Aref#d: 21596. BIOSTAT-CHF: A Systems Biology Study to Tailored Treatment in Chronic Heart Failure

Doney, Alexander (Investigator)
Guthrie, Bruce (Investigator)
Lang, Chim (Investigator)
Morris, Andrew (Investigator)
Palmer, Colin (Investigator)
Struthers, Allan (Investigator)

33 results

2024
Clinical and proteomic profiles of chronic kidney disease in heart failure with reduced and preserved ejection fraction
Voordes, G. H. D., Voors, A. A., Hoegl, A., Madsen, C. T., van Essen, B. J., Ouwerkerk, W., Tromp, J., de la Rambelje, M. A., Grønborg, M., Refsgaard, J. C., Lang, C. C., Barascuk-Michaelsen, N. & Damman, K. (Lead / Corresponding author), 15 Dec 2024, In: International Journal of Cardiology. 417, 8 p., 132580.
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IL-17 is associated with disease severity and targetable inflammatory processes in heart failure
Baumhove, L., van Essen, B. J., Dokter, M. M., Zijlstra, S. N., Deiman, F. E., Laman, J. D., Lang, C. C., Verstappen, G. M. P. J., van Veldhuisen, D. J., van der Meer, P., Bomer, N. & Voors, A. A. (Lead / Corresponding author), Dec 2024, In: ESC Heart Failure. 11, 6, p. 3530-3538 9 p.
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Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction
Streng, K. W., Hillege, H. L., ter Maaten, J. M., van Veldhuisen, D. J., Dickstein, K., Samani, N. J., Ng, L. L., Metra, M., Filippatos, G. S., Ponikowski, P., Zannad, F., Anker, S. D., van der Meer, P., Lang, C. C., Voors, A. A. (Lead / Corresponding author) & Damman, K., Feb 2024, In: Journal of cardiovascular translational research. 17, p. 3-12 10 p.
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2023
Clinical and prognostic associations of autoantibodies recognizing adrenergic/muscarinic receptors in patients with heart failure
Markousis-Mavrogenis, G., Minich, W. B., Al-Mubarak, A. A., Anker, S. D., Cleland, J. G. F., Dickstein, K., Lang, C. C., Ng, L. L., Samani, N. J., Zannad, F., Metra, M., Seemann, P., Hoeg, A., Lopez, P., van Veldhuisen, D. J., de Boer, R. A., Voors, A. A., van der Meer, P., Schomburg, L. (Lead / Corresponding author) & Bomer, N. & 1 others, BIOSTAT-CHF Consortium, Jun 2023, In: Cardiovascular Research. 119, 8, p. 1690–1705 16 p., cvad042.
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Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure
Ouwerkerk, W. (Lead / Corresponding author), Belo Pereira, J. P., Maasland, T., Emmens, J. E., Figarska, S., Tromp, J., Koekemoer, A., Nelson, C. P., Nath, M., Romaine, S. P. R., Cleland, J. G. F., Zannad, F., van Veldhuisen, D. J., Lang, C. C., Ponikowski, P., Filippatos, G. S., Anker, S. D., Metra, M., Dickstein, K. & Ng, L. L. & 10 others, de Boer, R. A., van Riel, N., Nieuwdorp, M., Groen, A. K., Stroes, E. S., Zwinderman, A. H., Samani, N. J., Lam, C. S. P., Levin, E. & Voors, A. A., 14 Nov 2023, In: Journal of the American College of Cardiology. 82, 20, p. 1921-1931 11 p.
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Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
de Koning, M.-S. L. Y. (Lead / Corresponding author), Emmens, J. E., Romero-Hernández, E., Bourgonjec, A. R., Assa, S., Figarska, S., Cleland, J. G. F., Samani, N. J., Ng, L. L., Lang, C. C., Metra, M., Filippatos, G. S., van Veldhuisen, D. J., Anker, S. D., Dickstein, K., Voors, A. A., Lipsic, E., van Goor, H. & van der Harst, P., Aug 2023, In: Clinical Research in Cardiology . 112, 8, p. 1056–1066 11 p.
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2022
Additional Burden of Iron Deficiency in Heart Failure Patients beyond the Cardio-Renal-Anaemia Syndrome: Findings from the BIOSTAT-CHF Study
Alnuwaysir, R. I. S., Grote Beverborg, N., Hoes, M. F., Markousis-Mavrogenis, G., Gomez, K. A., van der Wal, H. H., Cleland, J. G. F., Dickstein, K., Lang, C. C., Ng, L. L., Ponikowski, P., Anker, S. D., van Veldhuisen, D. J., Voors, A. A. & van der Meer, P. (Lead / Corresponding author), 27 Jan 2022, In: European Journal of Heart Failure. 24, 1, p. 192-204 13 p.
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Assessment of Proximal Tubular Function by Tubular Maximum Phosphate Reabsorption Capacity in Heart Failure
Emmens, J. E., De Borst, M. H., Boorsma, E. M., Damman, K., Navis, G., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., Lang, C. C., Filippatos, G. S., Metra, M., Samani, N. J., Ponikowski, P., Ng, L. L., Voors, A. A. & ter Maaten, J. M. (Lead / Corresponding author), Feb 2022, In: Clinical Journal of the American Society of Nephrology. 17, 2, p. 228-239 12 p.
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Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction
Savarese, G. (Lead / Corresponding author), Uijl, A., Ouwerkerk, W., Tromp, J., Anker, S. D., Dickstein, K., Hage, C., Lam, C. S. P., Lang, C. C., Metra, M., Ng, L. L., Orsini, N., Samani, N. J., van Veldhuisen, D. J., Cleland, J. G. F., Voors, A. A. & Lund, L. H., Aug 2022, In: ESC Heart Failure. 9, 4, p. 2107-2118 12 p.
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Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure
Pagnesi, M., Adamo, M., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Inciardi, R. M., Lang, C. C., Lombardi, C. M., Ng, L. L., Ponikowski, P., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Voors, A. A. & Metra, M. (Lead / Corresponding author), Aug 2022, In: Clinical Research in Cardiology . 111, 8, p. 912-923 12 p.
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Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure
Inciardi, R. M., Pagnesi, M., Lombardi, C. M., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Pellicori, P., Ponikowski, P., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Solomon, S. D., Voors, A. A. & Metra, M. (Lead / Corresponding author), 8 Dec 2022, In: European Journal of Heart Failure. 24, 11, p. 2131-2139 9 p.
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Clinical implications of low estimated protein intake in patients with heart failure
Streng, K. W., Hillege, H. L., ter Maaten, J. M., van Veldhuisen, D. J., Dickstein, K., Ng, L. L., Samani, N. J., Metra, M., Ponikowski, P., Cleland, J. G., Anker, S. D., Romaine, S. P. R., Damman, K., van der Meer, P., Lang, C. C. & Voors, A. A. (Lead / Corresponding author), 8 Jun 2022, In: Journal of Cachexia, Sarcopenia and Muscle. 13, p. 1762-1770 9 p.
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Distinct pathophysiological pathways in women and men with heart failure
Ravera, A., Santema, B. T., de Boer, R. A., Anker, S. D., Samani, N. J., Lang, C. C., Ng, L. L., Cleland, J. G. F., Dickstein, K., Lam, C. S. P., Van Spall, H., Filippatos, G. S., van Veldhuisen, D. J., Metra, M., Voors, A. A. (Lead / Corresponding author) & Sama, I. E., Sept 2022, In: European Journal of Heart Failure. 24, 9, p. 1532-1544 13 p.
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Heart failure with normal LVEF in BIOSTAT-CHF
Baumhove, L. (Lead / Corresponding author), Tromp, J., Figarska, S., van Essen, B. J., Anker, S. D., Dickstein, K., Cleland, J. G., Lang, C. C., Filippatos, G., Ng, L. L., Samani, N. J., Metra, M., van Veldhuisen, D. J., Lam, C. S. P., Voors, A. A. & van der Meer, P., Oct 2022, In: International Journal of Cardiology. 364, p. 85-90 6 p.
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Optimal carbohydrate antigen 125 cutpoint for identifying low-risk patients after admission for acute heart failure
Núñez, J., Bayés-Genís, A., Revuelta-López, E., Miñana, G., Santas, E., ter Maaten, J. M., de la Espriella, R., Carratalá, A., Lorenzo, M., Palau, P., Llàcer, P., Valle, A., Bodí, V., Núñez, E., Lupón, J., Lang, C., Ng, L. L., Metra, M., Sanchis, J. & Voors, A. A. (Lead / Corresponding author), 1 Apr 2022, In: Revista Española de Cardiología. 75, 4, p. 316-324 9 p.
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Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure
Ceelen, D., Voors, A. A. (Lead / Corresponding author), Tromp, J., van Veldhuisen, D. J., Dickstein, K., de Boer, R. A., Lang, C. C., Anker, S. D., Ng, L. L., Metra, M., Ponikowski, P. & Figarska, S., Feb 2022, In: European Journal of Heart Failure. 24, 2, p. 308-320 13 p.
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Surrogate markers of gut dysfunction are related to heart failure severity and outcome – from the BIOSTAT-CHF consortium
Israr, M. Z., Zhan, H., Salzano, A., Voors, A. A., Cleland, J. G., Anker, S. D., Metra, M., van Veldhuisen, D. J., Lang, C. C., Zannad, F., Samani, N. J., Ng, L. L. & Suzuki, T. (Lead / Corresponding author), Jun 2022, In: American Heart Journal. 248, p. 108-119 12 p.
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Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure
Nath, M., Romaine, S. P., Koekemoer, A., Hamby, S., Webb, T. R., Nelson, C. P., Castellanos-Uribe, M., Papakonstantinou, M., Anker, S. D., Lang, C. C., Metra, M., Zannad, F., Filippatos, G., van Veldhuisen, D. J., Cleland, J. G., Ng, L. L., May, S. T., Marelli-Berg, F., Voors, A. A. & Timmons, J. A. & 1 others, Samani, N. J. (Lead / Corresponding author), 3 Jun 2022, In: European Journal of Heart Failure. 24, 6, p. 1009-1019 11 p.
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2021
Impact of mitral regurgitation in patients with worsening heart failure: Insights from BIOSTAT-CHF
Pagnesi, M. (Lead / Corresponding author), Adamo, M., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Ponikowski, P., Ravera, A., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Voors, A. A. & Metra, M. (Lead / Corresponding author), Oct 2021, In: European Journal of Heart Failure. 23, 10, p. 1750-1758 9 p.
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Impaired high-density lipoprotein function in patients with heart failure
Emmens, J. E., Jia, C., Ng, L. L., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., Lang, C. C., Cleland, J. G. F., Voors, A. A., de Boer, R. A. & Tietge, U. J. F. (Lead / Corresponding author), 4 May 2021, In: Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease (JAHA). 10, 9, 41 p., e019123.
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Non-adherence to heart failure medications predicts clinical outcomes: Assessment in a single spot urine sample by liquid chromatography - tandem mass spectrometry (results of a prospective multicentre study)
Gupta, P. (Lead / Corresponding author), Voors, A. A., Patel, P., Lane, D., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G., Lang, C. C., van Veldhuisen, D. J., Metra, M., Zannad, F., Samani, N. J., Jones, D. J. L., Squire, I. B. & Ng, L. L., Jul 2021, In: European Journal of Heart Failure. 23, 7, p. 1182-1190 9 p.
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Pathophysiological Pathways in Patients with Heart Failure and Atrial Fibrillation
Santema, B. T., Arita, V. A., Sama, I. E., Kloosterman, M., Van den Berge, M., Nienhuis, H. L. A., Van Gelder, I. C., Meer, P. V. D., Zannad, F. M., Metra, M., ter Maaten, J. M., Cleland, J. G. F., Ng, L. L., Anker, S. D., Lang, C. C., Samani, N. J., Dickstein, K., Filippatos, G. S., van Veldhuisen, D. J. & Lam, C. S. P. & 2 others, Rienstra, M. & Voors, A. A. (Lead / Corresponding author), 23 Oct 2021, In: Cardiovascular Research. 118, 11, p. 2478-2487 10 p.
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Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure
Kobayashi, M., Voors, A. A., Ouwerkerk, W., Duarte, K., Girerd, N., Rossignol, P., Metra, M., Lang, C. C., Ng, L. L., Filippatos, G., Dickstein, K., van Veldhuisen, D. J., Zannad, F. & Ferreira, J. P. (Lead / Corresponding author), Jun 2021, In: Clinical Cardiology. 44, 6, p. 780-788 9 p.
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Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy questionnaire and the EuroQol 5 dimensions questionnaire
Ravera, A., Santema, B. T., Sama, I. E., Meyer, S., Lombardi, C. M., Carubelli, V., Ferreira, J. P., Lang, C. C., Dickstein, K., Anker, S. D., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Teerlink, J. R., Metra, M. (Lead / Corresponding author) & Voors, A. A., Apr 2021, In: European Journal of Heart Failure. 23, 4, p. 567-577 11 p.
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Telomere length is independently associated with all-cause mortality in chronic heart failure
Romaine, S. P. R. (Lead / Corresponding author), Denniff, M., Codd, V., Nath, M., Koekemoer, A., Anker, S. D., Cleland, J. G., Filippatos, G., Levin, D., Metra, M., Mordi, I. R., Ouwerkerk, W., Ter Maaten, J. M., van Veldhuisen, D. J., Zannad, F., Ng, L. L., van der Harst, P., Lang, C. C., Voors, A. A. & Nelson, C. P. & 1 others, Samani, N. J., 22 Dec 2021, In: Heart. 108, 6 p., 318654.
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The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure
Pandhi, P., Streng, K. W., Anker, S. D., Cleland, J. G., Damman, K., Dickstein, K., Pellicori, P., Lang, C. C., Ng, L. L., Samani, N. J., Metra, M., Rossignol, P., Filippatos, G. S., van Veldhuisen, D. J., Voors, A. A. & ter Maaten, J. M. (Lead / Corresponding author), Jun 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12, 3, p. 555-567 13 p.
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2020
Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure
BIOSTAT consortium, Kobayashi, M., ter Maaten, J. M., Stienen, S., Voors, A. A., Duarte, K., Lamiral, Z., Girerd, N., Rossignol, P., Zannad, F. & Ferreira, J. P. (Lead / Corresponding author), 1 Jun 2020, In: ESC Heart Failure. 7, 3, p. 953-963 11 p.
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Clinical Role of CA125 in Worsening Heart Failure: A BIOSTAT-CHF Study Subanalysis
Núñez, J., Bayés-Genís, A., Revuelta-López, E., Ter Maaten, J. M., Miñana, G., Barallat, J., Cserkóová, A., Bodi, V., Fernández-Cisnal, A., Núñez, E., Sanchis, J., Lang, C., Ng, L. L., Metra, M. & Voors, A. A. (Lead / Corresponding author), May 2020, In: JACC: Heart Failure. 8, 5, p. 386-397 12 p.
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Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment
Nauta, J. F., Hummel, Y. M., Tromp, J., Ouwerkerk, W., van der Meer, P., Jin, X., Lam, C. S. P., Bax, J. J., Metra, M., Samani, N. J., Ponikowski, P., Dickstein, K., Anker, S. D., Lang, C., Ng, L. L., Zannad, F., Filippatos, G. S., van Veldhuisen, D. J., van Melle, J. P. & Voors, A. A. (Lead / Corresponding author), 17 Sept 2020, In: European Journal of Heart Failure. 22, 7, p. 1147-1155 9 p.
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Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study
Lombardi, C. M. (Lead / Corresponding author), Ferreira, J. P., Carubelli, V., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. & Metra, M., 1 Aug 2020, In: Clinical Research in Cardiology . 109, 8, p. 967-977 11 p.
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Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets
Cao, T. H. (Lead / Corresponding author), Jones, D. J. L., Voors, A. A., Quinn, P. A., Sandhu, J. K., Chan, D. C. S., Parry, H., Mohan, P., Mordi, I., Sama, I. E., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J. & Zannad, F. & 2 others, Lang, C. & Ng, L. L. (Lead / Corresponding author), Jan 2020, In: European Journal of Heart Failure. 22, 1, p. 70-80 11 p.
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Selenium and outcome in heart failure
Bomer, N. (Lead / Corresponding author), Grote Beverborg, N., Hoes, M. F., Streng, K. W., Vermeer, M., Dokter, M. M., IJmker, J., Anker, S. D., Cleland, J. G. F., Hillege, H. L., Lang, C. C., Ng, L. L., Samani, N. J., Tromp, J., van Veldhuisen, D. J., Touw, D. J., Voors, A. A. & van der Meer, P. (Lead / Corresponding author), 18 Sept 2020, In: European Journal of Heart Failure. 22, 8, p. 1415-1423 9 p.
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The Role of Cathepsin D in the Pathophysiology of Heart Failure and its Potentially Beneficial Properties: a translational approach
Hoes, M. F., Tromp, J., Ouwerkerk, W., Bomer, N., Oberdorf-Maas, S. U., Samani, N. J., Ng, L. L., Lang, C., van der Harst, P., Hillege, H. L., Anker, S. D., Metra, M., van Veldhuisen, D. J., Voors, A. A. & van der Meer, P. (Lead / Corresponding author), Nov 2020, In: European Journal of Heart Failure. 22, 11, p. 2102-2111 10 p.
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Aref#d: 21596. BIOSTAT-CHF: A Systems Biology Study to Tailored Treatment in Chronic Heart Failure

Research output

Search results

2024

2023

2022

2021

2020