Van Aalten, D., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Wyatt, P. G. & Gilbert, I. H. & 1 others, Read, K. D., 11 Dec 2014, In: Journal of Medicinal Chemistry. 57, 23, p. 9855-9869 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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67 Citations (Scopus)

209 Downloads (Pure)

O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signalling?

Alonso , J., Schimpl, M. & van Aalten, D. M. F. (Lead / Corresponding author), 12 Dec 2014, In: Journal of Biological Chemistry. 289, 50, p. 34433-34439 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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50 Citations (Scopus)

288 Downloads (Pure)

Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

Lockhart, D. E. A., Schuettelkopf, A., Blair, D. E. & van Aalten, D. M. F. (Lead / Corresponding author), 25 Aug 2014, In: FEBS Letters. 588, 17, p. 3282-3290 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

221 Downloads (Pure)

2013

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sept 2013, In: ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

Mariappa, D., Pathak, S. & van Aalten, D. M. F., 2013, In: EMBO Journal. 32, 5, p. 612-613 2 p.

Research output: Contribution to journal › Editorial › peer-review

11 Citations (Scopus)

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., Macphee, C. E., van Aalten, D. M. F. & Stanley-Wall, N. R. (Lead / Corresponding author), 13 Aug 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13600-13605 6 p.

Research output: Contribution to journal › Article › peer-review

255 Citations (Scopus)

Chemical tools to probe cellular O-GlcNAc signalling

Ostrowski, A. & van Aalten, D. M. F. (Lead / Corresponding author), 15 Nov 2013, In: Biochemical Journal. 456, 1, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. (Lead / Corresponding author) & Van Aalten, D. M. F. (Lead / Corresponding author), 11 Jul 2013, In: Bioscience Reports. 33, 5, 11 p., e00063.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. (Lead / Corresponding author) & van Aalten, D. M. F. (Lead / Corresponding author), Aug 2013, In: Molecular Microbiology. 89, 3, p. 479-493 15 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B., 2013, In: Journal of Proteome Research. 12, 2, p. 927-936 10 p.

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F., 2 Oct 2013, In: Open Biology. 3, 130021.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

Striebeck, A., Robinson, D. A., Schüttelkopf, A. W. & van Aalten, D. M. F., Sept 2013, In: Open Biology. 3, 9, 130022.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

2012

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

Schimpl, M., Rush, C. L., Betou, M., Eggleston, I. M., Recklies, A. D. & van Aalten, D. M. F., 2012, In: Biochemical Journal. 446, 1, p. 149-157 9 p.

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H.-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H., 29 Jun 2012, In: Journal of Biological Chemistry. 287, 27, p. 22483-22496 14 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

Schimpl, M., Zheng, X., Borodkin, V. S., Blair, D. E., Ferenbach, A. T., Schüttelkopf, A. W., Navratilova, I., Aristotelous, T., Albarbarawi, O., Robinson, D. A., van Aalten, D. M. F. & Macnaughtan, M. A., 2012, In: Nature Chemical Biology.

Research output: Contribution to journal › Article › peer-review

125 Citations (Scopus)

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. (Lead / Corresponding author), 21 Mar 2012, In: EMBO Journal. 31, 6, p. 1394-1404 11 p.

Research output: Contribution to journal › Article › peer-review

144 Citations (Scopus)

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus

Penman, G. A., Lockhart, D. E. A., Ferenbach, A. & Van Aalten, D. M. F., 2012, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 68, 6, p. 705-708 4 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Structural and biochemical characterization of a trapped coenzyme a adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

Dorfmueller, H. C. (Lead / Corresponding author), Fang, W., Rao, F. V., Blair, D. E., Attrill, H. & van Aalten, D. M. F., 2012, In: Acta Crystallographica Section D: Biological Crystallography. 68, 8, p. 1019-1029 11 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Synergy of peptide and sugar in O-GlcNAcase substrate recognition

Schimpl, M., Borodkin, V. S., Gray, L. J. & van Aalten, D. M. F., 24 Feb 2012, In: Chemistry & Biology. 19, 2, p. 173-178 6 p.

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F., 2012, In: PLoS Pathogens. 8, 1, e1002373.

Research output: Contribution to journal › Article › peer-review

144 Citations (Scopus)

2011

Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E., 27 May 2011, In: Chemistry & Biology. 18, 5, p. 569-579 11 p.

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Bisdionin C-A rationally designed, submicromolar inhibitor of family 18 chitinases

Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M., Rush, C. L., Eggleston, I. M. & van Aalten, D. M. F., Jun 2011, In: ACS Medicinal Chemistry Letters. 2, 6, p. 428-432 5 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Charge-surrounded pockets and electrostatic interactions with small ions modulate the activity of retroviral fusion proteins

Lamb, D., Schuettelkopf, A. W., van Aalten, D. M. F. & Brighty, D. W. (Lead / Corresponding author), Feb 2011, In: PLoS Pathogens. 7, 2, p. - 12 p., e1001268.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations

Woodroof, H. I., Pogson, J. H., Begley, M., Cantley, L. C., Deak, M., Campbell, D. G., Van Aalten, D. M. F., Whitworth, A. J., Alessi, D. R. & Muqit, M. M. K. (Lead / Corresponding author), 1 Nov 2011, In: Open Biology. 1, NOVEMBER, 110012.

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Molecular recognition: O-GlcNAc transfer: size matters

Gay, L. M., Zheng, X. & van Aalten, D. M. F., Mar 2011, In: Nature Chemical Biology. 7, 3, p. 134-135 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

4 Citations (Scopus)

Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila

Mariappa, D., Sauert, K., Marino, K., Turnock, D., Webster, R., van Aalten, D. M. F., Ferguson, M. A. J. & Muller, H. A. J. (Lead / Corresponding author), 20 Dec 2011, In: Science Signaling. 4, 204, p. - 8 p., ra89.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Substrate and product analogues as human O-GlcNAc transferase inhibitors

Dorfmueller, H. C., Borodkin, V. S., Blair, D. E., Pathak, S., Navratilova, I. & van Aalten, D. M. F., Mar 2011, In: Amino Acids. 40, 3, p. 781-792 12 p.

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

2010

Acetazolamide-based fungal chitinase inhibitors

Schuettelkopf, A. W., Gros, L., Blair, D. E., Frearson, J. A., van Aalten, D. M. F. & Gilbert, I. H., 1 Dec 2010, In: Bioorganic & Medicinal Chemistry. 18, 23, p. 8334-8340 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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46 Citations (Scopus)

455 Downloads (Pure)

An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

Borodkin, V. S. & van Aalten, D. M. F., 25 Sept 2010, In: Tetrahedron. 66, 39, p. 7838-7849 12 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F., 24 Nov 2010, In: Chemistry & Biology. 17, 11, p. 1250-1255 6 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Human OGA binds substrates in a conserved peptide recognition groove

Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F., 15 Nov 2010, In: Biochemical Journal. 432, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F., 15 Mar 2010, In: Biochemical Journal. 426, p. 281-292 12 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Natural product-guided discovery of a fungal chitinase inhibitor

Rush, C. L., Schuettelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F., 22 Dec 2010, In: Chemistry & Biology. 17, 12, p. 1275-1281 7 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F. & Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G. (Lead / Corresponding author), 1 Apr 2010, In: Nature. 464, 7289, p. 728-732 7 p.

Research output: Contribution to journal › Article › peer-review

271 Citations (Scopus)

Pseudokinases-remnants of evolution or key allosteric regulators?

Zeqiraj, E. & van Aalten, D. M. F., Dec 2010, In: Current Opinion in Structural Biology. 20, 6, p. 772-781 10 p.

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

Dorfmueller, H. C. & van Aalten, D. M. F., 19 Feb 2010, In: FEBS Letters. 584, 4, p. 694-700 7 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

2009

ATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor

Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. (Lead / Corresponding author), Jun 2009, In: PLoS Biology. 7, 6, p. - 19 p., e1000126.

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi

Urch, J. E., Hurtado-Guerrero, R., Brosson, D., Liu, Z., Eijsink, V. G. H., Texier, C. & van Aalten, D. M. F., Jun 2009, In: Protein Science. 18, 6, p. 1197-1209 13 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F. (Lead / Corresponding author), 18 Dec 2009, In: Science. 326, 5960, p. 1707-1711 5 p.

Research output: Contribution to journal › Article › peer-review

291 Citations (Scopus)

Aref#d: 21559. Molecular Mechanisms of Fungal Cell Wall Assembly (Programme Grant)

Research output

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